400 articles

1er juillet

Kidney Int http://www.kidney-international.org/

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MRI findings of renal cortical hemosiderosis after cardiac valve surgery - Haijuan Lv, Hongwei Zhao Kidney Int

A 74-year-old female patient, at 9 years post mitral and tricuspid valve repairs with C-shaped annuloplasty rings, presented with proteinuria (2+) and anemia (Hb 97 g/l), and elevated lactate dehydrogenase levels at 845 U/L (reference range: 120–250 U/L), indicative of intravascular hemolysis. (…) (Kidney International 106, 1 (2024))
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Solitary kidney in a patient with Pallister-Hall syndrome - Ines Vanderheyden, Saskia Bulk, François Jouret Kidney Int

A 58-year-old female patient was referred for solitary kidney management. She was born following a full-term pregnancy, with a weight of 2.2 kg. Her medical history included the following: (i) “Y-shaped metacarpals” and postaxial polydactyly (15 fingers in toto) bilaterally operated (Figure 1); (…) (Kidney International 106, 1 (2024))
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Taking the amphoterism out of amphotericin: a wonder drug in the making - Andrew Beenken Kidney Int

Invasive fungal infections number up to 1,000,000 cases per year,1 and an increasing number exhibit multidrug resistance. Amphotericin B has been an important tool in fighting these infections ever since the 1950s when it was first isolated from the soil of the Orinoco basin in Venezuela.2 (…) (Kidney International 106, 1 (2024))
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Inflammasome activation: unraveling the link between chronic kidney disease and atrial fibrillation - Melis Sahinoz, T. Alp Ikizler Kidney Int

Atrial fibrillation (AF) is the most common cardiac arrhythmia, currently affecting ?60 million people worldwide, and it is associated with significant morbidity and mortality.1 Chronic kidney disease (CKD) is an independent risk factor for incident and prevalent AF, with a stepwise increase in (…) (Kidney International 106, 1 (2024))
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Corrigendum to “Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.” Kidney International 2023;103:115–133 - Jingyao Li, Xi’ang Sun, Ninghao Yang, Jiayun Ni, Hongyan Xie, Hengjiang Guo, Xin Wang, Li Zhou, Jun Liu, Sijia Chen, Xiaoxia Wang, Yingying Zhang, Chen Yu, Wei Zhang, Limin Lu Kidney Int

DOI of original article: https://doi.org/10.1016/j.kint.2022.08.022 (Kidney International 106, 1 (2024))
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Corrigendum to “Kidney involvement in Rosai-Dorfman disease.” Kidney International 2023;103:231–232 - Martina Mazzariol, Francesco Peyronel, Filippo Fagni, Andrea Minervini, Raffaella Santi, Simone Agostini, Augusto Vaglio Kidney Int

DOI of original article: 10.1016/j.kint.2022.09.005 (Kidney International 106, 1 (2024))
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Foscarnet-induced nephropathy in a kidney transplant recipient - Ian P. Rios, Christian H.L. Nguyen, Suman S. Misra, Margaret S. Ryan, Sumi S. Nair, Hasan A. Khamash Kidney Int

A 53-year-old man with type 2 diabetes–related kidney failure underwent cytomegalovirus (CMV)–mismatched (CMV positive to negative), deceased donor kidney transplant in July 2021. He was on a prophylactic dose of valganciclovir until September 2021 when he developed neutropenia, and (…) (Kidney International 106, 1 (2024))
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The Case | Rapid onset of severe hyponatremia after a dental procedure - Laura Scholz, Max Schuller, Michael Kolland, Philipp Eller, Alexander H. Kirsch Kidney Int

A 38-year-old woman presented at a peripheral hospital for progressive abdominal pain, nausea, and vomiting. Except for a 7-day course of antibiotic treatment following a dental procedure performed a few days before symptom onset, she had not been on any medication. Her medical history was not (…) (Kidney International 106, 1 (2024))
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Editorial Board Kidney Int

(Kidney International 106, 1 (2024))
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Erratum to “An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).” Kidney International 2023;105:1058–1076 - Zewu Zhu, Bryan Bo-Ran Ho, Alyssa Chen, James Amrhein, Andreea Apetrei, Thomas Oliver Carpenter, Marise Lazaretti-Castro, Juan Manuel Colazo, Kathryn McCrystal Dahir, Michaela Geßner, Evgenia Gurevich, Cathrine Alsaker Heier, Jill Hickman Simmons, Tracy Earl Hunley, Bernd Hoppe, Christina Jacobsen, Anne Kouri, Nina Ma, Sachin Majumdar, Arnaud Molin, Natalie Nokoff, Susan M. Ott, Helena Gil Peña, Fernando Santos, Peter Tebben, Lisa Swartz Topor, Yanhong Deng, Clemens Bergwitz Kidney Int

The publisher regrets that the definition of het-post (post-treatment levels of het carriers) was not included in the legends of Figure 3 and Supplementary Figure S3, and that descriptions of upper limit (%UL) and/or z-score were not included in the legends of Supplementary Figures S2–S4, S6, (…) (Kidney International 106, 1 (2024))
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Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? - Paulina X. Medina Rangel, Shuta Ishibe Kidney Int

Glomerular issues and affected podocytes are at the origin of 80% of chronic kidney disease cases. Thus, acquiring a deeper understanding in this domain is necessary to halt progressive kidney damage. In this study, the authors investigated the harmful impact of podocyte-cleaved soluble retinoic (…) (Kidney International 106, 1 (2024))
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Genomics in the kidney transplant clinic: the future standard of care? - Emilie Cornec-Le Gall, Andrew J. Mallett Kidney Int

New evidence indicates potential benefit of genomics to illuminate nonkidney monogenic morbidity and mortality risk among kidney transplant recipients. This might be of direct relevance to an equivalent proportion of patients to those who harbor a monogenic kidney disease. Further evidence and (…) (Kidney International 106, 1 (2024))
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journal club Kidney Int

Verma et al. (Ann Intern Med. 2024;177:467–475.) (Kidney International 106, 1 (2024))
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in this issue Kidney Int

Asowata and colleagues studied deceased donor transplant kidneys with impaired kidney function as a model of acute and chronic kidney injury using an integrated multi-omic approach. RNA sequencing demonstrated that T cell and macrophage tissue infiltration associated with changes in both donors’ (…) (Kidney International 106, 1 (2024))
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Factor XI inhibition in hemodialysis patients: the safer anticoagulation? - Eleni Stamellou, Heidi Noels, Jürgen Floege Kidney Int

Chronic hemodialysis patients exhibit an excessive cardiovascular risk and a marked increase in both thromboembolism and bleeding episodes. Factor XI inhibition may provide anticoagulation, with a low risk of bleeding, and several factor XI inhibitors, including fesomersen, an antisense (…) (Kidney International 106, 1 (2024))
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Table of Contents Kidney Int

(Kidney International 106, 1 (2024))
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Subscription Information Kidney Int

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AJKD https://www.ajkd.org/

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A Patient With Spontaneous Perinephric Hematoma: A Quiz - Prathap Kumar Simhadri, Deepak Chandramohan, Prabhat Singh, Rachana Marathi, Kyle Burton, Pradeep Vaitla AJKD

A 61-year-old white female patient with a history of hypertension and asthma with culture-negative L5-S1 lumbar diskitis was on intravenous cefepime, vancomycin, and minocycline for nearly 2 weeks when she presented with severe bilateral flank pain, hypotension, tachycardia, and severe anemia. (…) (American Journal of Kidney Diseases 84, 1 (2024))
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Editorial Board AJKD

(American Journal of Kidney Diseases 84, 1 (2024))
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Masthead AJKD

(American Journal of Kidney Diseases 84, 1 (2024))
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Table of Contents AJKD

(American Journal of Kidney Diseases 84, 1 (2024))

Lancet Diab Endocrinol https://www.thelancet.com/journals/landia/home

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[Correspondence] An integrated diabetes and mental health intervention for people with type 1 diabetes and severe disordered eating: a prospective proof-of-concept cohort study - Khalida Ismail, Diane Turner, Jennie Brown, Miranda Rosenthal, Salma Ayis, Nick Oliver, Yuk-Fun Liu, Amy Harrison, Chris Garrett, David Hopkins, Janet Treasure, Jonathan Valabhji, Stephen Thomas, Marietta Stadler Lancet Diab Endocrinol

Disordered eating is a phenomenon that affects approximately 30% of people with type 1 diabetes, and is characterised by omission of some amount of insulin secondary to fear of weight gain.1,2 Depending on the dose and type of insulin omitted, the subsequent persistent hyperglycaemia, polyuria, (…) (The Lancet Diabetes & Endocrinology 12, 7 (2024))

21 juin

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

12:51
ELM2?SANT Domain?Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human?Induced Pluripotent Stem Cells - Yu?An Lu, Jiacheng Sun , Lu Wang , Meimei Wang , Yalin Wu , Anteneh Getachew , Rachel C. Matthews , Hui Li , William Gao Peng , Jianyi Zhang , Rui Lu , and Yang Zhou 1 Department of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL 2 Department of Medicine, Division of Cardiovascular Disease, Heersink School of Medicine University of Alabama at Birmingham Birmingham AL 3 Department of Medicine, Division of Hematology/Oncology, Heersink School of Medicine University of Alabama at Birmingham Birmingham AL 4 O’Neal (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundELMSAN1 (ELM2?SANT domain?containing scaffolding protein 1) is a newly identified scaffolding protein of the MiDAC (mitotic deacetylase complex), playing a pivotal role in early embryonic development. Studies onElmsan1knockout (…) (Journal of the American Heart Association)
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Associations Between Life's Essential 8 and Insulin Resistance Among Nondiabetic Adults - Shuo Pang, Yue Wang , Shuaifeng Sun , Shen Wang , Fadong Li , Wenxin Zhao , and Xiaofan Wu 1 Department of Cardiology, Beijing Anzhen Hospital Capital Medical University Beijing China J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundInsulin resistance (IR) is closely linked to cardiometabolic diseases. Preventing and improving IR in nondiabetic populations is critically important. We aimed to investigate the relationship between Life's Essential 8 (LE8), (…) (Journal of the American Heart Association)
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Patterns of Gestational Hypertension or Preeclampsia Across 2 Pregnancies in Relationship to Chronic Hypertension Development: A Retrospective Cohort Study - Joseph Mussa, Elham Rahme , Mourad Dahhou , Meranda Nakhla , and Kaberi Dasgupta 1 Department of Medicine McGill University Montreal Quebec Canada 2 Centre for Outcomes Research and Evaluation (CORE) Research Institute of the McGill University Health Centre (RI?MUHC) Montreal Quebec Canada 3 Department of Pediatrics McGill University Montreal Quebec Canada J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundGestational hypertension (GHTN) and preeclampsia are established risk indicators for chronic hypertension. While recurrence is associated with a greater risk, it is unclear whether there are differences in risk when these (…) (Journal of the American Heart Association)
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Prevalence, Characteristics, and Impact on Prognosis of Aortic Stenosis in Patients With Cardiac Amyloidosis - Mohamed?Salah Annabi, Rasmus Carter?Storch , Amira Zaroui , Arnault Galat , Silvia Oghina , Mounira Kharoubi , Mélanie Bezard , Geneviève Derumeaux , Pascale Fanen , François Lemonnier , Elsa Poullot , Emmanuel Itti , Romain Gallet , Emmanuel Teiger , Philippe Pibarot , Thibaud Damy , and Marie?Annick Clavel 1 Institut Universitaire de Cardiologie et de Pneumologie Université Laval Québec Canada 2 Referral Center for Cardiac Amyloidosis, Mondor Amyloidosis Network, GRC Amyloid Research Institute and Cardiology Department APHP Henri Mondor Hospital Créteil France 3 INSERM Unit U955 Clinical (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundCardiac amyloidosis (CA) is frequently found in older patients with aortic stenosis (AS). However, the prevalence of AS among patients with CA is unknown. The objective was to study the prevalence and prognostic impact of AS (…) (Journal of the American Heart Association)
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Gender and Sex Differences in the Management, Intervention, and Outcomes of Patients With Severe Primary Mitral Regurgitation - Christina Waldron, Addiskidan Hundito , Markus Krane , Arnar Geirsson , and Makoto Mori 1 Division of Cardiac Surgery Yale University School of Medicine New Haven CT USA 2 Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich Technical University of Munich Munich Germany 3 Center for Outcomes Research and Evaluation Yale New Haven Hospital New Haven CT USA J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundGender? and sex?based disparities in mitral valve disease exist; however the factors associated with these differences are unknown. Identifying these differences is essential in devising mitigating strategies. We evaluated (…) (Journal of the American Heart Association)
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Short?Term Statin Treatment Reduces, and Long?Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy - Karima Ait?Aissa, Xutong Guo , Madelyn Klemmensen , Denise Juhr , Linette N. Leng , Olha M. Koval , and Isabella M. Grumbach 1 Abboud Cardiovascular Research Center, Department of Internal Medicine, Carver College of Medicine University of Iowa Iowa City IA USA 2 Department of Biomedical Sciences, College of Dental Medicine Lincoln Memorial University Knoxville TN USA 3 Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine University of Iowa Iowa City IA USA 4 Iowa City VA Healthcare System Iowa City IA USA J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundThe incidental use of statins during radiation therapy has been associated with a reduced long?term risk of developing atherosclerotic cardiovascular disease. We examined whether irradiation causes chronic vascular injury and (…) (Journal of the American Heart Association)
12:48
Advanced Heart Failure Characteristics and Outcomes in Women and Men - Naba Farooqui, Jill M. Killian , Jamie Smith , Margaret M. Redfield , and Shannon M. Dunlay 1 Department of Internal Medicine Mayo Clinic Rochester MN USA 2 Department of Quantitative Health Sciences Mayo Clinic Rochester MN USA 3 Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester MN USA 4 Department of Cardiovascular Medicine Mayo Clinic Rochester MN USA J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundThe epidemiology and pathophysiology of heart failure (HF) differ in women and men. Whether these differences extend to the subgroup of patients with advanced HF is not well defined.Methods and ResultsThis is a retrospective (…) (Journal of the American Heart Association)
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Temporal Trends in Clinical Characteristics and Outcomes for Peripartum Cardiomyopathy: The Nationwide Multicenter Registry Over 20 Years - Minjung Bak, Jong?Chan Youn , Dae?Hwan Bae , Ju?Hee Lee , Sunki Lee , Dong?Hyuk Cho , Jin?Oh Choi , and 1 Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea 2 Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Catholic Research Institute for Intractable Cardiovascular Disease, College of Medicine The Catholic University of Korea Seoul Republic of Korea 3 Division of Cardiology, Department of Internal Medicine, Chungbuk National (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundAlthough peripartum cardiomyopathy (PPCM) is a fatal disease affecting young patients and fetuses, little is known about its recent prognosis and risk factors. This study investigated temporal trends in clinical characteristics (…) (Journal of the American Heart Association)
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Prognostic Value of Serial Risk Stratification in Adult and Pediatric Pulmonary Arterial Hypertension: A Systematic Review - Chantal Lokhorst, Sjoukje van der Werf , Rolf M. F. Berger , and Johannes M. Douwes 1 Department of Pediatric Cardiology, Center for Congenital Heart Diseases, Beatrix Children’s Hospital University Medical Center Groningen, University of Groningen the Netherlands 2 Central Medical Library University Medical Center Groningen, University of Groningen the Netherlands J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundIn pulmonary arterial hypertension, it is recommended to base therapeutic decisions on risk stratification. This systematic review aims to report the prognostic value of serial risk stratification in adult and pediatric (…) (Journal of the American Heart Association)
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Validating a Curvature?Based Marker of Cervical Carotid Tortuosity for Risk Assessment in Heritable Aortopathies - Jin Vivian Lee, Anna L. Huguenard , Ralph G. Dacey , Alan C. Braverman , and Joshua W. Osbun 1 Department of Neurological Surgery Washington University School of Medicine St. Louis MO USA 2 Department of Biomedical Engineering Washington University in St. Louis St. Louis MO USA 3 Cardiovascular Division, Department of Medicine Washington University School of Medicine St. Louis MO USA J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundCervical arterial tortuosity is associated with adverse outcomes in Loeys?Dietz syndrome and other heritable aortopathies.Methods and ResultsA method to assess tortuosity based on curvature of the vessel centerline in (…) (Journal of the American Heart Association)
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Circulating Sphingolipids and All?Cause Mortality: The Strong Heart Family Study - Amanda M. Fretts, Paul N. Jensen , Colleen M. Sitlani , Andy Hoofnagle , Benjamin Lidgard , Jason G. Umans , David S. Siscovick , Irena B. King , Barbara V. Howard , Shelley A. Cole , and Rozenn N. Lemaitre 1 Department of Epidemiology University of Washington Seattle WA USA 2 Cardiovascular Health Research Unit University of Washington Seattle WA USA 3 Department of Medicine University of Washington Seattle WA USA 4 Department of Laboratory Medicine University of Washington Seattle WA USA 5 Department of Nephrology University of Washington Seattle Washington USA 6 MedStar Health Research (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundA growing body of research indicates that associations of ceramides and sphingomyelins with mortality depend on the chain length of the fatty acid acylated to the backbone sphingoid base. We examined associations of 8 ceramide (…) (Journal of the American Heart Association)
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Clinical Trial Exclusion Criteria Affect Trial Inclusivity by Race and Sex - Robert J. Stanton, Yasmin N. Aziz , Heidi Sucharew , Mary Haverbusch , David J. Robinson , Elisheva Coleman , Felipe De Los Rios La Rosa , Stacie Demel , Simona Ferioli , Jason Mackey , Adam Jasne , Tracy E. Madsen , Eva Mistry , Sabreena Slavin , Michael Star , Kyle Walsh , Daniel Woo , Pooja Khatri , Joseph Broderick , Brett Kissela , and Dawn O. Kleindorfer 1 Department of Neurology and Rehabilitation Medicine University of Cincinnati Cincinnati OH 2 Department of Emergency Medicine University of Cincinnati Cincinnati OH 3 Department of Neurology University of Chicago Chicago IL 4 Miami (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
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Aptamer Proteomics for Biomarker Discovery in Heart Failure With Preserved Ejection Fraction: The PARAGON?HF Proteomic Substudy - Natasha L. Patel?Murray, Luqing Zhang , Brian L. Claggett , Dongchu Xu , Pablo Serrano?Fernandez , Margaret Healey , Simon Wandel , Chien?Wei Chen , Jaison Jacob , Huilei Xu , Gordon M. Turner , William Chutkow , Denise P. Yates , Christopher J. O'Donnell , Margaret F. Prescott , Martin Lefkowitz , Claudio R. Gimpelewicz , Michael T. Beste , Faye Zhao , Liangke Gou , Akshay S. Desai , Pardeep S. Jhund , Milton Packer , Marc A. Pfeffer , Margaret M. Redfield , Jean L. Rouleau , Faiez Zannad , Michael R. Zile , John J. V. McMurray , Michael M. Mendelson , Scott D. Solomon , and Jonathan W. (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundPrognostic markers and biological pathways linked to detrimental clinical outcomes in heart failure with preserved ejection fraction (HFpEF) remain incompletely defined.Methods and ResultsWe measured serum levels of 4123 unique (…) (Journal of the American Heart Association)
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Diagnostic Performance of Coronary Angiography Derived Computational Fractional Flow Reserve - Madhurima Vardhan, Cyrus Tanade , S. James Chen , Owais Mahmood , Jaidip Chakravartti , W. Schuyler Jones , Andrew M. Kahn , Sreekanth Vemulapalli , Manesh Patel , Jane A. Leopold , and Amanda Randles 1 Department of Biomedical Duke University Durham NC USA 2 Department of Medicine University of Colorado Aurora CO USA 3 Department of Medicine Duke University Durham NC USA 4 Division of Cardiovascular Medicine University of California San Diego La Jolla CA USA 5 Division of Cardiovascular Medicine Brigham and Women’s Hospital Boston MA USA J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundComputational fluid dynamics can compute fractional flow reserve (FFR) accurately. However, existing models are limited by either the intravascular hemodynamic phenomarkers that can be captured or the fidelity of geometries (…) (Journal of the American Heart Association)
12:45
Correction to: Imbalance of Iron Availability and Demand in Patients With Acute and Chronic Heart Failure J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

16:43
Antihypertensive effect of esaxerenone and correlation between brachial and wrist home monitoring devices in patients with nocturnal hypertension: A post hoc analysis of the EARLY?NH study - Kazuomi Kario, Kazuhito Shiosakai, Takashi Taguchi J Clin Hypertens

The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
16:29
The association of dietary indices for hyperinsulinemia and insulin resistance with the risk of metabolic syndrome: a population?based cross?sectional study - Najmeh Seifi, Hossein Bahari, Elaheh Foroumandi, Elahe Hasanpour, Mahya Nikoumanesh, Gordon A. Ferns, Habibollah Esmaily, Majid Ghayour?Mobarhan J Clin Hypertens

The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Kidney Int Reports http://www.kireports.org/

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Prevalence of Mendelian kidney disease among patients with high-risk APOL1 genotypes undergoing commercial genetic testing in the United States - Ronaldo da Silva Francisco, Sumit Punj, Lisa Vincent, Nina Sanapareddy, Vivek Bhalla, Glenn M. Chertow, Dianne Keen-Kim, Vivek Charu Kidney Int Reports

Among individuals with high-risk APOL1 genotypes, the lifetime risk of developing kidney failure is ?15%, indicating that other genetic variants or non-genetic modifiers likely contribute substantially to an individual patient’s risk of progressive kidney disease. Here we estimate the prevalence (…) (Kidney International Reports (2024))

AJKD https://www.ajkd.org/

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Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank - Rui Tang, Ying Hu, Jian Zhou, Xuan Wang, Xiang Li, Yoriko Heianza, Lu Qi AJKD

While smoking is a recognized risk factor for chronic kidney disease (CKD), the relationship between the time smoking is initiated after awakening each day and CKD remains largely unstudied. This study examined the association between this timing and the risk of CKD, and the potential (…) (American Journal of Kidney Diseases (2024))

Kidney Int Reports http://www.kireports.org/

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Major Bleeding Rates in an International Cohort of Patients with End-Stage Kidney Disease - Catelyn R. Coyle, Lori D. Bash, Dena Rosen Ramey, G. Brandon Atkins, Irina Barash, Murilo Guedes, Roberto Pecoits-Filho, Calvin Andrews, Angelo Karaboyas, Marc Bonaca Kidney Int Reports

An estimated 2.5 million patients worldwide were being treated for end-stage kidney disease (ESKD) as of 2016.1 The vast majority of patients with ESKD are treated with hemodialysis (HD ?89%) and peritoneal dialysis (PD), however patterns of HD and PD vary internationally.2 Patients with ESKD on (…) (Kidney International Reports (2024))
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The importance of CNV analysis in patients with monogenic kidney disease - Laura R. Claus, Robert F. Ernst, Martin G. Elferink, Hanneke W.M. van Deutekom, Bert van der Zwaag, Albertien M. van Eerde Kidney Int Reports

Genetic testing can reveal monogenic causes of kidney diseases, offering diagnostic, therapeutic, and prognostic benefits. While single nucleotide variants (SNVs) and copy number variants (CNVs) can result in kidney disease, CNV analysis is not always included in genetic testing. (Kidney International Reports (2024))
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Response to “Impact of Prolonged SARS-CoV-2 Dosing Interval in Hemodialysis Patients” - Jathurong Kittrakulrat, Natavudh Townamchai, Jakapat Vanichanan Kidney Int Reports

We read the study submitted by Lamarche et al., which emphasized an impact of a shortened interval between COVID-19 vaccination doses on seroconversion rate among hemodialysis patients. (Kidney International Reports (2024))

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

07:43
Inter?observer reliability and anatomical landmarks for arm circumference to determine cuff size for blood pressure measurement - Bonaventure Oguaju, Darren Lau, Raj Padwal, Jennifer Ringrose J Clin Hypertens

The Journal of Clinical Hypertension, EarlyView. -- SHORT RESEARCH ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

20 juin

Circulation http://ahajournals.org/

11:00
CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association - Naveen L. Pereira Sharon Cresci Dominick J. Angiolillo Wayne Batchelor Quinn Capers Larisa H. Cavallari Dana Leifer Jasmine A. Luzum Dan M. Roden Konstantinos Stellos Stephanie L. Turrise Sony Tuteja Circulation

Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke. Clopidogrel, a prodrug, is the most used oral P2Y12 (…) (Circulation)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

13:59
Physician Transfer Versus Patient Transfer for Mechanical Thrombectomy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta?Analysis - Adnan I. Qureshi, Abdullah Lodhi , Hamza Maqsood , Xiaoyu Ma , Gordian J. Hubery , Camilo R. Gomez , Chun S. Kwok , Daniel E. Ford , Daniel F. Hanley , David R. Mehr , Qaisar A. Shah , and M. Fareed K. Suri 1 Zeenat Qureshi Stroke Institutes St Cloud MN USA 2 Department of Neurology University of Missouri Columbia MO USA 3 Department of Neurology, TEMPiS Telestroke Center München Klinik gGmbH Munich Germany 4 Department of Cardiology, Queen Elizabeth Hospital Birmingham University Hospitals of Birmingham NHS Trust Stoke?on?Trent UK 5 Department of Medicine Johns Hopkins University (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. BackgroundPhysician transfer is an alternate option to patient transfer for expedient performance of mechanical thrombectomy in patients with acute ischemic stroke.Methods and ResultsWe conducted a systematic review to identify studies (…) (Journal of the American Heart Association)

Diabetes https://diabetes.diabetesjournals.org

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Lipodystrophy Prevalence, “Lipodystrophy-Like Phenotypes,” and Diagnostic Challenges Diabetes

Familial partial lipodystrophy (FPLD) is a rare heterogeneous disease (1). By using a DEXA-derived fat mass ratio (FMR) (percent trunk fat divided by percent leg fat) with a cutoff (>1.2 in females and >1.7 in males), Agrawal et al. (2) identified “lipodystrophy-like phenotypes” in approximately (…)
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AKR1A1 and Kidney Disease: Promise and Perils of the Multiverse Diabetes

Janssen R&D LLCJohnson and Johnson Pharmaceutical Research and Development10.13039/100014489
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Response to Comment on Hu et al. Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy. Diabetes 2022;71:762–773 Diabetes

National Natural Science Foundation of China10.13039/501100001809819708218220123982271100National Key Research and Development Program of China10.13039/5011000121662017YFA01041002017YFA0104103
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Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al. Diabetes

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein–coupled receptor involved in the regulation of blood glucose levels and food intake. Stabilized agonists targeting GLP-1R are used in the treatment of type 2 diabetes and have recently become a breakthrough obesity therapy. (…)
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The Whole Human Pancreas: An Understudied Organ in Diabetes Diabetes

Type 1 and type 2 diabetes both cause life-changing morbidity and earlier mortality, with effects on the individual, their family, and wider society. Working lives are affected, with knock-on effects for the wider economy. Many questions remain about the etiology of both types of diabetes and (…)
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Issues and Events Diabetes
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Comment on Hu et al. Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy. Diabetes 2022;71:762–773 Diabetes

We are writing this letter to discuss the article by Hu et al. (1), which reported that retinal microglia are involved in fibrosis in fibrovascular membranes of proliferative diabetic retinopathy. Unfortunately, when we reanalyzed the online reposited data (GSE165784), we were unable to (…)

AJKD https://www.ajkd.org/

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A Close Look at Metabolic Dysfunction in Autosomal Dominant Polycystic Kidney Disease: From Bench to Imaging - Sol Carriazo, York Pei AJKD

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease, affecting up to 12 million people worldwide.1 Mutations in 2 major genes, PKD1 and PKD2, account for 70%-85% and 15%-30% of genetically resolved cases, respectively.2 Currently, algorithms employing (…) (American Journal of Kidney Diseases (2024))
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The Ties That Bind - Antonio Yaghy AJKD

Thrice weekly pilgrimage, (American Journal of Kidney Diseases (2024))
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Clinicopathologic Characteristics of Crystalglobulin-Induced Nephropathy: A Case Series - Samih H. Nasr, Satoru Kudose, Anthony M. Valeri, Ali Kashkouli, Samar M. Said, Dominick Santoriello, Glen S. Markowitz, Lihong Bu, Lynn D. Cornell, Adel Samad, Jahangir Ahmed, Sanjeev Sethi, Nelson Leung, Vivette D. D’Agati AJKD

Crystalglobulinemia is a rare syndrome characterized by intravascular crystallization of monoclonal immunoglobulins (MIgs). Data on kidney involvement are limited to case reports. This series characterizes the clinicopathologic spectrum of crystalglobulin-induced nephropathy (CIN). (American Journal of Kidney Diseases (2024))
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Transfers From In-Center Hemodialysis to Peritoneal Dialysis: Better Late Than Never? - Ankur D. Shah, Jeffrey Perl AJKD

Peritoneal dialysis (PD) remains an underutilized dialysis modality despite its many advantages compared to in-center hemodialysis (ICHD), including greater convenience and quality of life, relative preservation of residual kidney function (RKF), and improved early patient survival.1 The (…) (American Journal of Kidney Diseases (2024))

Am J Kidney Dis https://www.ajkd.org/

17:39
Real-World Effectiveness of Preventive Pharmacological Therapy in Patients With Urolithiasis: A Retrospective Cohort Study Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 83-93.e1 | Hollingsworth, John M.; Oerline, Mary K.; Hsi, Ryan S.;...Rationale & ObjectiveData supporting the efficacy of preventive pharmacological therapy (PPT) to reduce urolithiasis recurrence are based on clinical (…)
17:39
Enhancing Kidney Transplantation and the Role of Xenografts: Report of a Scientific Workshop Sponsored by the National Kidney Foundation Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 94-101 | Adams, Andrew B.; Blumberg, Emily A.; Gill, John S.;...Chronic kidney disease affects an estimated 37 million people in the United States; of these, >800,000 have end-stage renal disease requiring chronic dialysis (…)
17:39
Addressing Housing Issues Among People With Kidney Disease: Importance, Challenges, and Recommendations Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 111-119 | Novick, Tessa K.; King, BenKidney disease disproportionately impacts people with low socioeconomic status, and low socioeconomic status is associated with worse outcomes for people with kidney disease. Unstable (…)
17:39
Human Factors Contributing to Infection Prevention in Outpatient Hemodialysis Centers: A Mixed Methods Study Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 18-27 | Parker, Sarah Henrickson; Jesso, Matthew N.; Wolf, Laurie D.;...Rationale & ObjectiveInfection prevention efforts in dialysis centers can avert patient morbidity and mortality but are challenging to implement. The (…)
17:39
APOL1 Nephropathy Risk Variants Through the Life Course: A Review Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 102-110 | Itoku, Ai; Isaac, Jaya; Wilson, Scott;...Two variant alleles of the gene apolipoprotein L1 ( APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The (…)
17:39
Monoclonal Immunoglobulin Crystalline Membranous Nephropathy Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 120-125 | Mignano, Salvatore E.; Pascal, Virginie; Odioemene, Nnaemezie E.;...Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as intracellular or (…)
17:39
Association of Kidney Cysts With Progressive CKD After Radical Nephrectomy Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 62-72.e1 | Sabov, Moldovan; Denic, Aleksandar; Mullan, Aidan F.;...Rationale & ObjectiveSimple kidney cysts, which are common and usually considered of limited clinical relevance, are associated with older age and lower (…)
17:39
Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 49-61.e1 | Wulczyn, Kendra E.; Shafi, Tariq; Anderson, Amanda;...Rationale & ObjectiveThe toxins that contribute to uremic symptoms in patients with chronic kidney disease (CKD) are unknown. We sought to apply complementary (…)
17:39
Considering His Advanced Age Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages A17-A18 | Mesagna, LorraineIt is a balmy September afternoon, and upon entering my parents’ house, I find my father and mother, along with my older brother, huddled around a tablet computer at the kitchen table in the midst (…)
17:39
Urine Albumin-Creatinine Ratio Variability in People With Type 2 Diabetes: Clinical and Research Implications Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 8-17.e1 | Rasaratnam, Natasha; Salim, Agus; Blackberry, Irene;...Rationale & ObjectiveEvidence has demonstrated that albuminuria is a key diagnostic and prognostic marker of diabetic chronic kidney disease, but the impact (…)
17:39
Diabetes Insipidus in Deceased Donors and Outcomes in Kidney Transplant Recipients Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 129-132 | Nunez, Miguel, MD; Gardner, James, MD, PhD; Syed, Shareef, MBChB, MRCS;...Adjusted and Unadjusted Risk by Whether or Not KDPI Was Reclassified Using Peak Versus Terminal Creatinine for the Composite Outcome of (…)
17:39
Potentially Inappropriately Prescribed Medication Prescriptions Among Medicare Patients Receiving Hemodialysis Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 132-134 | Silva Almodóvar, Armando, PharmD, MPH; Donneyong, Macarius, MPH, PhD; Seiber, Eric, PhD;...List of Potentially Inappropriately Prescribed Medications With Exposure to At Least 0.5% of Patients Start of (…)
17:39
Chronic Hyponatremia and Brain Structure and Function Before and After Treatment Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 38-48.e1 | Suárez, Victor; Picotin, Rosanne; Fassbender, Ronja;...Rationale & ObjectiveHyponatremia is the most common electrolyte disorder and is associated with significant morbidity and mortality. This study investigated (…)
17:39
Changes in Cognitive Function After Kidney Transplantation: A Longitudinal Cohort Study Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 28-37.e1 | Gupta, Aditi; Mahnken, Jonathan D.; Bernal, Joshua;...Rationale & ObjectiveKidney disease negatively affects cognition. We assessed the effect of kidney transplantation (KT) on different cognitive domains. Study (…)
17:39
Designing an Implementable Clinical Prediction Model for Near-Term Mortality and Long-Term Survival in Patients on Maintenance Hemodialysis Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 73-82 | Goldstein, Benjamin A.; Xu, Chun; Wilson, Jonathan;...Rationale & ObjectiveThe life expectancy of patients treated with maintenance hemodialysis (MHD) is heterogeneous. Knowledge of life-expectancy may focus care (…)
17:39
The Impact of Kidney Transplantation on a Breadth of Cognitive Measures Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 6-7 | Ghildayal, Nidhi; Segev, Dorry L.; McAdams-DeMarco, MaraRelated Article, p. 28 Cognitive impairment is pervasive among kidney failure patients, reducing the chance of listing for kidney transplant (KT) , and (…)
17:39
A Patient With Spontaneous Perinephric Hematoma: A Quiz Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages A19-A21 | Simhadri, Prathap Kumar; Chandramohan, Deepak; Singh, Prabhat;...Panels A and B show the axial images of bilateral renal angiograms, which show multiple aneurysms of intrarenal arteries bilaterally. Some of those (…)
17:39
Table of Contents Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages A13-A16(no summary available)
17:39
Imprecise, Measure it Twice? Dealing With the Biological Variability of Albuminuria in Diabetes Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 1-3 | Claudel, Sophie E.; Waikar, Sushrut S.Related Article, p. 8 “Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the (…)
17:39
EKFC Versus CKD-EPI Equation in Young Adults? No Definitive Answer Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 126-126 | Delanaye, Pierre, MD, PhD; Pottel, Hans, PhDAs main developers of the European Kidney Function Consortium (EKFC) creatinine-based equation, we are puzzled by the results of the EKFC equation in comparison to the (…)
17:39
“Atypical” Anti-GBM Disease: Just Atypical, or Not Anti-GBM Disease at All? Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 127-129 | Ivkovi?, Vanja, MD, PhD; Kronbichler, Andreas, MD, PhD; Caza, Tiffany N., MD, PhDTwo large cohorts , of patients with “atypical” anti–glomerular basement membrane (GBM) disease shared heterogeneous clinical (…)
17:39
Reducing Infections in Outpatient Hemodialysis: The Impact of Human Factors Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 4-5 | Silberzweig, Jeffrey I.Related Article, p. 18 Improving the quality of care delivered to patients receiving maintenance dialysis and reducing their cost of care are central focuses for patients, providers, and payers. (…)
17:39
Masthead Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages A3-A3(no summary available)
17:39
Editorial Board Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages A5-A7(no summary available)
17:39
In Reply to “‘Atypical’ Anti-GBM Disease: Just Atypical, or Not Anti-GBM Disease at All?” Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 129-129 | Chauveau, Bertrand, MD; Gibier, Jean-Baptiste, MD, PhD; Rabant, Marion, MD, PhDWe read the Letter to the Editor by Ivkovi? et al, in response to our article, with interest and thank the authors for emphasizing (…)
17:39
In Reply to “EKFC Versus CKD-EPI Equation in Young Adults? No Definitive Answer” Am J Kidney Dis

American Journal of Kidney Diseases, Volume 84, Issue 1, 2024 Jul, Pages 126-127 | Inker, Lesley A., MD, MS; Adingwupu, Ogechi M., MD, MPH; Levey, Andrew S., MDWe agree with our European Kidney Function Consortium (EKFC) colleagues regarding the importance of the differing performance between (…)

Kidney Int Reports http://www.kireports.org/

00:00
Global aHUS Registry Analysis of Patients Switching to Ravulizumab from Eculizumab - Franz Schaefer, Imad Al-Dakkak, Katerina Anokhina, David Cohen, Larry A. Greenbaum, Gema Ariceta Kidney Int Reports

Atypical hemolytic uremic syndrome (aHUS) is a progressive rare disease that, if untreated, can result in severe organ damage and death. Ravulizumab, a next-generation terminal complement inhibitor, provides immediate, complete, and sustained complement C5 inhibition. Real-world data in patients (…) (Kidney International Reports (2024))
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Phase 1b/2a Study Assessing the Safety and Efficacy of Felzartamab in Anti–Phospholipase A2 Receptor Autoantibody-Positive Primary Membranous Nephropathy - Brad H. Rovin, Pierre M. Ronco, Jack F.M. Wetzels, Sharon G. Adler, Isabelle Ayoub, Philippe Zaoui, Seung Hyeok Han, Jaideep S. Dudani, Houston N. Gilbert, Uptal D. Patel, Paul T. Manser, Julia Jauch-Lembach, Nicola Faulhaber, Rainer Boxhammer, Stefan Ha¨rtle, Ben Sprangers Kidney Int Reports

Primary membranous nephropathy (PMN) is most often caused by autoantibodies to phospholipase A2 receptor (PLA2R). M-PLACE (NCT04145440) is an open-label, phase 1b/2a study that assessed the safety and efficacy of the fully human anti-CD38 monoclonal antibody felzartamab in high-risk anti-PLA2R+ PMN. (Kidney International Reports (2024))
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APOL1 high-risk genotype is not associated with new or worsening of proteinuria or kidney function decline following COVID-19 vaccination - Sarah E. Nystrom, Karen L. Soldano, Micki Rockett, Somenath Datta, Guojie Li, Daniel Silas, Melanie E. Garrett, Allison E. Ashley-Koch, Opeyemi A. Olabisi Kidney Int Reports

SARS-CoV-2 infection increases systemic inflammatory cytokines which act as a second-hit driver of APOL1-mediated collapsing glomerulopathy. SARS-CoV-2 vaccination also increases cytokines. Recent reports of new glomerular disease in individuals with APOL1 high-risk genotype (HRG) following (…) (Kidney International Reports (2024))

AJKD https://www.ajkd.org/

00:00
Clinical Characteristics and Prognosis of Genetic Focal Segment Glomerulosclerosis - Xu Hao, Shuwen Yu, Qinjie Weng, Zhengying Fang, Qimin Zheng, Yafei Zhao, Jian Liu, Jun Ma, Chunli Zhang, Yunzi Liu, Junru Li, Mingxin Yang, Hong Ren, Jingyuan Xie AJKD

Focal segmental glomerulosclerosis (FSGS) is a pathological lesion characterized by focal segmental sclerosis with foot-process effacement. The etiology of FSGS is complex, with clinical manifestations ranging from varying degrees of proteinuria to progressive kidney failure [1, 2]. According to (…) (American Journal of Kidney Diseases (2024))

J Human Hypertens http://www.nature.com/jhh/

00:00
Impact of COVID-19 on the management of hypertension: a perspective on disease severity, service use patterns and expenditures from Ghana’s health insurance claims data - Ama Pokuaa Fenny, Evans Otieku, Samuel Owusu Achiaw, Bernard Okoe Boye, Francis Asenso-Boadi, Vivian Addo-Cobbiah, Mariam Musah J Human Hypertens

Journal of Human Hypertension, Published online: 20 June 2024; doi:10.1038/s41371-024-00924-3Impact of COVID-19 on the management of hypertension: a perspective on disease severity, service use patterns and expenditures from Ghana’s health insurance claims data (Journal of Human Hypertension, Published online: 2024-06-20; | doi:10.1038/s41371-024-00924-3)

19 juin

Kidney Int Reports http://www.kireports.org/

00:00
Pilot study of a web-based tool for real-time adequacy assessment of kidney biopsies - Meysam Ahangaran, Emily Sun, Khang Le, Jiawei Sun, William M. Wang, Tian Herng Tan, Lingkai Yin, Lyle J. Burdine, Zeijko Dvanajscak, Clarissa A. Cassol, Shree Sharma, Vijaya B. Kolachalama Kidney Int Reports

Kidney biopsies are essential for diagnosing kidney disorders in both native and transplanted kidneys1,2. However, the increasing incidence of biopsies yielding insufficient tissue for diagnosis presents a dual challenge: it strains the healthcare system and endangers patients, who may require (…) (Kidney International Reports (2024))

Circulation http://ahajournals.org/

11:00
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL - Yi Wang Guo-Chong Chen Zheng Wang Kai Luo Yanbo Zhang Yang Li Amanda C. McClain Marta M. Jankowska Krista M. Perreira Josiemer Mattei Carmen R. Isasi Maria M. Llabre Bharat Thyagarajan Martha L. Daviglus Linda Van Horn David Goldsztajn Farelo Luis E. Maldonado Steven R. Levine Bing Yu Eric Boerwinkle Rob Knight Robert D. Burk Robert C. Kaplan Qibin Qi Brandilyn A. Peters Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.). Department of Nutrition and Food Hygiene, (…) Circulation

Circulation, Ahead of Print. BACKGROUND:Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US (…) (Circulation)
11:00
Childhood Opportunity and Acute Interstage Outcomes: A National Pediatric Cardiology Quality Improvement Collaborative Analysis - Benjamin Zielonka Emily M. Bucholz Minmin Lu Katherine E. Bates Garick D. Hill Nelangi M. Pinto Lynn A. Sleeper David W. Brown Department of Cardiology, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, MA (B.Z., M.L., L.A.S., D.W.B.). Children’s Hospital Colorado, University of Colorado, Denver (E.M.B.). C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (K.E.B.). Cincinnati Children’s Hospital Medical Center, OH (G.D.H.). Seattle Children’s Hospital, University of Washington, WA (N.M.P.). Circulation

Circulation, Ahead of Print. BACKGROUND:The interstage period after discharge from stage 1 palliation carries high morbidity and mortality. The impact of social determinants of health on interstage outcomes is not well characterized. We assessed the relationship between childhood opportunity and (…) (Circulation)

Hypertension https://www.ahajournals.org/

11:00
Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study - Sven Geurts Martijn J. Tilly Zuolin Lu Bruno H.C. Stricker Jaap W. Deckers Natasja M.S. de Groot Clint L. Miller M. Arfan Ikram Maryam Kavousi Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands. (S.G., M.J.T., Z.L., B.H.C.S., J.W.D., M.A.I., M.K.) Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands. (N.M.S.G.) Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville (C.L.M.). Hypertension

Hypertension, Ahead of Print. BACKGROUND:We investigated the potential impact of antihypertensive drugs for atrial fibrillation (AF) prevention through a drug target Mendelian randomization study to avoid the potential limitations of clinical studies.METHODS:Validated published single-nucleotide (…) (Hypertension)

AJKD https://www.ajkd.org/

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Chronic Tonsillitis and IgA Nephropathy: Findings From a Nationwide Japanese Cohort Study - Takashin Nakayama, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Hiroyuki Morita, Katsuhito Fujiu, Norifumi Takeda, Akira Fukui, Takashi Yokoo, Norihiko Takeda, Hideo Yasunaga, Masaomi Nangaku, Kaori Hayashi AJKD

Little is known regarding the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN). In the present study, we examined the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN. (American Journal of Kidney Diseases (2024))
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Efficacy and Safety of Allopurinol and Febuxostat in Patients With Gout and CKD: Subgroup Analysis of the STOP Gout Trial - Lindsay N. Helget, Anne Davis-Karim, James R. O’Dell, Ted R. Mikuls, Jeff A. Newcomb, Maria Androsenko, Mary T. Brophy, Bryant R. England, Ryan Ferguson, Michael H. Pillinger, Tuhina Neogi, Hongsheng Wu, Paul M. Palevsky AJKD

We conducted a prespecified examination of the efficacy and safety of allopurinol and febuxostat administered using a treat-to-target strategy in trial participants with chronic kidney disease (CKD). (American Journal of Kidney Diseases (2024))

Kidney Int Reports http://www.kireports.org/

00:00
Certain Red Yeast Rice Supplements in Japan Cause Acute Tubulointerstitial Injury - Yusuke Murata, Seiichiro Hemmi, Yurie Akiya, Kota Miyasato, Hiroki Kobayashi, Takashi Maruyama, Masanori Abe Kidney Int Reports

Historically, red yeast rice (Red koji) has been a cornerstone in the culinary and medicinal traditions of East Asia, contributing to the production of alcoholic beverages, fermented foods, and, notably, tofuyo—a fermented tofu delicacy originating from Okinawa, Japan, since the eighteenth (…) (Kidney International Reports (2024))

AJKD https://www.ajkd.org/

00:00
Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications - Devika Nair, Christine K. Liu, Rasha Raslan, Mara McAdams-DeMarco, Rasheeda K. Hall AJKD

Frailty is a multi-system syndrome of decreased physiologic reserve that has been shown to strongly and independently predict morbidity and mortality. Frailty is prevalent in patients living with kidney disease and occurs earlier in individuals with kidney disease as compared to the general (…) (American Journal of Kidney Diseases (2024))

Nature Reviews Nephrology http://www.nature.com/ncpneph/

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Natural killer cell-mediated innate microvascular rejection - Olivier Thaunat Nature Reviews Nephrology

Nature Reviews Nephrology, Published online: 19 June 2024; doi:10.1038/s41581-024-00862-wGraft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with innate immunity having a secondary role. The finding that recipient natural killer cells (…) (Nature Reviews Nephrology, Published online: 2024-06-19; | doi:10.1038/s41581-024-00862-w)

J Human Hypertens http://www.nature.com/jhh/

00:00
Variable effect of the post-partum menstrual cycle on aldosterone and renin in women with recent preeclampsia - Gregory P. Veldhuizen, Rawan M. Alnazer, Abraham A. Kroon, Marc E. A. Spaanderman, Peter W. de Leeuw J Human Hypertens

Journal of Human Hypertension, Published online: 19 June 2024; doi:10.1038/s41371-024-00926-1Variable effect of the post-partum menstrual cycle on aldosterone and renin in women with recent preeclampsia (Journal of Human Hypertension, Published online: 2024-06-19; | doi:10.1038/s41371-024-00926-1)

18 juin

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

14:59
Deciphering Abdominal Aortic Diseases Through T?Cell Clonal Repertoire of Perivascular Adipose Tissue - Luca Piacentini, Chiara Vavassori , Pablo J. Werba , Claudio Saccu , Rita Spirito , and Gualtiero I. Colombo 1 Bioinformatics and Artificial Intelligence Unit, Centro Cardiologico Monzino IRCCS Milan Italy 2 Immunology and Functional Genomics Unit, Centro Cardiologico Monzino IRCCS Milan Italy 3 Atherosclerosis Prevention Unit, Centro Cardiologico Monzino IRCCS Milan Italy 4 Department of Cardiovascular Surgery of the University of Milan, Centro Cardiologico Monzino IRCCS Milan Italy J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundRecent studies suggest that immune?mediated inflammation of perivascular adipose tissue of abdominal aortic aneurysms (AAAs) contributes to disease development and progression. Whether the perivascular (…) (Journal of the American Heart Association)

Hypertension https://www.ahajournals.org/

11:00
Centennial Collection: From Treating Hypertension to Lowering Cardiovascular Disease Risk - Cian P. McCarthy Rod Jackson John W. McEvoy Kazem Rahimi Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston (C.P.M.). Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, New Zealand (R.J.). Cardiology Department, University of Galway School of Medicine and National Institute for Prevention and Cardiovascular Health, Ireland (J.W.M.). Deep Medicine, Nuffield Department of Reproductive and Women’s Health, University of Oxford, United Kingdom (K.R.). Hypertension

Hypertension, Ahead of Print. (Hypertension)
11:00
Impact of Social Determinants of Health on Hypertension Outcomes: A Systematic Review - Faith E. Metlock Thomas Hinneh Chitchanok Benjasirisan Abeer Alharthi Oluwabunmi Ogungbe Ruth-Alma N. Turkson-Ocran Cheryl R. Himmelfarb Yvonne Commodore-Mensah Johns Hopkins School of Nursing, Baltimore, MD (T.H., C.B., O.O., C.R.H., Y.C.-M.). Johns Hopkins School of Medicine, Baltimore, MD (O.O., C.R.H.). Department of Medicine, Research Section, Beth Israel Deaconess Medical Center, Boston, MA (R.-A.N.T.-O.). Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (C.R.H., Y.C.-M.). Hypertension

Hypertension, Ahead of Print. Despite ample evidence linking social determinants of health (SDoH) and hypertension outcomes, efforts to address SDoH in the context of hypertension prevention and self-management are not commensurate with the burden and impact of hypertension. To provide valuable (…) (Hypertension)

J Am Soc Nephrol https://jasn.asnjournals.org/

07:00
Evolutionary Differences in Uric Acid Metabolism Inform about the Risks of Pig-to-Human Kidney Transplant - Percudani, Riccardo; Capelli, Cristian; Sassi, Giulia; Mori, Giulia J Am Soc Nephrol

No abstract available -- Perspective
07:00
Association between Acute Declines in Estimated Glomerular Filtration Rate during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes - Ku, Elaine; Tighiouart, Hocine; McCulloch, Charles E.; Inker, Lesley A.; Adingwupu, Ogechi; Greene, Tom; Estacio, Raymond O.; Woodward, Mark; de Zeeuw, Dick; Lewis, Julia B.; Hannedouche, Thierry; Hou, Fan Fan; Jafar, Tazeen H.; Ima, Enyu; Remuzzi, Guiseppe; Heerspink, Hiddo J.L.; Toto, Robert D.; Sarnak, Mark J. J Am Soc Nephrol

Background: Declines in glomerular filtration rate (GFR) occur commonly when renin-angiotensin system (RAS) inhibitors are started. Our objective was to determine the relation between declines in estimated GFR during trials of RAS inhibition and kidney outcomes. Methods: We included participants (…) -- Original Article: Chronic Kidney Disease
07:00
Estimated Effect of Restarting Renin-Angiotensin System Inhibitors after Discontinuation on Kidney Outcomes and Mortality - Hattori, Koki; Sakaguchi, Yusuke; Oka, Tatsufumi; Asahina, Yuta; Kawaoka, Takayuki; Doi, Yohei; Hashimoto, Nobuhiro; Kusunoki, Yasuo; Yamamoto, Satoko; Yamato, Masafumi; Yamamoto, Ryohei; Matsui, Isao; Mizui, Masayuki; Kaimori, Jun-Ya; Isaka, Yoshitaka J Am Soc Nephrol

Background: While renin-angiotensin system inhibitors (RASi) have been the mainstream treatment for patients with CKD, they are often discontinued due to adverse effects such as hyperkalemia and acute kidney injury. It is unknown whether restarting RASi after discontinuation improves clinical (…) -- Original Article: Chronic Kidney Disease

J Human Hypertens http://www.nature.com/jhh/

00:00
Clustering of 24H movement behaviors associated with clinic blood pressure in older adults: a cross-sectional study - Antonio H. Germano-Soares, Breno Q. Farah, José F. Da Silva, Mauro V. G. Barros, Rafael M. Tassitano J Human Hypertens

Journal of Human Hypertension, Published online: 18 June 2024; doi:10.1038/s41371-024-00925-2Clustering of 24H movement behaviors associated with clinic blood pressure in older adults: a cross-sectional study (Journal of Human Hypertension, Published online: 2024-06-18; | doi:10.1038/s41371-024-00925-2)

AJKD https://www.ajkd.org/

00:00
The Case for Incremental Thinking About Kidney Stone Disease - Alan C. Pao AJKD

From a patient’s perspective, you either have a kidney stone or you don’t. Detecting a stone represents an all-or-nothing event, foreshadowing what may come to pass (or not pass). In comparison, evaluating risk of a recurrent stone is a continuous, often iterative, process. Evaluating stone risk (…) (American Journal of Kidney Diseases (2024))

Nature Reviews Nephrology http://www.nature.com/ncpneph/

00:00
Unlocking the benefits of transplantation with kidneys from older donors - Vidya A. Fleetwood, Krista L. Lentine Nature Reviews Nephrology

Nature Reviews Nephrology, Published online: 18 June 2024; doi:10.1038/s41581-024-00851-zKidneys from older donors might improve the quality of life and survival of patients with kidney failure, yet these organs are often underutilized. Re-framing discussions of organ acceptance from older (…) (Nature Reviews Nephrology, Published online: 2024-06-18; | doi:10.1038/s41581-024-00851-z)
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Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes - Katarina Zeder, Edward D. Siew, Gabor Kovacs, Evan L. Brittain, Bradley A. Maron Nature Reviews Nephrology

Nature Reviews Nephrology, Published online: 18 June 2024; doi:10.1038/s41581-024-00857-7In this Review, the authors discuss potential pathophenotypes of coexisting chronic kidney disease and pulmonary hypertension, discuss the principles of clinical management of patients with chronic kidney (…) (Nature Reviews Nephrology, Published online: 2024-06-18; | doi:10.1038/s41581-024-00857-7)

Kidney Int http://www.kidney-international.org/

00:00
A meta-analysis of randomized controlled clinical trials implications of acute treatment effects on glomerular filtration rate for long-term kidney protection. - Hiddo J.L. Heerspink, Devin Eddington, Juhi Chaudhari, Raymond Estacio, Enyu Imai, Marian Goicoechea, Thierry Hannedouche, Richard Haynes, Tazeen H. Jafar, David W. Johnson, Rob C.M. van Kruijsdijk, Julia B. Lewis, Philip K.T. Li, Brendon L. Neuen, Ronald D. Perrone, Piero Ruggenenti, Christoph Wanner, Mark Woodward, Di Xie, Tom Greene, Lesley A. Inker Kidney Int

Pharmacologic interventions to slow chronic kidney disease progression, such as ACE-inhibitors, angiotensin receptor blockers, or sodium glucose co-transporter 2 inhibitors, often produce acute treatment effects on glomerular filtration rate (GFR) that differ from their long-term chronic (…) (Kidney International (2024))

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

02:00
Advancing Access to Cell and Gene Therapies in Medicaid J Am Med Assoc (JAMA)

This Viewpoint presents the components of the payment model and the implementation challenges among the Center for Medicare and Medicaid Innovation, state Medicaid agencies, patients, and manufacturers.
02:00
FTC Oversight of the Pharmaceutical Industry J Am Med Assoc (JAMA)

High drug prices in the US are a serious problem for both patients and the health care system. Prices of branded drugs are driven higher by monopoly dynamics: patents and other exclusive marketing rights allow companies to increase prices and restrict supply. Firms earn extraordinary profits (…)
02:00
Krill Oil for Knee Osteoarthritis J Am Med Assoc (JAMA)

This randomized clinical trial assesses the effect of krill oil supplementation vs placebo on knee pain improvement in patients with knee osteoarthritis, significant knee pain, and effusion-synovitis.
02:00
A Good Prognosis J Am Med Assoc (JAMA)

These are not the final few months of my life, not the last bowl of salad I add a few spoons of tuna and mayo to. I’m not going to die on a date printed in the calendar that hangs on my fridge with cheesy pictures of Yosemite and captions like Bike to Work Day. I can sit here at the kitchen (…)
02:00
Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke—Reply J Am Med Assoc (JAMA)

In Reply We thank Drs Sedghi and Siepmann for their comments. Indeed, all trials included in our individual participant meta-analysis enrolled only patients directly presenting at thrombectomy-capable stroke centers. Hence, the data presented in our study are applicable only to this exact (…)
02:00
Chronic Chagas Disease in the US J Am Med Assoc (JAMA)

This JAMA Insights provides recommendations for Chagas disease screening, diagnosis, and management in the US
02:00
Dispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020-2023 J Am Med Assoc (JAMA)

This study uses data from US retail pharmacies to assess national GLP-1RA dispensing to adolescents and young adults from 2020-2023.
02:00
Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke J Am Med Assoc (JAMA)

To the Editor A recent individual patient data meta-analysis of 6 randomized trials found that the beneficial effect of intravenous thrombolysis (IVT) before thrombectomy in patients with anterior-circulation large-vessel occlusion diminished with time from onset of stroke symptoms to (…)
02:00
Social Isolation and Loneliness in Older Adults J Am Med Assoc (JAMA)

This JAMA Patient Page discusses social isolation and loneliness as important public health concerns, especially among older adults.
02:00
The Other Side of the Curtain J Am Med Assoc (JAMA)

In this narrative medicine essay, a newly minted pediatric critical care physician learns firsthand what holistic medical care is from the love and attention she received during a hospitalization for mediastinal lymphoma.
02:00
Heard but Excluded: A Language Manifesto J Am Med Assoc (JAMA)

This Viewpoint discusses dismantling language barriers via multipronged approaches grounded in innovation, human-centered design, and systems thinking in 3 key areas.
02:00
Phoenix Criteria for Pediatric Sepsis and Septic Shock J Am Med Assoc (JAMA)

To the Editor We read Dr Sanchez-Pinto and colleagues’ study with interest, but we are concerned that the final Phoenix 4-organ model does not include acute kidney injury (AKI) assessment. Additionally, the Phoenix 8-organ model used only a single serum creatinine threshold. Despite inclusion of (…)
02:00
Phoenix Criteria for Pediatric Sepsis and Septic Shock—Reply J Am Med Assoc (JAMA)

In Reply We are grateful to Dr Thadani and colleagues for their interest in our work and applaud their efforts to improve outcomes from AKI around the world. We agree that AKI is important to assess and treat in children with sepsis in any environment and that children in some less-resourced (…)
02:00
Shingles Vaccination in Medicare Part D After Inflation Reduction Act Elimination of Cost Sharing J Am Med Assoc (JAMA)

This cross-sectional study uses data from retail pharmacies to examine shingles vaccine uptake among Medicare Part D beneficiaries following an IRA policy to eliminate cost sharing.
02:00
How AI Will Augment Radiologists J Am Med Assoc (JAMA)

This Medical News article is an interview with Saurabh Jha, a cardiothoracic radiologist and an associate professor of radiology at the University of Pennsylvania, and JAMA Editor in Chief Kirsten Bibbins-Domingo.
02:00
Public Health Preparedness and Response to Avian Influenza A(H5N1) Viruses J Am Med Assoc (JAMA)

US public health preparedness and response to highly pathogenic avian influenza A(H5N1) viruses are assessed in this survey study conducted by the CDC.
02:00
Congress, the Doctor J Am Med Assoc (JAMA)

Without a dissenting vote, the House of Delegates of the American Medical Association adopted last week a resolution calling on the Board of Trustees to use its best endeavors to have repealed such sections of the national prohibition acts as may interfere with the proper relation between the (…)
02:00
Monoclonal Antibody Protected Majority of Children From Malaria J Am Med Assoc (JAMA)

Current strategies to protect children from malaria—administration of new RTS,S/AS01 or R21/Matrix-M vaccines as well as seasonal medications—require about 20 health care visits by the time a child reaches age 5 years. However, an approach involving the annual administration of a monoclonal (…)
02:00
HHS Commits Millions to Improving Maternal, Infant Health J Am Med Assoc (JAMA)

The proportion of people who die while pregnant or within 42 days after their pregnancy ends has been steadily increasing in the US. Now, updated numbers from the National Vital Statistics System indicate promising trends in maternal mortality rates. About 22 people per 100 000 live births died (…)
02:00
Lower Dose of Mpox Vaccine Was Safe, Effective J Am Med Assoc (JAMA)

Intradermal injections that were one-fifth of the standard mpox vaccine dose generated antibody responses equivalent to those of subcutaneous injections of the standard dose at 6 weeks, based on results from 225 US adults aged 18 to 50 years. No participants experienced serious adverse events (…)
02:00
New Drug for UTIs Gets the Greenlight J Am Med Assoc (JAMA)

The US Food and Drug Administration recently approved pivmecillinam, sold as Pivya, for uncomplicated urinary tract infections (UTIs) in females aged 18 years or older with no structural abnormalities of their urinary tract. UTIs affect about 50% of females at some point during their life, the (…)
02:00
Progress in Heart Failure Deaths Reversed Over Past Decade J Am Med Assoc (JAMA)

Although heart failure mortality rates fell between 1999 and 2012, the proportion of people dying from the condition in the US has increased in recent years, according to a study published in JAMA Cardiology. By 2021, the heart failure mortality rate was higher than in 1999, signaling that (…)
02:00
Federal Trade Commission Bans Noncompete Clauses J Am Med Assoc (JAMA)

Up to 45% of physicians are subject to noncompete clauses, contractual requirements that can prevent them from changing jobs, which can limit competition and access to care, according to the American Medical Association. However, employers will no longer be allowed to enforce noncompete clauses (…)
02:00
Blood Pressure Drugs Linked to More Fractures, Falls in VA Nursing Homes J Am Med Assoc (JAMA)

Long-term Veterans Health Administration (VA) nursing home residents who started new medications to treat high blood pressure were more than twice as likely to experience a fracture than those who did not, according to a cohort study involving more than 29 600 VA participants, almost all male, (…)
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Monoclonal Antibody Authorized to Protect At-Risk People From COVID-19 J Am Med Assoc (JAMA)

The US Food and Drug Administration (FDA) granted emergency use authorization to pemivibart, marketed as Pemgarda, to protect people who are immunocompromised from COVID-19. Pemivibart is the only long-acting monoclonal antibody available in the US for preexposure prophylaxis after the FDA (…)
02:00
Microneedle Vaccine Patches Generated Immune Response in Children J Am Med Assoc (JAMA)

People who received a microneedle patch that delivered a measles and rubella vaccine mounted immune responses that were equivalent to those vaccinated via subcutaneous injection, according to data from a randomized clinical trial involving 285 participants from The Gambia, including 240 toddlers (…)
02:00
Maintenance of Certification’s Value to Patients and Physicians—Reply J Am Med Assoc (JAMA)

In Reply We appreciate the Letter by Drs Stern and Hafferty about our recent Viewpoint, which gave priority to highlighting the large and growing body of evidence that patients of physicians who demonstrate more medical knowledge have better prognoses on a host of important outcomes. In doing (…)
02:00
Federal Trade Commission Actions on Prescription Drugs, 2000-2022 J Am Med Assoc (JAMA)

This Special Communication examines the Federal Trade Commission’s policy and legal actions related to alleged misconduct, consolidation, and anticompetitive behavior in the pharmaceutical market between 2000 and 2022.
02:00
Blood Testing for Phosphatidylethanol J Am Med Assoc (JAMA)

A 36-year-old man with obesity and dyslipidemia presented with elevated liver enzymes following a liver transplant to treat acute-on-chronic liver failure due to alcohol-associated hepatitis. What would you do next?
02:00
Risks of Harm in Alzheimer Disease by Amyloid Lowering J Am Med Assoc (JAMA)

This Viewpoint discusses how data gaps in published research impede clinicians’ ability to clearly discuss the risks and benefits of amyloid-lowering drugs for treating Alzheimer disease.
02:00
Harnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing J Am Med Assoc (JAMA)

Approximately half of hospitalized adults in the US receive antibiotics, with pneumonia and urinary tract infection (UTI) being the 2 most frequent indications. Estimates suggest about 30% of all antibiotics prescribed in US hospitals are either unnecessary or suboptimal, and extended-spectrum (…)
02:00
Stewardship Prompts to Improve Antibiotic Selection for Pneumonia J Am Med Assoc (JAMA)

This clinical trial examines the effect of an antibiotic stewardship bundle (education, feedback, and real-time multidrug-resistant organism risk-based CPOE prompts) vs routine stewardship on antibiotic selection during the first 3 hospital days in adults with pneumonia.
02:00
Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection J Am Med Assoc (JAMA)

This clinical trial evaluates whether computerized provider order entry prompts providing patient- and pathogen-specific multidrug-resistant organism risk estimates could reduce use of empiric extended-spectrum antibiotics for treatment of urinary tract infections.
02:00
Audio Highlights J Am Med Assoc (JAMA)

Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
02:00
JAMA J Am Med Assoc (JAMA)
02:00
Maintenance of Certification’s Value to Patients and Physicians J Am Med Assoc (JAMA)

To The Editor The American Board of Internal Medicine (ABIM) has an outsized influence as the arbiter of internal medicine physician quality, given the alternatives of minimal state regulations, spotty insurance-based estimates, and random patient-based ratings. A recent Viewpoint responded to (…)

AJKD https://www.ajkd.org/

00:00
In Reply to “Considerations on Potential Modifiers of Glycated Albumin Levels in Patients With CKD” - Mengyao Tang, Sahir Kalim AJKD

We thank Dr. Chia-Ter Chao for highlighting the role of non-glycemic factors in influencing glycated albumin (GA) levels in patients with chronic kidney disease (CKD).1 (American Journal of Kidney Diseases (2024))
00:00
Considerations on Potential Modifiers of Glycated Albumin Levels in Patients With CKD - Chia-Ter Chao AJKD

I was intrigued by Tang et al.’s study on glycated albumin (GA) as a predictor for outcomes in patients with chronic kidney disease (CKD) within the Chronic Renal Insufficiency Cohort.1 Their findings linking higher GA levels to increased kidney and cardiovascular risks are commendable. However, (…) (American Journal of Kidney Diseases (2024))

Kidney Int http://www.kidney-international.org/

00:00
Effects of microplastics on the kidneys: A narrative review - Rodrigo Bueno de Oliveira, Lauter E. Pelepenko, Daniela A. Masaro, Glauco M.M. M. Lustosa, Mariana Cassani, Noemí A.V. Roza, Marina A. Marciano, Luciene M. dos Reis, Saïd Kamel, Loïc Louvet, Talita Mazon. Kidney Int

Micro- and nanoplastics (MPs) are small synthetic organic polymer particles ( (Kidney International (2024))
00:00
A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells. - Joseph C. Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Thitinee Vanichapol, Evan Streeter, Zainab Almuallim, Akira Oda, Takuto Chiba, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill, Haojia Wu, Katherine Pfister, Sara E. Howden, Simon C. Watkins, Melissa H. Little, Benjamin D. Humphreys, Samira Kiani, Alan Watson, Donna B. Stolz, Alan J. Davidson, Tom Carroll, Ondine Cleaver, Sunder Sims-Lucas, Mo R. Ebrahimkhani, Neil A. Hukriede Kidney Int

Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation hinge on achieving robust vascularization of in vitro engineered organs. Here, focusing on human kidney organoids, we overcame this hurdle by (…) (Kidney International (2024))
00:00
Imaging Kidney Inflammation Using An Oxidatively Activated MRI Probe - Ivy A. Rosales, Iris Yuwen Zhou, Ilknur Ay, Mozhdeh Sojoodi, Meghan E. Sise, Eric M. Gale Kidney Int

Imaging tools for kidney inflammation could improve care for patients suffering inflammatory kidney diseases by lessening reliance on percutaneous biopsy or biochemical tests alone. During kidney inflammation, infiltration of myeloid immune cells generates a kidney microenvironment that is (…) (Kidney International (2024))

17 juin

Circulation http://ahajournals.org/

11:00
Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association - Aeron M. Small Katherine E. Yutzey Bryce A. Binstadt Kaitlin Voigts Key Nabila Bouatia-Naji David Milan Elena Aikawa Catherine M. Otto Cynthia St. Hilaire Circulation

Circulation, Ahead of Print. Valvular heart disease is a common cause of morbidity and mortality worldwide and has no effective medical therapy. Severe disease is managed with valve replacement procedures, which entail high health care–related costs and postprocedural morbidity and mortality. (…) (Circulation)
11:00
Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition - Sohel Shamsuzzaman Rebecca A. Deaton Anita Salamon Heather Doviak Vlad Serbulea Victoria M. Milosek Megan A. Evans Santosh Karnewar Subhi Saibaba Gabriel F. Alencar Laura S. Shankman Kenneth Walsh Stefan Bekiranov Olivier Kocher Monty Krieger Bengt Kull Marie Persson Erik Michaëlsson Nils Bergenhem Sepideh Heydarkhan-Hagvall Gary K. Owens Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville. (S. Shamsuzzaman, R.A.D., A.S., V.S., V.M.M., S.K. S. Saibaba, L.S.S., G.K.O.) Department of Biochemistry and Molecular Genetics, University of (…) Circulation

Circulation, Ahead of Print. BACKGROUND:Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause of death worldwide. Although most mouse models of atherosclerosis develop lesions in the aorta (…) (Circulation)
11:00
Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR) - Aaron Long Christopher M. Haggerty Joshua Finer Dustin Hartzel Linyuan Jing Azadeh Keivani Christopher Kelsey Daniel Rocha Jeffrey Ruhl David vanMaanen Gil Metser Eamon Duffy Thomas Mawson Mathew Maurer Andrew J. Einstein Ashley Beecy Deepa Kumaraiah Shunichi Homma Qi Liu Vratika Agarwal Mark Lebehn Martin Leon Rebecca Hahn Pierre Elias Timothy J. Poterucha Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/New York–Presbyterian Hospital, NY (A.L., G.M., E.D., T.M., M.M., A.J.E., D.K., S.H., Q.L., V.A., M. Lebehn, M. (…) Circulation

Circulation, Ahead of Print. BACKGROUND:Artificial intelligence, particularly deep learning (DL), has immense potential to improve the interpretation of transthoracic echocardiography (TTE). Mitral regurgitation (MR) is the most common valvular heart disease and presents unique challenges for (…) (Circulation)
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Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy - Gregory A. Wyant Qinqin Jiang Madhu Singh Shariq Qayyum Clara Levrero Bradley A. Maron William G. Kaelin Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.A.W., Q.J., C.L., W.G.K.). Department of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (B.A.M.) Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (W.G.K.) Massachusetts General Hospital, Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Harvard Medical School, Charlestown (G.A.W., M.S., S.Q.). (…) Circulation

Circulation, Ahead of Print. BACKGROUND:HIF (hypoxia inducible factor) regulates many aspects of cardiac function. We and others previously showed that chronic HIF activation in the heart in mouse models phenocopies multiple features of ischemic cardiomyopathy in humans, including mitochondrial (…) (Circulation)
08:00
Response by Jeong et al to Letter Regarding Article, “Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial” - In-Seok Jeong Min Chul Kim Yongwhan Lim Youngkeun Ahn Department of Thoracic and Cardiovascular Surgery (I.-S.J.). Division of Cardiology, Department of Internal Medicine (M.C.K., Y.L., Y.A.), Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea. Circulation

Circulation, Volume 149, Issue 25, Page e1417-e1417, June 18, 2024. (Circulation)
08:00
Effects of Dapagliflozin on Body Composition and Its Relation to Hemodynamics in Heart Failure With Preserved Ejection Fraction - Jwan A. Naser Atsushi Tada Tomonari Harada Yogesh N.V. Reddy Rickey E. Carter Jeffrey M. Testani Michael D. Jensen Barry A. Borlaug Department of Cardiovascular Medicine (J.A.N., A.T., T.H., Y.N.V.R., B.A.B.), Mayo Clinic, Rochester, MN. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism (M.D.J.), Mayo Clinic, Rochester, MN. Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL (R.E.C.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New (…) Circulation

Circulation, Volume 149, Issue 25, Page 2026-2028, June 18, 2024. (Circulation)
08:00
Legend of MERLIN and the Quest for Cardiac Lineage Commitment - Rich Gang Li James F. Martin Cardiomyocyte Renewal Laboratory (R.G.L., J.F.M.), Houston. McGill Gene Editing Laboratory, Texas Heart Institute (R.G.L., J.F.M.), Houston. Department of Integrative Physiology (J.F.M.), Houston, TX. Center for Organ Repair and Renewal, Baylor College of Medicine (J.F.M.), Houston, TX. Circulation

Circulation, Volume 149, Issue 25, Page 1980-1981, June 18, 2024. (Circulation)
08:00
Letter by Jha Regarding Article, “Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial” - Ajay Kumar Jha Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. Circulation

Circulation, Volume 149, Issue 25, Page e1415-e1416, June 18, 2024. (Circulation)
08:00
Trajectories in Cardiac Aging: Journey to the Crossroads of Inflammation and Metabolism - Geneviève Derumeaux Daigo Sawaki Gabor Czibik Institut Mondor de Recherche Biomédicale, Institut national de la santé et de la recherche médicale U955, Université Paris Est Créteil (UPEC), AP-HP, Department of Physiology, Henri Mondor Hospital, FHU SENEC, Créteil, France (G.D., D.S., G.C.). Jichi Medical University, Department of Clinical Pharmacology and Cardiology, 3311-1 Shimotsuke-city, Tochigi-prefecture, Japan (D.S.). Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, (…) Circulation

Circulation, Volume 149, Issue 25, Page 1935-1937, June 18, 2024. (Circulation)
08:00
Numbing the Heart to Death: A Cautionary Tale About an In-Vogue Preoperative Analgesic - Benjamin B. Holmes Katherine T. Murray William G. Stevenson University of South Carolina School of Medicine Greenville (B.B.H.) Vanderbilt Heart and Vascular Institute (K.T.M., W.G.S.), Vanderbilt University School of Medicine, Nashville, TN Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (K.T.M.). Circulation

Circulation, Volume 149, Issue 25, Page 2021-2025, June 18, 2024. (Circulation)
08:00
Advanced Cardiac Patches for the Treatment of Myocardial Infarction - Tailuo Liu Ying Hao Zixuan Zhang Hao Zhou Shiqin Peng Dingyi Zhang Ka Li Yuwen Chen Mao Chen Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases (T.L., Y.H., H.Z., S.P., D.Z., Y.C., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Department of Cardiology (T.L., S.P., D.Z., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Medicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China (T.L., (…) Circulation

Circulation, Volume 149, Issue 25, Page 2002-2020, June 18, 2024. Myocardial infarction is a cardiovascular disease characterized by a high incidence rate and mortality. It leads to various cardiac pathophysiological changes, including ischemia/reperfusion injury, inflammation, fibrosis, and (…) (Circulation)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

17:13
Association of cardiovascular events with central systolic blood pressure: A systemic review and meta?analysis - Kaiyin Li, Lan Gao, Yimeng Jiang, Jia Jia, Jianping Li, Fangfang Fan, Yan Zhang, Yong Huo J Clin Hypertens

The Journal of Clinical Hypertension, EarlyView. -- META?ANALYSIS (Wiley: The Journal of Clinical Hypertension: Table of Contents)
16:49
Status of home blood pressure measurement in treated hypertensive patients. Results of a survey from two cities in Korea - Kyung?ju Lee, Moo?Yong Rhee J Clin Hypertens

The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Hypertension https://www.ahajournals.org/

11:00
Chronic Hypertension: A Neglected Condition but With Emerging Importance in Obstetrics and Beyond - Justin S. Brandt Cande V. Ananth Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, NYU Langone Health, New York, NY (J.S.B.). Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences; Cardiovascular Institute of New Jersey; and Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (C.V.A.). Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ (C.V.A.). Hypertension

Hypertension, Ahead of Print. (Hypertension)
11:00
Chronic Hypertension During Pregnancy: Prevalence and Treatment in the United States, 2008–2021 - Stephanie A. Leonard Sara Siadat Elliott K. Main Krista F. Huybrechts Yasser Y. El-Sayed Mark A. Hlatky Jheanelle Atkinson Ayesha Sujan Brian T. Bateman Department of Obstetrics and Gynecology, Stanford University School of Medicine, CA. (S.A.L., E.K.M., Y.Y.E.-S.) Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, CA. (S.S., A.S., B.T.B.) Departments of Health Policy and Medicine, Stanford University School of Medicine, CA. (M.A.H.) Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s (…) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Treatment of chronic hypertension during pregnancy has been shown to reduce the risk of adverse perinatal outcomes. In this study, we examined the prevalence and treatment of chronic hypertension during pregnancy and assessed changes in these outcomes (…) (Hypertension)
11:00
Projected Impact of Nonpharmacologic Management of Stage 1 Hypertension Among Lower-Risk US Adults - Kendra D. Sims Pengxiao Carol Wei Joanne M. Penko Susan Hennessy Pamela G. Coxson Nita H. Mukand Brandon K. Bellows Dhruv S. Kazi Yiyi Zhang Ross Boylan Andrew E. Moran Kirsten Bibbins-Domingo Department of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.-D.). Department of Epidemiology, Boston University School of Public Health, MA (K.D.S.). Department of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, NY (B.K.B., Y.Z., A.E.M.). Richard A. and Susan F. Smith Center (…) Hypertension

Hypertension, Ahead of Print. BACKGROUND:The 2017 American College of Cardiology/American Heart Association blood pressure guideline classified 31 million US adults as having stage 1 hypertension and recommended clinicians provide counseling on behavioral change to the low-risk portion of this (…) (Hypertension)
11:00
Immune Mechanisms in Hypertension - David G. Harrison David M. Patrick Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (D.G.H., D.M.P.). Department of Veterans Affairs, Nashville, TN (D.M.P.). Hypertension

Hypertension, Ahead of Print. It is now apparent that immune mediators including complement, cytokines, and cells of the innate and adaptive immune system contribute not only to blood pressure elevation but also to the target organ damage that occurs in response to stimuli like high salt, (…) (Hypertension)
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Relationship Between Sarcopenia and Intensive Blood Pressure Control Efficacy and Safety: A Secondary Analysis of SPRINT - Saeid Mirzai Ian Persits Richard Kazibwe Mohanad Gabani Austin Seals Matthew J. Singleton Rishi Rikhi Parag Chevli Salvatore Carbone W.H. Wilson Tang Joseph Yeboah Jeff D. Williamson Dalane W. Kitzman David Herrington Michael D. Shapiro Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC. (S.M., M.G., A.S., R.R., J.Y., D.W.K., D.H., M.D.S.) Section on Hospital Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC. (R.K., P.C.) Section on Gerontology and Geriatric (…) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Sarcopenia and hypertension are independently associated with worse cardiovascular disease (CVD) risk and survival. While individuals with sarcopenia may benefit from intensive blood pressure (BP) control, the increased vulnerability of this population (…) (Hypertension)

Nature Reviews Nephrology http://www.nature.com/ncpneph/

00:00
Healthy ageing and the kidney — lessons from centenarians - Yasumichi Arai, Motoko Yanagita Nature Reviews Nephrology

Nature Reviews Nephrology, Published online: 17 June 2024; doi:10.1038/s41581-024-00860-yCentenarians — who are a putative model of healthy longevity — often have a low risk of cardiovascular disease, despite an age-associated decline in kidney function. An understanding of the molecular and (…) (Nature Reviews Nephrology, Published online: 2024-06-17; | doi:10.1038/s41581-024-00860-y)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

07:16
Issue Information J Clin Hypertens

The Journal of Clinical Hypertension, Volume 26, Issue 6, Page 595-598, June 2024. -- ISSUE INFORMATION (Wiley: The Journal of Clinical Hypertension: Table of Contents)

16 juin

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

04:53
Glucagon?Like Peptide?1 Receptor Agonism and Suicide Risk: Evidence From Mendelian Randomization - Sizheng Steven Zhao, Stephen Burgess , and Dipender Gill 1 Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biological Medicine and Health The University of Manchester, Manchester Academic Health Science Centre Manchester UK 2 British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care University of Cambridge Cambridge UK 3 Heart and Lung Research Institute, University of Cambridge Cambridge UK 4 Medical Research Council Biostatistics Unit University of Cambridge Cambridge UK 5 Department of Epidemiology and (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. (Journal of the American Heart Association)
04:53
Principles of Artificial Intellgence for Medicine - Oguz Akbilgic 1 Wake Forest School of Medicine Winston?Salem NC USA J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. (Journal of the American Heart Association)
04:52
Evaluating the National Institutes of Health Pipeline for Resuscitation Science Investigators - Ryan A. Coute, Ryan Huebinger , Sarah M. Perman , Marina Del Rios , and Michael C. Kurz 1 Department of Emergency Medicine University of Alabama at Birmingham Heersink School of Medicine Birmingham AL USA 2 Department of Emergency Medicine University of New Mexico Health Science Center Albuquerque NM USA 3 Department of Emergency Medicine Yale New Haven Hospital New Haven CT USA 4 Department of Emergency Medicine University of Iowa Iowa City IA USA 5 Section of Emergency Medicine, Department of Medicine University of Chicago Pritzker School of Medicine Chicago IL USA J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. (Journal of the American Heart Association)
04:49
Role of Antitroponin Antibodies and Macrotroponin in the Clinical Interpretation of Cardiac Troponin - Erwan Salaun, Samuel Drory , Marc?André Coté , Veronic Tremblay , Elisabeth Bédard , Christian Steinberg , David Paré , Kim O'Connor , Tomas Cieza , Nancy Coté , Paul Poirier , Pierre Douville , Jonatan Blais , Philippe Desmeules , Dimitris Kalavrouziotis , Siamak Mohammadi , Pierre Voisine , Mathieu Bernier , Philippe Pibarot , and Sébastien Thériault 1 Institut Universitaire de Cardiologie et de Pneumologie de Québec Université Laval Québec Canada 2 Centre Hospitalier Universitaire de Québec Université Laval Québec Canada 3 Faculty of pharmacy Université Laval Québec Canada 4 Division of (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. Cardiac troponin is extensively used as a biomarker in modern medicine due to its diagnostic capability for myocardial injury, as well as its predictive and prognostic value for cardiac diseases. However, heterophile (…) (Journal of the American Heart Association)
04:49
Genetics and Pathophysiological Mechanisms of Lipoprotein(a)?Associated Cardiovascular Risk - Annabelle Santos Volgman, Marlys L. Koschinsky , Anurag Mehta , and Robert S. Rosenson 1 Division of Cardiology Rush University Medical Center Chicago IL USA 2 Robarts Research Institute, Schulich School of Medicine and Dentistry Western University London ON Canada 3 VCU Health Pauley Heart Center Richmond VA USA 4 Metabolism and Lipids Program, Mount Sinai Fuster Heart Hospital Icahn School of Medicine at Mount Sinai New York NY USA J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. Elevated lipoprotein(a) is a genetically transmitted codominant trait that is an independent risk driver for cardiovascular disease. Lipoprotein(a) concentration is heavily influenced by genetic factors, (…) (Journal of the American Heart Association)
04:47
New Perspectives in Management of Cardiovascular Risk Among People With Diabetes - Abhishek Gami, Roger S. Blumenthal , Darren K. McGuire , Sudipa Sarkar , and Payal Kohli 1 Department of Internal Medicine Johns Hopkins University School of Medicine Baltimore MD 2 Division of Cardiology Johns Hopkins University School of Medicine Baltimore MD 3 Division of Cardiology, Department of Internal Medicine University of Texas Southwestern Medical Center and Parkland Health Dallas TX 4 Division of Endocrinology, Diabetes, and Metabolism Johns Hopkins University School of Medicine Baltimore MD 5 Department of Cardiology University of Colorado Anschutz Aurora CO 6 Department of (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. Following the publication of results from multiple landmark cardiovascular outcome trials of antihyperglycemic medications over the past 8 years, there has been a major shift in the focus of care for people with type (…) (Journal of the American Heart Association)
04:53
Machine Learning–Based Critical Congenital Heart Disease Screening Using Dual?Site Pulse Oximetry Measurements - Heather Siefkes, Luca Cerny Oliveira , Robert Koppel , Whitnee Hogan , Meena Garg , Erlinda Manalo , Nicole Cresalia , Zhengfeng Lai , Daniel Tancredi , Satyan Lakshminrusimha , and Chen?Nee Chuah 1 Department of Pediatrics University of California Davis CA 2 Department of Electrical & Computer Engineering University of California Davis CA 3 Department of Pediatrics, Cohen Children’s Medical Center Zucker School of Medicine at Hofstra/Northwell New Hyde Park NY 4 University of Utah, Primary Children’s Hospital Salt Lake City UT 5 Department of Pediatrics University of California Los (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundOxygen saturation (Spo2) screening has not led to earlier detection of critical congenital heart disease (CCHD). Adding pulse oximetry features (ie, perfusion data and radiofemoral pulse delay) may improve (…) (Journal of the American Heart Association)
04:53
Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait?Times and Clinical Consequences - Aida Zaheer, Feng Qiu , Ragavie Manoragavan , Mina Madan , Maneesh Sud , Mamas A. Mamas , and Harindra C. Wijeysundera 1 Schulich Heart Program, Sunnybrook Health Sciences Centre University of Toronto Toronto Canada 2 ICES Toronto Canada 3 Temerty Faculty of Medicine University of Toronto Toronto Canada 4 Keele Cardiovascular Research Group Keele University Keele UK 5 Institute of Health Policy, Management and Evaluation University of Toronto Toronto Canada J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundTranscatheter aortic valve replacement (TAVR) has become the standard of care for severe aortic stenosis treatment. Exponential growth in demand has led to prolonged wait times and adverse patient outcomes. (…) (Journal of the American Heart Association)
04:52
Level of Perivascular Inflammation Is Significantly Lower Around the Left Internal Mammary Artery Than Around Native Coronary Arteries - Haruhito Yuki, Thoralf M. Sundt , Takayuki Niida , Keishi Suzuki , Daisuke Kinoshita , Daichi Fujimoto , Damini Dey , Hang Lee , Iris McNulty , Toru Naganuma , Sunao Nakamura , Eisuke Usui , Tsunekazu Kakuta , and Ik?Kyung Jang 1 Cardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA 2 Cardiac Surgery Division, Department of Surgery Massachusetts General Hospital, Harvard Medical School Boston MA 3 Biomedical Imaging Research Institute, Cedars?Sinai Medical Center Los Angeles CA 4 Biostatistics Center Massachusetts General Hospital, Harvard Medical School (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundThe left internal mammary artery (LIMA) is protected from developing atherosclerosis. Perivascular inflammation, which is closely associated with atherosclerosis, can be measured by perivascular adipose (…) (Journal of the American Heart Association)
04:52
Heart Size Difference Drives Sex?Specific Response to Cardiac Resynchronization Therapy: A Post Hoc Analysis of the MORE?MPP CRT Trial - Nadeev Wijesuriya, Vishal Mehta , Felicity De Vere , Sandra Howell , Steven A. Niederer , Haran Burri , Johannes Sperzel , Leonardo Calo , Bernard Thibault , Wenjiao Lin , Kwangdeok Lee , Andrea Grammatico , Niraj Varma , Marianne Gwechenberger , Christophe Leclercq , and Christopher A. Rinaldi 1 King’s College London London UK 2 Guy’s and St Thomas’s NHS Foundation Trust London UK 3 National Heart and Lung Institute Imperial College London London UK 4 University Hospital of Geneva Geneva Switzerland 5 Kerckhoff—Klinik Heart Center Bad Nauheim Germany 6 Casilino Policlinico Rome Italy 7 (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundStudies have reported that female sex predicts superior cardiac resynchronization therapy (CRT) response. One theory is that this association is related to smaller female heart size, thus increased relative (…) (Journal of the American Heart Association)
04:52
Comparison of Endovascular Therapy and Open Surgical Revascularization in Patients With Acute Superior Mesenteric Artery Occlusion: A Large?Scale Analysis Based on the JROAD?DPC Database - Daiki Goto, Kenji Yanishi , Takaaki Ozawa , Jun Yoshimura , Hirofumi Kawamata , Ayumu Fujioka , Tomotsugu Seki , Kan Zen , and Satoaki Matoba 1 Department of Cardiovascular Medicine, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundAcute mesenteric ischemia is rare, and few large?scale trials have evaluated endovascular therapy (EVT) and open surgical revascularization (OS). This study aimed to assess clinical outcomes after EVT or OS (…) (Journal of the American Heart Association)
04:52
Deciphering Popliteal Artery Aneurysm Patient Diversity: Insights From a Cluster Analysis of the POPART Registry - Maria Elisabeth Leinweber, Thomas Schmandra , Thomas Karl , Giovanni Torsello , Dittmar Böckler , Mikolaj Walensi , Phillip Geisbuesch , Thomas Schmitz?Rixen , Georg Jung , Amun Georg Hofmann 1 FIFOS—Forum for Integrative Research and Systems Biology Vienna Austria 2 Department of Vascular and Endovascular Surgery, Klinik Ottakring Vienna Austria 3 Department of Vascular Surgery, Sana Klinikum Offenbach Offenbach Germany 4 Department of Vascular and Endovascular Surgery, Klinikum am Plattenwald, SLK?Kliniken Heilbronn GmbH Bad Friedrichshall Germany 5 Department for Vascular Surgery (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundPopliteal artery aneurysms (PAAs) are the most common peripheral aneurysm. However, due to its rarity, the cumulative body of evidence regarding patient patterns, treatment strategies, and perioperative (…) (Journal of the American Heart Association)
04:51
Exploring Health?Related Quality of Life in Children With Hypertrophic Cardiomyopathy and Relationship to Physical Activity - Mitchell J. Wagner, Aamir Jeewa , Tara Pidborochynski , Samuel Lemaire?Paquette , Michael Khoury , Chentel Cunningham , Santokh Dhillon , Nassiba Alami Laroussi , Laurence Vaujois , Frederic Dallaire , Daryl Schantz , Kathryn Armstrong , Wadi Mawad , Timothy J. Bradley , and Jennifer Conway 1 Department of Surgery University of Alberta Edmonton AB Canada 2 Department of Pediatrics, Division of Cardiology The Hospital for Sick Children Toronto ON Canada 3 Department of Pediatrics University of Alberta Edmonton AB Canada 4 Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundHypertrophic cardiomyopathy is a burdensome condition that inflicts both physical and psychological impairment on those with the disease, negatively impacting health?related quality of life (HRQoL). Given (…) (Journal of the American Heart Association)
04:51
Age?Related Risk of Stroke Following Ocular Motor Cranial Nerve Palsy - Daye Diana Choi, Dae Young Cheon , Kyung?Ah Park , Kyung?Do Han , Jin?Hyung Jung , and Sei Yeul Oh 1 Department of Ophthalmology Kim’s Eye Hospital Seoul Korea 2 Division of Cardiology, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hwaseong Korea 3 Department of Ophthalmology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea 4 Department of Statistics Soong Sil University Seoul Korea 5 Department of Biostatistics The Catholic University College of Medicine Seoul Korea J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundThis cohort study aims to examine the relationship between the occurrence of cranial nerve palsy (CNP) affecting the third, fourth, or sixth cranial nerve and the subsequent risk of stroke, with a particular (…) (Journal of the American Heart Association)
04:51
Eicosapentaenoic Acid and the Outcomes in Older Patients Undergoing Atrial Fibrillation Ablation - Yuya Sudo, Takeshi Morimoto , Ryu Tsushima , Akihiro Oka , Masahiro Sogo , Masatomo Ozaki , Masahiko Takahashi , and Keisuke Okawa 1 Department of Cardiovascular Medicine Kagawa Prefectural Central Hospital Takamatsu Kagawa Japan 2 Department of Data Science/Clinical Epidemiology Hyogo Medical University Nishinomiya Hyogo Japan J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundA lower serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio (EPA/AA) level correlates with cardiovascular events. Nevertheless, elevated serum EPA levels increase the risk of new?onset atrial (…) (Journal of the American Heart Association)
04:51
Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution? - Christophe A. T. Stevens, Antonio J. Vallejo?Vaz , Joana R. Chora , Fotis Barkas , Julia Brandts , Alireza Mahani , Leila Abar , Mansour T. A. Sharabiani , and Kausik K. Ray 1 Department of Primary Care and Public Health School of Public Health, Imperial College London London United Kingdom 2 Department of Medicine, Faculty of Medicine Universidad de Sevilla Sevilla Spain 3 Clinical Epidemiology and Vascular Risk Instituto de Biomedicina de Sevilla (IBiS), IBiS/Hospital Universitario Virgen del Rocío/Universidad de Sevilla/CSIC Sevilla Spain 4 Centro de Investigación Biomédica en Red (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundFamilial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to (…) (Journal of the American Heart Association)
04:50
Prognostic Utility of Pericardial Effusion in the General Population: Findings From the STAAB Cohort Study - Floran Sahiti, Vladimir Cejka , Lena Schmidbauer , Judith Albert , Fabian Kerwagen , Stefan Frantz , Götz Gelbrich , Peter U. Heuschmann , Stefan Störk , Caroline Morbach 1 Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center University Hospital and University of Wurzburg Germany 2 Department of Medicine I, Division of Cardiology University Hospital of Wurzburg Germany 3 Institute of Clinical Epidemiology and Biometry University of Wurzburg Germany 4 Clinical Trial Center University Hospital and University of Wurzburg Germany 5 Institute of Medical Data (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundThe incidental finding of a pericardial effusion (PE) poses a challenge in clinical care. PE is associated with malignant conditions or severe cardiac disease but may also be observed in healthy individuals. (…) (Journal of the American Heart Association)
04:47
Advanced Atrioventricular Block in Athletes: Prevalence and Role of Anti?Ro/Sjögren Syndrome–Related Antigen A Antibodies - Pietro Enea Lazzerini, Iacopo Bertolozzi , Alessandra Cartocci , Vamsi Krishna Murthy Ginjupalli , Pietro Alberto Teneggi , Davide Pica , Giovanni Merico , Irene Bogazzi , Viola Salvini , Riccardo Accioli , Fabio Salvadori , Tommaso Marzotti , Gabriele Cevenini , Matteo Capecchi , Silvia Cantara , Anna Cantore , Maria Infantino , Stefania Bisogno , Francesco Finizola , Flavio D'ascenzi , Franco Laghi?Pasini , Maurizio Acampa , Pier Leopoldo Capecchi , and Mohamed Boutjdir 1 Department of Medical Sciences Surgery and Neurosciences, Division of Internal Medicine and Geriatrics, (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundAdvanced atrioventricular block (AVB), that is, higher than second?degree Mobitz?1, is an abnormal finding in athletes. Despite intensive investigation, in several cases the pathogenesis remains unknown, but (…) (Journal of the American Heart Association)

15 juin

Diabetes https://diabetes.diabetesjournals.org

10:16
Sans titre Diabetes

14 juin

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

13:07
Using Sex?Specific Polygenic Risk to Prognosticate Coronary Artery Disease in Women - Kaavya Paruchuri, Rohan Bhukar , Sarah Urbut , Yunfeng Ruan , Shriienidhie Ganesh , Darina Postupaka , and Pradeep Natarajan 1 Cardiovascular Research Center Massachusetts General Hospital Boston MA 2 Program in Medical and Population Genetics and Cardiovascular Disease Initiative Broad Institute of Harvard and MIT Cambridge MA 3 Department of Medicine Harvard Medical School Boston MA 4 Center for Genomic Medicine Massachusetts General Hospital Boston MA J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. (Journal of the American Heart Association)
13:06
Proteomic Signatures of Genetically Predicted and Pharmacologically Observed PCSK9 Inhibition - Jordan M. Kraaijenhof, Héléne T. Cronjé , G. Kees Hovingh , Nick S. Nurmohamed , Dipender Gill , and Loukas Zagkos 1 Department of Vascular Medicine Amsterdam University Medical Centers, University of Amsterdam Amsterdam The Netherlands 2 Department of Public Health, Section of Epidemiology University of Copenhagen Copenhagen Denmark 3 Department of Cardiology Amsterdam University Medical Centers, Vrije Universiteit Amsterdam Amsterdam The Netherlands 4 Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London United Kingdom J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. (Journal of the American Heart Association)
13:37
Improvements in Maternal Cardiovascular Health Over the Perinatal Period Longitudinally Predict Lower Postpartum Psychological Distress Among Individuals Who Began Their Pregnancies With Overweight or Obesity - Shannon D. Donofry, Riley J. Jouppi , Christine C. Call , Rachel P. Kolko Conlon , and Michele D. Levine 1 RAND Pittsburgh PA 2 Department of Psychology University of Pittsburgh Pittsburgh PA 3 Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh PA 4 Department of Obstetrics, Gynecology, and Reproductive Sciences University of Pittsburgh Pittsburgh PA J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundAdverse cardiovascular events during pregnancy (eg, preeclampsia) occur at higher rates among individuals with overweight or obesity (body mass index ?25 kg/m2) and have been associated with postpartum (…) (Journal of the American Heart Association)
13:08
Data?Driven Analysis Reveals Cortical Infarction Patterns Correlated With Inflammation and Prognosis: A Retrospective, Multicenter Cohort Study - Wen?Jie Wang, Lingling Ding , Qiang Zhang , Jing Jing , Yong Jiang , Xia Meng , Hongqiu Gu , Kaixuan Yang , Yilong Wang , Hao Li , Yongjun Wang , Xingquan Zhao , and Zixiao Li 1 Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing China 2 China National Clinical Research Center for Neurological Diseases Beijing China 3 Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical Sciences Beijing China 4 China National Clinical Research Center?Hanalytics Artificial Intelligence Research Centre for Neurological Disorders (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundWe aim to identify the distinct lesion patterns and regions associated with functional outcome and inflammation in patients with acute ischemic stroke, and investigate whether the association between lesion (…) (Journal of the American Heart Association)
13:08
Prognostic Significance of Proteomics?Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension - Tetsuro Yokokawa, Olivier Boucherat , Sandra Martineau , Sarah?Eve Lemay , Sandra Breuils?Bonnet , Vinod Krishna , Shanker Kalyana?Sundaram , Jey Jeyaseelan , François Potus , Sébastien Bonnet , and Steeve Provencher 1 Pulmonary Hypertension Research Group Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec Québec City Québec Canada 2 Department of Cardiovascular Medicine Fukushima Medical University Fukushima Japan 3 Department of Medicine Université Laval Québec City Québec Canada 4 Janssen Research & Development Spring House PA USA J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundPulmonary arterial hypertension (PAH) ultimately leads to right ventricular failure and premature death. The identification of circulating biomarkers with prognostic utility is considered a priority. As (…) (Journal of the American Heart Association)
13:07
CYP2C19 Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention - Kayla R. Tunehag, Cameron D. Thomas , Francesco Franchi , Joseph S. Rossi , Ellen C. Keeley , R. David Anderson , Amber L. Beitelshees , Julio D. Duarte , Yan Gong , Richard A. Kerensky , Caitrin W. McDonough , Anh B. Nguyen , Luis Ortega?Paz , Sanjay Venkatesh , Yehua Wang , Julie A. Johnson , Almut G. Winterstein , George A. Stouffer , Dominick J. Angiolillo , Larisa H. Cavallari , and Craig R. Lee 1 Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC USA 2 Department of Pharmacotherapy (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundCytochrome P450 2C19 (CYP2C19) intermediate and poor metabolizer patients exhibit diminished clopidogrel clinical effectiveness after percutaneous coronary intervention (PCI). However, outcome studies to (…) (Journal of the American Heart Association)
13:07
Outcomes Following Surgical Repair of Sinus Venosus Atrial Septal Defects: A Systematic Review and Meta?Analysis - Ryaan El?Andari, Muhammad Moolla , Kevin John , Ashley Slingerland , Sandra Campbell , Jeevan Nagendran , Yongzhe Hong , and Anoop Mathew 1 Division of Cardiac Surgery, Department of Surgery, Mazankowski Alberta Heart Institute University of Alberta Edmonton Alberta Canada 2 Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute University of Alberta Edmonton Alberta Canada 3 Division of Internal Medicine, Department of Medicine Tufts University Medford MA USA 4 Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta Canada 5 University of (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundSinus venosus atrial septal defect (SVASD) is a rare congenital cardiac anomaly comprising 5% to 10% of all atrial septal defects. Although surgical closure is the standard treatment for SVASD, data on (…) (Journal of the American Heart Association)
13:07
Joint Association of Sleep Onset Time and Sleep Duration With Cardiometabolic Health Outcome - Peipei Hu, Angela Vinturache , Yan Chen , Guodong Ding , and Yongjun Zhang 1 Department of Pediatrics, Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China 2 Shanghai Institute for Pediatric Research Shanghai China 3 Department of Obstetrics and Gynecology University of Alberta Edmonton Alberta Canada 4 Department of Neuroscience University of Lethbridge Lethbridge Alberta Canada J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundThe association of sleep onset time and duration with cardiometabolic health is not well characterized.Methods and ResultsThis study included 6696 adults aged 20 to 80 years from the NHANES (National Health (…) (Journal of the American Heart Association)
13:06
Systematic Review and Meta?Analysis of Prehospital Machine Learning Scores as Screening Tools for Early Detection of Large Vessel Occlusion in Patients With Suspected Stroke - Muath Alobaida, Martha Joddrell , Yalin Zheng , Gregory Y. H. Lip , Fiona J. Rowe , Wahbi K. El?Bouri , Andrew Hill , Deirdre A. Lane , and Stephanie L. Harrison 1 Liverpool Centre for Cardiovascular Science University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital Liverpool UK 2 Department of Cardiovascular and Metabolic Medicine Institute of Life Course and Medical Sciences, University of Liverpool Liverpool UK 3 Department of Basic Science, Prince Sultan Bin Abdulaziz College for Emergency Medical Services King Saud University Riyadh Saudi Arabia 4 (…) J Am Heart Assoc

Journal of the American Heart Association, Volume 13, Issue 12, June 18, 2024. BackgroundEnhanced detection of large vessel occlusion (LVO) through machine learning (ML) for acute ischemic stroke appears promising. This systematic review explored the capabilities of ML models compared with (…) (Journal of the American Heart Association)

J Am Soc Nephrol https://jasn.asnjournals.org/

07:00
Inflammasomes and Acute Kidney Injury - Muruve, Daniel A. J Am Soc Nephrol

No abstract available -- Editorial

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

14:38
Optimizing ChatGPT's performance in hypertension care: Correspondence - Hinpetch Daungsupawong, Viroj Wiwanitkit J Clin Hypertens

The Journal of Clinical Hypertension, EarlyView. -- LETTER TO THE EDITOR (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Circulation http://ahajournals.org/

11:00
Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension - Qi Zhang Nobuhiro Yaoita Arata Tabuchi Shaofei Liu Shiau-Haln Chen Qiuhua Li Niklas Hegemann Caihong Li Julie Rodor Sara Timm Hebatullah Laban Toren Finkel Troy Stevens Diego F. Alvarez Lasti Erfinanda Marc de Perrot Mariya M. Kucherenko Christoph Knosalla Matthias Ochs Stefanie Dimmeler Thomas Korff Subodh Verma Andrew H. Baker Wolfgang M. Kuebler Institute of Physiology, Charité–Universitätsmedizin, Berlin, Germany. (Q.Z., N.Y., A.T., S.L., Q.L., N.H., C.L., L.E., M.M.K., W.M.K.) Core Facility Electron Microscopy, Charité–Universitätsmedizin, Berlin, Germany. (S.T., M.O.) Institute of (…) Circulation

Circulation, Ahead of Print. BACKGROUND:Endothelial cell (EC) apoptosis and proliferation of apoptosis-resistant cells is a hallmark of pulmonary hypertension (PH). Yet, why some ECs die and others proliferate and how this contributes to vascular remodeling is unclear. We hypothesized that this (…) (Circulation)
11:00
Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy–Statin and Eicosapentaenoic Acid (RESPECT-EPA) - Katsumi Miyauchi Hiroshi Iwata Yuji Nishizaki Teruo Inoue Atsushi Hirayama Kazuo Kimura Yukio Ozaki Toyoaki Murohara Kenji Ueshima Yoshihiro Kuwabara Sachiko Tanaka-Mizuno Naotake Yanagisawa Tosiya Sato Hiroyuki Daida Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.M., H.I., Y.N., H.D.). Japan Red Cross Society, Nasu Red Cross Hospital, Otawara, Tochigi (T.I.). Dokkyo Medical University, Mibu, Tochigi, Japan (T.I.). Osaka Anti-Tuberculosis Association, Osaka Fukujyuji Hospital, Japan (A.H.). Department of Cardiology, (…) Circulation

Circulation, Ahead of Print. BACKGROUND:Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits of icosapent ethyl in patients with coronary artery disease, a low EPA/arachidonic acid (AA) ratio, and statin (…) (Circulation)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

13:07
Safety and Outcomes of Mechanical Thrombectomy in Acute Ischemic Stroke Attributable to Cardiological Diseases: A Scoping Review - Lucio D’Anna, Samir Abu?Rumeileh , Giovanni Merlino , Raffaele Ornello , Matteo Foschi , Francesco Diana , Lorenzo Barba , Vincenzo Mastrangelo , Michele Romoli , Kyriakos Lobotesis , Francesco Bax , Fedra Kuris , Mariarosaria Valente , Markus Otto , Eleni Korompoki , Simona Sacco , Gian Luigi Gigli , Thanh N. Nguyen , and Soma Banerjee 1 Department of Stroke and Neuroscience Charing Cross Hospital, Imperial College London NHS Healthcare Trust London United Kingdom 2 Department of Brain Sciences Imperial College London London United Kingdom 3 Department of Neurology (…) J Am Heart Assoc

Journal of the American Heart Association, Ahead of Print. There is limited evidence on the outcomes and safety of mechanical thrombectomy (MT) among patients with acute ischemic stroke (AIS) in the context of cardiac diseases. Our study reviews MT in AIS within the context of cardiac diseases, (…) (Journal of the American Heart Association)

Diabetes https://diabetes.diabetesjournals.org

02:00
2011-LB: Patterns of Genetic Risk for Type 2 Diabetes Are Specific to Ancestry Diabetes

Introduction & Objective. The heterogeneity of type 2 diabetes (T2D) risk has a genetic basis that can be reflected in genetic risk scores (GRS). It is currently unknown if the nature of genetic risk for T2D varies with ancestral backgrounds. The aim of this study was to determine if (…)
02:00
2012-LB: Type 2 Diabetes GWAS Signal C2CD4A/B Insulin Resistance Mechanisms in Skeletal Muscle Diabetes

Mechanisms of insulin action differ between fasting and postprandial states across tissues, with postprandial disturbance in insulin action being crucial in the development of type 2 diabetes (T2D). We generated single nucleus (sn-) chromatin accessibility and transcriptome profiles of 287 (…)
02:00
2013-LB: Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation Diabetes

Skeletal muscle, the largest human organ by weight, is relevant to several polygenic metabolic traits and diseases including type 2 diabetes (T2D). Identifying genetic mechanisms underlying these traits requires pinpointing the relevant cell types, regulatory elements, target genes, and causal (…)
02:00
2014-LB: Association between Variants in Genes Involved in the Metabolism of Uric Acid and the Risk of Type 2 Diabetes Diabetes

Introduction & Objective: Epidemiological and experimental evidence suggests that hyperuricemia is involved in the pathophysiology of type 2 diabetes (T2D), inducing insulin resistance or beta cell failure. Therefore, our objective was to investigate a possible association between variants (…)
02:00
2015-LB: Actionable Pharmacogenomic Variants in the Kuwaiti Population Diabetes

Pharmacogenomics plays a pivotal role in advancing precision medicine by addressing critical public health concerns like Adverse Drug Reactions (ADRs) and dosage regulations. The emergence of Next Generation Sequencing (NGS) techniques, coupled with the rapid expansion of pharmacogenomic data, (…)
02:00
2016-LB: Uptake Kinetics and Presentation of Donor Alloantigen by Lymph Node Stromal Cells for Attenuating the Alloimmune Response in Pancreatic Islet Transplantation Diabetes

Objective & Background: Pancreatic islet transplantation requires lifelong immunosuppression, reducing its applicability. We aim to eliminate the need for immunosuppression by co-transplanting fibroblastic reticular cells (FRCs), a lymph node stromal cell subtype. FRCs are unconventional (…)
02:00
2017-LB: Comparison of Nuclear Preparation for Single-Nucleus RNA-seq of Adipose Tissue Diabetes

Introduction & Objective: To appreciate the pathophysiological changes in the transcriptome and cell type landscape during obesity, single-nucleus (sn)RNA-seq overcomes the difficulty of maintaining intact transcripts. Sedimentation of dissociated live cells is used to concentrate adipocytes (…)
02:00
2018-LB: ABHD17B Modulates Diet-Induced Abdominal Obesity and Chronic Inflammation Diabetes

Overnutrition induces abdominal obesity and chronic inflammation in humans. Despite the central role of hyperactive pro-inflammatory macrophages, the mechanisms underlying macrophage dysregulation due to overnutrition remains poorly understood. Here, we present the first evidence of the (…)
02:00
2019-LB: The Characteristic Activity of Regulatory B Cells during the Occurrence and Development of Insulin Resistance Diabetes

Introduction & Objective: To investigate the aberrant distribution and clinical relevance of regulatory B cells (Bregs) subsets in the peripheral blood of individuals with different levels of insulin resistance (IR).Methods: A cohort of 124 subjects were divided into five groups according to (…)
02:00
201-OR: Fasting and Postprandial Triglycerides in Early Pregnancy Correlate with Mean Glucose and Time-in-Range by CGM at 28 Weeks of Gestation Diabetes

Recent studies of obesity in pregnancy have demonstrated a link between higher maternal fasting and postprandial triglycerides (FTG, PPTG) and neonatal subcutaneous and liver fat. Maternal TG can be hydrolyzed by placental lipases to free fatty acids (FFA) for fetal fat accretion, which may be (…)
02:00
2020-LB: Immunometabolomics Reveals Little Autoimmunity in Type 1 Diabetes (T1D)—Cross-Sectional Pathway Analysis across Multiple Autoimmune Diseases Diabetes

Introduction & Objective: Metabolic reprogramming has a critical role in the differentiation and function of PBMCs in autoimmune diseases. Here, comparative cellular immune-metabolomics was applied to multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and (…)
02:00
2021-LB: FABULINUS—A Randomized, Controlled Trial with FrexalimAB, to Assess Endogenous Insulin Secretion in New-Onset Stage 3 Type 1 Diabetes Adults and Adolescents Diabetes

Introduction: Type 1 diabetes (T1D) is caused by autoimmune destruction of pancreatic ?-cells. The CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells. Frexalimab is the first second-generation antibody against CD40L to be studied in T1D.Objective: To (…)
02:00
2022-LB: Diabetes Primes Neutrophils for Neutrophil Extracellular Trap by Metabolic Reprogramming Diabetes

Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates diabetes-induced NET priming in neutrophils. Under (…)
02:00
2023-LB: Type 2 or Type 3c Diabetes Not an Exclusion Criteria for Total Pancreatectomy with Islet Auto Transplantation (TPIAT) Diabetes

Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is now a standard of care for patients with severe chronic pancreatitis. However, evaluation and patient selection is necessary to benefit from this difficult procedure. Several patients with CP also have underlying diabetes, (…)
02:00
2024-LB: Reversal of Diabetes by Human Stem Cell–Derived Islets Implanted with an Immunomodulatory Microgel in a Retrievable Site Diabetes

Introduction & Objective: Islet transplantation for T1D is limited by donor availability and need for immunosuppression. Stem cell-derived islets could represent a solution as an unlimited source, but chronic immunosuppression remains a critical barrier. Immunomodulatory SA-FasL engineered (…)
02:00
2025-LB: Anti-apoptotic BCL2 Delivery to Protect Stem Cell–Derived Beta Cells from Transplantation-Induced Cell Death Diabetes

Cadaveric islet transplantation in most type 1 diabetic (T1D) patients restores euglycemia. However, cadaveric islets are limited, transplantation often requires multiple organ donors, and significant apoptotic cell death shortly after transplantation prevents widespread implementation of this (…)
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2026-LB: Investigating the Role of NKX6.1 in Pancreatic Endocrine Cell Differentiation Diabetes

Protocols to generate stem cell-derived beta cells have allowed novel investigations into the differentiation, specification and function of human beta cells. The transcription factor Nkx6.1 is critical to the specification of insulin-producing pancreatic ? cells in mice. Knockout of Nkx6.1 in (…)
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1499-P: Possible Association of GAD65 Antibody with Pancreatic Adenocarcinoma Diabetes

Objective: To demonstrate a role of serum anti-glutamic acid decarboxylase 65 antibodies titer (GAD65) as a possible paraneoplastic marker of pancreatic adenocarcinoma.Case Presentation: A 29-year-old male with polysubstance abuse presented to the emergency room with polyuria, polydipsia, and (…)
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149-OR: Liver Health in Adolescents with Youth-Onset Type 2 Diabetes Diabetes

Introduction: Youth-onset type 2 diabetes (Y-T2D) and metabolic liver disease (MASLD) commonly coexist. MASLD can advance to fibrosis/cirrhosis with no treatments beyond lifestyle intervention. Limited liver data in Y-T2D led us to investigate MASLD in the ST2OMP study, which will compare (…)
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14-OR: Autonomous Artificial Intelligence Diabetic Eye Exams Mitigates Disparities in Screening Completion for Youth Diabetes

Diabetic retinal disease (DRD) is a complication of diabetes mellitus that can lead to vision loss; early detection through screening and treatment can prevent this. Few individuals with diabetes meet recommended DRD screening guidelines, and racial/ethnic minority youth are even less likely to (…)
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14-PUB: The Effect of Structured Intensive Lifestyle Intervention on Muscle Mass in Patients with Type 2 Diabetes Receiving GLP-1 Receptor Agonists Diabetes

Glucagon-like-peptide-1 receptor agonists (GLP-1RAs) emerged as an important treatment option for type 2 diabetes (T2D) for their dual efficacy in improving glycemia and reducing body weight. However, they significantly reduce fat free mass (FFM), a surrogate for muscle mass, putting patients at (…)
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1500-P: Oral Exposure to Cigarette Smoke Condensate Leads to Glucose Intolerance and Immune-Cell Alterations in the Gut Diabetes

Introduction & Objective: Smoking is associated with an increased risk for diabetes, yet the underlying mechanism remains elusive. Since smoking correlates with many gastrointestinal tract diseases, we aimed to investigate whether cigarette smoke influences metabolic health through gut (…)
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1501-P: Four Loci, Four Fates—Differential Regulation of IRF5 Promoter in Prodiabetogenic Stress Diabetes

Introduction: Interferon regulatory factor (IRF)-5 is a transcription factor sitting at the crossroads of diverse cell processes. Emerging evidence supports its upregulation in response to different stimuli, however, the associated molecular mechanisms remain elusive.Methods: Four distinct IRF5 (…)
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1502-P: Metabolic Dysfunction Associated Steatohepatitis–Derived HCC Model Mouse for Cancer Immunology Diabetes

Introduction: Metabolic dysfunction-associated steatohepatitis (MASH) is a is linked to type II-diabetes and marked by steatosis, steatohepatitis, fibrosis and eventually HCC. The number of patients with MASH-derived HCC is increasing worldwide. Currently, the first line of cancer treatment (…)
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1503-P: Nano-thin Conformal Coating onto Human Islets to Preserve Cell Function and Induce Immunoprotection for Islet Transplantation Diabetes

Allogenic islet transplantation is a promising treatment option for patients with Type 1 Diabetes (T1D). Systemic immunosuppression is required to mitigate donor islet rejection, but this can present with adverse side-effects and reduce patient quality of life. To address this, it has been (…)
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1636-P: Targeting a Long Noncoding RNA lncMGC Ameliorates Obesity-Associated Adipose Tissue Dysfunction in Mice Diabetes

The long noncoding RNA (lncRNA) lncMGC, plays a pathological role in the diabetic kidney. However, its role in obesity, insulin resistance (IR), and type 2 diabetes is not known. Here we examined whether targeting lncMGC with a locked nucleic acid-modified LNA-GapmeR antisense oligonucleotide (…)
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1637-P: TLC-6740, a Liver-Targeted Mitochondrial Protonophore, Increases Energy Expenditure and Lipid Utilization in Obese Mice Diabetes

Background: TLC-6740, a liver-targeted mitochondrial protonophore, causes dose-dependent weight loss and metabolic benefit in diet-induced obese mice. Here, we evaluated mechanisms of TLC-6740-induced weight loss.Methods: Male C57 BL/6 mice housed at thermoneutrality (28°C) were fed a high-fat (…)
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1638-P: Metformin Enhances Upper Small Intestinal Lipid Sensing to Regulate Food Intake Independent of GDF15 Release Diabetes

Metformin, a first-line therapy for obesity-associated diabetes, lowers feeding and weight by increasing plasma growth differentiation factor 15 (GDF15) levels, but whether GDF15-independent mechanisms are involved is unknown. The upper small intestine (USI) detects lipids and triggers a (…)
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1639-P: Tirzepatide and Efruxifermin Demonstrate Therapeutic Benefits for NASH in a Preclinical Metabolic Syndrome Animal Model, B6-Alms1-del Mice Diabetes

The escalating prevalence of metabolic syndrome has led to NAFLD and its severe form, nonalcoholic steatohepatitis (NASH), becoming a major public health concern. While numerous anti-NAFLD/NASH agents have entered development pipelines, only Resmetirom has advanced to the NDA stage. There (…)
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163-OR: RNAseq Analysis Reveals Temporal Dynamics of Colonic Immune Response to High-Fat Diet in Mice Diabetes

Introduction & Objective: We previously showed that 1 week of high-fat diet (HFD) increases pro-inflammatory colonic macrophages (M?) and that their depletion was associated with improved glycemic control. The current study aimed to elucidate the temporal changes of gene expression of (…)
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1641-P: Effect of Specific Weight-Reducing Interventions on Metabolic and Immunological Outcomes in Mice Diabetes

Introduction & Objective: Obesity leads to glucose intolerance and immune cell alterations in different organs. Nevertheless, it remains unknown whether these metabolic and immunological changes are reversible following weight loss and if they differ with specific weight-reducing (…)
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1642-P: Metabolic Effects of Semaglutide and Resmetirom at Thermoneutrality in the Diet-Induced Obese Mouse Diabetes

Introduction & Objective: Semaglutide (GLP-1 receptor agonist) is currently approved for the treatment of type 2 diabetes and obesity and in late-stage clinical development for MASH. Resmetirom, a selective THR-? agonist, is waiting for approval for MASH. The present study aimed to compare (…)
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1643-P: P2Y 14 Receptor Regulates Whole-Body Glucose Homeostasis in High Fat Diet-Induced Obese and Diabetic Mice Diabetes

Diverse G protein-coupled receptors (GPCRs) are expressed in different metabolic tissues and are involved in the regulation of whole-body glucose and energy homeostasis. Dysregulation of glucose homeostasis contributes to hyperglycemia in obesity and type 2 diabetes (T2D). Thus, GPCRs have (…)
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1644-P: The Dose Makes the Poison—High-Fat Diet Based on Extra Virgin Olive Oil Leads to Increased Liver Lipogenesis and Glucose Intolerance in Mice Diabetes

Background & Objectives: Extra virgin olive oil (EVOO) has garnered attention for its potential anti-inflammatory and oxidative properties. However, the effect on metabolic health remains inconclusive. We previously showed that high-fat diets (HFD) based on coconut oil or lard led to glucose (…)
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1645-P: Metabolic and Adipogenic Effects of Di(isononyl) Cyclohexane-1,2-dicarboxylate (DINCH) In Vivo Diabetes

As a substitute for phthalate plasticizers, DINCH holds significance. Human studies indicate that lipophilic xenobiotics, including DINCH, accumulate in adipose tissue, potentially disrupting adipocyte biology and contributing to metabolic disturbances like insulin resistance and obesity. In (…)
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1646-P: Apolipoprotein A4 Improves Glucose Homeostasis through Activation of BAT Thermogenesis in Obese Mice Diabetes

Obesity is associated with impaired insulin sensitivity and the development of type 2 diabetes. Activation of brown adipose tissue (BAT) thermogenesis enhances triglyceride clearance and insulin sensitivity. Apolipoprotein A4 (ApoA4) induced by dietary lipids elevates BAT thermogenesis in lean (…)
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1647-P: Nonhuman Primate Obesity Model for the Translation of Target-Based Precision Medicine Diabetes

The prevalence of obesity has increased worldwide in the past few decades. Because of the similarity of their absorption, distribution, metabolism, and excretion profile compared to that of humans, non-human primates (NHP) models are highly valuable in predicting the clinical response to new (…)
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1648-P: Opposing Roles of Sphingosine 1 Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice Diabetes

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that regulates fundamental cellular processes such as proliferation, migration, apoptosis, and differentiation through five cognate G protein-coupled receptors (S1P1-S1P5). However, little is known about the role of S1P in obesity (…)
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1649-P: S-309309, a Novel MGAT2 Inhibitor, Enhances Intestinal Fatty Acid Beta Oxidation and Provides Metabolic Benefits in DIO Mice Diabetes

Introduction & Objective: Pharmacological inhibition of Monoacylglycerol acyltransferase 2 (MGAT2) suppresses the food intake and the gain of body weight in high fat diet (HFD)-induced obesity (DIO) mice. However, the effects on metabolic abnormalities associated with obesity and detailed (…)
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164-OR: Macrophage Ucp1 Deficiency Inhibits Cold Exposure–Induced Insulin Sensitivity in High-Fat Diet Mice Diabetes

Cold exposure (CE) could increase insulin sensitivity in high-fat-diet (HFD) mice, relying on adipose tissue Ucp1-induced heat release and macrophage M2 polarization. The function of thermogenic macrophages, a new subtype of macrophages that we have recently identified, has not been clearly (…)
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1650-P: Chronic Air Pollution Induces Brown Adipose Dysfunction and Insulin Resistance through Epigenetic Modification of Key Metabolic Circadian and Redox Targets Diabetes

Background: Prior studies have demonstrated a strong link between air pollution and type 2 diabetes including brown adipose tissue (BAT) dysfunction, common proximate regulators are poorly characterized. We hypothesized that exposure to ambient fine particulate matter (2.5) modulates insulin (…)
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1790-LB: The Value of Duke Treadmill Score in Predicting Severity of Coronary Artery Disease In Diabetic Patients by SYNTAX Score Diabetes

Aim & Object: One of the non invasive test is exercise tolerance test which carried out to identify prediction of severity of coronary artery disease and to assess the risk of major cardiac events. To establish prediction of coronary artery disease in patient having diabetic patient who (…)
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1791-LB: Metabolic Syndrome (MS) as a Risk Factor for Myocardial Infarction (MI), Coronary Heart Disease (CHD), Stroke, and Peripheral Artery Disease (PAD) in 41,215 People with Type 1 Diabetes (PwT1D) Diabetes

Objective: To address the association between components of the MS and the occurrence of CV end-points in PwT1D.Methods: 14,328 PwT1D with MS (?2 of 4 criteria: BMI>30kg/m2, RR?140/90mmHg, microalbuminuria, Trig?150mg/dl or HDL2 [24.0; 32.1] vs 23.8 [21.7;26.2]), RRsys (135mmHg [125; 145] vs 124 (…)
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1792-LB: Long-Term Impact of Glucose Status on Risk of Restenosis after Percutaneous Transluminal Coronary Angioplasty—A Six-Year Follow-up Study Diabetes

Patients with diabetes (DM) are at high risk for restenosis after coronary stenting. Information relating the long-term outcome of percutaneous transluminal coronary angioplasty (PTCA) to prediabetes is, however, limited. We retrospectively analyzed data of 951 patients (mean age 59.5±4.2 yrs, (…)
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1793-LB: Subclinical Atherosclerosis in Latent Autoimmune Diabetes—Insights from a Multicenter Prospective Interventional Study Diabetes

Objective: To compare subclinical atherosclerosis (AS) between latent autoimmune diabetes in adults (LADA) and type 2 diabetes mellitus (T2D) and to evaluate the impact of early insulin intervention on AS progression in LADA.Methods: Sixty-four LADA patients and forty T2D patients, matched for (…)
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1794-LB: Comparison of Metabolic Visceral Fat Score with Other Abdominal Obesity Indicators in Predicting Left Ventricular Hypertrophy in Individuals with Type 2 Diabetes Diabetes

Introduction & Objective: Left ventricular hypertrophy (LVH) is a common complication associated with higher cardiovascular risk in Type 2 diabetes mellitus (T2DM) patients. Although many abdominal obesity indices (AOIs) have been established, studies investigating their associations with (…)
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1795-LB: Elevation of Endogenous Glucose Production in Persons with Dysglycemia and Impaired Cardiac Function upon Myocardial Infarction Diabetes

Introduction & Objective: Prediabetes (PRE) and type 2 diabetes (T2D) associate with excess risk and worse outcome of myocardial infarction (MI). Increased endogenous glucose production (EGP) contributes to hyperglycemia in critical illness, however, if elevated EGP associates with worsening (…)
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1796-LB: Adipocyte-Derived Extracellular Vesicles (AdEVs) Contribute to Insulin Resistance and Atherosclerosis in Obesity Diabetes

Introduction: Cardiovascular disease is the leading cause of death worldwide. Obesity is a well-known major risk factor for atherosclerosis with 60% of all atherosclerotic burden due to metabolic syndrome, while other factors remain unknown. Adipose tissue (AT) inflammation is likely a (…)
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1797-LB: Detection of Potential Therapeutic Target Associated with Coronary Artery Disease in Type 2 Diabetes Patients—System Biology Approach Diabetes

Introduction & Objective: Type 2 diabetes (T2D) and coronary artery disease (CAD), co-morbidity of which presents mortality risk, are both systemic diseases linked with altered immune response. Treatments for the co-morbid condition of T2D and CAD are not yet developed to a satisfactory (…)
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1798-LB: STK25 Promotes Diabetic Atherosclerotic Plaque Formation via Septin2 Regulating Mitophagy Diabetes

Introduction & Objective: Serine/Threonine protein kinase 25 (STK25) was reported to regulate lipid accumulation and activation of inflammatory and fibrotic pathways as well as oxidative and endoplasmic reticulum stress in human aortic endothelial cell. However, the direct substrate of STK25 (…)
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1799-LB: Identification of Proteomics Signature for Vascular Complications in Type 2 Diabetes Diabetes

Introduction: Robust predictive measures for Type 2 diabetes (T2D) vascular complications to facilitate early intervention strategies are needed.Methods: Fasting plasma from 363 Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial participants (mean±SD) age: 61.3±6.4 yrs, (…)
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179-OR: Assessing the Impact of Hypoglycemia among People with Diabetes in the U.S. and EU Diabetes

Hypoglycemia, where blood glucose falls below 70 mg/dL, can be an unfortunately common and serious burden for people with diabetes (PWDs) on insulin. Despite this, its prevalence in the daily lives of PWDs is understudied among specific therapy types. This research aimed to comparatively assess (…)
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17-PUB: Glucagon-Like Peptide 1 Receptor Agonists' Heterogeneous Treatment Effects on Asthma Exacerbations—A Causal Machine-Learning Analysis Diabetes

While recent studies suggest GLP1RA may reduce the risk of asthma exacerbation, it is unclear which subpopulations may derive greatest benefit. To address this question, we identified GLP1RA vs sulfonylureas (SU) new user cohorts in commercially insured patients ages 18-65 from MarketScan data (…)
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1800-LB: Reprogramming of Macrophage Metabolism by Pyruvate Dehydrogenase Attenuates Atherosclerosis through Mitigation of iNOS-Induced Foam Cell Formation Diabetes

Background: Prior transcriptomic analyses have illuminated a correlation between the upregulation of glycolysis, induced by oxidized low-density lipoprotein (ox-LDL), and the extent of foam cell formation. This study aimed to elucidate the impact of metabolic redirection via pyruvate (…)
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1801-LB: Discovering Novel Cathepsin L Inhibitors Using Artificial Intelligence for Diabetic Nephropathy Diabetes

Introduction & Objective: Cathepsin L (CTSL) has been demonstrated to play a significant role in the pathogenesis and progression of Diabetic Nephropathy (DN). However, there are currently no CTSL inhibitors available for clinical use. This study utilizes artificial intelligence models to (…)
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1802-LB: Magnetic Peripheral Nerve Stimulation (mPNS) for Treatment of Painful Diabetic Neuropathy (PDN)—Sensory, QoL Results Diabetes

Objective: To determine if mPNS improved sensation, QoL in subjects with PDN over 90 days.Methods: Seventy-one subjects with PDN were treated in 6 site RCT comparing safety, effectiveness of mPNS and Conventional Medical Management (CMM). Subjects were randomized 3:1 to mPNS+CMM or Sham+CMM and (…)
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2009-LB: Deep Learning Enhances Chromatin Accessibility Signals and Discovers Links with Genetic Variations in Skeletal Muscle Rare Cells Diabetes

Chromatin accessibility quantitative trait loci (caQTL) discovery is vital for linking epigenomic features with genetic variations in Type 2 diabetes (T2D). However, caQTL scans require clear epigenomic signals, posing challenges in rare cell types from single nucleus (sn) studies. To address (…)
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200-OR: Postpartum Islet-Cell Function in Individuals With and Without Gestational Diabetes Diabetes

Gestational diabetes mellitus (GDM) affects approximately 10% of pregnancies. Although >60% individuals with GDM develop a disorder of glucose metabolism by 10 years postpartum, preventive care is lacking as the mechanisms leading to overt diabetes following pregnancy remain elusive. As part of (…)
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2010-LB: Glycemic Responses to Metformin Montherapy by SNP Clusters in Patients with Type 2 Diabetes Diabetes

Introduction and Objective: Glycemic responses to metformin based on 8 SNP clusters in diabetes individuals, published by Suzuki (Nature, 2024), are unknown. Employing dataset from part of Taiwan Precision Medicine Initiative (TPMI), we explored the glycemic responses to metformin by quintile (…)
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1490-P: Diabetes Induces Impaired Fibrotic Response to Mesh Involving Macrophage Dysfunction Diabetes

Introduction: Women with diabetes have ~5-fold increased risk of mesh exposure into vaginal cavity following synthetic mesh augmentation in the surgical repair of pelvic floor disorders. To define the mechanism relevant to host fibrotic response, we studied the impact of diabetes on (…)
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148-OR: Increased Insulin Secretion and Decreased Insulin Sensitivity in South Asian Youth without Diabetes Diabetes

Introduction & Objective: The mechanisms underlying increased T2DM risk at lower BMI in South Asians (SA) compared to other ancestries are not known, but greater visceral fat (VFAT) for given BMI has been implicated. We examined the relationships of VFAT with insulin sensitivity (Si) and (…)
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1386-P: Cause-Specific Mortality Is Diversifying in Those with Diabetes—A Multicountry Analysis Diabetes

Objective: This multi-country study explored trends in causes of death in people with diabetes.Methods: We used cause-specific mortality data in people with diabetes from 9 high-income countries (2000-2020). Data were from registries, health insurance, or other administrative sources. (…)
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1385-P: Association of Glycemic Variability with Brain Imaging Abnormalities in Persons with Type 2 Diabetes Diabetes

Introduction & Objective: Persons with diabetes are prone to have atherosclerosis, stenosis, poor blood fluid properties, and other adverse blood vessel health conditions, leading to occurrence of stroke. Thus, this study aims to examine the effects of glycemic variability on brain imaging (…)
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1384-P: COVID-19 Vaccination Uptake among 3,779,733 Adults With and Without Diabetes Diabetes

Introduction & Objective: Public health measures, especially vaccination, are important for COVID-19 risk reduction. Population level vaccine uptake in people with diabetes is understudied. We assessed COVID-19 vaccine uptake among adults with and without diabetes and the factors associated (…)
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1383-P: In the 21st Century, African Immigrants to the United States Do Not Value Obesity—The Africans in America Study Diabetes

With acculturation superimposed on nutritional transitions, urbanization and globalization, 21st century attitudes of African immigrants towards optimal body size are unknown. To gain perspective on body image, we assessed in 412 Africans living in America: 1) ideal body size 2) body size (…)
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842-P: Improvement in Time in Range after Smart Insulin Pen Initiation in Austria Diabetes

Introduction & Objectives: A prior multinational study showed improved time in range (TIR; 70-180 mg/dL) in people living with type 1 or type 2 diabetes (PLWD) after smart pen initiation for their bolus insulin. To understand country-specific experiences with smart pen use, this study (…)
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841-P: Efficacy and Safety of Once-Weekly Insulin Icodec vs. Once-Daily Basal Insulin in Type 2 Diabetes by Ethnicity and Race—ONWARDS 1–5 Diabetes

Introduction & Objective: To assess, post hoc, the impact of ethnicity and race on the efficacy and hypoglycemia rates with once-weekly (OW) insulin icodec (icodec) vs once-daily (OD) basal insulin in adults with T2D.Methods: Efficacy and safety outcomes were assessed within each trial (…)
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840-P: Efficacy and Safety of Once-Weekly Insulin Icodec vs. Once-Daily Basal Insulin in Type 2 Diabetes according to Baseline Glucagon-Like Peptide 1 Receptor Agonist Use—ONWARDS 1–5 Diabetes

Introduction & Objective: To assess the treatment effects of once-weekly (OW) insulin icodec (icodec) vs once-daily (OD) basal insulin comparators ± concomitant glucagon-like peptide-1 receptor agonist (GLP-1 RA) use in ONWARDS 1-5.Methods: A post hoc analysis by trial of insulin-naïve (…)
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83-OR: Metabolic Dysfunction–Associated Steatotic Liver Disease and Nonalcoholic Fatty Liver Disease Have Similar Clinical Profiles and Mortality Diabetes

Introduction & Objective: Metabolic dysfunction associated steatotic liver disease (MASLD) has recently replaced the term nonalcoholic fatty liver disease (NAFLD). Concern remains whether evidence generated under NAFLD definition is fully applicable to MASLD. We compared the clinical profile (…)
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534-P: Structured CGM Education Delivered via Mobile Phone Is Associated with Increased Time in Range—Proof-of-Concept Study Results Diabetes

Introduction & Objective: SmartStart CGM is a structured educational program for current users of continuous glucose monitoring (CGM) designed for use on a mobile phone. It presents basic and advanced information about using CGM and interpreting CGM data. We assessed the effects of (…)
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533-P: Geospatial Analysis of a Diabetes Management Program—Program Participation and Social Determinants of Health Diabetes

Introduction & Objective: The American Diabetes Association has recognized Health Extension for Diabetes (HED) as a practice-tested diabetes support program. HED is a community-based program that offers a standardized education and individualized support to those with diabetes. HED improves (…)
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532-P: Comprehensive Analysis of Cardiovascular and Metabolic Health in Type 2 Diabetes Mellitus—Insights from the UDF Study on ABI, BMI, and Neuropathy Across Diverse Population Diabetes

Studies link T2DM with obesity, poor glucose control, CV risk, peripheral arterial disease, and prevalent neuropathy in diverse populations. We analyzed 537 T2DM patients, across 18 centres (UDF Study), aged 12-89 for BMI, HbA1C, LDL, ABI, and neuropathy to assess obesity, cardiovascular, and (…)
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531-P: Role of Social and Family Status in Long-Term Follow-up of Patients with Diabetic Foot Diabetes

Patients and Methods: 396 patients were identified from 3 diabetic foot (DF) clinics with follow-up for 1 year (2019-2022). Patients constituted study groups according to their social status: living in family (Group 1, n=154), periodical care (Group 2, n=132), living alone (Group 3, n=110). We (…)
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530-P: Self- and Family-Management Experiences of Barriers and Facilitators in the People Living with Diabetic Foot Ulcers and Comorbidity—A Qualitative Study Diabetes

Objective: Diabetic foot ulcers are the leading cause of lower extremity amputations and require foot care for healing and prevention of recurrence, especially in family care settings. Patients’ high prevalence of co-morbidity is directly to risks of adverse outcomes including poor functional (…)
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52-OR: Emotional Distress and Insulin Initiation in the GRADE Trial Diabetes

Introduction & Objective: We evaluated if higher emotional distress (depressive symptoms [DS] or diabetes distress [DD]) were associated with lower initiation of basal or rapid-acting insulin among participants enrolled in the GRADE Emotional Distress Study (EDS).Methods: Individuals with (…)
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529-P: Diagnosis Approach of Suspected Osteitis in Diabetic Foot Ulcer—The Multicentric French 2023 Survey Diabetes

Bedside Blind Bone Biopsy (B4) through healthy skin is a valid alternative to bone biopsy usually performed in the operating (OR) or radiology (RR) room for the diagnosis of diabetic foot ulcer osteitis (DFU) (IWGDF/IFDSA 2023 guidelines). From 12.17.2015 to 12.31.2023, in our Diabetology unit, (…)
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527-P: How Stressed Are Feet? Novel Methods for Quantifying the Daily Cumulative Stress Imparted on Diabetic Foot Ulcers Diabetes

Introduction: Physical stress is a key factor in diabetic foot ulcer (DFU) formation and healing. However, knowledge on the association of stress with DFU is still limited due to the complexities in quantifying the magnitude of stress imparted on feet over 24hr periods. This project utilized (…)
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1407-P: Gaps in the Initiation of Diabetes Drugs with Cardiovascular and Kidney Benefits by Medical Specialists Diabetes

Introduction: Endocrinologists, cardiologists, and nephrologists commonly care for people with diabetes and coexisting cardiovascular disease (CVD), heart failure (HF), and chronic kidney disease (CKD). Guidelines recommend that GLP-1 receptor agonists (GLP-1RA) and SGLT2 inhibitors (SGLT2i) be (…)
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1406-P: Accessibility of Diabetes Prevention Programs in Historically Redlined Areas of the U.S. Diabetes

Introduction & Objective: Prior research demonstrated an association between historical redlining practices and diabetes-related mortality. The National DPP is an evidence-based, cost-effective, structured lifestyle change intervention to prevent type 2 diabetes (T2D). Whether historical (…)
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1404-P: U.S. Rural–Urban Disparities in Obesity Mortality, 2000–2019 Diabetes

Introduction: Obesity prevalence is higher in US rural vs nonrural counties. The objective was to evaluate trends in obesity-related mortality by rurality.Method: We used CDC WONDER data, 2000?2019, on obesity as a multiple cause of death (ie, top 20 contributor) among US residents aged ?25 (…)
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1403-P: Prescribing Trends of Glucose-Lowering Medications among Adult Kidney Transplant Recipients with Type 2 Diabetes—A U.S. Population-Based Cohort Study Diabetes

Introduction: Type 2 diabetes (T2D) is a common comorbidity among kidney transplant recipients (KTR) in the U.S. To date, there are no recent studies describing the use of glucose-lowering medications (GLM) in KTR. Thus, we investigated the prescribing trends of GLM among adult KTR with T2D in (…)
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1402-P: Novel Lipodystrophy Genotype Correlations Identified through the Rare and Atypical Diabetes Network (RADIANT) Diabetes

Introduction: Lipodystrophy (LD) encompasses a group of heterogeneous disorders characterized by either generalized or partial lack of adipose tissue. Discovery of the genetic etiologies of LD has advanced understanding of the molecular mechanisms that govern fat-cell differentiation, (…)
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1401-P: Long-Term Impact of Diabetes Prevention Program (DPP) Interventions on Walking Endurance Diabetes

Introduction & Objective: Type 2 diabetes (T2D) and prediabetes are associated with poor walking endurance, a marker of physical function. Our main aim was to examine the long-term effects of metformin or intensive lifestyle intervention (ILS) in adults at high risk of T2D on their 6-minute (…)
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1400-P: Hepatic Effectiveness of SGLT2 Inhibitors in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Diabetes

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated promising effects on liver outcomes. However, comprehensive evidence regarding liver outcomes in direct comparison with thiazolidinediones (TZD) and glucagon-like peptide-1 receptor agonists (GLP1RA), which are recommended in (…)
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13-PUB: Safety and Efficacy of Tirzepatide in Patients with Solid-Organ Transplant Diabetes

Objective: Preexisting diabetes mellitus (DM) and post-transplant diabetes mellitus (PTDM) impact outcomes post solid organ transplantation (SOT). Benefits of tirzepatide are well studied in DM but not in patients after SOT. This study describes safety and efficacy of tirzepatide in SOT.Methods: (…)
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650-P: Attitudes and Barriers to Implantable AID Solutions—Development of a New Assessment Tool Diabetes

Major limitations of current automated insulin delivery (AID) systems are the subcutaneous insulin route and the need to wear devices on the body. The EU project “FORGETDIABETES” (supported by H2020-FETPROACT, n.951933) will develop a fully implantable AID systems to overcome these barriers. To (…)
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64-PUB: Risk of Complications in Type 2 Diabetes Mellitus with Increase in Disease Duration—A Report of Real-World Data of Indian Population Diabetes

Introduction: T2DM is a progressive disease characterized by worsening of not only ? cell function but also an increased risk of complications with time.Methods: In this real world single center study we did a cross sectional analysis of patients to evaluate common markers of diabetes (…)
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64-OR: Continuous Glucose Monitoring among Pregnant Individuals with Glucose Intolerance Diabetes

Introduction & Objective: Glucose intolerance is common in pregnancy but incompletely characterized. We used continuous glucose monitor (CGM)-derived metrics to assess dysglycemia amongst pregnant individuals with a varying levels of glucose intolerance.Methods: In this prospective (…)
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649-P: Medical Students’ Recognition of Psychosocial Issues in a Behavioral Diabetes Case Diabetes

Introduction & Objective: Psychosocial care should be provided to all people with diabetes. Psychosocial problems can impair a person’s ability to carry out diabetes self-care. Thus, addressing these problems is critical to improve outcomes. To better understand medical students’ awareness (…)
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647-P: Outcomes Associated with the Medicare Diabetes Prevention Program Diabetes

Introduction & Objective: The National Diabetes Prevention Program lifestyle change program (LCP) is an evidence-based behavior change intervention to prevent or delay type 2 diabetes among adults at high risk for type 2 diabetes. In 2018, the Centers for Medicare & Medicaid Services (…)
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646-P: Improved Outcomes with Intensive Follow-up in Pediatric Diabetes Patients with Care Concerns Diabetes

Introduction: Standards of pediatric diabetes care recommend routine clinic visits quarterly, but in some cases more frequent visits may aid in improving hyperglycemia. This study aimed to determine if intensive follow-up affected DM outcomes.Methods: EHR data was reviewed (2020-23) to identify (…)
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645-P: Feasibility of Kanasina Gulabi, a Peer Support Intervention for Young Adults with Type 2 Diabetes in Mysore, India Diabetes

Introduction & Objective: To address the knowledge gap and emotional burden in young adults with type 2 diabetes (T2D), we designed a four-week education and goal-based peer support intervention, Kanasina Gulabi (Kannada: My Dream Rose), implemented in Mysore, India between June and July (…)
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644-P: Racial Ethnic Disparities in Prescription of GLP-1 Receptor Agonists for People at High Risk for Diabetes on Atypical Antipsychotics Diabetes

Introduction: Atypical antipsychotics (AAP) significantly increase the risk of obesity and type 2 diabetes (T2D). GLP-1 receptor agonists (GLP-1 RA) are weight-loss medications which may be beneficial in treating AAP-induced weight gain. We evaluated trends in prescriptions of GLP-1 RA among (…)
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47-OR: OPA1 Reprograms Macrophage Metabolism to Enforce Tolerance of Inflammation in Obesity Diabetes

Introduction & Objective: Adipose tissue macrophages (ATMs) are key players orchestrating metabolic homeostasis through regulating metabolic inflammation. Mitochondrial dynamics and metabolic remodeling are pivotal for the function of macrophages. The aim of our study is to explore the role (…)
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479-P: Imeglimin Improves Hyperglycemia-Induced Mitochondrial Dysfunction and Increases SIRT1 and NAD + Biosynthesis in Schwann Cells Diabetes

Hyperglycemia-induced oxidative stress is a major cause of the pathogenesis of diabetic neuropathy, and hyperglycemia-induced mitochondrial ROS production is considered as a significant mechanism of increased oxidative stress. On the other hand, imeglimin is the first in a new glimin class of (…)
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478-P: Preventing Peripheral Neuropathy in Adults with Type 2 Diabetes—A Meta-analysis of Randomized Clinical Trials Diabetes

Background: Diabetic Peripheral Neuropathy (DPN) is a debilitating complication of diabetes. Current diabetes management guidelines recommend targeting modifiable risk factors like glycemia, blood pressure (BP), lipids, obesity, and smoking to prevent DPN, but their individual effectiveness is (…)
02:00
1491-P: Examination of the Humanized Antibody to SerpinB13 in Autoimmune Diabetes Diabetes

Studies in our laboratory suggest that a combinatorial approach with a monoclonal antibody (mAb) to serpinB13, a cathepsin L (catL) inhibitor, and a suboptimal dose of antibody to CD3, is therapeutically superior to single antibody use, when these reagents are delivered into NOD mice during the (…)
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1492-P: Quiescent Adipose-Derived Mesenchymal Stromal Cells (ADSCs) Rejuvenate Themselves and Provide Factors That Remotely Restore Cellular Functions of Aged ADSCs Diabetes

Although a number of studies have shown therapeutic effects of mesenchymal stem cells (MSCs) on type 1 diabetes or diabetic complications, clinical applications of MSCs for these diseases are still limited. One of the reasons is aging of MSCs due to older donor age and ex vivo culture of MSCs (…)
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1493-P: Transglutaminase-Expressing Adipose Tissue Macrophages Positively Regulate Adipose Tissue Profibrotic Profile in Diet-Induced Obese Mice Diabetes

Introduction: Adipose tissue fibrosis (ATF) in obesity-driven diabetes is characterized by increased extracellular matrix (ECM) deposition. Cell populations that induce ATF in diabetes have yet to be fully elucidated. Transglutaminase 2 (TGM2) is known to contribute to ECM stabilization. The (…)
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1494-P: Gr1 + Myeloid Cell Governs Adipose Tissue Remodeling via Controlling Macrophage Infiltration Diabetes

Introduction & Objective: Pathological adipose tissue remodeling contributed to the development of insulin resistance and type 2 diabetes. The aberrant myeloid phenotype has recently been implicated in driving the diabetic environment. However, the role of myeloid cells in adipose remodeling (…)
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1496-P: The Highly Immunodeficient SRG Rat for Modeling Diabetes Diabetes

Immunocompromised rodents are essential for pre-clinical testing of cell-based therapies. The SRG rat (Sprague Dawley Rag2-/-, Il2rg-/-) lacks mature B, T, and NK cells, and is normoglycemic under standard conditions. Compared to mice, the SRG rat offers more human-like metabolism, easier (…)
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1498-P: Intermittent Hypoxia Increased the Expression ofIL-1ß, IL-6, and IL-8 in Human Monocytes through the Downregulation of MicroRNA-146a Diabetes

Sleep apnea syndrome (SAS) is characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]) and is a risk factor for systemic inflammation. Serum inflammation markers such as tumor necrosis factor (TNF)-?, interleukin (IL)-1?, IL-6, IL-8, IL-10, and (…)
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477-P: Peripheral Neuropathy—Evaluation of DPNCheck vs. mTCNS in Type 1 Diabetes Diabetes

Introduction: The handheld DPNCheck (DPNC) nerve conduction study (NCS) device has shown high sensitivity (SENS) and specificity (SPEC) against classical NCS for detecting peripheral neuropathy (PN), but studies comparing DPNC to clinical assessments are lacking. We aimed to evaluate DPNC (…)
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476-P: Investigating C-Fiber Activation and Pain Sensitivity in Diabetic Sensorimotor Neuropathy with Transcutaneous Electrical Nerve Stimulation Diabetes

Introduction & Objective: We aimed to assess C-fiber excitability via transcutaneous-electrical nerve stimulation (TENS) in diabetic sensorimotor neuropathy (DSPN) and its association with epidermal innervation and quantitative sensory testing. Pain perception was evaluated in (…)
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475-P: Peroxisome Proliferator-Activated Receptor Delta (PPAR?)—A Key Modulator in the Pathogenesis of Diabetes Mellitus and Mycobacterium Tuberculosis Comorbidity Diabetes

The interplay between lipid metabolism and immune response in macrophages plays a pivotal role in various infectious diseases, notably tuberculosis (TB). Herein, we illuminate the modulatory effect of heat-killed Mycobacteria tuberculosis (HKMT) on macrophage lipid metabolism and its (…)
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474-P: Novel Changes in Chromatin 3D Architecture under Diabetic Conditions in Human Macrophages Diabetes

Aberrant activation of monocytes and macrophages in diabetes increases chemokines and cytokines associated with chronic inflammation and diabetic vascular complications like atherosclerosis and nephropathy. Epigenetic mechanisms are implicated; however, the chromatin 3D reorganization during (…)
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473-P: Hyperglycemia Increases the Biomechanical Response in Endothelial Cells Diabetes

Introduction and Objective: Cardiovascular disease (CVD) is a common complication associated with diabetes. Hyperglycemia can lead to vascular changes resulting in endothelial dysfunction. While many studies have shown the molecular mechanisms by which hyperglycemia affects the vasculature, few (…)
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472-P: Molecular Pathogenesis of Sex-Specific Vascular Contributions to Cognitive Impairment and Dementia and in Type 1 Diabetes Diabetes

Introduction & Objective: Type 1 diabetes (T1D) is a serious disease that affects millions of people worldwide and is a major factor for vascular contributions to cognitive impairment and dementia (VCID). However, whether and how sex affects VCID in diabetics is rarely reported. In this (…)
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471-P: Anti-NFKB Inhibitor Beta Antibody Correlates with Cardiovascular Disease in Type 1 Diabetic Patients with Autoimmune Disease Diabetes

Cardiovascular disease (CVD) is a major cause of mortality in Type 1 diabetes (T1D). Studies suggest that autoimmunity may influence CVD development in T1D. We created a novel T1D-CVD mouse model by deleting ApoE via CRISPR/Cas9 editing in nonobese diabetic (ApoE-/-/NOD) mice, an autoimmune T1D (…)
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470-P: Severe Liver Fibrosis (F4) Assessed via Liver Fibroscan Is Associated with Elevated NT-ProBNP in Asymptomatic Type 2 Diabetes Mellitus Patients Receiving SGLT2i Therapy Diabetes

Aim: Identify relationship between different stages of liver fibrosis (LF) & N-terminal pro-B type natriuretic peptide (NT-ProBNP).Methods: Between Oct’ 22 & Mar’ 23, 66 T2DM patients receiving dapagliflozin & waist cmf > 80 cms (F) & > 90 cms (M) irrespective of their A1c & (…)
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46-PUB: A Quantitative Framework for Evaluating the Performance of Whole-Population Remote Patient Monitoring for Type 1 Diabetes Care Diabetes

Introduction: Care providers continue to adopt platforms that enable remote patient monitoring (RPM) for type 1 diabetes (T1D) care through the algorithmic analysis of continuous glucose monitor (CGM) data. No provider-facing quantitative framework is available to track how the use of such (…)
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46-OR: Palmitic Acid Coordinates Impaired Adipose Tissue ICOS high Treg Immunosuppression and Systemic Metabolic Disturbance during Obesity Diabetes

Treg cells serve essential roles in immunological tolerance and tissue homeostasis remodeling. However, the precise mechanism by which Treg cells specifically regulate the immune response in adipose tissue during obesity remains largely unexplored. Here we show that Foxp3, the master (…)
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469-P: Both LDL Cholesterol and LDL Particles Associated with MACE in Tibetan Patients with Type 2 Diabetes Diabetes

Background: LDL-C remains the primary treatment target for reducing major cardiovascular events (MACE) in patients with T2D. Our previous study revealed T2D patients residing in the Tibet Plateau exhibited elevated levels of LDL-C, LDL-particle number (LDL-P), but not small density LDL particles (…)
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468-P: Association between Sudomotor Function and Coronary Atherosclerosis in Patients with Type 2 Diabetes Diabetes

Object: This study aims to investigate the relationship between sudomotor function and coronary atherosclerosis in patients with type 2 diabetes.Methods: A total of 147 patients with type 2 diabetes were enrolled (64.60% male, 59.58±10.20 years). Using sudoscan detector to assess the mean (…)
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467-P: Type 2 Diabetes and Chronic Kidney Disease as Predictors of Cardiovascular Events in Patients with Coronary Artery Disease Diabetes

This study aims to investigate the single and joint effects of T2DM and CKD on cardiovascular events in patients with coronary artery disease (CAD). We prospectively investigated 1044 patients with CAD over 8.5±5.0 years. Cardiovascular events occurred more frequently in T2DM patients (n=347) (…)
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466-P: Therapeutic Efficacy of Monthly Semaglutide-Loaded Microsphere Injections in Zucker Diabetic Fatty Rats Diabetes

Introduction: This study aimed to develop semaglutide-loaded microsphere monthly injectables using a novel biodegradable microsphere manufacturing technology, and to compare its therapeutic efficacy with both semaglutide solution, administered weekly injectables, and semaglutide microsphere, (…)
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465-P: Distribution of Remnant Cholesterol in Patients with Type 2 Diabetes and in Nondiabetic Patients with Established Cardiovascular Disease Diabetes

High remnant cholesterol is associated with the metabolic syndrome and with type 2 diabetes (T2DM) and has attracted much interest as a cardiovascular risk factor. However, its distribution in T2DM patients with established cardiovascular disease is not clear. This issue is addressed in the (…)
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464-P: The Visceral Adiposity Index Predicts Cardiovascular Events Both in Coronary Artery Disease Patients With and in Those Without Diabetes Diabetes

The Visceral Adiposity Index (VAI) is calculated based on waist circumference, BMI, triglyceride and HDL-cholesterol levels and is a validated measure of visceral adiposity. In the general population, the VAI has been shown to be an independent risk factor for premature mortality. Its power to (…)
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463-P: Remnant Cholesterol as a Predictor of Major Cardiovascular Events in Cardiovascular Disease Patients with Differing Glycemic State Diabetes

Remnant cholesterol has attracted interest as a marker of cardiovascular event risk. The power of remnant cholesterol to predict major cardiovascular events (MACE) in patients with differing fasting glucose state is unclear and is addressed in the present study. We prospectively recorded MACE (…)
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462-P: Medication Documentation in Patients with Type 2 Diabetes Undergoing Coronary Angiography Diabetes

The utilization of multiple medications and the increasing complexity of medication regimens associated with chronic diseases such as type 2 diabetes (T2DM) necessitate the implementation of a medication documentation (MD). A complete medication plan serves to enhance medication safety and (…)
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461-P: Metabolic Profile Alterations in Patients with Obstructive Sleep Apnea and Type 2 Diabetes Diabetes

The co-occurrence of Obstructive Sleep Apnea (OSA) in individuals with Type 2 Diabetes (T2D) is well-established. Several studies have shown that T2D patients with moderate to severe OSA exhibit a more unfavorable glycemic profile. In this retrospective analysis, we conducted a chart review of (…)
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460-P: Dual Role of Factor XI in Mortality and Diabetes—Insights from the Ludwigshafen Risk and Cardiovascular Health Study Diabetes

Introduction & Objective: We investigated the effect of FXI on mortality in a cohort at increased risk for cardiac death, with a specific focus on risk-modification in case of type 2 diabetes (T2D) or current heart failure.Methods: The prospective LURIC study recruited 3063 persons (…)
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45-PUB: Persistent Performance Improvement Using Interdisciplinary Resources and Continuous Glucose Monitoring in Patients with Poorly Controlled Type 2 Diabetes Diabetes

Aims: The purpose of this study was to examine the effects of a pharmacist managed monitoring and interaction program using continuous glucose monitoring in a population of poorly controlled (A1C >10 %) patients with type 2 diabetes.Methods: This study was conducted in the outpatient clinical (…)
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459-P: Association of Intraoperative Mean Glucose with Clinical Outcomes in Patients with Acute Ischemic Stroke Treated by Mechanical Thrombectomy Diabetes

Introduction & Objective: Poststroke hyperglycemia is common and associated with adverse outcomes for patients with acute ischemic stroke (AIS). However, the evidence of glucose level during mechanical thrombectomy (MT) are limited. This study aimed to investigate the association between (…)
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458-P: Whole Left Ventricular Cardiac MRI in High-Risk People with Type 1 Diabetes Reveals Pathological Extracellular Volume Fraction and T1 Relaxation Times Diabetes

Introduction: Diffuse myocardial fibrosis is a negative CV prognostic marker. We employed advanced cardiac MRI (CMR) techniques for detailed left ventricular myocardial tissue characterization people with type 1 diabetes (PwT1D) and high CV risk.Methods: Quantitative native T1 mapping (T1) and (…)
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457-P: Association of System Inflammation Index with Risk of Cardiovascular Mortality among Individuals with Type 2 Diabetes Diabetes

Introduction & Objective: This study aimed to examine the associations of system inflammation index, including system inflammation response index (SIRI) and system immune-inflammation index (SII), with cardiovascular mortality in adults with type 2 diabetes (T2D).Methods: This analysis (…)
02:00
456-P: The ApoB/LDL-C Ratio Predicts Cardiovascular Events in Coronary Artery Disease Patients Independent of Type 2 Diabetes Status Diabetes

A high ApoB/LDL-C ratio reflects small LDL particle size which like type 2 diabetes (T2DM) is associated with insulin resistance. Whether the ApoB/LDL-C ratio and the presence of T2DM are mutually independent predictors of cardiovascular events is unclear and is addressed in the present study. (…)
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455-P: The Triglyceride–Glucose Index and Type 2 Diabetes are Mutually Independent Predictors of Major Cardiovascular Events in Patients with Established Cardiovascular Disease Diabetes

The triglyceride-glucose index (TyG) is a validated biomarker of insulin resistance. Its power to predict major cardiovascular events (MACE) in patients with established cardiovascular disease is unclear and is addressed in the present study. We enrolled 1790 consecutive patients, 1481 with (…)
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454-P: Screening for Cardiovascular Abnormalities in Chinese patients with Early-Onset Type 2 Diabetes Combined with Cluster Classification Diabetes

Introduction: Patients with early-onset type 2 diabetes (EOD) have 1.6-fold increased risk of cardiovascular death. Our study intends to screen for early cardiovascular abnormalities in EOD patients, and distinguish the population with cardiovascular risk through cluster classification.Method: A (…)
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453-P: Remnant Cholesterol Predicts Major Cardiovascular Events in Coronary Artery Disease Patients with NAFLD Diabetes

Remnant cholesterol has attracted interest as a marker of cardiovascular event risk. The power of remnant cholesterol to predict major cardiovascular events (MACE) in patients with non-alcoholic fatty liver disease (NAFLD) is unclear and is addressed in the present study. We enrolled a high-risk (…)
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452-P: Folic Acid on Homocysteine Levels in Type 2 Diabetes Patients—Systematic Review and Meta-analysis of Randomized Controlled Trials Diabetes

Introduction and objectives: The beneficial effect of folate has been observed in various conditions; however, the available evidence on homocysteine and reduction of cardiovascular disease (CVD) in type 2 diabetes (T2D) is limited. This study aims to quantitatively assess the effects of folate (…)
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2099-LB: Increased Expression of PFKFB3 in Diabetic Pancreatic ß-Cells May Compensate for the Maintenance of Glucose Metabolism Diabetes

Background: In diabetic pancreatic ?-cells, glycolysis is activated, and the up-regulation of the glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) has been suggested to be involved in these intracellular metabolic changes, but its physiological significance remains (…)
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2098-LB: Identification and Structural Elucidation of a Novel KATP Channel Modulator Demonstrating Dual Pharmacochaperone and Inhibitory Actions Diabetes

Introduction & Objectives: Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as pharmacochaperones (…)
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2097-LB: HNF4A and HNF1A Exhibit Tissue-Specific Target Gene Regulation in Pancreatic Beta Cells and Hepatocytes Diabetes

HNF4A and HNF1A encode transcription factors that are important for the development and function of the pancreas and liver. Mutations in both genes have been directly linked to Maturity Onset Diabetes of the Young (MODY) and type 2 diabetes (T2D) risk. To better define the pleiotropic gene (…)
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2096-LB: Mitochondrial DNA Integrity Is Required for ß-Cell Health In Vivo Diabetes

Type 2 diabetes (T2D) is a metainflammatory disease characterized by impairments in mitochondrial function and ultrastructure that contribute to the overall disruption of ?-cell function. Mitochondria rely on both the nuclear genome as well as their own 16.6 kilobase-pair circular genome to (…)
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2093-LB: Aging and Beta-Cell Function Diabetes

Introduction and Objective: Alterations of glucose homeostasis and insulin secretory capacity increase with age and represent leading causes of morbidity and mortality. In order to prevent and/or improve diabetes-associated ailments of the pancreatic beta cell during aging we propose to leverage (…)
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2092-LB: Receptor-Mediated G12 Signaling Strongly Promotes Insulin Secretion from Pancreatic Beta Cells Diabetes

Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. The inability of pancreatic ?-cells to release enough insulin is key pathological sign. Glucose-induced insulin secretion is regulated by G protein-coupled receptors (GPCRs) located on the cell (…)
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2091-LB: Viral Infection Drives Aberrant Pancreatic Beta-Cell Bioenergetics and Autophagy via a Candidate Type 1 Diabetes Gene PGM1 Diabetes

Introduction & Objective: Viral infection is one of the major environmental factors in Type 1 Diabetes (T1D). PGM1 is a T1D GWAS gene encoding phosphoglucomutase 1, which bidirectionally converts G6P to G1P. PGM1 resides at the junction between many arms of metabolic pathways. Our previous (…)
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2090-LB: Characters of Intra-islet Ductal Cells Related to Alpha-Cell Regeneration in Zinc-Binding Site–Mutated CRY1-Expressing Diabetic Mice Diabetes

Introduction & Objective: We previously suggested that the regions of intra-islet ductal cells (IIDCs) play roles as the source for endocrine cells, particularly for ?-cells, in C414A-CRY1 transgenic mice (TG) (ADA 2023), the characters of IIDCs relevant to the ?-cell neogenesis are yet (…)
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208-OR: Impact of Carbohydrate-Restricted Nutrition Therapy and Continuous Remote Care among People with Type 2 Diabetes in Rural vs. Urban Areas Diabetes

Diabetes outcomes and complications are often worse in rural (R) versus urban (U) areas, commonly due to challenges accessing health services. Our telemedicine clinic aims to address these barriers, offering carbohydrate-restricted nutrition therapy via continuous remote care for people with (…)
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2089-LB: An Adult Clock Component Links Circadian Rhythms to Pancreatic ß-Cell Maturation Diabetes

Pancreatic ? cell clocks attune insulin secretion to daily energy cycles, and desynchrony from genetic or behavioral disruptions triggers metabolic dysfunction, fueling type 2 diabetes risk. How ubiquitous circadian clocks orchestrate ? cell-specific outputs, however, is not well understood. In (…)
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2088-LB: The Downregulation of SCGN Induced by Lipotoxicity Promotes NLRP3-Mediated ß-Cell Pyroptosis Diabetes

Background & Objective:Lipotoxicity exacerbates ?-cell injury to contribute type 2 diabetes development. In lipotoxic conditions, secretagogin (SCGN), a protein highly expressed in islets, is found to undergo downregulation. Thus, we aim to explore the role of SCGN in lipotoxicity-induced (…)
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2087-LB: Novel Human Islet Spheroid Models of Type 1 Diabetes Diabetes

Recently, it has emerged that ?-cells co-orchestrate their own demise by increasing their visibility to the immune system, stressing the importance of studying both the immune and the ?-cell components of T1D simultaneously. To enable accurate, high-throughput and longer-term studies of these (…)
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2086-LB: Islet Surface Modification with Bissulfosuccinimidyl Suberate Prevents the Instant Blood-Mediated Inflammatory Reaction—A Novel Approach Diabetes

Introduction and Objectives: In pancreatic islet cell transplantation, the early graft loss is due to the instant blood-mediated reaction (IBMIR). Control of early inflammatory events could improve the efficacy of islet cell transplantation and may enhance the long-term function of transplanted (…)
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2085-LB: Alleviation of Instant Blood-Mediated Inflammatory Reaction in Human Islets with Aptamers Diabetes

Introduction and Objective: The instant blood-mediated inflammatory reaction (IBMIR) is a major factor that causes damage to transplanted islets. The blockade of pro-inflammatory mediators is a promising approach to improve islet engraftment. We hypothesized that blocking of key pro-inflammatory (…)
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2084-LB: Real-World Effectiveness of Tirzepatide among People with Obesity or Overweight without Type 2 Diabetes (T2D) Diabetes

Introduction & Objective: Tirzepatide is a once weekly GIP and GLP-1 receptor agonist approved in the US for treatment of T2D (May 2022) and obesity (Nov 2023). We assessed real-world patient characteristics and effectiveness in people with obesity or overweight without T2D.Methods: This (…)
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2083-LB: Effect of 8-Hour Time-Restricted Eating vs. Daily Calorie Restriction on Sleep in Adults with Type 2 Diabetes Diabetes

Objective: This study compared the effect of 8-h time-restricted eating (TRE) versus calorie restriction (CR) and a no-intervention control (CON) group on body weight and sleep in adults with obesity and type 2 diabetes (T2D).Methods: Adults with obesity and type 2 diabetes (n = 75) were (…)
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2082-LB: Heterogeneity in Adipose Progenitor (AP) Populations from Subcutaneous Abdominal and Thigh Adipose Tissues of Women Diabetes

Introduction & Objective: Lower body fat distribution decreases risk for T2D, but the mechanisms involved are poorly understood. The objective of this study was to compare AP populations of paired samples of upper body abdominal (A) vs lower body thigh (T) adipose tissues that may contribute (…)
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2081-LB: Efficacy and Safety of Semaglutide and Tirzepatide—A Comparative Analysis of Clinical Trials Diabetes

Introduction & Objective: In the past years, many obesity drugs were approved by the FDA and withdrawn. Semaglutide and tirzepatide are dominating the obesity market. We analyzed published phase 2/3 clinical trials to evaluate their efficacy and safety.Methods: We selected 17 randomized (…)
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2080-LB: Metabolite Profiles of Liver Fat and BMI in the MultiEthnic Study of Atherosclerosis (MESA) and Mediators of Atherosclerosis in South Asians Living in America (MASALA) studies Diabetes

Introduction: Hepatic steatosis occurs across the body mass index (BMI) spectrum. We aimed to identify a metabolite signature for hepatic steatosis and BMI in a diverse population.Methods: We included participants from the MESA (n=1,226) and MASALA (N=668) cohorts with untargeted LC-MS (…)
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207-OR: Food Insecurity Patterns and Mental Health among Youth and Young Adults with Diabetes Diabetes

Introduction & Objective: We explored the associations of food insecurity (FI) patterns with symptoms of depression, anxiety, stress, and changes therein in youth and young adults (YYA) with type 1 (T1D) and type 2 diabetes (T2D).Methods: Longitudinal data (2016-2022) from 747 YYA with T1D (…)
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2079-LB: Sociodemographic Profile and Obesity—An Indian Perspective Diabetes

Introduction & Objective: Diverse sociodemographic profiles play a pivotal role in shaping health behaviours. This survey presents the lifestyle habits and health profiles among different socio-economic populations in India.Methods: A pan-Indian survey using social media and awareness camps, (…)
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2078-LB: Effects of Obesity on Bladder Cancer and the Intervention Effect of Semaglutide Diabetes

Objective: Limited research has been conducted on the impact of semaglutide on bladder cancer in individuals with obesity. Hence, this study employed proteomics in conjunction with bioinformatics technology to demonstrate that semaglutide potentially operates through a mechanism that reduces the (…)
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1519-P: Endothelial Injury Predicts Carbohydrate Metabolism Trajectories after COVID-19 Diabetes

Introduction & Objective: Diabetes and SARS-CoV-2 infection target the endothelium causing perfusion abnormalities. We hypothesized that COVID-19 impairs insulin action and/or insulin secretion, and that systemic endothelial injury (EI) slows post-hospitalization recovery of these (…)
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1429-P: Multimorbidity among Adults with Diabetes in India Diabetes

Introduction: Limited information is available on the burden of multimorbidity among diabetics in India.Methods: We conducted a cross-sectional study among 12284 adults aged ? 30 years, using multistage cluster random sampling, from rural and urban areas of North and South India. Trained (…)
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1428-P: Impact of Socioeconomic Inequalities on COVID-19 Mortality of People Living with Diabetes during the 2020 Epidemic Waves in France Diabetes

Introduction & Objective: The aim was to describe the impact of socioeconomic inequalities (SEI) on COVID-19 mortality in people living with pharmacologically treated diabetes (TD) during the two 2020 epidemic waves (W1: March-May; W2: September-December) in European France.Methods: TD were (…)
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1427-P: Factors Predicting Significant Improvement in Glycemic Control after Endocrinology Referral in Patients with Type 2 Diabetes Mellitus and Hemoglobin A1c ? 10% Diabetes

Endocrinology referral has been shown in several studies to significantly improve glycemic control in patients with uncontrolled type 2 diabetes mellitus (DM2). However, studies identifying factors that predict glycemic improvement are lacking. This is a retrospective study of adults (N =138, (…)
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1487-P: Obesity Induces Metabolic Dysfunction in Adipose Tissue T-Cells Diabetes

Individuals with obesity or diabetes often have impaired immune responses to infection despite elevated systemic inflammation. T cells are essential for controlling adaptive immune responses, and during chronic obesity, adipose tissue T (ATT) cells display features of exhaustion, which are (…)
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935-P: Cardiovascular and Mortality Outcomes with SGLT2 Inhibitors in Patients with Atrial Fibrillation and Type 2 Diabetes Diabetes

Introduction & Objective: Sodium glucose cotransporter 2 (SGLT2) inhibitors have shown clinical benefits in patients with heart failure (HF), chronic kindey disease and type 2 diabetes(T2DM). However, limited data exist on their effects on clinical outcomes in patients with AF and (…)
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934-P: Prescribing Patterns of Sodium–Glucose Cotransporter 2 Inhibitors in Patients with Heart Failure With or Without Type 2 Diabetes—A Continuing Review Diabetes

Introduction: The prevalence of heart failure (HF) continues to increase and guidelines strongly recommend initiation of quadruple pharmacologic therapy including a sodium glucose co-transport 2 inhibitor (SGLT2i) for patients with all classifications of HF irrespective of type 2 diabetes (T2D). (…)
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933-P: Effects of Dapagliflozin and Metformin on Vascular Function in Newly Diagnosed Type 2 Diabetes—A Randomized Controlled Trial (DMVascular Study) Diabetes

Aims: We aim to evaluate impact of Metformin vs Dapagliflozin vs combination (Dapagliflozin/Metformin) on surrogate measures of cardiovascular risk - endothelial function, artery stiffness and carotid artery intima-media thickness (CIMT) in a 12 week, randomized controlled study.Methods: We (…)
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932-P: Clinical Efficacy, Safety, and Tolerability of Single-Pill Combination of Dapagliflozin and Linagliptin in Uncontrolled Indian Type 2 Diabetes Mellitus Patients—A Randomized Double-Blind Study Diabetes

Introduction: While Dapagliflozin and Linagliptin are known for robust glycaemic efficacy T2DM patients when used individually, although it remained unknown whether their combined use is associated with further improved efficacy, safety and tolerability in Indian scenario.Objective: To determine (…)
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62-OR: Continuous Glucose Monitoring in Pregnancies with Type 1 Diabetes—A Retrospective Study Diabetes

Introduction & Objective: Prior studies do not identify if continuous glucose monitor (CGM) metrics at a critical gestational age (GA) can distinguish risk of adverse pregnancy outcomes (APOs). We evaluated 3rd trimester CGM metrics by GA and APO status in gravidas with type 1 diabetes (…)
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629-P: Serum Creatinine–to–Cystatin C Ratio Is Related to Handgrip Strength as Well as Muscle and Fat Mass in People with Type 2 Diabetes Independently of Glycemic Control and Daily Protein Intake Diabetes

Sarcopenia is one of the serious diabetic complications and it is related to poorer glycemic control and other diabetic chronic complications. Therefore, it is necessary to diagnose sarcopenia as early as possible in people living with diabetes. Serum creatinine to cystatin C ratio (Scr/Scys) (…)
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628-P: Receipt and Perceived Importance of Nutrition Counseling among Older Adults with Type 1 Diabetes (T1D) Diabetes

Introduction & Objective: Dietetics guidelines recommend adults with T1D are referred to nutrition counseling for individualization of an eating plan. We characterized the extent to which older adults receive nutrition counseling and how important they perceive it to be.Methods: Adults (?65 (…)
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627-P: Prediabetes Reduction from Food Allergen Elimination—A Controlled Pilot Study Diabetes

Currently Diabetes affects over 500 million people, worldwide, and the expense of treating this disease exceeded $870 Billion US dollars. Diabetes Mellitus Type 2 (DM2) is comorbid with numerous other pathologies including obesity and hypertension. The objective of this 6-month controlled pilot (…)
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626-P: Insulin Dosing Strategies Surrounding Food Intake among Older Adults with Type 1 Diabetes (T1D) Diabetes

Introduction & Objective: T1D management evolves over the lifespan, as the risk for hypoglycemia increases. Data are limited to guide diabetes education and nutrition in older adults. Our objective was to assess strategies employed by older adults with T1D employ to accurately dose insulin (…)
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625-P: Association between Vitamin D Status and Thyroid Function in Individuals with Type 2 Diabetes Mellitus Diabetes

Background: More studies have revealed role of vitamin D(VD) in chronic diseases. Our study aimed to investigate its association with thyroid function in Type 2 Diabetes Mellitus(T2DM).Methods: 730 patients with T2DM were enrolled. Thyroid and VD levels were measured. Patients were divided into (…)
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624-P: Cardiometabolic Improvements Increase with Weight Loss among People with Type 2 Diabetes in a Carbohydrate-Restricted Nutrition Therapy Diabetes

Background: Recent therapeutic advancements yield cardiovascular benefit with weight loss (WL) significantly greater than the 5% target, but carbohydrate restriction has been associated with improved cardiometabolic markers independent of WL. We explored differences in cardiometabolic outcomes (…)
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623-P: Remission of Type 2 Diabetes by Low-Calorie Meal Replacement and Real Food–Based Diets—A Six-Month Pilot Intervention in China Diabetes

Objective: To determine the feasibility of achieving type 2 diabetes (T2D) remission by low calorie meal replacement diet (LCMRD) and real food-based diet (LCRFD) in Chinese people with T2D.Methods: This 6-month intervention consisted of a 3-month isocaloric intensive weight loss phase (815-835 (…)
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622-P: Carbohydrate Counting and Bolus Calculator Mobile-Based Application in Adults with Type 1 Diabetes Mellitus—A Randomised Controlled Study Diabetes

Introduction & Objective: Carbohydrates counting is crucial for proper glycaemic control of Type 1 diabetes mellitus (T1DM). We aimed to study the usefulness and safety of a mobile application (app) for Carbohydrates counting and bolus calculation (CHOC/BC) developed at King Fahad medical (…)
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621-P: A First Glimpse into the Usual Dietary Intake of Older Adults with Type 1 Diabetes (T1D) Diabetes

Introduction & Objective: We characterized dietary intake of older adults with T1D as a first step towards developing interventions and informing guidelines in this growing and understudied population.Methods: Older adults (?65 years) with T1D recruited through a university-affiliated (…)
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620-P: Snack-Related Insulin Adjustments in Type 1 Diabetes—A Delphi Consensus Diabetes

Introduction & Objective: Snacks are a part of normal eating patterns for many people, including those living with type 1 diabetes (T1D). However, the research on snacks and related insulin adjustments is limited. The aim of this Delphi study was to define a list of recommendations related (…)
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61-PUB: Factors Associated with Pancreatic Anti-islet Antibodies in Persons with Newly Diagnosed Diabetes Mellitus Diabetes

Introduction: Individuals initially diagnosed with diabetes mellitus (DM) may be positive for diabetes-associated autoantibodies (DAA+). The aim was to identify characteristics associated with DAA+ in a group of individuals with newly diagnosed DM, by comparing DAA+ individuals with their (…)
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61-OR: Effectiveness of Telemedicine plus Conventional Care vs. Conventional Care Alone in Reducing Complications of Diabetes—A Pilot Study Diabetes

Telehealth interventions are increasingly recognized as effective strategies for improving health and ensuring better patient outcomes. This study focuses on Diabetes Tele-Management System (DTMS®), a comprehensive telemedicine program established in Kerala, India in 1997. In this (…)
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619-P: Oral Hygiene Practices Linked to Dietary Fiber and Essential Nutrients Intake and Glycemic Management in Type 2 Diabetes Diabetes

Introduction & Objective: In type 2 diabetes (T2D), dietary therapy focusing on high-fiber foods is recommended for better glycemic management. However, oral health issues like tooth loss disturb essential nutrient intake. This study investigates the relationship between oral hygiene, (…)
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618-P: Development of a New Index Based on 24-Hour Urinary Creatinine to Predict Improvement of Lumbar Spine BMD after One Year of Zoledronic Acid Treatment for Osteoporosis Diabetes

Introduction & Objective: Muscle and bone can interact with each other, but the effect of muscle on osteoporosis treatment is not clear. This study aims to study the correlation between 24 h Ucr (24-hour urinary creatinine excretion, an indicator of muscle mass) and the change of lumbar (…)
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617-P: Impact of Culturally Sensitive, Mobile Health Based Nutrition Platform in Metabolic Health of African Americans in Southeast Virginia Diabetes

Mobile health (mHealth) lifestyle interventions for obesity have gained popularity. However, acceptance and efficacy of these in minority populations is less known. The aim of this study was to assess efficacy of a 12-week culturally sensitive mHealth dietary intervention on weight in African (…)
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317-OR: Identification of Genetic Regulators of Circulating Biomarkers of Kidney Decline in Diabetes Diabetes

Background: Over the past decade, major progress has been made in identifying predictors of kidney disease progression in patients with diabetes mellitus (DM). Despite this progress, however, a key feature that has yet to be considered in current prognostic models, and one that is critical (…)
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316-OR: Interoception Predicts Impaired Awareness of Hypoglycemia (IAH) in Adults with Type 1 Diabetes (T1D) Diabetes

Introduction: Recurrent hypoglycemia attenuates hypoglycemia symptoms, making symptom detection more challenging and leading to IAH. However, some with T1D maintain hypoglycemia awareness despite symptom attenuation. Interoception, or the ability to sense, interpret, and integrate internal (…)
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315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes Diabetes

Introduction & Objective: Patients with Type 1 Diabetes (T1D) have altered brain functional connectivity (FC) at resting state, particularly in attention and decision-making brain regions. Recent studies have shown that assessing FC during a cognitive task may be more predictive of (…)
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314-OR: A Randomized Study of a GPR119 Agonist on Glucagon Counterregulation during Hypoglycemia in Type 1 Diabetes Mellitus (T1DM) Diabetes

Introduction: Activation of GPR119 receptors (expressed on enteroendocrine and pancreatic islet cells) augments glucagon counter-regulatory responses to hypoglycemia in pre-clinical models. This response is studied using MBX-2982, a GPR119 agonist, in participants with T1D.Methods: This phase 2a (…)
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313-OR: Metoclopramide Improves Hypoglycemic Counterregulation in Diabetic Rats Diabetes

Introduction & Objective: To investigate the potential of metoclopramide, a dopamine antagonist, in mitigating impaired hypoglycemic counterregulation in a diabetic animal model.Methods: Diabetes was induced in 10-week-old Sprague-Dawley rats with streptozotocin (STZ, 65 mg/kg IP). Rats were (…)
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312-OR: OPAT Is Protective of Major Amputation following Hospitalization for Diabetic Foot Infection Diabetes

Introduction & Objectives: Diabetic foot ulcers are a common complication of diabetes associated with high morbidity and mortality. It is estimated that the United States spends up to $13 billion USD each year on DFUs, with individual costs rising to $15,000 per year. Much of this (…)
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1708-P: Effect of Oral Semaglutide in Glycemic Control and Weight Reduction for People with Type 2 Diabetes Mellitus Having a BMI ?25 kg/m2—A Six-Month Real-World Study Diabetes

Overweight and obesity are increasingly recognized as potential targets for early intervention. Unlike injectable treatments, oral formulations are more easily accepted by people with diabetes. In Asian Indians, BMI ? 25 kg/m2 is considered obesity. Study participants were de-identified from the (…)
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170-OR: Case-Control Study on Whole-Methylome Analysis of Monocytes in Acute Diabetic Charcot Foot—Identifying Differentially Methylated Genes Diabetes

Introduction: Diabetic Charcot Foot (DCF) is a serious diabetes complication that damages bones and joints. Monocyte epigenetic modifications, notably DNA methylation, during DCF are unresolved. This study aims to analyze the whole-methylome of monocytes in acute DCF to identify differentially (…)
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1579-P: Altered Serum Ceramides as Part of Dyslipidemia in Adolescents with Metabolic Dysfunction–Associated Steatotic Liver Disease Diabetes

Introduction & Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) in adults is associated with altered plasma ceramides, and may serve as liver metabolic biomarkers. However, less is known about whether similar changes are present in adolescents. We performed a (…)
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1851-LB: “You feel isolated. You’re kind of in over your head”—Experiences of Caregivers of Aging People with Diabetes Diabetes

Type 1 diabetes (T1D) is becoming more prevalent in the aging U.S. population due to treatment advancements resulting in people with T1D living longer and more people being diagnosed with T1D as adults. Unfortunately, resources to care for aging people with T1D are sparse. This dearth of (…)
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1850-LB: Role of Cardiovascular Risk Communication in Motivating Self-Management of Young-Onset Type 2 Diabetes (YOD)—A Mixed-Methods Study Diabetes

Introduction & Objective: Optimal self-management may help mitigate the high cardiovascular risk of YOD (defined as age at type 2 diabetes diagnosis DisclosureM. Abraha: None. J. Senga: None. C.H. Yu: None. B.R. Shah: None. C. Ke: Advisory Panel; Sanofi. Speaker's Bureau; (…)
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184-OR: Association between Composite Dietary Antioxidant Index and Stroke among U.S. Adults with Diabetes—Insights from NHANES Diabetes

Introduction & Objective: While previous research suggests a negative correlation between the Composite Dietary Antioxidant Index (CDAI) and stroke prevalence, particularly in pre-diabetes, data on this relationship in diabetic individuals remain limited. This study aims to assess the (…)
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1849-LB: Social Determinants of Health and Early-Onset Type 2 Diabetes—A Qualitative Study Diabetes

Objective: To explore how social determinants of health (SoDH) affect disease perception and diabetes care in Koreans with early-onset type 2 diabetes (T2D).Methods: A qualitative research study included 35 Koreans (54.29% men) out of 83 contacts, diagnosed with T2D prior to 40 years of age. (…)
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1578-P: Recombinant Decorin Improves Features of Diabetes-Related Steatotic Liver Disease in Mice Diabetes

Although type 2 diabetes closely associates with metabolic dysfunction-associated steatotic liver disease (MASLD) and accelerates its progression to steatohepatitis (MASH), fibrosis and hepatocellular carcinoma (HCC), still no treatment has been approved for MASLD. The extracellular matrix (…)
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1707-P: Real-World 12-Month Weight Loss Outcomes of Tirzepatide—The Mayo Clinic Experience Diabetes

Introduction: Tirzepatide, a dual GIP/GLP-1 receptor agonist, has been recently approved for the treatment of overweight and obesity given its proven effectiveness and safety in phase 3 clinical trials. In this study, we aim to evaluate weight loss outcomes associated with tirzepatide in the (…)
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1706-P: Software-Aided Self Selection of Weight Loss Diet Plan for Facilitating Diabetes Management in Primary Care Diabetes

Introduction and Objectives: The addition of a new anti-diabetes drugs have further strengthened pharmacological management of diabetes. However, attention to diet continues to be a cornerstone of diabetes management, particularly because of the preponderance of obesity in individuals with (…)
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1705-P: Obesity Phenotype Exhibit Differential Signatures of Circulating Biomarkers with Susceptible Obesity-Related Comorbidities Diabetes

Background: Obesity is a heterogeneous disease with different phenotypes based on physiological and biological differences in energy intake and expenditure. A recent study determined that guided therapy based on the classification of obesity phenotypes achieved better outcomes with respect to (…)
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1704-P: Misperception of One’s Own Obesity Status—Causes and Consequences—Insights from a Large Nationwide Survey Diabetes

Introduction & Objective: Correct self-perception of BMI (Body Mass index) status is essential to adopt a healthy lifestyle and experience improved quality of life. The current study evaluates the extent of misperception in the Indian population and its influence on an individual’s (…)

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