02:00
AbstractBackground and AimsGlobal regulation of mRNA translation has emerged as a central mechanism driving cellular adaptation to innate or acquired metabolic challenges. tRNA modifications are emerging as key drivers in the reprogramming of mRNA translation. Metabolic dysregulation is a (…)
02:00
AbstractBackground and AimsFabry disease (FD), an X-linked lysosomal storage disorder caused by alpha-galactosidase A (?-Gal A) deficiency, leads to significant morbidity and early mortality due to progressive organ failure. Given the availability of enzyme replacement therapy, early (…)
02:00
AbstractBackground and AimsObesity is a modifiable risk factor for the development and progression of chronic kidney disease (CKD). Pathways through which obesity might cause renal disease are not completely understood, as not all obese subjects develop CKD. In terms of deepening the knowledge (…)
02:00
AbstractBackground and AimsAcute kidney injury (AKI) in tropical countries is strikingly different from the other countries with a temperate climate. The epidemiology of AKI is largely influenced by environmental factors and climatic conditions and differ significantly its outcome and the (…)
02:00
AbstractBackground and AimsDiabetes nephropathy (DN) remains the primary cause of end-stage renal disease (ESRD), warranting equal attention and separate analysis of glomerular, tubular, and interstitial lesions in its diagnosis and intervention. This study aims to identify the specific (…)
02:00
AbstractBackground and AimsAcute renal injury can cause electrolyte disorders that increase patient morbidity and mortality. There are few data in the literature describing these alterations and the possible correlation between them in patients with community-acquired AKI (CA-AKI).The purpose of (…)
02:00
AbstractBackground and AimsProliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is an entity characterized by glomerular deposition of monoclonal immunoglobulins, typically IgG. Recently, a cohort of 17 patients presenting with light chain only variant of PGNMID was (…)
02:00
AbstractBackground and AimsIntact podocyte foot processes (FP) play a crucial role in ensuring proper selective filtration in the kidney. Changes in FP morphology are thought to be the initial trigger for proteinuria, but definitive proof is still missing. As FP structures are below the optical (…)
02:00
AbstractBackground and AimsThe autologous vein transposition was commonly used for hemodialysis vascular access (VA) in selected patient. The saphenous vein was used as a vascular graft; while, the contralateral cephalic vein was used as a bridge. We describe a new technique of autologous (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN) is one of the most common forms of glomerulonephritis and causes hematuria and proteinuria by damaging the mesangial and podocyte cells. Urinary extracellular vesicles (uEVs) derived from damaged podocytes may reflect podocyte damage in various (…)
02:00
AbstractBackground and AimsRecent evidence suggests that AVF creation may slow estimated glomerular filtration rate (eGFR) decline. The aim of the present study was to assess the impact of the pre dialysis AVF creation on eGFR decline and the need for dialysis, after controlling for key (…)
02:00
AbstractBackground and AimsAKI associated with COVID19 is highly prevalent; there is controversy if it is similar to AKI in sepsis of bacterial origin. Macrophage differentiation M1-M2 is a predictor of outcomes. Macrophage expression in kidney tissue is not known in patients with severe COVID19 (…)
02:00
AbstractBackground and AimsCare for patients receiving maintenance haemodialysis (MH) is critically dependent on multi-professional coordination of care for multimorbidity and complex care needs. Design and coordination of care models is an important clinical concern (Kharbanda et al., 2020). We (…)
02:00
AbstractBackground and AimsPXDN is a multifunctional heme peroxidase responsible for the crosslinking of type IV collagen protomers at basement membranes, playing a crucial role in the extracellular matrix dynamics. In renal pathophysiology, increased PXDN expression has been associated with (…)
02:00
AbstractBackground and AimsIn nephrology, there is a growing interest in identifying patients’ priorities to achieve meaningful outcomes. A particular relevant outcome in end stage kidney disease is fatigue, with prevalence ranging from 60% to 97% in patients receiving hemodialysis. Different (…)
02:00
AbstractBackground and AimsInterstitial inflammation in acute interstitial nephritis can advance into tubular epithelial cells and produce proximal tubular dysfunction, which may be clinically expressed as renal glycosuria. Previous studies have shown that the presence of renal glycosuria in (…)
02:00
AbstractBackground and AimsHealth-related quality of life (HRQOL) as self-reported health status is known to predict mortality in hemodialysis (HD) patients. Infection is one of the major causes for death in those patients, although limited studies have examined possible associations of HRQOL (…)
02:00
AbstractBackground and AimsThe hospitalization rate of patients undergoing hemodialysis (HD) is high, due to complications related to renal failure and hemodialysis treatment. Therefore, it is crucial to provide rehabilitation for hospitalized HD patients to improve their activities of daily (…)
02:00
AbstractBackground and AimsClinically, left renal vein (LRV) entrapment is almost equivalent to the nutcracker phenomenon (NCP). However, there is still much uncertainty and debate about the prevalence of NCP and its diagnostic criteria. As a particular type of LRV entrapment, the LRV (…)
02:00
AbstractBackground and AimsThere is now increased interest in the study of morpho-functional myocardial changes in excess NaCl consumption, which develop independently of AD dynamics. Myocardial remodeling may involve microRNAs that modulate gene expression at the post-transcription level. (…)
02:00
AbstractBackground and AimsIgA Vasculitis (IgAV) frequently has a relapsing/refractory course despite glucocorticoids and immunosuppressive therapies and the management of severe disease remains controversial [1]. Plasma exchange (PLEX) has been used as a rescue treatment in other vasculitides, (…)
02:00
AbstractBackground and AimsPax2 mutations are known to cause kidney disease; both syndromic conditions, as kidney coloboma syndrome, and kidney specific disorders, as FSGS, have been described. Due to the rarity of Pax2-related nephropathies, data on genotype-phenotype correlation are (…)
02:00
AbstractBackground and AimsPersisting proteinuria has been associated with worse kidney outcomes in ANCA-associated glomerulonephritis (AAGN). However, it remains unclear whether this reflects damage from the initial injury or ongoing inflammation.MethodA retrospective, single centre study of (…)
02:00
AbstractBackground and AimsThe von Hippel-Lindau (VHL) syndrome is a rare genetic disease caused by inactivating mutations of the VHL tumor suppressor gene. VHL syndrome patients frequently develop clear cell renal cell carcinomas (ccRCCs). pVHL acts as the substrate recognition subunit of an E3 (…)
02:00
AbstractBackground and AimsComplement activation is involved in IgA nephropathy (IgAN), opening up new avenues for complement-targeting therapies. However, precise patient selection and optimal timing for these therapies are essential. Current diagnostic methods of complement activation in IgAN, (…)
02:00
AbstractBackground and AimsX?linked hypophosphatemia (XLH), the most common form of hypophosphatemic rickets, is caused by genetic alterations in the PHEX gene. Prevalence of the X?linked disease is ?1/20,000. The PHEX gene has 22 exons and encodes a 749 amino acid protein with homology to zinc (…)
02:00
AbstractBackground and AimsInterstitial lung disease (ILD) in ANCA-associated vasculitis (AAV) has the appearance of a progressive fibrotic disease on imaging and primarily affects the interstitial lung compartment and is usually associated with MPO-ANCA. Whether patients with AAV-ILD display a (…)
02:00
AbstractBackground and AimsRecent studies suggest a close association between low serum magnesium levels and kidney injury. However, whether dietary magnesium intake relates with kidney function is not well known. In this study, the relationship of dietary magnesium intake with the development (…)
02:00
AbstractBackground and AimsActivated neutrophils can release web-like chromatin structures known as neutrophil extracellular traps (NETs), but their roles in the immunopathogenesis of diabetic kidney disease (DKD) remains elusive.MethodThe characteristic NETs associated targets of differentially (…)
02:00
AbstractBackground and AimsLiver failure poses a significant clinical challenge with compromised functionality of the liver and accumulation of toxic metabolites. The lack of bedside-compatible methods to evaluate treatment response during therapy underscores the urgent need for refined (…)
02:00
AbstractBackground and AimsOver the past decade, an unanswered question has emerged: which is the best equation for estimating glomerular filtration rate (eGFR) in older patients with chronic kidney disease (CKD)? Despite the lack of consensus, cystatin C appears to hold promise, as it is not (…)
02:00
AbstractBackground and AimsOlder patients with antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) commonly experience renal impairment and poor prognosis. The European Vasculitis Study Group trials showed that approximately 16.7% and 22.5% of older patients with AAV suffered (…)
02:00
AbstractBackground and AimsKidney biopsy (KB) is the gold standard in diagnosing the majority of kidney diseases. While generally KB is a safe procedure, a complication rate of 6-8% has been reported, mainly bleeding. Halimi et al. proposed “The Major Bleeding Risk Score” (MBRS) identifying 11 (…)
02:00
AbstractBackground and AimsMultimorbidity, frailty and sarcopenia are increasingly prevalent in people with chronic kidney disease (CKD). Creatinine Muscle Index (CMI) has been proposed as a novel surrogate marker of muscle mass, and lower CMI was associated with frailty and increased mortality (…)
02:00
AbstractBackground and AimsSecondary hyperparathyroidism (SHPT) remains one of the main problems in patients with chronic kidney disease (CKD), associated with deterioration in quality of life, progression of cardiovascular complications and mortality.MethodPatients on HD (n = 2517) were treated (…)
02:00
AbstractBackground and AimsThe presence of malnutrition in elderly patients with chronic kidney disease (CKD) is associated with adverse events such as mortality, functional decline, and worse outcomes during hospital admission. However, it is not well defined which subgroups would benefit most (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) and heart failure (HF) affect many people worldwide and both diseases remain associated with considerable morbidity and mortality. Aim of the study was to features of changes in cardiac remodelling parameters depending on the degree of (…)
02:00
AbstractBackground and AimsPatients with CKD show high cardiovascular complication rates. There are classical cardiovascular risk factors, such as obesity, dyslipidemia, and diabetes; however, other cardiovascular disease risk factors are associated with mineral metabolism disorders (phosphorus, (…)
02:00
AbstractBackground and AimsChronic kidney disease of unknown etiology (CKDu) has exponentially increased in the rural areas of the Pacific Coast in Central America. A multifactorial etiology has been postulated including exposure to environmental nephrotoxins such as heavy metals. The Pacific (…)
02:00
AbstractBackground and AimsAssessing volume status in heart failure (HF) and end-stage chronic kidney disease (CKD) is challenging. Plasma volume expansion is an early step in the pathophysiology of decompensated HF and an independent risk factor for death and HF hospitalization, and should be (…)
02:00
AbstractBackground and AimsBariatric and metabolic surgery is the treatment of choice for severe obesity aiming to improve quality of life and control comorbidities, including chronic kidney disease (CKD). Careful monitoring of metabolic components, including markers of kidney function, are (…)
02:00
AbstractBackground and AimsThe prevalence of chronic kidney disease (CKD) has been increasing, affecting 850 million people worldwide and 13 million individuals in Japan. CKD is a risk factor for cardiovascular complications including heart failure, and dialysis. KDIGO risk classification is (…)
02:00
AbstractBackground and AimsHigh food intake of NaCl is the traditional factor of increase in blood pressure (BP) and cardiovascular risks also hurts kidneys. The purpose of the paper is to evaluate the morphological changes in the myocardium of normotensive Wistar rats with an early stage of (…)
02:00
AbstractBackground and AimsQuantifying the kidney function is crucial for diagnosing and monitoring kidney disorders in clinical practice. Recently, the CKD-EPI 2021 formula was developed for estimating glomerular filtration rate (eGFR), excluding the ethnicity variable. In this study, we aimed (…)
02:00
AbstractBackground and AimsLeptin, the anorexic hormone, also appears to have a proatherogenic effect, contributing to the development of cardiovascular morbidity and mortality. Current data on factors related to serum leptin levels in different stages of chronic kidney disease (CKD) are (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) represents a significant and growing global health challenge, especially among aging populations. Despite declines in mortality from other non-communicable diseases, CKD-related mortality has remained stable, underscoring the need for (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) is a progressive disorder that affects more than 10% of the general population worldwide. Despite great achievements in the field of treatment of CKD, patient mortality remains at a high level. Research into the pathophysiology and (…)
02:00
AbstractBackground and AimsDetection of HLA antibodies (HLA-Abs) impacts on the access and outcomes of kidney transplantation (KT). Currently, evaluation of HLA-Abs in serum is performed using single antigen bead assays (SAB). The analysis of circulating HLA-specific memory B cells (mBc), (…)
02:00
AbstractBackground and AimsFrailty is a common geriatric syndrome of significant public health importance. The kidney is one of the organs that progressively loses function with aging leading a decrease of glomerular filtration rate (GFR). In elderly the definition of eGFR threshold for the (…)
02:00
AbstractBackground and AimsSubpopulations of CD4+ cells, play a major role in mediation of rejection and tolerance to a renal transplant. This study examined subsets of CD4+ T cells and CD4+CD25+CD127lo Treg in blood of renal graft recipients with grafts surviving >10 years for changes in (…)
02:00
AbstractBackground and AimsThe effect of vaccinations against SARS-CoV-2 on risk of infection and subsequent adverse outcomes in patients with kidney dysfunction beyond end-stage kidney disease remains uncertain. Based on nationwide data from multiple health care registers, the study aims to (…)
02:00
AbstractBackground and AimsGenome sequencing is rapidly becoming a routine approach to investigating inherited human diseases in clinical practice. Nevertheless, data generated from genome sequencing requires extensive bioinformatic analysis and filtering of variants to determine pathogenicity (…)
02:00
AbstractBackground and AimsKidney disease is a global health problem in which various aetiologies contribute to renal injury and dysfunction. Renal ischaemia-reperfusion injury (IRI) is a condition caused by early oxidative stress due to renal tissue ischaemia and a rapid immune response after (…)
02:00
AbstractBackground and AimsKidney transplantation (KT) is the main treatment option for patients with end-stage kidney disease (ESKD). However, it is limited by the low number of donor organs. Moreover, donor–recipient size mismatching is a common problem in KT given the various types of donors. (…)
02:00
AbstractBackground and AimsAutosomal dominant polycystic kidney disease (ADPKD) is an adult-onset, multi-systemic disorder, that affects ?12.5 million people worldwide. ADPKD is characterised by progressive kidney enlargement caused by uncontrollable growth of cysts, alongside extra-renal (…)
02:00
AbstractBackground and AimsThe selection of the appropriate living kidney donor can be challenging, given the absence of a definitive method to determine the quality of the renal graft. This decision requires a delicate balance, weighing the recipient's benefits while prioritizing the safety of (…)
02:00
AbstractBackground and AimsPercutaneous kidney biopsy remains the gold standard for diagnosis of kidney disease. The incidence of bleeding complications following kidney biopsy ranges from 13 to 34%. This study aimed to evaluate the effect of prebiopsy administration of intranasal desmopressin (…)
02:00
AbstractBackground and AimsKidney transplantation is the optimal treatment for end-stage renal disease. To meet the growing demand for kidney allografts and to ensure the well-being of donors, laparoscopic nephrectomy has been adopted leading to superior donor outcomes. However, data on (…)
02:00
AbstractBackground and AimsPatients with nephrotic syndrome are at increased risk of thrombotic events. The risk of thromboembolism is particularly high in patients with primary membranous nephropathy, elderly patients and patients with severe hypoalbuminemia. Although increased incidence of (…)
02:00
AbstractBackground and AimsThe adequate perfusion pressure to the graft is essential for proper graft function in kidney transplantation, especially in deceased donor kidney transplantation. In particular, Mean arterial pressure (MAP) during operation can affect early graft function because MAP (…)
02:00
AbstractBackground and AimsImmunoglobulin A (IgA) nephropathy is one of the most frequent glomerular diseases and is sometimes refractory, requiring kidney replacement therapy. Although corticosteroids are mainly used for treatment, infection is a serious adverse event, and evidence for (…)
02:00
AbstractBackground and AimsValvular heart disease (VHD) is a risk factor for adverse outcomes in end-stage kidney disease (ESKD) patients. However, the impact of individual valvular heart lesions on outcomes in patients on the kidney transplant waitlist is unclear. This study aims to analyse the (…)
02:00
AbstractBackground and AimsThere is a detrimental effect of chronic kidney disease (CKD) on health states, with many patients worldwide experiencing considerable symptom burden and development of comorbidities, leading to frequent medical appointments and hospitalisations. Patients experience (…)
02:00
AbstractBackground and AimsThe COVID-19 pandemic had a profound impact on global health, particularly affecting high-risk individuals such as solid organ transplant recipients (SOTRs). SOTRs have an elevated risk of severe COVID-19 disease and increased mortality. Kidney transplant recipients (…)
02:00
AbstractBackground and AimsPatients with chronic kidney disease (CKD) often rely on informal caregivers for support with their condition, but the effect of these responsibilities on caregivers’ lives is poorly understood. The aim of this study was to quantify the effect of CKD on caregivers’ (…)
02:00
AbstractBackground and AimsAlthough widely used during deceased kidney donor selection, donor plasma creatinine has limited capacity to predict future recipient kidney graft function. Cystatin C is a muscle-mass independent kidney function marker that could serve as alternative for this purpose. (…)
02:00
AbstractBackground and AimsThe diagnostic criteria for chronic kidney disease (CKD) recognise that measures of kidney function may fluctuate in the short term by requiring that abnormalities must persist for at least 90 days to support the diagnosis. Nevertheless, studies have reported that even (…)
02:00
AbstractBackground and AimsKidney transplant recipients are predisposed to chronic infections and malignancies because they receive chronic immunosuppressive therapy. Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. HPV is a significant cause of cervical, (…)
02:00
AbstractBackground and AimsCalciphylaxis is a rare, severe complication of chronic kidney disease mineral bone disorder. It is hosphorzed by arteriolar calcification of the subcutaneous fat and dermis, and associated with a mortality rate of approximately 50% within a year of diagnosis. The (…)
02:00
AbstractBackground and AimsSeveral guidelines suggest screening for peripheral artery disease before kidney transplantation including the Kidney Disease: Improving Global Outcomes. There is currently no consensus on whom or how to screen for peripheral artery disease. We examined the clinical (…)
02:00
AbstractBackground and AimsThe cardiovascular and kidney benefits of sodium-glucose co-transporter-2 (SGLT2) inhibitors in people with chronic kidney disease (CKD) are well established. The implementation of updated SGLT2 inhibitor guidelines and prescribing in the real-world CKD population (…)
02:00
AbstractBackground and AimsKidney transplantation is a treatment for many patients with end stage renal disease leading to increased quality of life. In last decades results in kidney transplantation have been improving, but allograft rejection remains an important clinical problem. Graft biopsy (…)
02:00
AbstractBackground and AimsNo data exists on humoral or cellular responses to mRNA vaccines in kidney transplant recipients (KTR) with HIV. We compared these responses in HIV-positive and negative KTR, as well as in people living with HIV (PLWH) without kidney transplantation.MethodIn a (…)
02:00
AbstractBackground and AimsUltra-processed foods (UPF) are formulations of ingredients that are mostly of exclusive industrial use and may contain additives like artificial colors, flavors, or stabilizers. The sale and consumption of these foods has been increasing despite their associations (…)
02:00
AbstractBackground and AimsHospital Acute kidney injury (H-AKI) is a complex entity associated with an increased risk of complications and mortality. Its occurrence and outcome are influenced by several patient and organizational-related factors.Due to the biological and genetic differences, sex (…)
02:00
AbstractBackground and AimsAcute kidney injury (AKI) is frequent in hospitalized patients and contributes to adverse short- and long-term outcomes. We aimed to evaluate the association of AKI and long-term adverse renal events and mortality in a cohort of patients hospitalized with (…)
02:00
AbstractBackground and AimsObesity is intimately linked to the initiation and progression of chronic kidney disease, but questions on causality still remain. The diagnosis of chronic kidney disease is often based solely on creatinine- and/or cystatin C-based estimated glomerular filtration rate (…)
02:00
AbstractBackground and AimsTherapeutic plasmapheresis (TP) is an established therapy in different pathology according to international guidelines. There is different method of TP such as single plasma exchange (SPE) and Double plasmafiltration (DFPP) defined as non selective or semi selective (…)
02:00
AbstractBackground and AimsHepatitis B virus (HBV) infection presents a global health burden. Despite notable advancements over recent decades, it still accounts for 42% of liver cirrhosis, 40% of hepatocellular carcinoma (HCC) and 60% of viral hepatitis-related deaths. Acute kidney injury (AKI) (…)
02:00
AbstractBackground and AimsThe use of CD offers anticoagulation with a reduced dose of heparin while the use of L-Ascorbic acid offers better management of the patients' anemia. The purpose of the study is to record the experience of using CD solution with Vitamin-C in patients with ESRD under (…)
02:00
AbstractBackground and AimsIntensive care patients had higher mortality and SOFA score is used for mortality prediction. The SOFA score was developed more than 25 years ago to monitor organ dysfunction. Nowadays, blood lactate levels indicate septic shock and work as a new vital sign. This study (…)
02:00
AbstractBackground and AimsGenetic testing has increasingly been employed to provide definitive diagnoses and prognostic information in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). We aim to explore the genetic landscape of ADPKD in a Chinese cohort utilizing whole genome (…)
02:00
AbstractBackground and AimsCurrent literature presents conflicting evidence regarding the benefits of Color Doppler Ultrasound (DUS) in the preoperative vascular mapping of arteriovenous fistula (AVF) for haemodialysis. Thus, we conducted a systematic review and meta-analysis of RCTs to evaluate (…)
02:00
AbstractBackground and AimsThe association between Body Mass Index (BMI) and the risk of mortality in patients with end stage renal diseases and dialysis treatment is debated. The aim of this study was to assess the association between BMI and the risk of all-cause mortality in patients with (…)
02:00
AbstractBackground and AimsCardiovascular complications in patients with autosomal dominant polycystic kidney disease (ADPKD) are one of the most frequently investigated extrarenal manifestations. The results are many times contradictory. This is caused by a limited size of studied populations (…)
02:00
AbstractBackground and AimsFamilial hematuria diseases are a heterogeneous group of monogenic conditions caused by mutations in one of the collagen IV genes: COL4A3 (2q36.3), COL4A4 (2q36.3), and COL4A5 (Xq22.3) that are expressed in the glomerular basement membranes (GBM) and are responsible (…)
02:00
AbstractBackground and AimsHypertension in autosomal dominant polycystic kidney disease is in part mediated by reduced polycystin-regulated nitric oxide synthase activity. In this study, the hypothesis that beetroot juice (BRJ, a rich natural dietary source of nitrate) reduces blood pressure in (…)
02:00
AbstractBackground and AimsAdenine phosphoribosyltransferase (APRT) deficiency is a rare disorder of purine metabolism, characterized by urinary excretion of the poorly soluble 2,8-dihydroxyadenine (DHA), leading to nephrolithiasis and chronic kidney disease (CKD). Treatment with xanthine (…)
02:00
AbstractBackground and AimsAutosomal dominant polycystic kidney disease (ADPKD) is the most common single-gene inherited kidney disorder, affecting approximately 1 in 500-1000 newborns and often leading to end-stage renal disease. It involves cyst formation in various organs, with renal (…)
02:00
AbstractIntroductionAlport syndrome is a genetic condition stemming from mutation in Type IV collagen and is characterized by kidney disease and frequently hearing loss and ocular abnormalities. Renal involvement is from an abnormality of the glomerular basement membrane with hematuria and (…)
02:00
AbstractBackground and AimsFabry disease (FD) is an X-linked rare lysosomal storage disease causing progressive nervous system, kidney and heart disorders. Progressive kidney impairment is common, and an important cause of morbidity and mortality. In FD females, treatment guidelines recommend (…)
02:00
AbstractBackground and AimsGenetic risk for elevated blood pressure (BP) has been associated with a higher risk of hypertension and cardiovascular disease. However, the generalizability of previous findings has been limited due to a lack of studies among Asian populations. This study aimed to (…)
02:00
AbstractBackground and AimsWith the rising prevalence of chronic kidney disease (CKD), particularly among the elderly, the need for effective renal replacement therapy has become increasingly crucial. Peritoneal dialysis (PD), recognized as a gentler alternative to haemodialysis, offers (…)
02:00
AbstractBackground and AimsDiabetes mellitus (DM) and chronic kidney disease (CKD) are risk factors for vascular atherosclerosis, a pathological process with an important inflammatory component. The coexistence of these conditions in patients with diabetic kidney disease (DKD) has additive (…)
02:00
AbstractBackground and AimsGeneral and abdominal obesity are prevalent, with established associations to frailty in the elderly. However, few studies investigated these associations in patients with chronic kidney disease (CKD), yielding inconsistent results. We explored the relationship between (…)
02:00
AbstractBackground and AimsHeart failure (HF) is frequent in chronic kidney disease (CKD) and leads to high morbidity and mortality in this patient category. The aim of our study is to assess the clinical and biological profile, and outcomes in CKD patients with preserved left ventricular (…)
02:00
AbstractBackground and AimsEven mild fluid overload and prolonged exposure to salt excess showed to be associated with all-cause mortality in hemodialysis patients. This analysis aims to estimate the effect of fluid and sodium imbalance on cause-specific mortality.MethodThe study followed 68,196 (…)
02:00
AbstractBackground and AimsDiabetic kidney disease (DKD), occurs in 20–40% of patients with diabetes mellitus (DM), is the leading cause of end-stage renal disease (ESRD). DKD is a clinical diagnosis mainly based on the persistent albuminuria and reduced estimated glomerular filtration rate (…)
02:00
AbstractBackground and AimsDespite numerous population pharmacokinetic studies on polymyxin B, a gap exists in establishing uniform dosing strategies among sepsis patients due to various clinical and patient related factors. The International Consensus guidelines, provide detailed dosing (…)
02:00
AbstractBackground and AimsWe tested the effectiveness of a village doctor-led multifaceted strategy on blood pressure (BP) control over 36 months among patients with hypertension in rural China. Village doctors are community health workers who provide basic primary health care in rural (…)
02:00
AbstractBackground and AimsMortality within the first year after dialysis start is estimated to be 20-30%, and it is mostly due to cardiovascular disease. Prognostic assessment after starting hemodialysis is challenging. Clark et al. developed the Recovery and Death Outcome risk score, which (…)
02:00
AbstractBackground and AimsAs the leading cause of chronic kidney disease, diabetic kidney disease (DKD) is an enormous burden for all healthcare systems around the world. However, its early diagnosis has no effective methods.MethodFirst, gene expression data in GEO database were extracted, and (…)
02:00
AbstractBackground and AimsTo study the functional state of the kidneys and cardiorenal relationships in patients with chronic heart failure, depending on the representation of components of metabolic syndromeMethodTo achieve the objectives, 227 male patients with chronic heart failure (CHF) of (…)
02:00
AbstractBackground and AimsDiabetic microangiopathy is a specific vascular complication of diabetes mellitus type 2, which matters to patients' mortality and individual prognosis. Therefore, an important problem is the development of non-invasive methods for the diagnosis of diabetic (…)
02:00
AbstractBackground and AimsIn acute kidney damage, the monitoring of hemodynamic status is best achieved by determining the blood pressure value. It is considered that the values of diastolic blood pressure in young and healthy people are constant from the aorta to the periphery, and the values (…)
02:00
AbstractBackground and AimsAs shown in a proof-of-concept study, renal function of fast immediate-release tacrolimus (IR-Tac) metabolizers can recover after conversion to prolonged-release tacrolimus (LCP-Tac), whereas slow Tac metabolizers showed no benefit over a 3-year follow-up [1]. The aim (…)
02:00
AbstractBackground and AimsAcute kidney injury (AKI) is a clinical syndrome with heterogeneous pathophysiological mechanisms, associated with higher morbidity and mortality risk. The existing evidence shows that an episode of AKI increases the risk of chronic kidney disease and end-stage kidney (…)
02:00
AbstractBackground and AimsResponses to vaccinations among kidney transplant recipients (KTRs) tend to be impaired compared to those of healthy individuals, a fact that can, to some degree, be attributed to their more senescent immune system profile. However, in the current literature, few data (…)
02:00
AbstractBackground and AimsThe most worldwide used classification system for staging AKI is KDIGO-2012, it was based on a combination of the RIFLE and AKIN criteria. KDIGO severity stages are defined:Stage 1 ? in SCr by >0.3 mg/dl or increase in SCr to >1.5x baseline.Stage 2 ? in SCr ?2.0–2.9x (…)
02:00
AbstractBackground and AimsAcute kidney INJURY (AKI) is a common complication (40%) in ICU patients, especially in septic patients, and it´s associated with high morbidity and mortality [2, 4].Even though sepsis-associated AKI (S-AKI) is multifactorial, the elevation of cytokines plays a major (…)
02:00
AbstractBackground and AimsAutosomal dominant polycystic kidney disease (ADPKD) is a common form of hereditary kidney disease, with an estimated prevalence of 1 out of 1000 individuals worldwide. Although its key clinical manifestation is progressive formation and growth of renal cysts, (…)
02:00
AbstractBackground and AimsContinuous renal replacement therapy (CRRT) is pivotal for managing acute kidney injury (AKI) unstable patients. However, questions persist regarding prescription and the role of anticoagulation. This study aims to examine CRRT practices, focus on citrate-based (…)
02:00
AbstractBackground and AimsAutosomal dominant tubulointerstitial kidney disease (ADTKD) due to pathogenic variants in the MUC1 gene is difficult to diagnose since these variants lie in a large variable number tandem repeats (VNTR) and require specialized genetic testing, such as SNaPshot (…)
02:00
AbstractBackground and AimsGenetic insights are becoming increasingly influential in the understanding and treatment of various kidney diseases (KD). Hundreds of genes associated with monogenic kidney disease have been identified, providing valuable insights into their diagnosis, management, and (…)
02:00
AbstractBackground and AimsTolvaptan, a selective vasopressin V2 receptor antagonist, was first approved by Korean FDA in 2015 as a treatment option in autosomal dominant polycystic kidney disease (ADPKD). In order to prescribe Tolvaptan safely and effectively, we designed the phase 4 clinical (…)
02:00
AbstractBackground and AimsThe kidney has been described as one of the most estrogen-responsive organs after reproductive ones. Many non-X-linked renal diseases present with sex differences. Although not completely elucidated, an influence of estrogens has been described in several transporters (…)
02:00
AbstractBackground and AimsRenal amyloidosis is the pathological phenomenon of amyloid deposition in the kidney with marked differences in renal function impairment, proteinuria, need for renal replacement therapy (RRT) and exitus, depending on the protein involved.Light chain amyloidosis (AL) (…)
02:00
AbstractBackground and AimsCardiovascular disease (CVD) is one of the leading causes of death in patients with ANCA-associated vasculitis (AAV). However, in current clinical guidelines, limited evidence is available to support the recommendation of AAV-specific screening for cardiovascular (…)
02:00
AbstractBackground and AimsKidney transplantation is the module of choice to reduce mortality in comparison with dialysis [1]. Many patients on transplant waiting list undergoing haemodialysis via central venous catheters [2]. Cardiovascular morbidity control is one of the pillars of successful (…)
02:00
AbstractBackground and AimsProtein tyrosine kinases (PTKs) are enzymes responsible for the phosphorylation of tyrosine residues in lymphocytes. In 2017, Mkaddem et al. suggested that unique PTK signatures in peripheral leukocytes (PBMC) are associated with lupus nephritis (LN) activity [1]. (…)
02:00
AbstractBackground and AimsWe investigated the incidence rate and type of cancer in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in our Institute.MethodWe retrospectively included 210 patients with AAV [106 patients with microscopic polyangiitis (MPA), 93 (…)
02:00
AbstractBackground and AimsDiagnostic applications of machine learning in nephropathology are only beginning to emerge. We hypothesized that we could develop a machine learning classifier for 12 different classes of glomerulonephritis with CNN and self-attention-based architectures, following (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) affects more than 10% of the population and it is associated with high risk of death for cardiovascular causes or progression towards end stage kidney disease (ESKD) requiring dialysis or kidney transplantation. CKD is characterized by (…)
02:00
AbstractBackground and AimsThe efficacy and long-term outcomes of anti-viral therapies used for hepatitis B treatment or prevention continue to be a challenging area in kidney transplantation practice. This study aimed to determine the effectiveness of anti-viral treatment in a hepatitis B (…)
02:00
AbstractBackground and AimsKidney transplantation (KTX) is the current treatment of choice in patients with kidney failure. Since immunosuppressive medication to prevent acute rejection is still needed in high doses with frequent adverse events, new strategies to achieve risk-appropriate (…)
02:00
AbstractBackground and AimsDuring chronic kidney disease (CKD) progresses, there is an increased phosphate load and the concentration of the phosphaturic hormones PTH and FGF23 rises. In patients, phosphate and FGF23 are discussed as risk factors for CKD progression. We have recently shown that (…)
02:00
AbstractBackground and AimsThe beneficial effects of administering sodium-glucose transport protein 2 (SGLT2i) inhibitors in patients with Chronic Kidney Disease, with or without Type 2 Diabetes (T2D), has been proven in large randomized controlled trials. Nevertheless, there is limited data (…)
02:00
AbstractBackground and AimsRecent investigations have elucidated the complex system involving human adult renal stem/progenitor cells (ARPCs) and their pivotal role in maintaining homeostasis and in facilitating regenerative processes within the adult kidneys. CD133+/CD24+ ARPCs can repair (…)
02:00
AbstractBackground and AimsChronic active antibody mediated graft rejection (caAMR) caused by immune-mediated injury is the leading cause of long-term graft loss in kidney transplant recipients. Nevertheless, no effective treatment exists for caAMR to date, highlighting a great unmet need for (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) is a global health threat, affecting around 12% of the population. The uremic phenotype associated with CKD is considered a predictor for the high cardiovascular and overall mortality in these patients and inflammation is regarded as an (…)
02:00
AbstractBackground and AimsC3 glomerulopathy (C3G) is a clinical-pathological entity resulting from dysregulation of the alternative pathway of the complement system (APC) in the fluid phase. The recurrence risk of C3G after kidney transplantation is about 70% with high risk of graft loss. (…)
02:00
AbstractBackground and AimsThe physiological function of sclerostin (SOST) remains unknown. It is known that SOST is produced in osteocytes and functions as an inhibitor of the Wnt/?-catenin pathway. Similarly, it is well-established that low levels of SOST lead to bone alterations affecting (…)
02:00
AbstractBackground and AimsThe recent treatments for antibody-mediated rejection (AMR) have been carried out in a small number of controlled clinical trials and are based on limited data. In recent research on AMR treatment, new drugs targeting B cells, plasma cells, the complement system, and (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) affects over 10% of the worldwide population and entails a significant risk for cardiovascular disease (CVD), leading to an up to 500-fold increase in cardiovascular mortality in advanced stages. However, the pathophysiological mechanisms (…)
02:00
AbstractBackground and AimsSerum chloride is an emerging marker of mortality in patients with hypertension, heart failure, sepsis, and chronic kidney disease. The causes of this finding are still unknown, although it is suggested that both haemodynamic and inflammatory factors may play a role. (…)
02:00
AbstractBackground and AimsThe Anemia Control Model (ACM) is a certified medical device aimed at optimizing the management of CKD-related anemia among patients on dialysis. ACM is based on an artificial neural network (ANN) trained on over 900’000 patients treated in the European Nephrocare (…)
02:00
AbstractBackground and AimsFocal segmental glomerulosclerosis (FSGS) is a histopathologic lesion observed in chronic kidney disease characterized by scarring of the glomerulus due to the injury and irreversible loss of highly specialized glomerular epithelial cells called podocytes. Recent (…)
02:00
AbstractBackground and AimsCell-matrix adhesion molecules in podocytes play a critical role in attaching these cells to the glomerular basement membrane, ensuring the proper functioning of the glomerular filtration barrier. Previous studies have shown that patients with proteinuric glomerular (…)
02:00
AbstractBackground and AimsThe study of intradialytic oxygen saturation (SO2) in hemodialysis (HD) patients is a significant yet under-explored area. This study's objective was to evaluate the epidemiological aspects of SO2 during HD. MethodSO2 levels during HD were measured using the Crit-Line (…)
02:00
AbstractBackground and AimsProteinuria is not only a biomarker of chronic kidney disease (CKD) and a risk predictor of adverse outcomes but also a driver of kidney disease progression. The excessive filtration of plasma proteins through the glomerular filtration barrier exerts a toxic effect on (…)
02:00
AbstractBackground and AimsPatients undergoing dialysis have an impaired health-related quality of life (HRQOL). There are conflicting data from small series whether patient-related factors such as educational level have an impact on experienced HRQOL. The aim of this study was to investigate (…)
02:00
AbstractBackground and AimsDespite huge efforts to accomplish equitable access to high-quality healthcare, large disparities in kidney care delivery remain across Europe. Economic factors are considered to be the driving force behind differences in access to kidney replacement therapy (KRT), (…)
02:00
AbstractBackground and AimsDiabetic nephropathy (DN), a prevalent complication of diabetes mellitus, stands as the primary contributor to chronic kidney disease and end-stage renal disease. The progression of diabetic nephropathy is facilitated by endoplasmic reticulum stress and the excessive (…)
02:00
AbstractBackground and AimsDespite prior studies on the clinical impact of COVID-19 and the documented efficacy of COVID-19 vaccinations in hemodialysis (HD) patients, the exact effects of COVID-19 vaccinations on various clinical biomarkers before and after the diagnosis of COVID-19 have not (…)
02:00
AbstractBackground and AimsIncreasing life expectancy worldwide underscores the importance of addressing the effects of aging on organ and cell function. Aging is characterized by a gradual decline in organ function that varies among individuals and is influenced by lifestyle choices and various (…)
02:00
AbstractBackground and AimsHaemodialysis (HD) represents the most common renal replacement therapy for end-stage renal disease worldwide. Despite recent advances in HD the health-related quality of life (HRQoL) should be monitored in conjunction with clinical variables to optimize a (…)
02:00
AbstractBackground and AimsMultiple factors may contribute to development and progression of glomerulopathies (GN), one of them is oxidative stress (OS). 2-cysteine-peroxiredoxins (PRDXs) possess the ability to reduce excessive levels of OS mediators and are crucial for cellular OS regulation. (…)
02:00
AbstractBackground and AimsIgA nephropathy is the most common primary glomerular disease and an important cause of end-stage renal disease. Factors such as decreased renal function, persistent proteinuria, hypertension, and older age predict a poor prognosis in IgA nephropathy. Current (…)
02:00
AbstractBackground and AimsPatient-centered outcomes play an important role when assessing treatment effects. Patient-reported outcome (PRO) measures assessing symptoms and impacts are important tools to capture the patient perspective in clinical trials. However, careful consideration is needed (…)
02:00
AbstractBackground and AimsPathogenesis of IgA nephropathy (IgAN) is known to be dependent upon multiple factors, one being the complement system. Since overactivity of the complement Alternative Pathway (AP) has been proposed to contribute to pathogenesis of IgAN, it has been hypothesized that (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) constitutes a public health concern due to its notable morbidity & mortality and associated costs. The Patient Care Coordination program (PCC) provides comprehensive and personalized care to haemodialysis (HD) patients. This study (…)
02:00
AbstractBackground and AimsImmune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a systemic autoimmune genetic disorder caused by mutation of the forkhead box protein 3 (FOXP3) gene. We performed this study to analyze the clinical and demographic characteristics of (…)
02:00
AbstractBackground and AimsEnzyme replacement therapy (ERT) is an established treatment for Fabry disease (FD), notably for its efficacy in reducing plasma globotriaosylceramide (Gb3) levels. FD is characterized by the accumulation of Gb3 in lysosomes, resulting in the formation of (…)
02:00
AbstractBackground and AimsHereditary kidney diseases are the fifth cause of chronic kidney disease (CKD). They are responsible for around 10% of adults with kidney replacement therapy. Genetic testing in suspected cases allows us to make a definitive diagnosis, prognosis, therapeutic options (…)
02:00
AbstractBackground and aimsAlport syndrome (AS) and thin basement membrane nephropathy (TBMN) are genetically heterogeneous kidney diseases that manifest with kidney involvement, AS also with hearing and visual impairment. Electron microscopic examination shows characteristic ultrastructural (…)
02:00
AbstractBackground and AimsNovel therapies are needed to address the unmet clinical need of patients suffering from end stage kidney disease (ESKD) and cell therapy is an innovative strategy to deliver effective, curative treatment options to renal patients. There are several reports that have (…)
02:00
AbstractBackground and AimsThe theory of medicine-food homology is long-standing and has been widely applied in traditional Chinese medicine. The Sichuan dark tea-based medicated dietary formula (alternatively referred to as Qing, or clarity in Chinese) is previously used for its lipid-lowering (…)
02:00
AbstractBackground and AimsTargeting the renal sodium phosphate cotransporter 2a (Npt2a) offers a novel strategy for treating hyperphosphatemia in chronic kidney disease (CKD). In patients with and without reduced kidney function, hyperphosphatemia is associated with cardiovascular complications (…)
02:00
AbstractBackground and AimsCognitive impairment and reduced exercise tolerance are common in patients with chronic kidney disease (CKD), in part due to reduced brain function. Cerebral perfusion and oxygenation are significant determinants of brain activation and have been shown to be (…)
02:00
AbstractBackground and AimsThe risk of developing cardiovascular disease is exceedingly high in patients with chronic kidney disease (CKD), therapeutic options are limited. In order to develop specific therapies, a comprehensive molecular understanding of the underlying pathomechanisms is (…)
02:00
AbstractBackground and AimsFibrosis is the final common pathway in all progressive kidney disease. Macrophages are a major myeloid cell component of the renal mononuclear phagocyte system, with roles in defence against infection, renal injury, and repair. Using single-cell RNA sequencing, we (…)
02:00
AbstractBackground and AimsOur investigation was motivated by the underutilization of the “Kidney Disease Improving Global Outcomes” (KDIGO) classification in evaluating the burden and impact of renal and cardiovascular (CV) adverse outcomes in individuals with type 1 diabetes mellitus (T1DM). (…)
02:00
AbstractBackground and AimsThe exploration of early biomarkers for diagnosing vascular alterations in CKD-MBD holds significant clinical potential. Previous evidence has demonstrated profound alterations in immune cell populations linked to vascular homeostasis in CKD dialysis patients. This (…)
02:00
AbstractBackground and AimsKidney volume is used as predictive and therapeutic marker for several clinical conditions. However, there is a lack of large-scale studies examining the relationship between kidney volume and various clinicodemographic factors, including kidney function, body (…)
02:00
AbstractBackground and AimsPatients with chronic kidney disease (CKD) have a higher risk of developing heart failure with preserved ejection fraction (HFpEF). We developed a model of CKD-HFpEF and showed that renal-cardio pathophysiology is associated with decreased expression and availability (…)
02:00
AbstractBackground and AimsKidney biopsy is a useful tool to establish the diagnosis and provide information about the activity and chronicity of kidney disease. Chronic changes are generally irreversible and act as a prognostic marker. The Mayo clinic chronicity score (MCCS) standardizes and (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) represents a major global healthcare challenge, affecting approximately 850 million people worldwide [1], and is an independent risk factor for the progression to kidney replacement therapy (KRT) and all-cause mortality [2]. However, CKD (…)
02:00
AbstractBackground and AimsInfective endocarditis (IE) is a frequent pathology among patients treated with long-term hemodialysis (HD). Its epidemiology and risk factors are scarcely reported in this specific population in France. This study aims to describe the frequency and characteristics of (…)
02:00
AbstractBackground and AimsStandard ultrasound mainly provides information about structural changes in the kidney, whereas parenchymal Doppler ultrasound provides the renal resistance index (RI), which correlates with plasma creatinine levels. Unfortunately, in the case of isolated proteinuria (…)
02:00
AbstractBackground and AimsThe gut microbiome plays a beneficial role in human health, including kidney function and chronic kidney disease progression. Potential therapeutic strategies for CKD and hypertension that target the gut microbiota include dietary interventions, mainly probiotic, (…)
02:00
AbstractBackground and AimsSmall, cross-sectional, cohort studies suggest a relationship between low estimated glomerular filtration rate (eGFR) and risk of developing abdominal aortic aneurysm (AAA). We here explored the possible association between eGFR and annual eGFR decline with future risk (…)
02:00
AbstractBackground and AimsRenal tubulointerstitial damage is a risk for renal failure. However, the association between renal tubulointerstitial damage and all-cause and cardiovascular mortality in the general population remains unclear. In this prospective cohort study, we examined this point (…)
02:00
AbstractBackground and AimsHyperkalaemia often occurs in patients with comorbidities that are treated with renin-angiotensin-aldosterone system inhibitors (RAASi), e.g., chronic kidney disease (CKD), heart failure or resistant hypertension. However, RAASi use can exacerbate hyperkalaemia. The (…)
02:00
AbstractBackground and AimsPatients with advanced chronic kidney disease (CKD) require significant resources in order to manage the complications of CKD, and provide education and planning for renal replacement therapy (RRT). To better gauge the clinical trajectory of these patients, we aimed to (…)
02:00
AbstractBackground and AimsRenin-angiotensin-system inhibitors (RASi) have been a foundational therapy in chronic kidney disease (CKD) for several decades. Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have also emerged as a critical disease-modifying therapy in CKD, with contemporary data (…)
02:00
AbstractBackground and AimsTransforming growth factor ?1 (TGF-?1) is a recognized driver of both mesothelial-to-mesenchymal transition (MMT) and cellular senescence observed in vitro in human peritoneal mesothelial cells (HPMCs), and have a significant role in adverse peritoneal remodelling of (…)
02:00
AbstractBackground and AimsObesity is a representative modifiable risk factor for chronic kidney disease (CKD). This study aimed to investigate whether both body mass index (BMI), waist-to-hip ratio (WHR) and changes of WHR during follow-up are risk factors for development of incident (…)
02:00
AbstractBackground and AimsPregnancy in patients with CKD is associated with maternal and fetal risks. The data about pregnancy outcome in Alport syndrome (AS) is limited. The aim was to evaluate the fetal and maternal pregnancy outcome in women with AS.MethodOne center retrospective study (…)
02:00
AbstractBackground and AimsCultured kidney cell lines are broadly used to model the physiology and pathophysiology of the kidney. Due to immortalization, passaging and culture conditions, a cell line's gene expression profile might differ greatly from the primary cells it was originally derived (…)
02:00
AbstractBackground and AimsA hypomorphic TMEM67 variant c.1843T>C (p.Cys615Arg) (rs201893408) is associated with an autosomal-recessive condition characterized by a combination of nephronophthisis and liver fibrosis, and, in some cases, neurologic manifestations. According to the gnomAD (…)
02:00
AbstractBackground and AimsVascular calcification associated with a maladaptive bone response is common in CKD and is a major cause of mortality (up to 60% depending on CKD stage). Alterations in several intracellular signaling pathways have been reported during the cellular phenotype transition (…)
02:00
AbstractBackground and AimsThe approval of Tolvaptan for treatment of ADPKD heralds a new era when mechanism-based therapy is now possible. However, Tolvaptan is an expensive drug associated with potentially serious side effects and is currently reserved for patients at high-risk for progression (…)
02:00
AbstractBackground and AimsFabry disease (FD) is a rare inherited lysosomal storage disease caused by pathogenic GLA gene variants which result in a deficiency of the enzymatic activity of ?-galactosidase A. Enzyme replacement therapy (ERT) is the mainstay of FD-specific treatment, but there are (…)
02:00
AbstractBackground and AimsPatients with CKD have significantly increased cardiovascular risk, and heart failure is a leading cause of morbidity and mortality in these patients. Myocardial hypertrophy is a hallmark of cardiac remodeling and dysfunction in CKD and is known to be mediated by (…)
02:00
AbstractBackground and AimsSince 2017, the clinical value of podocyte injury in IgA nephropathy (IgAN) has been studied, the presence of podocyte hypertrophy and tip- lesions are markers of podocyte damage. It has been observed that these histological findings tend to be treated with (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) is a prevalent condition that affects millions of people. Patients with CKD have an increased cardiovascular risk, mostly due to vascular calcification (VC). By now, it's quite clear how, in vitro and in vivo, vascular smooth muscle cells (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN) represents a significant global health concern, contributing substantially to chronic kidney disease and renal failure. Despite its widespread impact, the Bulgarian population lacks comprehensive epidemiological data and specific biomarkers for (…)
02:00
AbstractBackground and AimsSystemic sclerosis (SSc) is characterized by progressive derangement of the microcirculation leading to a state of chronic tissue hypoxia with release of several inflammatory cytokines such as neutrophil gelatinase-associated lipocalin (NGAL), fibroblast growth (…)
02:00
AbstractBackground and AimsMinimal change disease (MCD) and focal sclerosing glomerulosclerosis (FSGS) are both podocytopathies and are possibly diseases that lie on a similar spectrum with FSGS being the severe form. We aim to describe the clinical and laboratory parameters along with treatment (…)
02:00
AbstractBackground and AimsRenal fibrosis (RF) is the final common pathway that determines the progression of many glomerular disease including IgA nephropathy (IgAN). Till date there is no definite therapy available to retard RF. Being the key mediator of fibrosis, TGF-? is being targeted in (…)
02:00
AbstractBackground and AimsABBA (antibrush border antibody) disease is a rare autoimmune tubulointerstitial kidney disease with few descriptions in the literature. Diagnosis is based on light microscopy, immunofluorescence, electron microscopy and immunostaining for LRP2 (LDL receptor related (…)
02:00
AbstractBackground and AimsDiabetic kidney disease (DKD) is the leading cause of chronic kidney disease and a predominant reason for renal failure. Evidence from previous research indicates that abnormal expression of microRNAs (miRs) links closely to the occurrence and progression of (…)
02:00
AbstractBackground and AimsMonoclonal gammopathy of renal significance (MGRS) comprises a diverse group of renal disorders related to a nephrotoxic monoclonal immunoglobulin. Due to the rarity of the disease and the recent definition of MGRS-associated kidney lesions, data about long-term (…)
02:00
AbstractBackground and AimsPatients with kidney disease, especially those on dialysis, are more susceptible to infections such as peritonitis, sepsis, pneumonia, and are at a higher risk for infection-related mortality. Pathogenic mechanisms underlying the secondary immunodeficiency in kidney (…)
02:00
AbstractCardiovascular disease (CVD) and chronic kidney disease (CKD) are currently the 1st and 10th leading cause of global mortality, respectively. By 2050, CKD is predicted to be the 5th leading cause, with most of those individuals dying of CVD. Recent single cell RNA sequencing data has (…)
02:00
AbstractBackground and AimsRenal failure secondary to ANCA-associated vasculitis (AAV) represents a clinical and therapeutic challenge [1]. Fifteen percent to 38% of the patients develop end-stage kidney disease within 5 years, and once patients need dialysis, 29% to 82% die or remain on (…)
02:00
AbstractBackground and AimsCardiovascular disease (CVD) is the main cause of mortality in chronic kidney disease (CKD). However, the pathogenesis of CVD in CKD remains incompletely understood. Extracellular vesicles (EVs) emerged as mediators of inter-organ cross-talk and endothelial EVs (…)
02:00
AbstractBackground and AimsPercutaneous renal biopsy is a key procedure for the work-up of renal diseases. Among the possible complications of such procedure, prevalence, risk factors and clinical outcome of arterio-venous fistula (AVF) formation is unclear. We present here a single-center (…)
02:00
AbstractBackground and AimsBartter (BS) and Gitelman (GS) syndromes are rare tubulopathies caused by mutations affecting renal NaCl transporters, resulting in similar symptoms like muscle weakness, cramps, and electrolyte imbalances, with GS also presenting with hypomagnesemia. Treatment focuses (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) and kidney failure are connected to increased oxidative stress and vascular calcification, which are indicators for development of comorbidities and mortality outcome. Mitochondrial (mt)DNA copy number has been reported as independent (…)
02:00
AbstractBackground and AimsComplement is involved in numerous kidney diseases. However, functional approaches to properly examine individual's susceptibility to complement dysregulation are limited.MethodWe assessed ex vivo complement activation induced by sera from 38 healthy donors on resting (…)
02:00
AbstractBackground and AimsGut dysbiosis has been associated with chronic kidney disease (CKD) and nephrolithiasis and may thus be a factor explaining variability of outcome in autosomal dominant polycystic kidney disease (ADPKD). However, beside a single pilot study the gut microbiome has not (…)
02:00
AbstractBackground and AimsOsteocytes represent about 95% of bone cells. They are located in mineralized bone tissue and connect with each other, with osteoblasts, osteoclasts, blood vessels and bone marrow cells. These cells express several proteins that regulate phosphorus-calcium metabolism (…)
02:00
AbstractBackground and AimsVericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is approved for treating heart failure (HF) with reduced ejection fraction (HFrEF). This study aims to assess the short-term improvement in cardio-function resulting from in-hospital initiation of (…)
02:00
AbstractBackground and AimsThere are no FDA approved drugs for the treatment of acute kidney injury (AKI), which affects 10-15% of hospitalized patients and often results in renal transplantation or lifelong dialysis. UNI-494 is a novel nicotinamide ester derivative and selective mitochondrial (…)
02:00
AbstractBackground and AimsPatient outcomes can be influenced by dialysis initiation and subsequent modality choices. This systematic review and meta-analysis aimed to explore the rate and reasons for peritoneal dialysis (PD) dropout following a haemodialysis (HD) to PD switch.MethodThis (…)
02:00
AbstractBackground and AimsPolycystic kidney diseases (PKDs) are the most prevalent inherited kidney disease [1]. They are caused by pathogenic variants in genes encoding for proteins with roles in the functioning of primary cilium, a sensory organelle at the cell surface of almost all cells (…)
02:00
AbstractBackground and AimsWhile diuretics are considered the first-line therapy to control volume overload in heart failure (HF), diuretic resistance can develop, limiting the effectiveness of pharmacological therapy. Peritoneal dialysis (PD) is a kidney replacement therapy usually implemented (…)
02:00
AbstractBackground and AimsANCA associated vasculitis (AAV) is closely correlated to elevated cardiovascular disease (CVD) rates, positioning it a one of the leading causes of death among these patients. The impact of AAV on the risk of CVD has not been described in large prospective cohorts (…)
02:00
AbstractBackground and AimsCytomegalovirus (CMV) has had a significant impact on solid organ transplantation. It can affect allograft function and increase patient morbidity and mortality. We have made several efforts to prevent CMV infection after kidney transplantation (KT), but we have not (…)
02:00
AbstractBackground and AimsAcute kidney injury (AKI) is a common clinical syndrome characterized by rapid loss of kidney function but with limited diagnostic and treatment options. Annexins (ANXA) are a superfamily of calcium-dependent and lipid-binding proteins involved in multiple (…)
02:00
AbstractBackground and AimsAcute kidney injury caused by renal ischemia/reperfusion (I/R) is a major clinical problem in many aspects of urology fields such as kidney transplantation and partial nephrectomy, but there is no effective treatment. Linaclotide, a guanylate cyclase C agonist (…)
02:00
AbstractBackground and AimsMultidisciplinary guidelines recommend parathyroidectomy to slow the progression of chronic kidney disease in patients with primary hyperparathyroidism (PHPT) and an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2. However, this is a weak (…)
02:00
AbstractBackground and AimsThe Phase 2b ZENITH-CKD trial demonstrated that combined treatment with the endothelin A receptor (ETAR) antagonist zibotentan and the sodium-glucose co-transporter-2 inhibitor (SGLT2i) dapagliflozin yields a robust and significant reduction in albuminuria in (…)
02:00
AbstractBackground and AimsHigh salt intake is accompanied by the development of cardiovascular disorders, not always associated with an increase in blood pressure (BP). Recently, it has been found that the introduction of soy protein into the diet can have some nephroprotective and (…)
02:00
AbstractBackground and AimsMyokines secreted from myocytes are related to improving metabolic diseases such as diabetes, obesity, and chronic kidney disease (CKD). Patients with diabetic kidney disease (DKD) have lower irisin levels, suggesting that a low level of irisin is a risk factor for the (…)
02:00
AbstractBackground and AimsMultiple trials have reported that SGLT2 inhibitors reduce the risk of its primary composite outcome of kidney disease progression or cardiovascular death in a wide range of patients with CKD. Our aim was to compare effects on kidney outcomes among the different types (…)
02:00
AbstractBackground and AimsKidney disease, including chronic kidney disease (CKD), affects more than 850 million people globally. At least 40% of people with diabetes develop CKD, and many progress to end-stage kidney disease (ESKD) and kidney failure. Globally, diabetes is the leading cause of (…)
02:00
AbstractBackground and AimsThe aryl hydrocarbon receptor (AhR) is a transcription factor that can be activated by a variety of endogenous and exogenous ligands, and is involved in varieties of biological processes. It has been confirmed that the expression of AhR in kidney is elevated in chronic (…)
02:00
AbstractBackground and AimsHyperkalemia is a common and potentially serious medical condition in patients with chronic kidney disease and is associated with high rates of mortality. Partiromer and Lokelma are available recently, however, edema is the common adverse event resulted from the exceed (…)
02:00
AbstractBackground and AimsProteinuria induces proximal tubule (PT) injury, oxidative stress, lysosomal dysfunction, and inflammation, which contribute to the progression of CKD. Cellular senescence and the associated secretory phenotype, where cells secrete proinflammatory and profibrotic (…)
02:00
AbstractBackground and AimsOver the past decade, there has been a growing interest in classifying foods based on the extent and purpose of industrial processing according to the NOVA system, which outlines four main food categories: unprocessed and minimally processed foods, processed culinary (…)
02:00
AbstractBackground and AimsTo determine the degree of influence of endothelial dysfunction on the hemodynamics of renal and central vessels in respiratory pathology, as well as to determine the effectiveness of complex therapy regimens with carvedilol.MethodStudies were conducted in 26 patients (…)
02:00
AbstractBackground and AimsSGLT2 inhibitors confer kidney and cardiovascular protection in patients with chronic kidney disease (CKD). Some studies have analyzed the effects of SGLT2is on hemoglobin levels. Potential mechanisms for rising hemoglobin include hypoxia-induced activation of HIF2?, (…)
02:00
AbstractBackground and AimsTo study the frequency of metabolic disorders in patients with hypertension depending on the stage of chronic kidney disease (CKD).MethodThe study analyzed 594 case histories of patients with AH of I-III degree (ESC/ESH 2018). CKD stages were determined according to (…)
02:00
AbstractBackground and AimsAs the ageing population continues to grow worldwide, aging-related diseases are becoming an excessive burden on the global healthcare system. The kidney is one of the organs most affected by aging, which undergoes changes of decreased glomerular filtration rate (GFR), (…)
02:00
AbstractBackgroundOur retrospective observational study aims to describe the epidemiology of cancer after KTx and to investigate its risk factors and the impact on therapeutic management and survival, in a big monocentric cohort of kidney transplant patients (KT-ps). The association between a (…)
02:00
AbstractBackground and AimsA retrospective analysis of peculiarities of development of malignant neoplasms in patients after kidney transplantation receiving long-term immunosuppression.MethodIn this study we evaluated incidence of malignancies observed among 718 renal transplant recipient with (…)
02:00
AbstractBackground and AimsEpitope and antibody diversity allows Bw4+ or Bw6+ patients to produce antibodies to Bw4 or Bw6 epitopes without breaking self-tolerance. This study assessed the prevalence of mismatched Bw4/6 or missing donor Bw6 allele in kidney transplant (KT) recipients with early (…)
02:00
AbstractBackground and AimsMetabolic acidosis is a common problem in patients of chronic kidney disease and patients on maintenance hemodialysis. In resource poor countries, due to financial constraints frequency of dialysis and compliance to medication is adversely affected. This leads to (…)
02:00
AbstractBackground and AimsTuberculosis (TB) is the leading cause of infectious-disease death worldwide. Post-transplant TB is a problem in successful long-term outcome of kidney transplantation recipients (KT) and is often associated with high morbidity and mortality. The aim of this study was (…)
02:00
AbstractBackground and AimsControlling and reducing protein intake is the most used approach to preserve renal function in CKD patients. Compared to protein restriction alone, plant-based diets have received particular attention. However, data on the potential risks and benefits of a plant-based (…)
02:00
AbstractBackground and AimsThe optimal hemoglobin (Hb) target for treating anemia in pre-dialysis chronic kidney disease (CKD) remains controversial. This study investigates the efficacy and safety of methoxy polyethylene glycol-epoetin beta, in delaying the initiation of kidney replacement (…)
02:00
AbstractBackground and AimsAfter kidney transplant there is often need of red blood cell (RBC) transfusion because acute bleeding associated with surgery; or because multifactorial progressive anemization the days after. The aim of this work is to describe the characteristics of transfused (…)
02:00
AbstractBackground and AimsKidney disease is a worldwide public health problem, affecting between 8%-16% of the global population. Chronic Kidney Disease (CKD) is a silent disease and its detection is often late, making the treatment difficult. Considering the emerging Fourier-Transform Infrared (…)
02:00
AbstractBackground and AimsHyperkalemia is a serious condition among kidney transplant (KT) recipients, which can lead to life-threatening complications such as cardiac arrhythmias.Following kidney transplantation, the causes of hyperkalemia are multifactorial owing to graft function, excess (…)
02:00
AbstractBackground and AimsSerum chloride (Cl-) is an emerging marker of mortality in hypertension, sepsis, heart failure and chronic kidney disease. The pathophysiological mechanism is unclear, but haemodynamic and inflammatory factors have been suggested. As C-reactive protein (CRP) is an (…)
02:00
AbstractBackground and AimsOver the years, concerns have increased about the harmlessness of kidney donation. This is more relevant in an Arab Muslim developing country like Tunisia, where lack of cadaveric donors is continuously leading to an increase in living donor numbers. The aim of this (…)
02:00
AbstractBackground and AimsIn patients on hemodialysis, muscle weakness is highly prevalent and may lead to frailty, limitation of mobility and functional impairment. Moreover, low muscle strength was associated with an increase in mortality risk in these patients. Despite the fact that some (…)
02:00
AbstractBackground and AimsMinimal changes disease (MCD) is responsible for 10-25% of nephrotic syndrome cases in adults. It can have a primary or secondary aetiology, being associated with diseases like infections, atopy or even haematological malignancies. There is a described association (…)
02:00
AbstractBackground and AimsThe rising diversity of food preferences and the desire to provide better personalized care provide challenges to renal dietitians working in dialysis clinics. To address this situation, we explored the use of a Large Language Model (LLM), specifically, ChatGPT using (…)
02:00
AbstractBackground and AimsKidney involvement is common among patients with systemic lupus erythematosus (SLE) and it is an important cause of morbidity and mortality among this population. Recently, the EULAR 2023 update of the recommendations for the management of SLE advised considering the (…)
02:00
AbstractBackground and AimsBiologic agents like tumor necrosis factor ? inhibitors/ anti-TNF-?/, IL6 and CD80/26 are widely used in many rheumatologic diseases but these may also elicit effects on renal function. These drugs, as well as rheumatic diseases themselves, can cause autoimmune renal (…)
02:00
AbstractBackground and AimsObstructive Sleep Apnea (OSA) prevalence was found to be higher in an intermittent hemodialysis (iHD) population of the French-speaking Switzerland than in the general population of the same geographical area. The high prevalence of OSA in iHD patients was linked to (…)
02:00
AbstractBackground and AimsFibrillary glomerulonephritis (FGN) is an uncommon but serious kidney disease with unclear aetiology, variable prognosis, and a not well-established treatment. FGN has been associated with autoimmune diseases including SLE. Other aetiologies comprise diabetes, (…)
02:00
AbstractBackground and AimsVadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor approved in Europe, Australia, Japan for the treatment of anemia in patients with dialysis-dependent (DD)-CKD. In the INNO2VATE global phase 3 trials in patients with DD-CKD, including 2 (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN) is a complex disease diagnosed only upon evaluation of a kidney biopsy. Since the threshold to perform this invasive procedure is higher and symptoms usually more indolent in children, the true prevalence might be underestimated, with fewer (…)
02:00
AbstractBackground and AimsPentraxin-3 (PTX3), a novel inflammatory biomarker, has been recognized as a predictor of cardiovascular events in the general population, including coronary artery disease (CAD). Although PTX3 is elevated in dialysis patients, its potential diagnostic value for the (…)
02:00
AbstractBackground and AimsGlomerulonephritis (GN) have been known to be associated with both chronic lymphocytic leukemia and non-Hodgkin's lymphoma. Membranoproliferative Glomerulonephritis (MPGN) is the most commonly reported histological diagnosis in these diseases.MethodThis report (…)
02:00
AbstractBackground and AimsPeople with chronic kidney disease on hemodialysis present many comorbidities, including malnutrition and frailty. These factors contribute to a sedentary lifestyle, cognitive impairment, and decreased emotional well-being. Intradialytic exercise with non-immersive (…)
02:00
AbstractBackground and AimsPeople with chronic kidney disease on hemodialysis have low levels of physical activity and low lower-limbs muscle strength, partly due to the sedentary lifestyle, and a big number of hours sitting or in a recumbent position.The GoodRENal project aimed at creating an (…)
02:00
AbstractBackground and AimsThe serum uremic toxins of end-stage renal disease (ESRD) patients is intricately linked to the metabolism of gut microbiota. Despite the pivotal role played by gut mycobiome in the pathogenesis of several renal diseases, limited investigations have been conducted on (…)
02:00
AbstractBackground and AimsThe prevalence of malnutrition increases with age and is common in elderly patients on haemodialysis. Malnutrition increases complications, disability, mortality, length of hospital stay and healthcare costs. The Global Leadership Initiative on Malnutrition (GLIM) (…)
02:00
AbstractBackground and AimsThe epidemiology of Acute Kidney Injury (AKI) in hospitalized and critically ill populations has been well described but less is known about AKI in the emergency department (ED) patients. Community-acquired AKI represents about a quarter of AKI events observed in the (…)
02:00
AbstractBackground and AimsWarfarin-related nephropathy (WRN) is defined as acute kidney injury subsequent to excessive anticoagulation with warfarin. Patients with mechanical valves required long-term anticoagulant therapy, and warfarin remains the sole available option for anticoagulant (…)
02:00
AbstractBackground and AimsVitamin D is crucial for musculoskeletal and general health. Low levels are associated with an increased risk of death and morbidity, including cancer, cardiovascular, autoimmune diseases and infections. In hemodialysis (HD) patients vitamin D deficiency plays (…)
02:00
AbstractBackground and AimsThe purpose of this study was to see how remdesivir affected renal ferroptotic damage in hamsters following a human Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. We evaluated the inhibitory effects of remdesivir on the ferroptosis of (…)
02:00
AbstractBackground and AimsThe management of anemia in hemodialysis patients (HD-ps) is influenced by many factors, including inflammation, martial balance (MB) and mineral metabolism (MM). Recent data would identify the Erythropoietin Resistance Index (ERI) as an indicator of mortality risk in (…)
02:00
AbstractBackground and AimsChronic fatigue remains, despite all the technological advances, one of the most important symptoms in prevalent hemodialysis (HD) subjects and has a strong impact on mortality and health-related quality of life. The objective of our work was to characterize fatigue in (…)
02:00
AbstractBackground and AimsConcerns regarding the safety of gadolinium-based contrast agents (GBCA), which are often employed in medical imaging, have been raised in light of reports of free gadolinium's [Gd (III)] cytotoxicity. It appears that GBCAs having macrocyclic structures, like gadoteric (…)
02:00
AbstractBackground and AimsCardiovascular (CV) disease is the leading cause of death in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD). The two major marine n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may have (…)
02:00
AbstractBackground and AimsIn recent years, the incidence of membranous nephropathy (MN) with malignancy has gradually increased, but the clinical and pathological characteristics of these patients are still unclear.MethodPatients diagnosed with renal biopsy-proven MN and comorbid malignancy (…)
02:00
AbstractBackground and AimsPrimary Hyperoxaluria type 1 (PH1) is caused by biallelic variants in the AGXT gene, leading to alanine:glyoxylate aminotransferase deficiency, hepatic overproduction of oxalate, hyperoxaluria, nephrolithiasis (NL), and/or nephrocalcinosis (NC), often progressing to (…)
02:00
AbstractBackground and AimsThe arrival of eculizumab revolutionized the treatment of Atypical Hemolytic Uremic Syndrome (aHUS). Ravulizumab also offers C5 inhibition, but with 3-4 times longer half- life. We describe the experience with ravulizumab in patients with aHUS in two scenarios: 1. (…)
02:00
AbstractBackground and AimsEvidence on the risks of adverse outcomes associated with glomerular filtration rate (GFR) has been limited to estimated GFR (eGFR), due to limited availability of large-scale data with measured GFR (mGFR). These studies either used creatinine (eGFRcr), cystatin C (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN) is a chronic, rare, and slow progressing glomerular disease. IgAN treatment currently consists of angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB), sodium-glucose co-transporter 2 (SGLT2) inhibitors, (…)
02:00
AbstractBackground and AimsImmunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerulonephritis globally; it has a significant health burden and a highly variable disease course. As IgAN is a heterogeneous disease, it is important to appreciate the associated patient (…)
02:00
AbstractBackground and AimsThe impact of social deprivation on the progression of Chronic Kidney Disease (CKD) to End Stage Kidney Disease (ESKD) requiring Renal Replacement Therapies (RRTs) and death has been demonstrated by large cohort studies produced both in the US and the UK. Nonetheless, (…)
02:00
AbstractBackground and AimsIdiopathic hypercalciuria (IH) is the main metabolic abnormality that causes kidney stones. It is linked to high intestinal calcium absorption and osteopenia. However, not all patients diagnosed with IH develop kidney stones. In this study, we examined a cohort of (…)
02:00
AbstractBackground and AimsUltrasound-based elastography has been utilized as an imaging method with high utility in the liver or thyroid, but it is not yet being implemented in evaluating the chronic kidney disease (CKD) because current research indicates a high level of heterogeneity between (…)
02:00
AbstractBackground and AimsNephrotic syndrome (NS) is a clinical condition characterized by massive urinary loss of proteins, mostly albumin, but also hormones and their carrier proteins among others. The most frequently reported hormonal complication is thyroid dysfunction. The study aimed to (…)
02:00
AbstractBackground and AimsThe relationship between haemoglobin (Hb) levels and clinical outcomes in chronic kidney disease (CKD) is more intricate than previously understood, as both low and high values can have detrimental effects. Although the association between Hb and patient outcomes is (…)
02:00
AbstractBackground and AimsTo assess the Doppler sonographic findings of the left renal vein (LRV) in children with orthostatic proteinuria compared to normal urine children.MethodRenal Doppler ultrasound examinations were routinely performed on 50 consecutive children with orthostatic (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN), the predominant primary glomerulonephritis in adults,, frequently affects women in childbearing age. There is a dearth of information about the impact of pregnancy on the outcome in IgAN especially in the Indian population where it is known to (…)
02:00
AbstractBackground and AimsImpaired cognitive function and reduced health-related quality of life (HRQoL) are common in older patients with chronic kidney disease (CKD) with severely reduced GFR and kidney failure. Older patients with CKD often regard HRQoL as a health priority, but it is (…)
02:00
AbstractBackground and AimsThe objective of our study was to describe the characteristics and outcomes of Nephrotic Syndrome (SN) in children from three major hospitals in one of the world's poorest countries, Chad.MethodThis observational, cross-sectional, descriptive, and multicenter study (…)
02:00
AbstractBackground and AimsCystinosis-associated metabolic bone disease (CMBD) is a major challenge in the treatment of patients with infantile nephropathic cystinosis (NC). Study data are limited due to small case numbers, lack of adults or patients on renal replacement therapy and/or (…)
02:00
AbstractBackground and AimsIsolated perinephric lymphoma is uncommon clinicopathological entity, reported in less than 10% of cases. Although this is rare finding, every perirenal mass require prompt diagnosis and multidisciplinary approach if needed.MethodWe described a case of a asymptomatic (…)
02:00
AbstractBackground and AimsIron deficiency (ID) is a poor prognostic factor in chronic diseases such as chronic kidney disease (CKD). Indeed, independently of anemia, ID is associated with more rapid clinical worsening of CKD and is a risk factor for mortality in this condition. In older (…)
02:00
AbstractBackground and AimsGenetic kidney diseases (GKD) are rarely seen in pregnancy and some diagnosis will only be made during gestation, due to a high proportion of chronic kidney diseases (CKD) of unknown etiology and recent advances in genetic testing. Genetic counseling and, when (…)
02:00
AbstractBackground and AimsDialysis patients are at high risk of circulatory dysregulation and hypotension during treatment. Intradialytic hypotension (IDH) is a potentially life-threatening complication. The main causes are high ultrafiltration volumes and high ultrafiltration rates when (…)
02:00
AbstractBackground and AimsKidneys and lungs have a strong pathophysiological link. However, studies on the association between chronic conditions involving these two organs, chronic kidney disease (CKD) and chronic obstructive pulmonary disease (COPD), are limited. Nephrologists better (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) leads to the accumulation and production of uremic toxins, such as Indoxyl Sulphate (IS) and P-cresyl sulphate (p-CS). These toxins have been found to activate various processes that promote tumor growth. The literature has reported a (…)
02:00
AbstractBackground and AimsSurvival is a core outcome of hemodialysis (HD) therapy. Progressive improvement in the permeability and biocompatibility of membranes for HD, dialysis techniques and clinical processes around these therapies have been developed. Recently, expanded hemodialysis (HDx) (…)
02:00
AbstractBackground and AimsT cells play crucial role in the pathogenesis of autoimmune diseases such as ANCA associated vasculitis-glomerulonephritis (AAV/GN) by secreting immune mediators and helping B cell-mediated long-lived humoral immunity development. Specific T and B cells subsets can be (…)
02:00
AbstractBackground and AimsEven though IgA nephropathy is the most common primary glomerular disease worldwide, being accounted with 22% of kidney biopsy results in Europe and despite great advances in comprehending its pathogenesis, little has changed in the standard of care over the last (…)
02:00
AbstractBackground and AimsThe CONVINCE trial and others studies, demonstrates that high-dose hemodiafiltration offers a survival advantage and benefits in reducing cardiovascular complications for patients in high-flux hemodiafiltration group compared to hemodialysis.MethodWe compared the (…)
02:00
AbstractBackground and AimsANCA negative small vessel vasculitis with renal involvement has been described in a number of cohorts. Though comprehensive studies comparing these individuals to ANCA positive patients are lacking and they are routinely excluded from clinical trials. Whilst the (…)
02:00
AbstractBackground and AimsMyoglobin, due to its molecular weight of 17 kDa and a Einstein-Stoke radius greater than expected, is classed as a middle molecular weight uremic toxin and presents a two-compartment model of distribution in the body. Rhabdomyolysis is a condition in which muscle cell (…)
02:00
AbstractBackground and AimsIn many patients on chronic hemodialysis, interdialytic weight gain (IDWG) is greater than 4.0%-4.5% of dry weight, the value recommended by the international guidelines. High IDWG is a condition associated with risk of all-cause mortality and hospitalization and it (…)
02:00
AbstractBackground and AimsBicarbonate is delivered to hemodialysis (HD) patients via diffusion following a concentration gradient across the dialyzer membrane. However, the concentration of bicarbonate in the dialysis fluid ([HCO3]d) is usually not individualized for the specific patient's (…)
02:00
AbstractBackground and AimsSGLT2 inhibitors, namely dapagliflozin, proved to slow progression of kidney disease in randomized clinical trials. Our aim was to assess real world efficacy of dapagliflozin on proteinuria level in primary glomerulopathies (GN).Methodadult patients with biopsy proven (…)
02:00
AbstractBackground and AimsHypertension results from complex genetic and environmental interactions, mediated by cardiac, vascular, endocrine, and renal systems. The immune system may modulate all of these, though the exact mechanisms linking immune activation with hypertension and organ damage (…)
02:00
AbstractBackground and ObjectivesIgA nephropathy (IgAN) is a progressive kidney disease characterized by the mesangial deposition of galactose-deficient IgA1, leading to kidney damage and may eventually lead to end-stage kidney disease. Current treatment decisions for IgAN patients rely on the (…)
02:00
AbstractBackground and AimsAutosomal Dominant Polycystic Kidney Disease (ADPKD) is the predominant genetic disease leading to End Stage Kidney Disease (ESKD). Genetic identity could correlate to the disease profile. Correlations between genetic and phenotype characteristics in a cohort of ADPKD (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD), impacting over 850 million people worldwide, is a diverse group of inherited and acquired nephropathies. While only about 10% of adult CKD is hereditary, predominantly due to mutations in genes like PKD1, PKD2, and PKHD1, the etiology (…)
02:00
AbstractBackground and AimsHealth trajectories of patients with lupus nephritis (LN) are poorly understood in the setting of moderate and advanced chronic kidney disease (CKD). Furthermore, data on comparison of outcomes of LN to other forms of CKD are scarce. Therefore, the aim of this study (…)
02:00
AbstractBackground and AimsChronic glomerulonephritis (CGN)-glomerular, autoimmune kidney disease, where baseline therapy is clinically proven to be successful. The study evaluates hemodynamic disorders of renal blood flow in patients with CGN on the background of baseline treatment with the (…)
02:00
AbstractClinical PresentationA 48-year-old female of Asian heritage was referred for renal assessment after experiencing recurrent acute kidney injury (AKI) with incomplete recovery between episodes. This was initially attributed to dehydration and interstitial nephritis stemming from (…)
02:00
AbstractBackground and AimsConsidering the pathogenetic role of factor X of the coagulation system in the formation and progression of chronic glomerulonephritis (CGN), as well as the mechanism of action of rivaroxaban, this study examined the concentration of coagulation factor X in peripheral (…)
02:00
AbstractBackground and AimsMagnesium (Mg2+) is a critical component in numerous biological processes. Hypomagnesemia is associated with an increased risk of cardiovascular events and vascular calcification in individuals with and without chronic kidney disease (CKD). Sodium-glucose (…)
02:00
AbstractBackground and AimsPrevious research has indicated that ATO treatment at low doses may decrease the likelihood of flares in active systemic lupus erythematosus (SLE) patients, but the pharmacological mechanisms of such effect have not been studied.MethodMachine learning and network (…)
02:00
AbstractBackground and AimsRefeeding syndrome is a severe, potentially life-threatening condition characterized by fatal shifts in fluids and electrolytes that may occur in malnourished patients receiving parenteral or enteral artificial refeeding. This condition may present with hypokalemia, (…)
02:00
AbstractBackground and AimsAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare but potentially serious diseases with high mortality. Renal involvement is frequent in AAV with patients developing end-stage renal disease (ESRD) or becoming dependent on (…)
02:00
AbstractBackground and AimsImmunoglobulin A Nephropathy (IgAN) has several well-known predictors of renal outcomes, including persistent proteinuria, hypertension, and baseline eGFR at the time of diagnosis. However, the effect of hemoglobin (Hb) levels on the progression of IgAN is rarely (…)
02:00
AbstractBackground and AimsLight chain (LA) deposition amyloidosis is the most common type of renal amyloidosis. It may be associated with monoclonal gammopathy of uncertain significance (MGUS), meeting criteria for monoclonal gammopathy of renal significance (MGRS), or present in the course of (…)
02:00
AbstractBackground and AimsAA amyloidosis is a multisystem disease characterized by the deposition of serum amyloid A protein, which is secondary to chronic inflammation. Tocilizumab (an interleukin-6 inhibitor monoclonal antibody) is effective in suppressing inflammation, normalizing serum (…)
02:00
AbstractBackground and AimsIn patients with type 2 diabetes (T2D) and chronic kidney disease (CKD), persistent, low-grade inflammation is a significant risk factor for adverse kidney outcomes. Previously, we identified interleukin-33 (IL-33) as an over-expressed inflammatory cytokine in kidney (…)
02:00
AbstractBackground and AimsThis study evaluates an integrated care program for chronic kidney disease (CKD), which has demonstrated effectiveness in delaying kidney function decline in the rural population of Thailand. Efficacy of the program was initially established through the ESCORT-1 study, (…)
02:00
AbstractBackground and AimsHypertensive disorders in pregnancy (HDP) are a major cause of maternal and perinatal morbidity and mortality. There is still a need for the development of biomarkers for early diagnosis of the severity of the condition. Thoracic electrical bioimpedance (TEB) is a (…)
02:00
AbstractBackground and AimsBillions of people have obesity induced diabetic nephropathy. Promoting the browning of white adipose tissue has been suggested as a potential strategy for, but a drug still needs to be identified.MethodFirst, WT and ATF3 knockout mice fed a high-fat diet were treated (…)
02:00
AbstractBackground and AimsAlbuminuria is the hallmark of diabetic nephropathy (DN) and progression of albuminuria denotes declining renal functions culminating in End Stage Renal Disease. Intensive blood glucose control (HbA1c Methodit is an observational study including patients who attended (…)
02:00
AbstractBackground and AimsNutritional intervention constitutes a key part of the clinical management of individuals with chronic kidney disease (CKD). The gut emerged as an important source of uremic retention solutes, including indoxyl sulfate, p-cresyl sulfate and TMAO among the others. (…)
02:00
AbstractBackground and AimsPhysical function is a crucial outcome in nephrology. In alignment with the Patient-Reported Outcomes Measurement Information System (PROMIS) Initiative, physical function is characterized as the ability to execute activities involving physical actions, ranging from (…)
02:00
AbstractBackground and AimsStudies showed that early thrombectomy of dialysis vascular access (VA) is associated with better outcomes [1], especially for native VA [2]. Timely treatment of VA thrombosis within 24-48 hours is recommended by GIRFT to minimize access loss and requirement for (…)
02:00
AbstractBackground and AimsCopper is a trace element essential for numerous biological activities, whereas the mitochondria serve as both major sites of intracellular copper utilization and copper reservoir. Pyruvate dehydrogenase complex (PDHC) is a rate-limiting enzyme of glucose oxidation in (…)
02:00
AbstractBackground and AimsAntibodies to myeloperoxidase (anti-MPO) and proteinase 3 (anti-PR3) are recognized as the only clinically relevant antineutrophil cytoplasmic antibodies (ANCA) specificities so far. ANCA testing can be used in different clinical settings, especially in situations that (…)
02:00
AbstractBackground and AimsDespite serum albumin levels being predictive for clinical outcome in ANCA-associated renal vasculitis, implications providing a direct link between low serum albumin levels and intrarenal lesions remain elusive. Therefore, we here aimed to systematically assess the (…)
02:00
AbstractBackground and AimsPrediction of pre-eclampsia early in pregnancy can reduce its incidence and subsequent maternal and fetal morbidity and mortality. The sensitivity of current biomarkers is fair despite being used in clinical settings. Podocyturia was found to be a useful biomarker of (…)
02:00
AbstractBackground and AimsThe native arteriovenous fistula is considered the best vascular access for hemodialysis, whose ultimate complication is thrombosis. The risk factors for this complication are multiple. The aim of our work is to determine the risk factors for thrombosis of the first (…)
02:00
AbstractBackground and AimsA considerable proportion of primary membranous nephropathy (PMN) patients do not achieve early clinical remission with current immunosuppression regimens. The goal of the study was to evaluate efficacy and safety of the multi-targeted treatment regimen including (…)
02:00
AbstractBackground and AimsInfections are a leading cause of morbidity and mortality in hemodialysis patients. Tunneled catheters (TC) have been associated with increased risk of infection and death, but mortality rates are not widely reported. Our study aimed to analyse catheter infection-free (…)
02:00
AbstractBackground and AimsMembranous nephropathy (MN) is a leading cause of nephrotic syndrome in nondiabetic adults. Rituximab has become the first-line therapy for patients with MN after the recognition of MN as an autoimmune disease. However, 40% of patients with MN do not respond to (…)
02:00
AbstractBackground and AimsAvacopan was approved in the UK for severe ANCA associated vasculitis (AAV) in December 2022. The ADVOCATE trial found the differential effect of avacopan on kidney function was greatest in patients with the lowest estimated glomerular filtration rate (eGFR), at (…)
02:00
AbstractBackground and AimsCurrently, there is insufficient real-world study on the kidney outcomes of SGLT2i in mainland Chinese patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). This study aimed to investigate the association between the utilization of Sodium-dependent (…)
02:00
AbstractBackground and AimsPatients with kidney disease receiving dialysis are a highly vulnerable population. Psychosocial determinants of Self-Efficacy (SE) and Social Support (SS) have been suggested as potentially important outcomes for people with end stage kidney disease. We investigated (…)
02:00
AbstractBackground and AimsNutritional interventions and a low-protein diet (LPD) are a critical point in the management of chronic kidney disease (CKD). Several protein-restricted dietary regimens have been proposed in patients with end stage kidney disease: a typical LPD provides around (…)
02:00
AbstractBackground and AimsThe use of biocompatible glucose solutions is associated with longer preservation of residual renal function and less frequent occurrence of complications in patients on peritoneal dialysis. The aim of this study was to examine the influence of conventional and (…)
02:00
AbstractBackground and AimsStandard of care of high-risk idiopathic membranous nephropathy patients is immunosuppressive treatment with cyclophosphamide and corticosteroids or rituximab. Our aim was to assess outcome and safety of rituximab therapy in COVID19 era in comparison to modified (…)
02:00
AbstractBackground and AimsCurrently, there are various definitions for peritoneal dialysis technique failure, and several related factors are described. There is controversy regarding whether mortality should be considered a form of technique failure or not, as it involves an event of a (…)
02:00
AbstractBackground and AimsChronic obstructive pulmonary disease, COPD, is a common cause of morbidity and mortality. Comorbidities are frequent among COPD patients, some of which are explained by shared risk factors of smoking and increased age. Chronic kidney disease, leading to end-stage (…)
02:00
AbstractBackground and AimsLupus nephritis represents one of the most serious manifestations of systemic lupus erythematosus. The gold standard for determining the class of lupus nephritis is percutaneous kidney biopsy and the histopathological analysis of the biopsy specimen. The aim of this (…)
02:00
AbstractBackground and AimsEndothelial dysfunction caused by the accumulation of uremic toxins is an important contributor to the development of cardiovascular disease in patients with chronic kidney disease (CKD). The uremic toxin trimethylamine n-oxide (TMAO) is associated with oxidative (…)
02:00
AbstractBackground and AimsFactors affecting poor health-related quality of life (HRQoL) for people with chronic kidney disease (CKD) have been previously described in literature, and worse HRQoL is associated with CKD progression and death. Little emphasis has been placed on which factors may (…)
02:00
AbstractBackground and AimsRenally adjusted lamivudine dosages are effective. However, some of the kidney failure patients managed with lamivudine-containing regimens are failing to suppress HIV in peritoneal dialysis (CAPD) effluent. The steady-state lamivudine pharmacokinetics among these (…)
02:00
AbstractBackground and AimsLupus nephritis (LN) is a major course of morbidity and mortality in patients with systemic lupus erythematosus (SLE), best managed by a multidisciplinary group. Recent management advances require greater collaboration between specialists and individualized treatments (…)
02:00
AbstractBackground and AimsOur aim was to investigate the prevalence of venous thromboembolic events (VTE) in a cohort of patients with ANCA-associated vasculitis (AAV) and define factors associated with the frequency of VTE considering there is data on high incidence of VTE in AAV patients. In (…)
02:00
AbstractBackground and AimsThe Spanish Peritoneal Dialysis Support Group (GADDPE) aim to enhance peritoneal dialysis (PD) education among young nephrologists to increase the incidence and prevalence of PD in Spain.MethodAiming to develop initiatives to make PD a more attractive and suitable for (…)
02:00
AbstractBackground and AimsThe histone lysine demethylases 5 (KDM5) are members of the family of Jumonji C domain-containing histone demethylases and catalyze the removal of di- and tri-methyl moieties from the fourth lysine of histone 3 (H3K4me2/3). It has been reported that the KDM5 family (…)
02:00
AbstractBackground and AimsFinerenone is a new drug for the treatment of patients with albuminuric diabetic kidney disease (DKD) that has protective cardiorenal effects, with hyperkalemia being a possible side effect. Our pilot study aimed to obtain real-life clinical data in patients with DKD (…)
02:00
AbstractBackground and AimsIn recent years, hypoxia-inducing factor prolyl hydroxylase inhibitors (HIF-PHIs) have been widely used in the treatment of renal anemia, bringing a revolutionary breakthrough in the treatment of anemia in CKD patients. However, HIF-PHIs acts on a variety of cells and (…)
02:00
AbstractBackground and AimsAs a major public health problem, chronic kidney disease (CKD) has substantial comorbidities and disease burden. It is necessary to discover new therapeutic targets considering its irreversibly. Traditional Chinese medicine (TCM) has become indispensable for the (…)
02:00
AbstractBackground and AimsInfections of tunneled hemodialysis central venous catheters (CVCs) are a serious problem, and the outcome of dialysis patients strongly depends on their clinical management. Several specialists are involved in choosing the appropriate technical and clinical strategy (…)
02:00
AbstractBackground and AimsMorbimortality and quality of life in hemodialysis patients is directly related to the reliability and integrity of the vascular access. Current guidelines recommend a shift from a "fistula first" approach to a patient-centered approach due to the aging dialysis (…)
02:00
AbstractBackground and AimsThe primary screening methods for monitoring vascular access in haemodialysis involve measuring access blood flow and dialysis venous pressure. However, challenges are present in both aspects, potentially hindering the attainment of desired results. Research in this (…)
02:00
AbstractBackground and AimsVeins are frequently exposed to arterial circulation, as coronary artery bypass grafts (CABG) and as a peripheral venous bypass to treat atherosclerotic disease, or in the case of arterio-venous fistulas (AVF) to provide a vascular access for hemodialysis. Therapeutic (…)
02:00
AbstractBackground and AimsFor older people with kidney failure, especially those with comorbidities or poor performance status, the survival benefits of dialysis are uncertain and its quality of life impact greatest. Conservative kidney management (CKM) can be a beneficial alternative. However, (…)
02:00
AbstractBackground and AimsThe decision on the type of vascular access for hemodialysis is based on several factors including the timing of renal replacement therapy initiation and certain patients’ clinical and demographic features. We hypothesized that the increasing age of patients on (…)
02:00
AbstractBackground and AimsAnti-B-cell treatment has been shown to be an efficient tactic for glomerular disease. Ripertamab as a novel anti-CD20 monoclonal antibody developed by China, has been structurally optimized to specifically bind to the transmembrane antigen CD20, with an amino acid (…)
02:00
AbstractBackground and AimsSarcopenia is considered a frequent cause of morbidity and mortality among patients with chronic kidney disease (CKD). In clinical practice, tools such as handgrip strength and bioelectrical impedance analysis (BIA) can help us diagnose sarcopenia and possibly predict (…)
02:00
AbstractBackground and AimsGuidelines recommend renin-angiotensin-aldosterone system inhibitor (RAASi) therapy at the maximum tolerated dose in patients with chronic kidney disease (CKD) and/or heart failure (HF). Hyperkalaemia (HK) may be a barrier to achieving guideline-directed targets, with (…)
02:00
AbstractBackground and AimsPeritoneal dialysis (PD) is as effective as hemodialysis and provides a better quality of life. However, it remains underused, particularly in our country, for several reasons, especially the unavailability of surgeons with the necessary skills to insert catheters. The (…)
02:00
AbstractBackground and AimsHospital-acquired infection (HAIs) is a problem for 6-8% of hospitalized patients. HAIs has personal costs, prolongs the hospital stay, increasing the risk of morbidity, mortality, time and staff consuming. Hand hygiene (HH) is essential for preventing infections. (…)
02:00
AbstractBackground and AimsKocuria species, gram-positive actinobacteria, are typically found in the environment, on human skin and as oral flora. These microorganisms are considered saprophytes and non-pathogenic. They rarely cause infections. Patients generally have some compromise due to (…)
02:00
AbstractBackground and AimsEvidence about nefroprotective effect with RAAS blockers in elderly patients with chronic kidney disease (CKD) without proteinuria is lacking. The primary outcome of our study is to evaluate the impact of RAAS blockers in CKD progression in elderly patients without (…)
02:00
AbstractBackground and AimsThe guidelines of the International Society of Peritoneal Dialysis suggest regular control of small solute removal. During the COVID-19 pandemic we did not perform additional controls of dialysis adequacy in our peritoneal dialysis patients. We judged patients (…)
02:00
AbstractBackground and AimsPostpartum acute kidney injury (PPAKI) is a formidable health problem in pregnant woman especially in developing country. Monitoring outcomes like serum creatinine levels and glomerular filtration rates is vital. Understanding these short-term results is crucial for (…)
02:00
AbstractBackground and AimsHyperkalaemia is a barrier to achieving guideline-directed renin-angiotensin-aldosterone system inhibitor (RAASi) therapy. This observational cohort study compared the likelihood of maintained (stabilised or up-titrated) RAASi therapy at 6 months following an episode (…)
02:00
AbstractBackground and AimsProstate cancer is the most common malignancy in men. Secondary nephrotic syndrome as part of the paraneoplastic syndrome occurs in 11% of cases and is most often associated with membranous glomerulopathy. The association of minimal change disease (MCD) and prostate (…)
02:00
AbstractBackground and AimsPsychosocial interventions for depressive and anxiety symptoms are effective in CKD, but studies mainly focus on people on dialysis. Little is known about the role of screening and prevention of common mental health difficulties in early CKD.This trial assessed the (…)
02:00
AbstractBackground and AimsHypervolemia is associated with inflammation in hemodialysis patients (HD). How hypervolemia triggers inflammation is not entirely known. We hypothesized that hypervolemia affects signaling via the NF-kB transcription factor system and thus analyzed the phosphorylated (…)
02:00
AbstractBackground and AimsHypertensive nephropathy (HN) is a significant contributor to chronic kidney disease, yet the factors influencing the disease progression remains elusive. Notably, late-stage chronic kidney disease significantly impacts patient outcome. This project aims to unveil (…)
02:00
AbstractBackground and AimsChronic Kidney Disease (CKD) patients have increased risk of cardiovascular disease and dyslipidemia is a frequent comorbidity. Many patients are medicated with anti-lipidemic agents to reduce atherosclerotic disease and coronary vascular events. Fenofibrates are (…)
02:00
AbstractBackground and AimsFabry's disease (FD) is a rare lysosomal disorder linked to the X chromosome due to a mutation in the gene encoding alpha-galactosidase A (alpha-Gal A). This mutation leads to a defect in the metabolism of glycosphingolipids, causing the progressive accumulation of (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) lead to the accumulation of uremic toxins in the bloodstream, among which indoxyl sulfate (IS) is the most prominent. IS causes damage to endothelial cells lining blood vessels, ultimately leading to cardiovascular diseases in patients with (…)
02:00
AbstractBackground and AimsKidney biopsy is the gold standard for lupus nephritis diagnosis, defining histologic class, disease activity and chronicity in detail and providing guidance for treatment. The updated 2018 ISN/RPS histopathological classification in lupus nephritis is widely used for (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN) is associated with chronic inflammation. Platelet-related parameters, such as platelet (PLT) count, platelet-to-albumin ratio (PAR) and platelet-to-lymphocyte ratio (PLR), were examined as potential prognostic indicators for renal and (…)
02:00
AbstractBackground and AimsKidney stones have been described in multiple studies as an independent risk factor for chronic kidney disease (CKD). However, this relationship remains partially understood, and there is limited local, regional, and national information available. While common factors (…)
02:00
AbstractBackgroundC3 glomerulonephritis (C3GN) and C3 dominant infection related glomerulonephritis (C3-IRGN) comprise two important immune complex mediated diseases. C3GN is caused by dysregulation of the alternate pathway by congenital or acquired abnormalities in the complement pathway. (…)
02:00
AbstractBackground and AimsNephrolithiasis is the most common expression of kidney involvement in chronic inflammatory bowel disease (IBD), especially in Crohn's disease (CD). Stone formation favoring factors are hyperoxaluria, dehydration, acidosis, common conditions in CD patient, who present (…)
02:00
AbstractBackground and AimsIncreased risk of bleeding is a well-known complication of chronic kidney disease (CKD). However, these patients also have an increased risk of thrombotic events. Several studies have implicated both impaired and enhanced platelet function in patients with chronic (…)
02:00
AbstractBackground and AimsThe regional epidemiology of Systemic lupus erythematosus (SLE) and lupus nephritis (LN) within the same country is poorly understood. Being a rare disease, its severity may be influenced by local expertise and treatment protocols, especially when healthcare systems (…)
02:00
AbstractBackground and AimsSeveral studies demonstrated non-osmotic sodium-storage, especially in the skin. Patients with chronic kidney disease often suffer from skin symptoms and furthermore an association of advanced CKD-stages with inflammatory skin diseases has been shown. Additionally, in (…)
02:00
AbstractBackground and AimsIgA nephropathy (IgAN) is the most common glomerulonephritis with a high risk of progression to end-stage renal disease (ESRD). Because machine learning models developed for research have limited use in clinical settings, this study developed and validated prediction (…)
02:00
AbstractBackground and AimsImproving the risk prediction of adverse outcomes of chronic kidney disease at the level of primary care physicians, through early diagnosis of chronic kidney disease, can help reduce the progression of the disease, improve the clinical condition of patients and the (…)
02:00
AbstractBackground and AimsSeveral studies have been conducted on immune checkpoint inhibitor (ICI)-associated nephrotoxicity. However, current clinical analyses for nephrotoxicity are inadequate owing to the diagnostic criteria, which are mostly based on an increase in serum Cre levels rather (…)
02:00
AbstractBackground and AimsIn both classical hemodialysis (HD) and its high convective version, the hemodiafiltration (HDF), the unavoidable contact of blood cells with the filters (e.g. polysulfone), may cause the formation of microaggregates and the release of Inflammatory cytokines. Reducing (…)
02:00
AbstractBackground and AimsRenal Fanconi syndrome (FS) presented dysfunctions of renal proximal tubular (PT) transport with or without excessive urine amino acids (AAs) excretion, which might contribute to the progression of eGFR decline. This study aimed to explore the clinical benefit of 21 (…)
02:00
AbstractBackground and AimsOverhydration is considered a significant risk factor for cardiovascular and all-cause mortality in end-stage kidney disease patients. Measurement of total and extracellular water with bioelectrical impedance analysis (BIA), inferior vena cava diameter (IVCd) (…)
02:00
AbstractBackground and AimsDNA methylation (DNAm) is an epigenetic mechanism which can therefore induce changes in gene expression without any change to the underlying DNA sequence. Although generally quite stable, DNAm patterns in whole blood do vary across individuals, with DNAm levels (…)
02:00
AbstractBackground and AimsSalbutamol/albuterol is a moderately selective beta-2-adrenergic receptor agonist that acts as an airway smooth muscle relaxant. It is used to prevent and treat acute bronchospasm in various respiratory conditions. Due to its large volume of distribution, it is not (…)
02:00
AbstractBackground and AimsDiabetic kidney disease (DKD) is driven by a set of pathophysiological processes, including fibrosis. Endotrophin (ETP), a pro-fibrotic fragment generated during collagen type VI formation, has previously been shown to be a biomarker of DKD progression. The aim of this (…)
02:00
AbstractBackground and AimsIn end-stage kidney disease, solutes with a wide spectrum of molecular weight, called uremic toxins, are retained due to impaired kidney cleansing capacity. Particularly, the retention of toxins in the middle molecular weight range 15–45 kDa might negatively affects (…)
02:00
AbstractBackground and AimsEndotrophin is a pro-fibrotic and pro-inflammatory molecule derived from the post-translational processing of type VI collagen. Evidence for an association of increased circulating levels of endotrophin with increased risk of kidney and cardiovascular-related outcome (…)
02:00
AbstractBackground and AimsHypertriglyceridemia (HTG) is defined as the plasmatic concentration of triglycerides above 150 mg/dl. With a current prevalence ranging from 15% to 20% in clinical practice, it's a prevalent condition that´s increasing alongside other cardiovascular risk factors such (…)
02:00
AbstractBackground and AimsObesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney dysfunction in obesity-induced kidney disease (OIKD) remain unclear. MicroRNAs (miRNAs) have been implicated in the development and (…)
02:00
AbstractBackground and AimsHepatitis B (HBV) and hepatitis C (HCV) viral infections significantly contribute to morbidity and mortality among hemodialysis patients, posing substantial challenges in the management of these individuals. These infections present a critical global public health (…)
02:00
AbstractBackground and AimsThe bi-directional relationship between the kidneys and heart leads to different forms of cardiorenal syndrome (CRS) in which acute or chronic dysfunction in one organ affects the other. CRS type 4 is characterized by chronic kidney disease leading to the impairment of (…)
02:00
AbstractBackground and AimsLight-chain cast nephropathy is the result of intra-tubular precipitation of light-chains produced by a multiple myeloma. Treatment often includes high cut-off filters hemodialysis (HCO) with the purpose of purifying these chains until the chemotherapy response is (…)
02:00
AbstractBackground and AimsChronic kidney disease (CKD) is characterized by endothelial dysfunction, that is partly caused by reduced bioavailability of NO. In addition to volume overload, endothelial dysfunction may contribute to hypertension in CKD. High sodium consumption affects NO levels, (…)
02:00
AbstractBackground and AimsChronic kidney disease affects 10% of the world population (15.1% in Spain, ENRICA 2019 study), being a health problem with important physical, emotional, and socio-occupational repercussions.Deciding on the most appropriate renal replacement therapy (RRT) for each (…)
02:00
AbstractBackground and AimsThe NICE chronic kidney disease (CKD) treatment guidelines recommend regular laboratory measurements of both kidney function (eGFR) and damage (proteinuria) to appropriately inform efforts to prevent and treat progression of CKD. Recommendations also indicate frequency (…)
02:00
AbstractBackground and AimsTechnological innovation has revolutionized medical assistance. Peritoneal dialysis (PD) patients, who prioritize their autonomy and freedom choosing to undergo dialysis at home, are the paradigm of patients willing to use telemedicine. Remote monitoring allows (…)
02:00
AbstractBackground and AimsRenal cortical interstitial fibrosis is a well-established prognostic indicator for renal health, conventionally estimated by biopsy. Our prior research has enhanced DW-MRI sequencing, facilitating precise distinction between the renal cortex and medulla. This has (…)
02:00
AbstractBackground and AimsThere is great variability in free water carrying capacity (FFWC) in incident patients, but the extent to which this variability impacts inherent ultrafiltration failure (UF) is unknown. The peritoneal equilibration test (PET) with 3.86% glucose allows measurement of (…)
02:00
AbstractBackground and AimsA reduction in the serum level of albumin following the initiation of peritoneal dialysis (PD) has been reported to associate with impaired survival. Our aim was to identify pre-PD risk factors of drop of serum albumin, and to estimate how a decrease in albumin level (…)
02:00
AbstractBackground and AimsStudies have demonstrated that chronic dialysis with residual kidney function (RKF) had better survival rates in comparison to those with diminished or absent RKF and are also further associated with improved cardiovascular outcomes. Thus, the strategic preservation of (…)
02:00
AbstractBackground and AimsPeritoneal dialysis (PD) patients seem to have a higher incidence of acute alithiasic pancreatitis. Though rare and with some suggested triggers described in the literature, this is still a poorly understood and potentially life-threatening complication. We present a (…)
02:00
AbstractBackground and AimsTo explore body composition and metabolic profile changes in type 2 diabetes mellitus and chronic kidney disease (T2DM-CKD) using Semaglutide added to sodium-glucose transporter 2 inhibitors (SGLT-2Is).MethodThe study was performed on patients with T2DM-CKD in West (…)
02:00
AbstractBackground and AimsT2DM is a global pandemic, frequently complicated by DKD, that may result in ESRD and cardiovascular complications. Despite advancements in diabetes and cardiovascular risk management, the prevalence of DKD continues to grow.During the last years SGLT2i and GLP1RAs (…)