1er juillet

AJKD https://www.ajkd.org/

• 00:00
  A Patient With Spontaneous Perinephric Hematoma: A Quiz - Prathap Kumar Simhadri, Deepak Chandramohan, Prabhat Singh, Rachana Marathi, Kyle Burton, Pradeep Vaitla AJKD
  A 61-year-old white female patient with a history of hypertension and asthma with culture-negative L5-S1 lumbar diskitis was on intravenous cefepime, vancomycin, and minocycline for nearly 2 weeks when she presented with severe bilateral flank pain, hypotension, tachycardia, and severe anemia. (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Editorial Board AJKD
  (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Masthead AJKD
  (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Table of Contents AJKD
  (American Journal of Kidney Diseases 84, 1 (2024))

21 juin

AJKD https://www.ajkd.org/

• 00:00
  Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank - Rui Tang, Ying Hu, Jian Zhou, Xuan Wang, Xiang Li, Yoriko Heianza, Lu Qi AJKD
  While smoking is a recognized risk factor for chronic kidney disease (CKD), the relationship between the time smoking is initiated after awakening each day and CKD remains largely unstudied. This study examined the association between this timing and the risk of CKD, and the potential (…) (American Journal of Kidney Diseases (2024))

20 juin

AJKD https://www.ajkd.org/

• 00:00
  A Close Look at Metabolic Dysfunction in Autosomal Dominant Polycystic Kidney Disease: From Bench to Imaging - Sol Carriazo, York Pei AJKD
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease, affecting up to 12 million people worldwide.1 Mutations in 2 major genes, PKD1 and PKD2, account for 70%-85% and 15%-30% of genetically resolved cases, respectively.2 Currently, algorithms employing (…) (American Journal of Kidney Diseases (2024))
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  The Ties That Bind - Antonio Yaghy AJKD
  Thrice weekly pilgrimage, (American Journal of Kidney Diseases (2024))
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  Clinicopathologic Characteristics of Crystalglobulin-Induced Nephropathy: A Case Series - Samih H. Nasr, Satoru Kudose, Anthony M. Valeri, Ali Kashkouli, Samar M. Said, Dominick Santoriello, Glen S. Markowitz, Lihong Bu, Lynn D. Cornell, Adel Samad, Jahangir Ahmed, Sanjeev Sethi, Nelson Leung, Vivette D. D’Agati AJKD
  Crystalglobulinemia is a rare syndrome characterized by intravascular crystallization of monoclonal immunoglobulins (MIgs). Data on kidney involvement are limited to case reports. This series characterizes the clinicopathologic spectrum of crystalglobulin-induced nephropathy (CIN). (American Journal of Kidney Diseases (2024))
• 00:00
  Transfers From In-Center Hemodialysis to Peritoneal Dialysis: Better Late Than Never? - Ankur D. Shah, Jeffrey Perl AJKD
  Peritoneal dialysis (PD) remains an underutilized dialysis modality despite its many advantages compared to in-center hemodialysis (ICHD), including greater convenience and quality of life, relative preservation of residual kidney function (RKF), and improved early patient survival.1 The (…) (American Journal of Kidney Diseases (2024))
• 00:00
  Clinical Characteristics and Prognosis of Genetic Focal Segment Glomerulosclerosis - Xu Hao, Shuwen Yu, Qinjie Weng, Zhengying Fang, Qimin Zheng, Yafei Zhao, Jian Liu, Jun Ma, Chunli Zhang, Yunzi Liu, Junru Li, Mingxin Yang, Hong Ren, Jingyuan Xie AJKD
  Focal segmental glomerulosclerosis (FSGS) is a pathological lesion characterized by focal segmental sclerosis with foot-process effacement. The etiology of FSGS is complex, with clinical manifestations ranging from varying degrees of proteinuria to progressive kidney failure [1, 2]. According to (…) (American Journal of Kidney Diseases (2024))

19 juin

AJKD https://www.ajkd.org/

• 00:00
  Chronic Tonsillitis and IgA Nephropathy: Findings From a Nationwide Japanese Cohort Study - Takashin Nakayama, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Hiroyuki Morita, Katsuhito Fujiu, Norifumi Takeda, Akira Fukui, Takashi Yokoo, Norihiko Takeda, Hideo Yasunaga, Masaomi Nangaku, Kaori Hayashi AJKD
  Little is known regarding the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN). In the present study, we examined the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN. (American Journal of Kidney Diseases (2024))
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  Efficacy and Safety of Allopurinol and Febuxostat in Patients With Gout and CKD: Subgroup Analysis of the STOP Gout Trial - Lindsay N. Helget, Anne Davis-Karim, James R. O’Dell, Ted R. Mikuls, Jeff A. Newcomb, Maria Androsenko, Mary T. Brophy, Bryant R. England, Ryan Ferguson, Michael H. Pillinger, Tuhina Neogi, Hongsheng Wu, Paul M. Palevsky AJKD
  We conducted a prespecified examination of the efficacy and safety of allopurinol and febuxostat administered using a treat-to-target strategy in trial participants with chronic kidney disease (CKD). (American Journal of Kidney Diseases (2024))
• 00:00
  Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications - Devika Nair, Christine K. Liu, Rasha Raslan, Mara McAdams-DeMarco, Rasheeda K. Hall AJKD
  Frailty is a multi-system syndrome of decreased physiologic reserve that has been shown to strongly and independently predict morbidity and mortality. Frailty is prevalent in patients living with kidney disease and occurs earlier in individuals with kidney disease as compared to the general (…) (American Journal of Kidney Diseases (2024))

18 juin

AJKD https://www.ajkd.org/

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  The Case for Incremental Thinking About Kidney Stone Disease - Alan C. Pao AJKD
  From a patient’s perspective, you either have a kidney stone or you don’t. Detecting a stone represents an all-or-nothing event, foreshadowing what may come to pass (or not pass). In comparison, evaluating risk of a recurrent stone is a continuous, often iterative, process. Evaluating stone risk (…) (American Journal of Kidney Diseases (2024))
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  In Reply to “Considerations on Potential Modifiers of Glycated Albumin Levels in Patients With CKD” - Mengyao Tang, Sahir Kalim AJKD
  We thank Dr. Chia-Ter Chao for highlighting the role of non-glycemic factors in influencing glycated albumin (GA) levels in patients with chronic kidney disease (CKD).1 (American Journal of Kidney Diseases (2024))
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  Considerations on Potential Modifiers of Glycated Albumin Levels in Patients With CKD - Chia-Ter Chao AJKD
  I was intrigued by Tang et al.’s study on glycated albumin (GA) as a predictor for outcomes in patients with chronic kidney disease (CKD) within the Chronic Renal Insufficiency Cohort.1 Their findings linking higher GA levels to increased kidney and cardiovascular risks are commendable. However, (…) (American Journal of Kidney Diseases (2024))

12 juin

AJKD https://www.ajkd.org/

• 00:00
  Extreme Humid-Heat Exposure and Mortality Among Patients Receiving Dialysis - Matthew F. Blum, Yijing Feng, Cascade P. Tuholske, Byoungjun Kim, Mara A. McAdams DeMarco, Brad C. Astor, Morgan E. Grams AJKD
  Exposure to extreme heat events has been linked to increased morbidity and mortality in the general population. Patients receiving maintenance dialysis may be vulnerable to greater risks from these events, but this is not well understood. We sought to characterize the association of extreme heat (…) (American Journal of Kidney Diseases (2024))
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  Frailty and Duration of Maintenance Dialysis: A Japanese Nationwide Cross-Sectional Study - Suguru Yamamoto, Kakuya Niihata, Tatsunori Toida, Masanori Abe, Norio Hanafusa, Noriaki Kurira AJKD
  End-stage kidney disease increases the risk of frailty. Understanding how long-term dialysis affects physical function may help patients and caregivers plan their lives better. Our research explores the relationship between duration of maintenance dialysis and frailty. We found that longer (…) (American Journal of Kidney Diseases (2024))

10 juin

AJKD https://www.ajkd.org/

• 00:00
  Severe Presentation of Mpox With Skin, Lung and Pleural Involvement in a Non-HIV Infected Kidney Transplant Recipient - Julio Francisco Colina-García, José María Caso, Celia González-García, María Dolores Folgueira, Ana María Hernández, Pilar Auñón, Amado Andrés, Teresa Cavero, Francisco López-Medrano, Enrique Morales AJKD
  Monkeypox (mpox) is an orthopoxviral zoonotic disease with a similar, but less severe, clinical presentation as smallpox. However, immunocompromised patients such as solid organ transplant recipients are at higher risk of developing severe forms of the disease. Herein, we describe the case of a (…) (American Journal of Kidney Diseases (2024))

6 juin

AJKD https://www.ajkd.org/

• 00:00
  Kidney Care in Times of Crises: A Review - Sami Alasfar, Sahar H. Koubar, Samir C. Gautam, Bernard G. Jaar AJKD
  The global burden of kidney disease is increasing, paralleled by a rising number of natural and man-made crises. During these tumultuous times, accessing vital healthcare resources becomes challenging, posing significant risks to individuals, particularly those with kidney disease. This review (…) (American Journal of Kidney Diseases (2024))
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  Enhancing Clinical Decision Support in Nephrology: Addressing Algorithmic Bias Through Artificial Intelligence Governance - Benjamin A. Goldstein, Dinushika Mohottige, Sophia Bessias, Michael P. Cary AJKD
  There has been a steady rise in the use of clinical decision support (CDS) tools to guide Nephrology, as well as general clinical care. Through guidance set by federal agencies and concerns raised by clinical investigators, there has been an equal rise in understanding whether such tools exhibit (…) (American Journal of Kidney Diseases (2024))
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  Identifying Major Barriers to Home Dialysis (The IM-HOME Study): Findings From a National Survey of Patients, Care Partners, and Providers - Yuvaram N.V. Reddy, Matthew D. Kearney, Michaela Ward, Robert E. Burke, Ann M. O’Hare, Peter P. Reese, Meghan B. Lane-Fall, IM-HOME Advisory Board AJKD
  Developing strategies to improve home dialysis use requires a comprehensive understanding of barriers. We sought to identify the most important barriers to home dialysis use from the perspective of patients, care partners, and providers. (American Journal of Kidney Diseases (2024))

2 juin

AJKD https://www.ajkd.org/

• 00:00
  Going From Point A to Point B: Changes in the Mobility of Older Persons With CKD - Ana Jessica Alfaro, Christine K. Liu AJKD
  From the Standardized Outcomes for Nephrology (SONG) initiative, we know persons living with chronic kidney disease (CKD) prioritize the ability to undertake activities that provide joy, hope, fulfillment, and autonomy.1 Often called life participation, examples include socialization with family (…) (American Journal of Kidney Diseases (2024))

1er juin

AJKD https://www.ajkd.org/

• 00:00
  Erratum regarding “Predicting Kidney Failure With the Kidney Failure Risk Equation: Time to Rethink Probabilities” (Am J Kidney Dis. 2023;82(4):381-383) AJKD
  In the Editorial entitled “Predicting Kidney Failure With the Kidney Failure Risk Equation: Time to Rethink Probabilities” that appeared in the October 2023 issue of AJKD,1 there was an error in the identity of the corresponding author. The corresponding author appeared as Chava Rampspek; the (…) (American Journal of Kidney Diseases 83, 6 (2024))
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  Erratum regarding “Serum ?-Trace Protein and ?2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study” (Am J Kidney Dis. 2016;68(1):68-76) AJKD
  In the Original Investigation entitled “Serum ?-Trace Protein and ?2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study” that appeared in the July 2016 issue of AJKD,1 there was an error regarding (…) (American Journal of Kidney Diseases 83, 6 (2024))
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  Erratum regarding “Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD” (Am J Kidney Dis. 2016;68(6):892-900) AJKD
  In the Original Investigation entitled “Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD” that appeared in the December 2016 issue of AJKD,1 there was an error regarding the source of the ?-Trace Protein (BTP) and ?2-Microglobulin (B2M) samples. The samples (…) (American Journal of Kidney Diseases 83, 6 (2024))
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  A Case of Inadequate Ultrafiltration on Peritoneal Dialysis: A Quiz - Rui Zhi Ng, Jie Ming Nigel Fong AJKD
  A 35-year-old female patient with end-stage kidney failure secondary to focal segmental glomerulosclerosis was initiated on continuous cyclic peritoneal dialysis (CCPD). The PD regimen comprised 5L of 2.5% tonicity dextrose and 5L of 1.5% dextrose, administered in 5 cycles of 2L over 10 hours (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Erratum regarding “A New Panel-Estimated GFR, Including ?2-Microglobulin and ?-Trace Protein and Not Including Race, Developed in a Diverse Population” (Am J Kidney Dis. 2021;77(5):673-683) AJKD
  In the Original Investigation entitled “A New Panel-Estimated GFR, Including ?2-Microglobulin and ?-Trace Protein and Not Including Race, Developed in a Diverse Population” that appeared in the May 2021 issue of AJKD,1 there was an error regarding the source of the ?-Trace Protein (BTP) and (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Table of Contents AJKD
  (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Editorial Board AJKD
  (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Masthead AJKD
  (American Journal of Kidney Diseases 83, 6 (2024))

29 mai

AJKD https://www.ajkd.org/

• 00:00
  In Reply to “The Use of Ultrasound in Peritoneal Dialysis Setting” - Vandana Dua Niyyar AJKD
  We read with interest Curto et al’s letter1 regarding the use of ultrasound in peritoneal dialysis (PD). The authors make a valid suggestion that use of ultrasound in PD therapy should also be included in Core Curricula. We agree with the authors, as sonography is immensely helpful in evaluation (…) (American Journal of Kidney Diseases (2024))
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  The Use of Ultrasound in Peritoneal Dialysis Setting - Andreia Curto, Tiago Assis Pereira, Ana Carina Ferreira AJKD
  We read with interest the article by O’Neill et al.1, recently published in AJKD, focused on ultrasound (US) for nephrology practice across the spectrum of kidney disease. We agree that the use of US technology will improve diagnostic accuracy and increase quality outcomes in nephrology (…) (American Journal of Kidney Diseases (2024))

28 mai

AJKD https://www.ajkd.org/

• 00:00
  Associations of Urine and Plasma Metabolites with Kidney Failure and Death in a CKD Cohort - Inga Steinbrenner, Ulla T. Schultheiss, Helena Bächle, Yurong Cheng, Charlotte Behning, Matthias Schmid, Wan-Jin Yeo, Bing Yu, Morgan E. Grams, Pascal Schlosser, Helena Stockmann, Wolfram Gronwald, Peter J. Oefner, Elke Schaeffner, Kai-Uwe Eckardt, Anna Köttgen, Peggy Sekula, GCKD Investigators AJKD
  Biomarkers that enable better identification of persons with chronic kidney disease (CKD) who are at higher risk for disease progression and adverse events are needed. This study sought to identify urine and plasma metabolites associated with progression of kidney disease. (American Journal of Kidney Diseases (2024))

27 mai

AJKD https://www.ajkd.org/

• 00:00
  Improving Diverse and Equitable Involvement of Patients and Caregivers in Research in CKD: Report of a Better Evidence and Translation – Chronic Kidney Disease (BEAT-CKD) Workshop - Rosanna Cazzolli, Amanda Sluiter, Samantha Bateman, Hayley Candler, Yeoungjee Cho, Tess Cooper, Jonathan C. Craig, Amanda Dominello, Emily Duncanson, Chandana Guha, Carmel M. Hawley, Erandi Hewawasam, Laura Hickey, Kathy Hill, Kirsten Howard, Martin Howell, Brooke M. Huuskes, Georgina L. Irish, Shilpanjali Jesudason, David W. Johnson, Ayano Kelly, Diana Leary, Karine Manera, Jasmin Mazis, Stephen McDonald, Helen McLennan, Shyamsundar Muthuramalingam, Margaret Pummeroy, Nicole Scholes-Robertson, Armando Teixeira-Pinto, David J. Tunnicliffe, Anita van Zwieten, Andrea K. Viecelli, Germaine (…) AJKD
  Patient and caregiver involvement can enhance the uptake and impact of research, however, the involvement of patients and caregivers who are underserved and marginalized is often limited. A better understanding of how to make involvement in research more broadly accessible, supportive, and (…) (American Journal of Kidney Diseases (2024))

23 mai

AJKD https://www.ajkd.org/

• 00:00
  Vitamin D Metabolites Before and After Kidney Transplantation in Patients Who Are Anephric - Hanne Skou Jørgensen, Henriette de Loor, Jaak Billen, Nele Peersman, Pieter Vermeersch, Annemieke C. Heijboer, Fiona Ivison, Dirk Vanderschueren, Roger Bouillon, Maarten Naesens, Dirk Kuypers, Pieter Evenepoel AJKD
  Kidneys are vital for vitamin D metabolism and disruptions in both production and catabolism occur in chronic kidney disease. Although vitamin D activation occurs in numerous tissues, the kidneys are the most relevant source of circulating active vitamin D. This study investigates extrarenal (…) (American Journal of Kidney Diseases (2024))

22 mai

AJKD https://www.ajkd.org/

• 00:00
  Organization and Structures for Detection and Monitoring of CKD Across World Countries and Regions: Observational Data From a Global Survey - Somkanya Tungsanga, Winston Fung, Ikechi G. Okpechi, Feng Ye, Anukul Ghimire, Philip Kam-Tao Li, Michael G. Shlipak, Sri Lekha Tummalapalli, Silvia Arruebo, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, Adeera Levin, Syed Saad, Marcello Tonelli, Aminu K. Bello, David W. Johnson AJKD
  Established therapeutic interventions effectively mitigate the risk and progression of chronic kidney disease (CKD). Countries and regions have a compelling need for organizational structures that enable early identification of people with CKD who can benefit from these proven interventions. We (…) (American Journal of Kidney Diseases (2024))

14 mai

AJKD https://www.ajkd.org/

• 00:00
  Anatomy of a Foley Catheter Tray - Oscar Li, Yeonsoo Sara Lee AJKD
  Prior to medical school, I had never even heard of a Foley catheter. As students, the transition from the preclinical classroom setting to the clinical environment can be met with some resistance—not unlike placing a Foley and feeling a little pushback at the junction between the penile and (…) (American Journal of Kidney Diseases (2024))
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  Intensity-Specific Physical Activity Measured by Accelerometer, Genetic Susceptibility, and the Risk of Kidney Stone Disease: Results From the UK Biobank - Yashu Liu, Po-Wen Ku, Zhenhua Li, Honghao Yang, Tingjing Zhang, Liangkai Chen, Yang Xia, Song Bai AJKD
  Kidney stone disease (KSD), a significant healthcare problem within both developed and developing countries, has been associated with genetic risk factors. As well, an association between physical activity and KSD risk has been hypothesized but studies have yielded inconsistent findings. This (…) (American Journal of Kidney Diseases (2024))

13 mai

AJKD https://www.ajkd.org/

• 00:00
  Clinicopathological Characteristics of Light and Heavy Chain Deposition Disease: A Case Series - Yujie Wang, Dacheng Chen, Ruimin Hu, Yuan Zhang, Dandan Liang, Feng Xu, Feng Liu, Xiaodong Zhu, Yao Lin, Xue Yang, Xumeng Liu, Guolan Xing, Shaoshan Liang, Caihong Zeng AJKD
  Light and heavy chain deposition disease (LHCDD) is a rare form of monoclonal immunoglobulin deposition disease (MIDD), and limited clinical data are available characterizing this condition. We described the clinicopathological characteristics and outcomes of LHCDD. (American Journal of Kidney Diseases (2024))
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  Association of Obesity With Kidney and Cardiac Outcomes Among Patients With Glomerular Disease: Findings From the Cure Glomerulonephropathy Network - Evan M. Zeitler, Dorey A. Glenn, Yichun Hu, Ronald J. Falk, Susan L. Hogan, Amy K. Mottl, CureGN Investigators AJKD
  The influence of obesity on cardiorenal outcomes in individuals with glomerular disease is incompletely known. This study examined the association between obesity and kidney and cardiovascular outcomes in children and adults with glomerular kidney disease. (American Journal of Kidney Diseases (2024))

10 mai

AJKD https://www.ajkd.org/

• 00:00
  Time-Varying Proteinuria in Predicting Outcome of IgA Nephropathy - Takaya Sasaki, Nobuo Tsuboi AJKD
  We read the article by Tang et al1 with great interest. Owing to the ever-changing disease activity and case-by-case response to treatment, it is often difficult to comprehensively recognize the long-term clinical course of patients with immunoglobulin A nephropathy (IgAN).2 The lack of a (…) (American Journal of Kidney Diseases (2024))

1er mai

AJKD https://www.ajkd.org/

• 00:00
  Efficacy and Safety of Iptacopan in Patients with Iga Nephropathy (IGAN): Interim Analysis (IA) of The Phase 3 Applause-Igan Study: AJKD
  (American Journal of Kidney Diseases 83, 5 (2024))
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  2 Treatment with Chlorthalidone vs Hydrochlorothiazide and Renal Outcomes: The Diuretic Comparison Project (DCP): AJKD
  (American Journal of Kidney Diseases 83, 5 (2024))
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  1 Matching-Adjusted Indirect Comparisons of Egfr Slopes in The Protect Study With UK Radar Iga Nephropathy Population and The Control Arm of Nefigard: AJKD
  (American Journal of Kidney Diseases 83, 5 (2024))
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  National Kidney Foundation 2024 Spring Clinical Meeting Late-Breaking Abstracts May 14-18, 2024 AJKD
  W Gong1, U Diva1, M Bensink1, X Chai2, Y Xie2, S Gao2, B Hendry1, A Mercer3, Z-Y Zhou2, B Rovin4, J Barratt5. 1Travere Therapeutics, Inc, San Diego, CA, United States; 2Analysis Group, Boston, MA, United States; 3JAMCO Pharma Consulting, Stockholm, Sweden; 4Ohio State University, Wexner (...) (American Journal of Kidney Diseases 83, 5 (2024))
• 00:00
  Table of Contents AJKD
  (American Journal of Kidney Diseases 83, 5 (2024))
• 00:00
  Editorial Board AJKD
  (American Journal of Kidney Diseases 83, 5 (2024))
• 00:00
  Masthead AJKD
  (American Journal of Kidney Diseases 83, 5 (2024))
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  Hypertension and Proteinuria in a Pregnancy: A Quiz - Massimo Torreggiani, Maria Rita Stancanelli, Linda Njandjo, Antioco Fois, Giorgina Barbara Piccoli AJKD
  A 17-year-old woman with a medical history of miscarriages at age 14 and 16 and 1 noncomplicated pregnancy at age 15 was hospitalized at 30 gestational weeks owing to the development of hypertension, proteinuria, and edema, with a weight gain of 17kg, mainly in the last few weeks. Her (...) (American Journal of Kidney Diseases 83, 5 (2024))

27 avril

AJKD https://www.ajkd.org/

• 00:00
  The Importance of Hope for Patients With CKD - David L. Feldman, Lindsey J. Fuller AJKD
  Receiving a diagnosis of chronic kidney disease (CKD) can be devasting to patients and their families. Patients with CKD and their care partners often face a lifetime of daily battles resulting from numerous symptoms and the disease’s complex pathophysiology. Many face progressive decline in (…) (American Journal of Kidney Diseases (2024))

24 avril

AJKD https://www.ajkd.org/

• 00:00
  Referral and Beyond: Restructuring the Kidney Transplant Process to Support Greater Access in the United States - Catherine R. Butler, Peter P. Reese, Xingxing S. Cheng AJKD
  Advocates for improved equity in kidney transplants in the United States have recently focused their efforts on initiatives to increase referral for transplant evaluation. However, because donor kidneys remain scarce, increased referrals are likely to result in an increasing number of patients (…) (American Journal of Kidney Diseases (2024))

23 avril

AJKD https://www.ajkd.org/

• 00:00
  Imprecise, Measure it Twice? Dealing With the Biological Variability of Albuminuria in Diabetes - Sophie E. Claudel, Sushrut S. Waikar AJKD
  “Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions which we know as disease…” Osler, Aequanimitas1 (American Journal of Kidney Diseases 84, 1 (2024))

21 avril

AJKD https://www.ajkd.org/

• 00:00
  How Low Can You Go With Dose of Continuous Kidney Replacement Therapy? Is That the Right Question to Ask? - J. Pedro Teixeira, Ashita Tolwani, Javier A. Neyra AJKD
  Less is more. Illustrations of the validity of this mantra in life and clinical medicine are not hard to find. Examples abound in the realm of critical care, such as with mechanical ventilation1 and transfusion targets.2 Perhaps the best example in critical care nephrology is in dose of (…) (American Journal of Kidney Diseases (2024))
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  Living With a Rare Glomerular Disease: A Call to Action for Early Diagnosis and Innovation in Treatment - Antonia King, Fernando Caravaca-Fontán AJKD
  My Story (Antonia’s Perspective) (American Journal of Kidney Diseases (2024))

20 avril

AJKD https://www.ajkd.org/

• 00:00
  Defining Risk in APOL1-Associated Kidney Disease: The Story is Evolving! - Ashima Gulati, Marva Moxey-Mims AJKD
  APOL1 (OMIM 603743) encoding apolipoprotein L1 (apoL1) is an evolutionarily new gene found only in humans and some primates with key roles in innate immunity against African trypanosomiasis.1,2 Two African ancestry–related APOL1 gain-of-function haplotypes, G1 and G2, individually confer (…) (American Journal of Kidney Diseases (2024))

17 avril

AJKD https://www.ajkd.org/

• 00:00
  American Board of Internal Medicine Nephrology Procedure Requirements for Initial Certification: Time for a Change and Pursuing Consensus in the Nephrology Community - Rudolph A. Rodriguez, Matthew A. Sparks, Paul T. Conway, Anamika Gavhane, Siddharta Reddy, Linda Awdishu, Sana Waheed, Sandra Davidson, Deborah B. Adey, Janice P. Lea, John C. Lieske, Furman S. McDonald AJKD
  In 1988, the American Board of Internal Medicine (ABIM) defined essential procedural skills in nephrology, and candidates for ABIM certification were required to present evidence of possessing the skills necessary for placement of temporary dialysis vascular access, hemodialysis, peritoneal (…) (American Journal of Kidney Diseases (2024))

16 avril

AJKD https://www.ajkd.org/

• 00:00
  Association of Race and Ethnicity With High Longevity Deceased Donor Kidney Transplantation Under the US Kidney Allocation System - Nour W. Asfour, Kevin C. Zhang, Jessica Lu, Peter P. Reese, Milda Saunders, Monica Peek, Molly White, Govind Persad, William F. Parker AJKD
  The US Kidney Allocation System (KAS) prioritizes candidates with a?20% estimated posttransplant survival (EPTS) to receive high-longevity kidneys defined by a?20% Kidney Donor Profile Index (KDPI). Use of EPTS in the KAS deprioritizes candidates with older age, diabetes, and longer dialysis (…) (American Journal of Kidney Diseases (2024))
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  Peritoneal Dialysis Technique Survival: A Cohort Study - Caroline M. Hsu, Nien Chen Li, Eduardo K. Lacson, Daniel E. Weiner, Susan Paine, Karen Majchrzak, Christos Argyropoulos, Maria-Eleni Roumelioti, V. Shane Pankratz, Dana Miskulin, Harold J. Manley, Page Salenger, Doug Johnson, H. Keith Johnson, Antonia Harford AJKD
  Reasons for transfer from peritoneal dialysis (PD) to hemodialysis (HD) remain incompletely understood. Among incident and prevalent patients receiving PD, we evaluated the association of clinical factors, including prior treatment with HD, with PD technique survival. (American Journal of Kidney Diseases (2024))
• 00:00
  Difference Between Estimated GFR Based on Cystatin C Versus Creatinine and Incident Atrial Fibrillation: A New Instrument on the Horizon to Improve Risk Assessment in This High-Risk Population? - Veronica T. Costa e Silva, Ogechi M. Adingwupu, Lesley A. Inker AJKD
  Atrial fibrillation (AF) is the most common sustained arrythmia in the general population and an independent risk factor for death.1,2 AF occurs in up to 18% of patients with chronic kidney disease.3 The association of lower glomerular filtration rate (GFR) as a risk factor for incident AF is (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Association of Blood Mitochondrial DNA Copy Number With Risk of Acute Kidney Injury After Cardiac Surgery - Vasantha Jotwani, Heather Thiessen-Philbrook, Dan E. Arking, Stephanie Y. Yang, Eric McArthur, Amit X. Garg, Ronit Katz, Gregory J. Tranah, Joachim H. Ix, Steve Cummings, Sushrut S. Waikar, Mark J. Sarnak, Michael G. Shlipak, Samir M. Parikh, Chirag R. Parikh AJKD
  Acute kidney injury (AKI) is a common complication of cardiac surgery and its occurrence is associated with increased risk of all-cause mortality, adverse cardiovascular outcomes, and chronic kidney disease (CKD).1 Mitochondria are essential for healthy function of the kidneys due to their roles (…) (American Journal of Kidney Diseases (2024))

15 avril

AJKD https://www.ajkd.org/

• 00:00
  Erythrocytosis and CKD: A Review - Mabel Aoun, Michel Jadoul, Hans-Joachim Anders AJKD
  Erythrocytosis or polycythemia is defined as an increase in red blood cell concentration above the age- and sex-specific normal levels. Unlike anemia, which is very common in patients with chronic kidney disease (CKD), erythrocytosis is less frequent but requires specific understanding by health (…) (American Journal of Kidney Diseases (2024))

13 avril

AJKD https://www.ajkd.org/

• 00:00
  Kidney Energetics and Cyst Burden in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study - Petter Bjornstad, Gabriel Richard, Ye Ji Choi, Kristen L. Nowak, Cortney Steele, Michel B. Chonchol, Kristen J. Nadeau, Timothy Vigers, Laura Pyle, Kalie Tommerdahl, Daniel H. van Raalte, Allison Hilkin, Lynette Driscoll, Carissa Birznieks, Katharina Hopp, Wei Wang, Charles Edelstein, Robert G. Nelson, Adriana V. Gregory, Timothy L. Kline, Denis Blondin, Berenice Gitomer AJKD
  In this pilot study, we hypothesized that autosomal dominant polycystic kidney disease (ADPKD) is characterized by impaired kidney oxidative metabolism that associates with kidney size and cyst burden. (American Journal of Kidney Diseases (2024))

11 avril

AJKD https://www.ajkd.org/

• 00:00
  The Impact of Kidney Transplantation on a Breadth of Cognitive Measures - Nidhi Ghildayal, Dorry L. Segev, Mara McAdams-DeMarco AJKD
  Cognitive impairment is pervasive among kidney failure patients, reducing the chance of listing for kidney transplant (KT)1,2 and increasing time until KT for those who are listed.2 Yet, KT is the preferred form of kidney replacement therapy3 and has been shown to improve cognition.2,4,5 (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Reducing Infections in Outpatient Hemodialysis: The Impact of Human Factors - Jeffrey I. Silberzweig AJKD
  Improving the quality of care delivered to patients receiving maintenance dialysis and reducing their cost of care are central focuses for patients, providers, and payers. While numerous quality measures are employed throughout the dialysis and kidney care spaces, the most important for patients (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Unraveling Barriers in Access to Living Donor Kidney Transplantation for South Asian Canadian Populations - Amy D. Waterman, LaShara A. Davis, Solaf Al Awadhi AJKD
  Globalization of the world and international migration have led to the development of diasporic communities and the evolution of internationally diverse countries such as Canada. As one of the most multicultural countries in the world, Canada comprises more than 8 million immigrants that roughly (…) (American Journal of Kidney Diseases 83, 6 (2024))

10 avril

AJKD https://www.ajkd.org/

• 00:00
  Visceral Adiposity and Progression of ADPKD: A Cohort Study of Patients From the TEMPO 3:4 Trial - Kristen L. Nowak, Federica Moretti, Nicole Bussola, Cortney N. Steele, Adriana V. Gregory, Timothy L. Kline, Sumana Ramanathan, Giovanni Trapletti, Cesare Furlanello, Linda McCormick, Michel Chonchol AJKD
  Body mass index (BMI) is an independent predictor of kidney disease progression in individuals with autosomal dominant polycystic kidney disease (ADPKD). Adipocytes do not simply act as a fat reservoir but are active endocrine organs. We hypothesized that greater visceral abdominal adiposity (…) (American Journal of Kidney Diseases (2024))

9 avril

AJKD https://www.ajkd.org/

• 00:00
  In Reply to “‘Atypical’ Anti-GBM Disease: Just Atypical, or Not Anti-GBM Disease at All?” - Bertrand Chauveau, Jean-Baptiste Gibier, Marion Rabant AJKD
  We read the Letter to the Editor by Ivkovi? et al,1 in response to our article, with interest and thank the authors for emphasizing that atypical anti–glomerular basement membrane (GBM) nephritis remains a diagnosis of exclusion. Indeed, differential diagnoses, notably monoclonal immunoglobulin (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  “Atypical” Anti-GBM Disease: Just Atypical, or Not Anti-GBM Disease at All? - Vanja Ivkovi?, Andreas Kronbichler, Tiffany N. Caza AJKD
  Two large cohorts1,2 of patients with “atypical” anti–glomerular basement membrane (GBM) disease shared heterogeneous clinical presentations and a single common inclusion criterion—linear IgG staining along the GBM, found on biopsy. (American Journal of Kidney Diseases 84, 1 (2024))

8 avril

AJKD https://www.ajkd.org/

• 00:00
  Addressing Methodological and Interpretive Concerns in a Systematic Review on Dialysis Experiences of Indigenous Patients in British Colonized Countries - Junxia Wei, WeiWei Liang, Panpan Liu, Wei Wang AJKD
  We read the systematic review by the authors that investigated the experiences of Indigenous patients receiving dialysis in British colonized countries1. The authors identified four themes: the centrality of family and culture, marginalization due to structural and social inequities, (…) (American Journal of Kidney Diseases (2024))
• 00:00
  In Reply to “Addressing Methodological and Interpretive Concerns in a Systematic Review on Dialysis Experiences of Indigenous Patients in British Colonized Countries” - Jacqueline H. Stephens, Jonathan C. Craig, Allison Jaure AJKD
  We thank Wei et al (1) for their commentary on our article. Firstly, the assessment of the quality of the conduct of qualitative studies is contentious and there is no universally accepted framework for assessing the quality of the conduct of studies (2). Also, there is no empiric basis to (…) (American Journal of Kidney Diseases (2024))

6 avril

AJKD https://www.ajkd.org/

• 00:00
  It Is Time to Replace the Term “Patient Care Technician” in Dialysis - Laura C. Plantinga, Danilo B. Concepcion, Susan A. Chapman, Jennifer Craft Morgan, Fran Rickenbach, Clarica Douglas-Ajayi, Delphine S. Tuot, Bernard G. Jaar, Megan Urbanski AJKD
  In the United States,>40,000 dialysis patient care technicians (PCTs) play a critical, frontline role in the care of patients who receive dialysis. While PCTs primarily care for patients receiving in-center, outpatient hemodialysis (HD; 462,539 in 2021),1 they can also assist with HD in the (…) (American Journal of Kidney Diseases (2024))

5 avril

AJKD https://www.ajkd.org/

• 00:00
  Klotho and Clinical Outcomes in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study - Daniel Edmonston, Michaela A.A. Fuchs, Emily J. Burke, Tamara Isakova, Myles Wolf, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators AJKD
  Klotho deficiency may affect clinical outcomes in chronic kidney disease (CKD) through fibroblast growth factor-23 (FGF23)-dependent and -independent pathways. However, the association between circulating Klotho and clinical outcomes in CKD remains unresolved and was the focus of this study. (American Journal of Kidney Diseases (2024))

4 avril

AJKD https://www.ajkd.org/

• 00:00
  24-Hour Urinary Chemistries and Kidney Stone Risk - Pietro Manuel Ferraro, Eric N. Taylor, Gary C. Curhan AJKD
  Most previous studies of the relationship between urinary factors and kidney stone risk have either assumed a linear effect of urinary parameters on kidney stone risk or implemented arbitrary thresholds suggesting biologically implausible “all-or-nothing” effects. In addition, little is known (…) (American Journal of Kidney Diseases (2024))

24 mars

AJKD https://www.ajkd.org/

• 00:00
  The Dialysis Social Worker: Patients’ Best Defense to Meet Health-Related Social Needs - Megan Urbanski, Teri Browne, Laura Plantinga AJKD
  Kidney failure presents physical and psychosocial challenges for patients owing to a high symptom burden, multiple comorbid conditions, demanding treatment schedules, and potentially adverse effects on employment, quality of life, socioeconomic status, relationships, and mental health.1 The (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  An Incidental Finding: My Journey to Patient Advocacy - Janet Tennyson AJKD
  In 2021, life moved along as it does for most people. The sun was shining, and plans were made without a second thought about health. But for me, 2021 marked the beginning of a journey that redefined my life. That year, I was diagnosed with chronic kidney disease (CKD) with kidney damage and (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Glomerular Filtration Rate Estimation Using ?2-Microglobulin and ?-Trace Protein in Adults With Solid Tumors: A Prospective Cross-Sectional Study - Verônica T. Costa e Silva, Luiz A. Gil, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro, Maria D.P. Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonângelo, Lia Marçal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann AJKD
  ?2-Microglobulin (B2M) and ?-trace protein (BTP) are novel endogenous filtration markers that may improve the accuracy of estimated glomerular filtration rate (eGFR) beyond creatinine and cystatin C (eGFRcr-cys), but they have not been assessed in patients with cancer. (American Journal of Kidney Diseases (2024))

22 mars

AJKD https://www.ajkd.org/

• 00:00
  Anti-Neuron–Derived Neurotrophic Factor Antibodies in Secondary Membranous Nephropathy Caused by Syphilis: A Case Report - Daisuke Honda, Issei Okunaga, Daichi Omote, Hiroko Inoue, Kaho Yamasaki, Hanae Wakabayashi, Michiko Suzuki, Masashi Aizawa, Shigeki Tomita, Jun-ichiro Ikeda, Katsuhiko Asanuma AJKD
  We present the case of a 61-year-old man who developed nephrotic syndrome as a result of syphilis-associated secondary membranous nephropathy (MN). The patient showed nephrotic syndrome remission following antibiotic treatment for syphilis alone. Pathologically, the target antigen of immune (…) (American Journal of Kidney Diseases (2024))

20 mars

AJKD https://www.ajkd.org/

• 00:00
  Glycated Albumin and Adverse Clinical Outcomes in Patients With CKD: A Prospective Cohort Study - Mengyao Tang, Anders H. Berg, Hui Zheng, Eugene P. Rhee, Andrew S. Allegretti, Sagar U. Nigwekar, S. Ananth Karumanchi, James P. Lash, Sahir Kalim AJKD
  Hemoglobin A1c (HbA1c) is widely used to estimate glycemia, yet it is less reliable in patients with chronic kidney disease (CKD). There is growing interest in the complementary use of glycated albumin (GA) to improve glycemic monitoring and risk stratification. However, whether GA associates (…) (American Journal of Kidney Diseases (2024))

19 mars

AJKD https://www.ajkd.org/

• 00:00
  Clinical Significance of the Cystic Phenotype in Alport Syndrome - Letizia Zeni, Federica Mescia, Diego Toso, Chiara Dordoni, Cinzia Mazza, Gianfranco Savoldi, Laura Econimo, Roberta Cortinovis, Simona Fisogni, Federico Alberici, Francesco Scolari, Claudia Izzi AJKD
  Alport syndrome (AS) is the most common genetic glomerular disease caused by mutations that affect type IV collagen. However, the clinical characteristics and significance of AS with kidney cysts are not well defined. This study investigated the prevalence and clinical significance of cystic (…) (American Journal of Kidney Diseases (2024))
• 00:00
  2024 Update on Classification, Etiology, and Typing of Renal Amyloidosis: A Review - Nelson Leung, Samih H. Nasr AJKD
  Amyloidosis is a protein folding disease that causes organ injuries and even death. In humans, 42 proteins are now known to cause amyloidosis. Some proteins become amyloidogenic as a result of a pathogenic variant as seen in hereditary amyloidoses. In acquired forms of amyloidosis, the proteins (…) (American Journal of Kidney Diseases (2024))

15 mars

AJKD https://www.ajkd.org/

• 00:00
  Urine Albumin-Creatinine Ratio Variability in People With Type 2 Diabetes: Clinical and Research Implications - Natasha Rasaratnam, Agus Salim, Irene Blackberry, Mark E. Cooper, Dianna J. Magliano, Peter van Wijngaarden, Suresh Varadarajan, Julian W. Sacre, Jonathan E. Shaw AJKD
  Evidence has demonstrated that albuminuria is a key diagnostic and prognostic marker of diabetic chronic kidney disease, but the impact of its day-to-day variability has not been adequately considered. This study quantified within-individual variability of albuminuria in people with type 2 (…) (American Journal of Kidney Diseases 84, 1 (2024))

14 mars

AJKD https://www.ajkd.org/

• 00:00
  Anti–Glomerular Basement Membrane Disease: Broadening the Spectrum - Lynn D. Cornell AJKD
  Diseases are often first recognized in their most severe forms. After a disease is initially described and diagnostic criteria are proposed, we gain experience and may broaden the spectrum to include manifestations that may be related but do not have all of the characteristics of a disease as (…) (American Journal of Kidney Diseases 83, 6 (2024))

13 mars

AJKD https://www.ajkd.org/

• 00:00
  Low-Dose Continuous Kidney Replacement Therapy and Mortality in Critically Ill Patients With Acute Kidney Injury: A Retrospective Cohort Study - Keisuke Okamoto, Hidetada Fukushima, Masahiko Kawaguchi, Kazuhiko Tsuruya AJKD
  Continuous kidney replacement therapy (CKRT) is preferred when available for hemodynamically unstable acute kidney injury (AKI) patients in the intensive care unit (ICU). The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend a delivered CKRT dose of 20-25mL/kg/h; however, in (…) (American Journal of Kidney Diseases (2024))

12 mars

AJKD https://www.ajkd.org/

• 00:00
  Trajectories of Physical Resilience Among Older Veterans With Stage 4 CKD - C. Barrett Bowling, Theodore S.Z. Berkowitz, Brett T. Burrows, Jessica E. Ma, Heather E. Whitson, Battista Smith, Steven D. Crowley, Virginia Wang, Matthew L. Maciejewski, Maren K. Olsen AJKD
  Although functional impairment is common among older adults with chronic kidney disease (CKD), functional reserve before an acute health event and physical resilience after the event have not been characterized in this population. The purpose of this study was to identify distinct patterns of (…) (American Journal of Kidney Diseases (2024))
• 00:00
  Hereditary Transthyretin Amyloidosis and the Impact of Classic and New Treatments on Kidney Function: A Review - Evelyn Meléndrez-Balcázar, Karla Aranda-Vela, Alberto Cervantes-Hernández, Samuel López-Cureño AJKD
  Hereditary transthyretin amyloidosis (ATTRv) is a rare, progressive, and life-threatening disease caused by misfolded transthyretin (TTR) proteins that aggregate as abnormal amyloid fibrils and accumulate throughout the body. The kidney is one of the main organs affected in amyloid light chain (…) (American Journal of Kidney Diseases (2024))

11 mars

AJKD https://www.ajkd.org/

• 00:00
  EKFC Versus CKD-EPI Equation in Young Adults? No Definitive Answer - Pierre Delanaye, Hans Pottel AJKD
  As main developers of the European Kidney Function Consortium (EKFC) creatinine-based equation,1 we are puzzled by the results of the EKFC equation in comparison to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) in young adults presented by Inker et al,2 especially in the 18-25 (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Gestational Exposure to Maternal Systemic Glucocorticoids and Childhood Risk of CKD - You-Lin Tain, Lung-Chih Li, Hsiao-Ching Kuo, Chien-Ning Hsu AJKD
  The potential effects of antenatal glucocorticoid exposure on the health of children are unclear. We examined the association of gestational exposure to maternal systemic glucocorticoids and the risk of developing chronic kidney disease (CKD) in childhood. (American Journal of Kidney Diseases (2024))

7 mars

AJKD https://www.ajkd.org/

• 00:00
  In Reply to “EKFC Versus CKD-EPI Equation in Young Adults? No Definitive Answer” - Lesley A. Inker, Ogechi M. Adingwupu, Andrew S. Levey AJKD
  We agree with our European Kidney Function Consortium (EKFC) colleagues regarding the importance of the differing performance between the CKD-EPI equation and that of the EKFC and CKiD U25 equations in the younger age subgroup (18 to 25 years).1,2 At older ages and overall, the performance of (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Thiazides for Nephrolithiasis Prevention: Written in Stone? - Anna L. Zisman AJKD
  Kidney stone disease (KSD) is highly prevalent worldwide—approximately 1 in 10 individuals are affected during their lifetime—and rates are growing worldwide.1 In the United States, NHANES data document a 70% increase in prevalence of nephrolithiasis over the last 20 years.2 KSD is tremendously (…) (American Journal of Kidney Diseases (2024))

6 mars

AJKD https://www.ajkd.org/

• 00:00
  Addressing Housing Issues Among People With Kidney Disease: Importance, Challenges, and Recommendations - Tessa K. Novick, Ben King AJKD
  Kidney disease disproportionately impacts people with low socioeconomic status, and low socioeconomic status is associated with worse outcomes for people with kidney disease. Unstable housing, which includes housing insecurity and homelessness, is increasing due to rising housing costs. There is (…) (American Journal of Kidney Diseases 84, 1 (2024))

5 mars

AJKD https://www.ajkd.org/

• 00:00
  Enhancing Kidney Transplantation and the Role of Xenografts: Report of a Scientific Workshop Sponsored by the National Kidney Foundation - Andrew B. Adams, Emily A. Blumberg, John S. Gill, Eliezer Katz, Tatsuo Kawai, Jesse D. Schold, Megan Sykes, Alfred Tector, David H. Sachs AJKD
  Chronic kidney disease affects an estimated 37 million people in the United States; of these,>800,000 have end-stage renal disease requiring chronic dialysis or a kidney transplant to survive. Despite efforts to increase the donor kidney supply, approximately 100,000 people are registered on (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  A Holistic Framework for the Evaluation of Kidney Function in a Gender-Diverse Landscape - Keila Turino Miranda, Dina N. Greene, David Collister, Matthew D. Krasowski, Sofia B. Ahmed, Lauren R. Cirrincione, Sylvia E. Rosas, Nathalie Saad, Christina C. Pierre AJKD
  The most commonly used equations to estimate glomerular filtration rate incorporate a binary male-female sex coefficient, which has important implications for the care of transgender, gender-diverse, and nonbinary (TGD) people. Whether “sex assigned at birth“ or a binary “gender identity“ is (…) (American Journal of Kidney Diseases (2024))
• 00:00
  Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease - Marina de Cos, Gohar Mosoyan, Kinsuk Chauhan, Jonathan P. Troost, Jenny S. Wong, Sean Lefferts, Paul Morgan, Kristin Meliambro, Marc Egerman, Justina Ray, Tom Parker, Daniel Levine, Surya Seshan, Yoni Bardash, Benjamin Horowitz, Candice A. Kent, Melissa M. Shaw, Alan Perlman, Dennis G. Moledina, Steven G. Coca, Kirk N. Campbell AJKD
  Glomerular disorders have a highly variable clinical course, and biomarkers that reflect the molecular mechanisms underlying their progression are needed. Based on our previous work identifying plasminogen as a direct cause of podocyte injury, we designed this study to test the association (…) (American Journal of Kidney Diseases (2024))

4 mars

AJKD https://www.ajkd.org/

• 00:00
  Human Factors Contributing to Infection Prevention in Outpatient Hemodialysis Centers: A Mixed Methods Study - Sarah Henrickson Parker, Matthew N. Jesso, Laurie D. Wolf, Kerry Avondet Leigh, Stephanie Booth, Nicole Gualandi, Renee E. Garrick, Alan S. Kliger, Priti R. Patel AJKD
  Infection prevention efforts in dialysis centers can avert patient morbidity and mortality but are challenging to implement. The objective of this study was to better understand how the design of the work system might contribute to infection prevention in outpatient dialysis centers. (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Impact of Prior Abdominal Procedures on Peritoneal Dialysis Catheter Outcomes: Findings From the North American Peritoneal Dialysis Catheter Registry - Wazaira A. Khan, Matthew J. Oliver, John H. Crabtree, Alix Clarke, Sean Armstrong, Danielle Fox, Rachel Fissell, Arsh K. Jain, Sarbjit V. Jassal, Susie L. Hu, Peter Kennealey, Scott Liebman, Brendan McCormick, Bogdan Momciu, Robert P. Pauly, Beth Pellegrino, Jeffrey Perl, James L. Pirkle, Troy J. Plumb, Pietro Ravani, Rebecca Seshasai, Ankur Shah, Nikhil Shah, Jenny Shen, Gurmukteshwar Singh, Karthik Tennankore, Jaime Uribarri, Murray Vasilevsky, Robert Yang, Robert R. Quinn AJKD
  A history of prior abdominal procedures may influence the likelihood of referral for peritoneal dialysis (PD) catheter insertion. To guide clinical decision making in this population, this study examined the association between prior abdominal procedures and outcomes in patients undergoing PD (…) (American Journal of Kidney Diseases (2024))
• 00:00
  Residential Racial and Ethnic Segregation and Post–Kidney Transplant Dementia, Allograft Loss, and Mortality - Yusi Chen, Yiting Li, Yi Liu, Byoungjun Kim, Jessica M. Ruck, Maya N. Clark-Cutaia, Aarti Mathur, Tanjala S. Purnell, Roland J. Thorpe, Deidra C. Crews, Sarah L. Szanton, Dorry L. Segev, Mara McAdams-DeMarco AJKD
  Racial/ethnic segregation (hereafter referred to as segregation), the inequitable allocation of resources and opportunities in racially/ethnically segregated neighborhoods, leads to numerous disadvantages for residents1 and associates with access to kidney transplantation (KT).2 Based on the (…) (American Journal of Kidney Diseases (2024))

1er mars

AJKD https://www.ajkd.org/

• 00:00
  Real-World Effectiveness of Preventive Pharmacological Therapy in Patients With Urolithiasis: A Retrospective Cohort Study - John M. Hollingsworth, Mary K. Oerline, Ryan S. Hsi, Joseph J. Crivelli, Noah Krampe, John R. Asplin, Vahakn B. Shahinian AJKD
  Data supporting the efficacy of preventive pharmacological therapy (PPT) to reduce urolithiasis recurrence are based on clinical trials with composite outcomes that incorporate imaging findings and have uncertain clinical significance. This study evaluated whether the use of PPT leads to fewer (…) (American Journal of Kidney Diseases 84, 1 (2024))

29 février

AJKD https://www.ajkd.org/

• 00:00
  Use of Immunoadsorption and Plasma Exchange for Treating Anti–Glomerular Basement Membrane Disease: Clinical Experience in Germany - Friedrich A. von Samson-Himmelstjerna, Nassim Kakavand, Jakob C. Voran, Benedikt Kolbrink, Kevin Schulte AJKD
  Anti–glomerular basement membrane (anti-GBM) disease presents with acute glomerulonephritis and pulmonary hemorrhage.1 In the absence of plasma exchange (PLEX) therapy and immunosuppression, anti-GBM disease typically takes on a lethal course.2 Immunoadsorption (IA) offers potential benefits (…) (American Journal of Kidney Diseases (2024))

27 février

AJKD https://www.ajkd.org/

• 00:00
  Changes in Cognitive Function After Kidney Transplantation: A Longitudinal Cohort Study - Aditi Gupta, Jonathan D. Mahnken, Joshua Bernal, Palash Sharma, Rebecca J. Lepping, Robert N. Montgomery, David K. Johnson, Adam Parks, Jeffrey M. Burns, David A. Drew, Mark J. Sarnak, William M. Brooks AJKD
  Kidney disease negatively affects cognition. We assessed the effect of kidney transplantation (KT) on different cognitive domains. (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Hot Spot of Complement Factor I Rare Variant p.Ile357Met in Patients With Hemolytic Uremic Syndrome - Nora Schwotzer, Fadi Fakhouri, Paula Vieira Martins, Yahsou Delmas, Sophie Caillard, Julien Zuber, Olivier Moranne, Laurent Mesnard, Véronique Frémeaux-Bacchi, Carine El-Sissy AJKD
  Atypical hemolytic uremic syndrome (aHUS) is a rare kidney disease due to a dysregulation of the complement alternative pathway. Complement factor I (CFI) negatively regulates the alternative pathway and CFI gene rare variants have been associated to aHUS with a low disease penetrance. We report (…) (American Journal of Kidney Diseases (2024))
• 00:00
  Plasma Levels of Polyunsaturated Fatty Acids and Adverse Kidney Outcomes - Hee Byung Koh, Hyung Woo Kim, Young Su Joo, Chan-Young Jung, Hyo Jeong Kim, Tae Ik Chang, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han AJKD
  Many studies have reported polyunsaturated fatty acids (PUFA) as significant predictors of cardiovascular disease, but little is known about the relationship between PUFA levels and chronic kidney disease (CKD). This study explored this relationship among individuals with and without CKD. (American Journal of Kidney Diseases (2024))

20 février

AJKD https://www.ajkd.org/

• 00:00
  Designing an Implementable Clinical Prediction Model for Near-Term Mortality and Long-Term Survival in Patients on Maintenance Hemodialysis - Benjamin A. Goldstein, Chun Xu, Jonathan Wilson, Ricardo Henao, Patti L. Ephraim, Daniel E. Weiner, Tariq Shafi, Julia J. Scialla AJKD
  The life expectancy of patients treated with maintenance hemodialysis (MHD) is heterogeneous. Knowledge of life-expectancy may focus care decisions on near-term versus long-term goals. The current tools are limited and focus on near-term mortality. Here, we develop and assess potential utility (…) (American Journal of Kidney Diseases 84, 1 (2024))

17 février

AJKD https://www.ajkd.org/

• 00:00
  Considering His Advanced Age - Lorraine Mesagna AJKD
  It is a balmy September afternoon, and upon entering my parents’ house, I find my father and mother, along with my older brother, huddled around a tablet computer at the kitchen table in the midst of a telehealth visit with my father’s nephrologist. My father had gone for his quarterly bloodwork (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Magnesium Disorders: Core Curriculum 2024 - Emmanuel A. Adomako, Alan S.L. Yu AJKD
  Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the genome. Despite its abundance, hypomagnesemia (…) (American Journal of Kidney Diseases 83, 6 (2024))

14 février

AJKD https://www.ajkd.org/

• 00:00
  Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative - Michelle C. Starr, Katja M. Gist, Huaiyu Zang, Nicholas J. Ollberding, Shanthi Balani, Andrea Cappoli, Eileen Ciccia, Catherine Joseph, Aadil Kakajiwala, Aaron Kessel, Melissa Muff-Luett, María J. Santiago Lozano, Matthew Pinto, Stephanie Reynaud, Sonia Solomon, Cara Slagle, Rachana Srivastava, Weiwen V. Shih, Tennille Webb, Shina Menon, Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) Collaborative AJKD
  There are limited studies describing the epidemiology and outcomes in children and young adults receiving continuous kidney replacement therapy (CKRT). We aimed to describe associations between patient characteristics, CKRT prescription, and survival. (American Journal of Kidney Diseases (2024))
• 00:00
  Time-Varying Proteinuria and Progression of IgA Nephropathy: A Cohort Study - Chen Tang, Pei Chen, Feng-Lei Si, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang AJKD
  Proteinuria is a surrogate end point for predicting long-term kidney outcomes in IgA nephropathy (IgAN) with levels (American Journal of Kidney Diseases (2024))

8 février

AJKD https://www.ajkd.org/

• 00:00
  APOL1 Nephropathy Risk Variants Through the Life Course: A Review - Ai Itoku, Jaya Isaac, Scott Wilson, Kimberly Reidy, Frederick Kaskel AJKD
  Two variant alleles of the gene apolipoprotein L1 (APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The APOL1 protein contributes to innate immunity and may protect against Trypanosoma, HIV, Salmonella, and leishmaniasis. (…) (American Journal of Kidney Diseases 84, 1 (2024))

26 janvier

AJKD https://www.ajkd.org/

• 00:00
  Aptamer-Based Proteomics in CKD - Taesoo Kim, Eugene P. Rhee AJKD
  The plasma proteome spans thousands of proteins whose levels are dynamic and vary by orders of magnitude, are diverse in origin, and play a wide range of biological roles.1 This scope and variation present challenges for analysis and quantitation, leaving this rich domain for biomedical (…) (American Journal of Kidney Diseases 83, 6 (2024))

25 janvier

AJKD https://www.ajkd.org/

• 00:00
  Association of Kidney Cysts With Progressive CKD After Radical Nephrectomy - Moldovan Sabov, Aleksandar Denic, Aidan F. Mullan, Anthony C. Luehrs, Timothy L. Kline, Bradley J. Erickson, Theodora A. Potretzke, R. Houston Thompson, Vidit Sharma, Peter C. Harris, Andrew D. Rule AJKD
  Simple kidney cysts, which are common and usually considered of limited clinical relevance, are associated with older age and lower glomerular filtration rate (GFR), but little has been known of their association with progressive chronic kidney disease (CKD). (American Journal of Kidney Diseases 84, 1 (2024))

22 janvier

AJKD https://www.ajkd.org/

• 00:00
  Monoclonal Immunoglobulin Crystalline Membranous Nephropathy - Salvatore E. Mignano, Virginie Pascal, Nnaemezie E. Odioemene, William Forehand, Vincent Javaugue, Samar M. Said, Sanjeev Sethi, Christophe Sirac, Samih H. Nasr AJKD
  Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as intracellular or extracellular crystals. We describe a patient with multiple myeloma (IgG?) and diabetes who presented with nephrotic range proteinuria. Kidney biopsy (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Potentially Inappropriately Prescribed Medication Prescriptions Among Medicare Patients Receiving Hemodialysis - Armando Silva Almodóvar, Macarius Donneyong, Eric Seiber, Milap C. Nahata AJKD
  Treatment of patients with end-stage kidney disease (ESKD) in the United States accounted for expenditures of approximately $50 billion in 2020.1 This spending was largely attributed to costs associated with dialysis care and inpatient hospitalizations.1 One means of reducing potentially (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study - Kendra E. Wulczyn, Tariq Shafi, Amanda Anderson, Hernan Rincon-Choles, Clary B. Clish, Michelle Denburg, Harold I. Feldman, Jiang He, Chi-yuan Hsu, Tanika Kelly, Paul L. Kimmel, Rupal Mehta, Robert G. Nelson, Vasan Ramachandran, Ana Ricardo, Vallabh O. Shah, Anand Srivastava, Dawei Xie, Eugene P. Rhee, Sahir Kalim, CRIC Study Investigators AJKD
  The toxins that contribute to uremic symptoms in patients with chronic kidney disease (CKD) are unknown. We sought to apply complementary statistical modeling approaches to data from untargeted plasma metabolomic profiling to identify solutes associated with uremic symptoms in patients with CKD. (American Journal of Kidney Diseases 84, 1 (2024))

17 janvier

AJKD https://www.ajkd.org/

• 00:00
  Navigating Living Kidney Donation and Transplantation Among South Asian Canadians: The ACTION Project - Reetinder Kaur, Kara Schick-Makaroff, Phuc Dang, Ayumi Sasaki, Paula Neves, Istvan Mucsi, Jagbir Gill AJKD
  South Asian (SA) Canadians with kidney failure have a 50%-77% lower likelihood of kidney transplant and are less likely to identify potential living donors (LDs). This study aimed to identify health system–, patient-, and community-level barriers and facilitators for accessing LD kidney (…) (American Journal of Kidney Diseases 83, 6 (2024))

13 janvier

AJKD https://www.ajkd.org/

• 00:00
  In Reply to Cystatin C to Creatinine Ratio and Measured GFR in Hospitalized Older Adults - Anders O. Grubb, Anna Åkesson, Anders Christensson AJKD
  The study referred to by Houlind et al1 demonstrates that an abnormally low eGFRcystatin C:eGFRcreatinine ratio in hospitalized older Danish adults is associated not only with lower kidney function, but also with higher rates of malnutrition and greater established comorbidity. This agrees with (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Cystatin C to Creatinine Ratio and Measured GFR in Hospitalized Older Adults - Morten Baltzer Houlind, Ove Andersen, Esben Iversen AJKD
  In their editorial, Grubb et al1 examine differences between cystatin C– and creatinine-based estimated glomerular filtration rate (eGFRcys and eGFRcr, respectively). An eGFRcys:eGFRcr ratio (American Journal of Kidney Diseases 83, 6 (2024))

11 janvier

AJKD https://www.ajkd.org/

• 00:00
  Patients’ Perspectives on Health-Related Social Needs and Recommendations for Interventions: A Qualitative Study - Tessa K. Novick, Michelle Osuna, Caroline Emery, Francisco Barrios, Daniel Ramirez, Deidra C. Crews, Elizabeth A. Jacobs AJKD
  People with low socioeconomic status are disproportionately affected by kidney failure, and their adverse outcomes may stem from unmet health-related social needs. This study explored hemodialysis patient perspectives on health-related social needs and recommendations for intervention. (American Journal of Kidney Diseases 83, 6 (2024))

9 janvier

AJKD https://www.ajkd.org/

• 00:00
  A Deep Intronic PKHD1 Variant Identified by SpliceAI in a Deceased Neonate With Autosomal Recessive Polycystic Kidney Disease - Felix Richter, Kayleigh D. Rutherford, Anisha J. Cooke, Malorie Meshkati, Vanessa Eddy-Abrams, Daniel Greene, Jordana Kosowsky, Yeaji Park, Surabhi Aggarwal, Rebecca J. Burke, Weili Chang, Jillian Connors, Peter J. Giannone, Thomas Hays, Divya Khattar, Mark Polak, Liana Senaldi, Matthew Smith-Raska, Shanthy Sridhar, Laurie Steiner, Jonathan R. Swanson, Kate A. Tauber, Mafalda Barbosa, Katherine F. Guttmann, Ernest Turro AJKD
  The etiologies of newborn deaths in neonatal intensive care units usually remain unknown, even after genetic testing. Whole-genome sequencing, combined with artificial intelligence–based methods for predicting the effects of non-coding variants, provide an avenue for resolving these deaths. (…) (American Journal of Kidney Diseases 83, 6 (2024))

3 janvier

AJKD https://www.ajkd.org/

• 00:00
  Chronic Hyponatremia and Brain Structure and Function Before and After Treatment - Victor Suárez, Rosanne Picotin, Ronja Fassbender, Hannes Gramespacher, Stefan Haneder, Thorsten Persigehl, Polina Todorova, Matthias Johannes Hackl, Oezguer A. Onur, Nils Richter, Volker Burst AJKD
  Hyponatremia is the most common electrolyte disorder and is associated with significant morbidity and mortality. This study investigated neurocognitive impairment, brain volume, and alterations in magnetic resonance imaging (MRI)–based measures of cerebral function in patients before and after (…) (American Journal of Kidney Diseases 84, 1 (2024))

1er janvier

AJKD https://www.ajkd.org/

• 00:00
  Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Series From the French Nephropathology Group - Bertrand Chauveau, Jean-Baptiste Gibier, Jérôme Olagne, Antoine Morel, Selda Aydin, Stephen P. McAdoo, Nicolas Viallet, Hélène Perrochia, Emilie Pambrun, Virginie Royal, Nathalie Demoulin, Jean-Louis Kemeny, Carole Philipponnet, Alexandre Hertig, Jean-Jacques Boffa, Emmanuelle Plaisier, Camille Domenger, Isabelle Brochériou, Clément Deltombe, Jean-Paul Duong Van Huyen, David Buob, Candice Roufosse, Thomas Hellmark, Vincent Audard, Fabrice Mihout, Samih H. Nasr, Karine Renaudin, Anissa Moktefi, Marion Rabant, CFPR–French Nephropathology Group AJKD
  Atypical anti-glomerular basement membrane (GBM) nephritis is characterized by a bright linear immunoglobulin staining along the GBM by immunofluorescence without a diffuse crescentic glomerulonephritis nor serum anti-GBM antibodies by conventional enzyme-linked immunosorbent assay (ELISA). We (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Difference Between Estimated GFR Based on Cystatin C Versus Creatinine and Incident Atrial Fibrillation: A Cohort Study of the UK Biobank - Ga Young Heo, Hee Byung Koh, Chan-Young Jung, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Hyung Woo Kim AJKD
  The difference between cystatin C–based and creatinine-based estimated glomerular filtration rate (eGFRdiff) has been suggested to reflect factors distinct from kidney function that are associated with cardiovascular risk. However, the association between eGFRdiff and atrial fibrillation (AF) (…) (American Journal of Kidney Diseases 83, 6 (2024))

29 décembre

AJKD https://www.ajkd.org/

• 00:00
  Diabetes Insipidus in Deceased Donors and Outcomes in Kidney Transplant Recipients - Miguel Nunez, James Gardner, Shareef Syed, Allison Webber, Jun Shoji, Timothy P. Copeland, Charles E. McCulloch, Elaine Ku, Garrett R. Roll AJKD
  Transplant providers fielding kidney offers often encounter deceased donors with diabetes insipidus (DI), which is present in 49%-60% of donors after brain death (DBD).1 Because the standard management of DI includes vasopressin and fluid resuscitation to prevent kidney injury,2 the fluid shifts (…) (American Journal of Kidney Diseases 84, 1 (2024))
• 00:00
  Infections Following Kidney Transplantation After Exposure to Immunosuppression for Treatment of Glomerulonephritis - David Massicotte-Azarniouch, Randal K. Detwiler, Yichun Hu, Ronald J. Falk, Manish K. Saha, David van Duin, Susan L. Hogan, Vimal K. Derebail AJKD
  Kidney transplant patients with glomerulonephritis (GN) as their native disease commonly have received pretransplant immunosuppression (PTI). This may contribute to the immunosuppression burden potentially increasing the risk for infections after transplantation. (American Journal of Kidney Diseases 83, 6 (2024))

24 décembre

AJKD https://www.ajkd.org/

• 00:00
  Kidney Function Measures and Mortality: A Mendelian Randomization Study - Ying Shan, Jingwen Zhang, Yueqi Lu, Jinlan Liao, Yuyang Liu, Liang Dai, Jing Li, Congying Song, Guobin Su, Sara Hägg, Zuying Xiong, Dorothea Nitsch, Juan Jesus Carrero, Xiaoyan Huang AJKD
  Individuals with a low estimated glomerular filtration rate (eGFR) are at a high risk of death. However, the causes underpinning this association are largely uncertain. This study aimed to assess the causal relationship of low eGFR with all-cause and cause-specific mortality. (American Journal of Kidney Diseases 83, 6 (2024))

23 décembre

AJKD https://www.ajkd.org/

• 00:00
  Tips for Testing Adults With Suspected Genetic Kidney Disease - Judy Savige AJKD
  Genetic kidney disease is common but often unrecognized. It accounts for most cystic kidney diseases and tubulopathies, many forms of congenital abnormalities of the kidney and urinary tract (CAKUT), and some glomerulopathies. Genetic kidney disease is typically suspected where the disease (…) (American Journal of Kidney Diseases 83, 6 (2024))

8 décembre

AJKD https://www.ajkd.org/

• 00:00
  Epidemiology and Clinical Outcomes of Community-Acquired Acute Kidney Injury in the Emergency Department: A Multisite Retrospective Cohort Study - Michael R. Ehmann, Eili Y. Klein, Xihan Zhao, Jonathon Mitchell, Steven Menez, Aria Smith, Scott Levin, Jeremiah S. Hinson AJKD
  The prevalence of community-acquired acute kidney injury (CA-AKI) in the United States and its clinical consequences are not well described. Our objective was to describe the epidemiology of CA-AKI and the associated clinical outcomes. (American Journal of Kidney Diseases 83, 6 (2024))

7 décembre

AJKD https://www.ajkd.org/

• 00:00
  Characteristics of Nephrologists Participating in Medicare’s Comprehensive ESRD Care Initiative - Kelsey Drewry, Janet R. Cummings, Rachel E. Patzer, Adam S. Wilk AJKD
  Medicare’s Kidney Care Choices models, voluntary alternative payment models implemented in 2022, aim to expand access to high-value nephrology care.1,2 These models build on incentives tested in the Comprehensive ESRD [End-Stage Renal Disease] Care (CEC) Initiative during 2015-2021. Under the (…) (American Journal of Kidney Diseases 83, 6 (2024))
• 00:00
  Cigarette Smoking and Risk of Hospitalization With Acute Kidney Injury: The Atherosclerosis Risk in Communities (ARIC) Study - Mengkun Chen, Ning Ding, Morgan E. Grams, Kunihiro Matsushita, Junichi Ishigami AJKD
  Smoking is a modifiable risk factor for various adverse events. However, little is known about the association of smoking with the incidence of acute kidney injury (AKI) in the general population. This study investigated the association of cigarette smoking with the risk of AKI. (American Journal of Kidney Diseases 83, 6 (2024))