21 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Prevalence of Mendelian kidney disease among patients with high-risk APOL1 genotypes undergoing commercial genetic testing in the United States - Ronaldo da Silva Francisco, Sumit Punj, Lisa Vincent, Nina Sanapareddy, Vivek Bhalla, Glenn M. Chertow, Dianne Keen-Kim, Vivek Charu Kidney Int Reports
  Among individuals with high-risk APOL1 genotypes, the lifetime risk of developing kidney failure is ?15%, indicating that other genetic variants or non-genetic modifiers likely contribute substantially to an individual patient’s risk of progressive kidney disease. Here we estimate the prevalence (…) (Kidney International Reports (2024))
• 00:00
  Major Bleeding Rates in an International Cohort of Patients with End-Stage Kidney Disease - Catelyn R. Coyle, Lori D. Bash, Dena Rosen Ramey, G. Brandon Atkins, Irina Barash, Murilo Guedes, Roberto Pecoits-Filho, Calvin Andrews, Angelo Karaboyas, Marc Bonaca Kidney Int Reports
  An estimated 2.5 million patients worldwide were being treated for end-stage kidney disease (ESKD) as of 2016.1 The vast majority of patients with ESKD are treated with hemodialysis (HD ?89%) and peritoneal dialysis (PD), however patterns of HD and PD vary internationally.2 Patients with ESKD on (…) (Kidney International Reports (2024))
• 00:00
  The importance of CNV analysis in patients with monogenic kidney disease - Laura R. Claus, Robert F. Ernst, Martin G. Elferink, Hanneke W.M. van Deutekom, Bert van der Zwaag, Albertien M. van Eerde Kidney Int Reports
  Genetic testing can reveal monogenic causes of kidney diseases, offering diagnostic, therapeutic, and prognostic benefits. While single nucleotide variants (SNVs) and copy number variants (CNVs) can result in kidney disease, CNV analysis is not always included in genetic testing. (Kidney International Reports (2024))
• 00:00
  Response to “Impact of Prolonged SARS-CoV-2 Dosing Interval in Hemodialysis Patients” - Jathurong Kittrakulrat, Natavudh Townamchai, Jakapat Vanichanan Kidney Int Reports
  We read the study submitted by Lamarche et al., which emphasized an impact of a shortened interval between COVID-19 vaccination doses on seroconversion rate among hemodialysis patients. (Kidney International Reports (2024))

20 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Global aHUS Registry Analysis of Patients Switching to Ravulizumab from Eculizumab - Franz Schaefer, Imad Al-Dakkak, Katerina Anokhina, David Cohen, Larry A. Greenbaum, Gema Ariceta Kidney Int Reports
  Atypical hemolytic uremic syndrome (aHUS) is a progressive rare disease that, if untreated, can result in severe organ damage and death. Ravulizumab, a next-generation terminal complement inhibitor, provides immediate, complete, and sustained complement C5 inhibition. Real-world data in patients (…) (Kidney International Reports (2024))
• 00:00
  Phase 1b/2a Study Assessing the Safety and Efficacy of Felzartamab in Anti–Phospholipase A2 Receptor Autoantibody-Positive Primary Membranous Nephropathy - Brad H. Rovin, Pierre M. Ronco, Jack F.M. Wetzels, Sharon G. Adler, Isabelle Ayoub, Philippe Zaoui, Seung Hyeok Han, Jaideep S. Dudani, Houston N. Gilbert, Uptal D. Patel, Paul T. Manser, Julia Jauch-Lembach, Nicola Faulhaber, Rainer Boxhammer, Stefan Ha¨rtle, Ben Sprangers Kidney Int Reports
  Primary membranous nephropathy (PMN) is most often caused by autoantibodies to phospholipase A2 receptor (PLA2R). M-PLACE (NCT04145440) is an open-label, phase 1b/2a study that assessed the safety and efficacy of the fully human anti-CD38 monoclonal antibody felzartamab in high-risk anti-PLA2R+ PMN. (Kidney International Reports (2024))
• 00:00
  APOL1 high-risk genotype is not associated with new or worsening of proteinuria or kidney function decline following COVID-19 vaccination - Sarah E. Nystrom, Karen L. Soldano, Micki Rockett, Somenath Datta, Guojie Li, Daniel Silas, Melanie E. Garrett, Allison E. Ashley-Koch, Opeyemi A. Olabisi Kidney Int Reports
  SARS-CoV-2 infection increases systemic inflammatory cytokines which act as a second-hit driver of APOL1-mediated collapsing glomerulopathy. SARS-CoV-2 vaccination also increases cytokines. Recent reports of new glomerular disease in individuals with APOL1 high-risk genotype (HRG) following (…) (Kidney International Reports (2024))

19 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Pilot study of a web-based tool for real-time adequacy assessment of kidney biopsies - Meysam Ahangaran, Emily Sun, Khang Le, Jiawei Sun, William M. Wang, Tian Herng Tan, Lingkai Yin, Lyle J. Burdine, Zeijko Dvanajscak, Clarissa A. Cassol, Shree Sharma, Vijaya B. Kolachalama Kidney Int Reports
  Kidney biopsies are essential for diagnosing kidney disorders in both native and transplanted kidneys1,2. However, the increasing incidence of biopsies yielding insufficient tissue for diagnosis presents a dual challenge: it strains the healthcare system and endangers patients, who may require (…) (Kidney International Reports (2024))
• 00:00
  Certain Red Yeast Rice Supplements in Japan Cause Acute Tubulointerstitial Injury - Yusuke Murata, Seiichiro Hemmi, Yurie Akiya, Kota Miyasato, Hiroki Kobayashi, Takashi Maruyama, Masanori Abe Kidney Int Reports
  Historically, red yeast rice (Red koji) has been a cornerstone in the culinary and medicinal traditions of East Asia, contributing to the production of alcoholic beverages, fermented foods, and, notably, tofuyo—a fermented tofu delicacy originating from Okinawa, Japan, since the eighteenth (…) (Kidney International Reports (2024))

11 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Is It Prime Time for Neutrophil Gelatinase-Associated Lipocalin? - Lui G. Forni, S. Sudha Mannemuddhu Kidney Int Reports
  “Prediction is very difficult, especially if it is about the future” (Neils Bohr) (Kidney International Reports (2024))
• 00:00
  Trend and Monitoring of Skin Autofluorescence in Patients Receiving Hemodialysis - Natasha J. McIntyre Kidney Int Reports
  All cause and cardiovascular mortality is significantly increased in people receiving maintenance hemodialysis (HD), compared to the general population.1 A contributing factor to the development of vascular damage is the formation and accumulation of advanced glycation end products (AGEs) formed (…) (Kidney International Reports (2024))
• 00:00
  Enriched-Culture PCR, a Promising Approach for Diagnosing Tuberculous Peritonitis - Preeyarat Pavatung, Talerngsak Kanjanabuch, Theerachai Thammathiwat, Thunvarat Saejew, Dhammika Leshan Wannigama, Patnarin Kanjanabuch, Gompol Suwanpimolkul, Tanittha Chatsuwan, Nibondh Udomsantisuk, David W. Johnson, The Advisory Board of Peritoneal Dialysis, Nephrology Society of Thailand Kidney Int Reports
  Mycobacterium tuberculosis (TB) peritonitis in patients receiving peritoneal dialysis (PD) carries poor outcomes with reported mortality rates ranging from 15% to 58%.1-4 Although the 2022 International Society for PD (ISPD) Guidelines recommend anti-tuberculous therapy without mandatory PD (…) (Kidney International Reports (2024))
• 00:00
  Timing and modality of kidney replacement therapy in children and adolescents - Julia Thumfart, Steffen Wagner, Marietta Kirchner, Karolis Azukaitis, Aysun K. Bayazit, Lukasz Obrycki, Nur Canpolat, Ipek Kaplan Bulut, Ali Duzova, Ali Anarat, Lucie Bessenay, Rukshana Shroff, Dusan Paripovic, Lale Sever, Cengiz Candan, Francesca Lugani, Alev Yilmaz, Fatos Yalcinkaya, Klaus Arbeiter, Aysel Kiyak, Aleksandra Zurowska, Matthias Galiano, Uwe Querfeld, Anette Melk, Franz Schaefer, 4C Study Group Kidney Int Reports
  The choice and timing of kidney replacement therapy (KRT) is influenced by clinical factors, laboratory features, feasibility issues, family preferences and clinicians´ attitudes. We analyzed the factors associated with KRT modality and timing in a multicenter, multinational prospective (…) (Kidney International Reports (2024))
• 00:00
  Virtual Nephron: evaluation of a novel virtual reality educational tool - Georges N. Nakhoul, Jonathan J. Taliercio, Elias H. Bassil, Susana Arrigain, Jesse D. Schold, Richard Wardrop, John O’Toole, Joseph V. Nally, S. Beth Bierer, John R. Sedor, Ali Mehdi Kidney Int Reports
  Recent technological advancements have allowed for the development of innovative and engaging technological tools. Using funding from the ASN, we developed a 3D Virtual Reality (VR) physiology course entitled DiAL-Neph (Diuretic Action and eLectrolyte transport in the Nephron), and we hereby (…) (Kidney International Reports (2024))

10 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Acute Kidney Injury and Hair-Straightening Products - Aurélie Huber, Christine Deffert, Solange Moll, Sophie de Seigneux, Lena Berchtold Kidney Int Reports
  Acute kidney injury (AKI) is common and can affect 8.3% of ambulatory patients and up to 32% of the hospitalized patients1. Main causes of acute kidney injury are acute tubular necrosis, prerenal and acute on chronic renal failure. Recently, T Robert and al2 describe a case of acute kidney (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “Atypical Clinical Presentation of Autosomal Recessive Polycystic Kidney Mimicking Medullary Sponge Kidney Disease” [Kidney International Reports Volume 7, Issue 4, April 2022, Pages 916-919] - Emmanuel Letavernier, Madeline Schwoehrer, Marine Livrozet, Camille Saint-Jacques, Laure Raymond, Radoslava Saraeva, Jean-Philippe Haymann, Vincent Frochot, Michel Daudon, Laurent Mesnard Kidney Int Reports
  The authors regret that the PKHD1 gene product was incorrectly named “polycystin,” whereas it is known as polyductin or fibrocystin. (Kidney International Reports (2024))

9 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Cinacalcet: addressing the unmet clinical need in the management of CKD-MBD in infants on dialysis - Evelien Snauwaert, Agnieszka Prytu?a Kidney Int Reports
  Since the introduction of the first pediatric renal replacement therapy program in the 1960s, the number of infants and young children started on renal replacement therapy has gradually increased, i.e. currently 28.0-32.1 per million age-related population (…) (Kidney International Reports (2024))
• 00:00
  Comprehensive conservative care for kidney failure - The need for evidence-based guidance - Olalekan Lee Aiyegbusi Kidney Int Reports
  Kidney failure is an increasing global health challenge.1 Whilst the precise global prevalence is unknown, there are estimates as high as 9.7 million affected people.2 In areas where there is access to care, a diagnosis of kidney failure generally connotes a lifetime of dialysis, as kidney (…) (Kidney International Reports (2024))

7 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Corrigendum to “WCN24-2499 CAVEOLIN-1 AND CAVEOLIN-2 AS POTENTIAL URINARY EARLY BIOMARKERS OF RENAL INJURY IN ACUTE CHOLESTASIS IN RATS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S541] - Anabel Brandoni, María Herminia Hazelhoff, Romina Valeria Campagno, Romina Paula Bulacio, María Fermanda Fussi, Sara María Molinas Kidney Int Reports
  The authors regret that the listing of authors and affiliations were incorrect. These are now correctly listed below. We apologize for any inconvenience caused. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-2021 KNOWLEDGE ATTITUDES AND BELIEFS ABOUT KIDNEY TRANSPLANTATION IN JAMAICAN RESIDENTS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S482] - Davlyn Dewar, Kareen Somers-Brown Kidney Int Reports
  The authors regret that the above abstract was incomplete and is now correctly posted below. We apologize for any inconvenience caused. (Kidney International Reports (2024))

6 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Combination of cardiovascular, kidney, and metabolic diseases in a syndrome named CKM, with new risk prediction equations - Ziad A. Massy, Tilman B. Drueke Kidney Int Reports
  Associations of chronic kidney disease (CKD) with metabolic syndrome and cardiovascular disease have long been recognized. Until recently, however, taking into account such associations was mainly limited to interrationships between either heart and kidney, heart and metabolic syndrome, or (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-218 PRURITUS ASSESSMENT USING A BATTERY OF PATIENT-REPORTED OUTCOME MEASURES IN RUSSIAN PATIENTS WITH CHRONIC KIDNEY DISEASE: PSYCHOMETRIC PROPERTIES OF RUSSIAN VERSIONS AND TESTING OF THEIR USEFULNESS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Pages S52-S53] - Ekaterina PARSHINA, Tatiana Nikitina, Tatiana Ionova, Alexet Tolkach, Mariya Lisova Kidney Int Reports
  The authors regret that the Results text was missing from the above abstract, which is now included below. The authors apologize for any inconvenience caused. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-465 RISK OF MORTALITY IN PATIENTS RECEIVING HIGH-VOLUME ONLINE HEMODIAFILTRATION (OL-HDF) VERSUS HIGH-FLOW HEMODIALYSIS (HD) THERAPY IN 14 FRESENIUS MEDICAL CARE ECUADOR (FMC) CLINICS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S359] - Gabriela Vanessa Tamayo Albán, Jorge Oswaldo Quinchuela Hidalgo, Jadira Natalia Benavides Altamirano Kidney Int Reports
  We regret that the first author’s name was listed in error and should have instead been listed as Gabriela Vanessa Tamayo. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-660 Comparative Analysis of High Flux and Low Flux Dialysis Membranes: In-Situ Synchrotron Imaging and Experimental Ex-Vivo Studies” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S363] - Amira Abdelrasoul, Ahmed Shoker, Jumanah Bahig Kidney Int Reports
  The authors regret that the author names were presented in the wrong order, and should have instead been listed as Jumanah Bahig, Ahmed Shoker, and Amira Abdelrasoul. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-658 Comparative Analysis of Zwitterionic Materials and Polyvinyl Pyrrolidone for Enhancing Dialysis Membrane Hemocompatibility and Psychological Symptoms in Patients” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Pages S362-S363] - Amira Abdelrasoul, Ahmed Shoker, Victoria Doan Kidney Int Reports
  The authors regret that the author names were presented in the wrong order, and should have instead been listed as Victoria Doan, Ahmed Shoker, and Amira Abdelrasoul. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-786 PHASE I DOSE ESCALATION STUDY OF SHR6508, A CALCIUM-SENSING RECEPTOR AGONIST, IN HEMODIALYSIS PATIENTS WITH SECONDARY HYPERPARATHYROIDISM” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Pages S368-S369] - Zhiming Ye, Li Fan, Rui Yan, Bicheng Liu, Linghui Zhou, Guangqun Xing, Wei Zhao, Zunsong Wang, Deguang Wang, Min Zhang, Xin Zhang, Xinyu Yang, Xue Yang, Xueqing Yu Kidney Int Reports
  The authors regret that an important part of the Results text was missing from the above abstract, which is now included below. The authors apologize for any inconvenience caused. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1924 SOCIODEMOGRAPHIC AND CLINICAL PROFILE OF OLDER ADULTS IN A HEMODIALYSIS UNIT IN NORTHEASTERN BRAZIL: CHALLENGES AND PERSPECTIVES” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Pages S282-S283] - Laurisson Costa, Thaisa Valverde, Marcia Juliana Silva, Thiago Mello, Gustavo Presidio, Keila Kamile Sousa Kidney Int Reports
  The authors regret that the Results and Conclusions text was missing from the above abstract, which is now included below. The authors apologize for any inconvenience caused. (Kidney International Reports (2024))

3 juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Bridging the Gap in Genomic Implementation: Identifying User Needs for Precision Nephrology - Jerard Kneifati-Hayek, Teena Zachariah, Wooin Ahn, Atlas Khan, Krzysztof Kiryluk, Sumit Mohan, Chunhua Weng, Ali G. Gharavi, Jordan G. Nestor Kidney Int Reports
  Genomic medicine holds transformative potential for personalized nephrology care; however, its clinical integration poses challenges. Automated clinical decision support (CDS) systems in the electronic health record (EHR) offer a promising solution but have shown limited impact. This study aims (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1709 NON-CADAVERIC HOMOLOGOUS VEIN AS VASCULAR ACCESS IN A PATIENT WITH EXHAUSTED NATIVE VEINS ON HEMODIALYSIS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Pages S398-S399] - Edwin Castillo Velarde, José A. Ruiz-Peñafiel, Tushar J. Vachharajani Kidney Int Reports
  We regret that the affiliation listed for author Edwin Castillo Velarde was incomplete, and should have instead been listed as INICIB, Instituto de Investigación de Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1066 BRIDGING THE GAP: INTEGRATING THE MULTIDISCIPLINARY EQUIPMENT ON HEMODIALYSIS VASCULAR ACCESS FROM LATIN AMERICA AND PERÚ” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S379-S380] - Edwin Castillo Velarde Kidney Int Reports
  We regret that the affiliation listed was incomplete, and should have instead been listed as INICIB, Instituto de Investigación de Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú. (Kidney International Reports (2024))

1er juin

Kidney Int Reports http://www.kireports.org/

• 00:00
  Mind the Gap in Kidney Care: Translating What We Know into What We Do - Valerie A. Luyckx, Katherine R. Tuttle, Dina Abdellatif, Ricardo Correa-Rotter, Winston W.S. Fung, Agnès Haris, Li-Li Hsiao, Makram Khalife, Latha A. Kumaraswami, Fiona Loud, Vasundhara Raghavan, Stefanos Roumeliotis, Marianella Sierra, Ifeoma Ulasi, Bill Wang, Siu-Fai Lui, Vassilios Liakopoulos, Alessandro Balducci, World Kidney Day Joint Steering Committee Kidney Int Reports
  Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we (…) (Kidney International Reports 9, 6 (2024))

30 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Health Competence Is a Determinant of Exercise Frequency in Older Adults With CKD - Devika Nair, Jonathan S. Schildcrout, Heather L. Prigmore, Robert Greevy, Ricardo J. Trochez, Justin M. Bachmann, Ebele M. Umeukeje, Rachel B. Fissell, Warren D. Taylor, Sunil Kripalani, Kerri L. Cavanaugh Kidney Int Reports
  Adults aged >60 years comprise the fastest-growing population with chronic kidney disease (CKD) in the United States. Older adults with advanced CKD face high mortality rates because of hospitalizations owing to cardiovascular diseases and high morbidity owing to falls and frailty.1 Exercise, (…) (Kidney International Reports (2024))

29 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Prospective Study on Kidney Dysfunction Markers and Risk for Mortality among South Asians - Ram Jagannathan, Shuchi Anand, Dimple Kondal, Jialin Han, Maria Montez-Rath, Mohammed K. Ali, Shivani A. Patel, Kavita Singh, Roopa Shivashankar, RM Anjana, Ruby Gupta, Sailesh Mohan, Glenn M. Chertow, Viswanathan Mohan, Nikhil Tandon, K.M. Venkat Narayan, Dorairaj Prabhakaran Kidney Int Reports
  Associations between markers of impaired kidney function and adverse outcomes among South Asians is understudied and could differ from existing data derived mostly from North American or European cohorts. (Kidney International Reports (2024))
• 00:00
  Corticosteroids in Patients With IgA Nephropathy: Is the Lower the Better? - Thomas Rauen, Kristian Vogt, Claudia Seikrit Kidney Int Reports
  Since its first description in 1968 by J. Berger et al.,1 IgA nephropathy (IgAN) has been mainly characterized by the eponymous IgA. Since then, key pathogenetic contributors have been unraveled involving distinct predisposing susceptibility gene loci, a disturbed gut-kidney axis, aberrant (…) (Kidney International Reports (2024))

28 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Dialysis Discontinuation, Prognosis, and Shared Decision-Making - Denisse Arellano-Mendez, Keren Ladin Kidney Int Reports
  Dialysis discontinuation (withdrawal) generally refers to the intentional cessation of dialysis in patients with end-stage kidney disease; a decision often made collaboratively by the patient, their family, and the health care team, considering the patient's overall medical condition, quality of (…) (Kidney International Reports (2024))

27 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  The Path to Progress: Glucagon-like Peptide 1 Agonists, Individualized Care, and Overcoming Goal-Directed Medical Therapy Barriers in Diabetes and CKD - Sophia L. Ambruso, Matthew R. Weir Kidney Int Reports
  The origin of glucagon-like peptide 1 (GLP-1) agonists (GLP-1RA) can be traced back to a shy, unassuming, slow-moving reptile found within the southwestern regions of the United States. In 1990, an endocrinologist named John Eng from the veterans’ administration center in Bronx, NY, isolated (…) (Kidney International Reports (2024))
• 00:00
  Pathogenic PHIP Variants are Variably Associated With CAKUT - Jonathan de Fallois, Tobias Sieckmann, Ria Schönauer, Friederike Petzold, Johannes Münch, Melissa Pauly, Georgia Vasileiou, Christin Findeisen, Antje Kampmeier, Alma Kuechler, André Reis, Eva Decker, Carsten Bergmann, Konrad Platzer, Velibor Tasic, Karin Michaela Kirschner, Shirlee Shril, Friedhelm Hildebrandt, Wendy K. Chung, Jan Halbritter Kidney Int Reports
  Congenital anomalies of the kidney and urinary tract (CAKUT) represent the most common cause of chronic kidney disease in children. Although only 20% of cases can be genetically explained, the majority remain without an identified underlying etiology. The neurodevelopmental disorder Chung-Jansen (…) (Kidney International Reports (2024))
• 00:00
  Salt Taste Sensitivity in CKD: Does it Affect Salt Intake? - Mythri Shankar, Qais Al-Awqati Kidney Int Reports
  Hypertension is the leading risk factor for cardiovascular diseases and chronic kidney disease (CKD), and salt intake is a major factor affecting blood pressure. Most individuals consume more salt than recommended, increasing their risk of cardiovascular diseases and CKD progression. Salt intake (…) (Kidney International Reports (2024))

26 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Key Points in Managing PLA2R-Associated Membranous Nephropathy - Raja Ramachandran, Vivekanand Jha, Bhadran Bose Kidney Int Reports
  The therapeutic approach to primary membranous nephropathy (PMN) typically revolves around the optimization of antiproteinuric therapy and cyclophosphamide and corticosteroids (CYC/CS) or rituximab as first-line interventions in those at high risk of progressive disease.1 Economic (…) (Kidney International Reports (2024))

24 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Cardioprotective Effect of SGLT2 Inhibitor in Diabetic Kidney Transplant Recipients: A Multicenter Propensity Score Matched Study - Jeong-Hoon Lim, Soie Kwon, Yu Jin Seo, Young Hoon Kim, Hyunwook Kwon, Yon Su Kim, Hajeong Lee, Yong-Lim Kim, Chan-Duck Kim, Sun-Hee Park, Deokbi Hwang, Woo-Sung Yun, Hyung-Kee Kim, Seung Huh, Jong Soo Lee, Kyung Don Yoo, Jong Cheol Jeong, Jeonghwan Lee, Jung Pyo Lee, Jang-Hee Cho Kidney Int Reports
  Kidney transplantation (KT) improves the cardiovascular outcomes of patients with end-stage kidney disease. However, cardiovascular disease remains the leading cause of premature death and graft loss in KT recipients (KTRs) with diabetes. We evaluated the cardioprotective effects of (…) (Kidney International Reports (2024))
• 00:00
  Response to (Challenges and Considerations in Managing Thrombotic Microangiopathy and Disseminated Intravascular Coagulation in Postpartum Hemorrhage) - Jessica K. Kaufeld, Ulf Schönermarck, Lucas Kühne, Jan Hinrich Bräsen, Constantin von Kaisenberg, Bodo B. Beck, Florian Erger, Carsten Bergmann, Anke von Bergwelt-Baildon, Paul T. Brinkkötter, Jan Menne, Linus A. Voelker Kidney Int Reports
  We highly appreciate the thoughtful comments by Orsi et al. and Rafat et al. on our recent report on the impact of short-term complement inhibition in patients with thrombotic microangiopathy (TMA)-associated with postpartum hemorrhage. (Kidney International Reports (2024))
• 00:00
  One Size Doesn’t Fit All: Revisiting the Threshold, Target, and Type of Erythropoietin-Stimulating Agent Therapy in Anemia of CKD - Pallavi Prasad, Kunihiro Yamagata Kidney Int Reports
  Anemia has multisystem effects in patients with chronic kidney disease (CKD). Not only does it affect quality of life but is also associated with cardiovascular morbidity, worsening of kidney function, and mortality. (Kidney International Reports (2024))

22 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Dialysis Outcomes Across Countries and Regions: A Global Perspective From the International Society of Nephrology Global Kidney Health Atlas Study - Emily See, Isabelle Ethier, Yeoungjee Cho, Htay Htay, Silvia Arruebo, Fergus J. Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, Adeera Levin, Masaomi Nangaku, Syed Saad, Marcello Tonelli, Feng Ye, Ikechi G. Okpechi, Aminu K. Bello, David W. Johnson Kidney Int Reports
  Kidney failure treated with hemodialysis (HD), or peritoneal dialysis (PD) is a major global health problem that is associated with increased risks of death and hospitalization. This study aimed to compare the incidence and causes of death and hospitalization during the first year of HD or PD (…) (Kidney International Reports (2024))
• 00:00
  Effects of Once-Weekly Semaglutide on Kidney Disease Outcomes by KDIGO Risk Category in the SUSTAIN 6 Trial - Katherine R. Tuttle, Stephen C. Bain, Heidrun Bosch-Traberg, Kamlesh Khunti, Søren Rasmussen, Ekaterina Sokareva, David Z. Cherney Kidney Int Reports
  Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are recommended by Kidney Disease: Improving Global Outcomes (KDIGO) as risk-based treatment for hyperglycemia, weight management, and cardiovascular (CV) risk reduction in people with type 2 diabetes (T2D) and chronic kidney disease (CKD). (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1051 CLINICAL PROFILE, DIAGNOSIS, THERAPEUTIC INTERVENTION AND COMPLICATIONS IN RENAL BIOPSY IN CKD POPULATION – SINGLE CENTER 20 YEARS’ EXPERIENCE” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S86] - Souryasourabh Mohakuda, Dharmendra Singh Bhadauria, Anupma Kaul, Narayan Prasad, Manas Ranjan Patel, Monika Yachha, Manas Ranjan Behera, Ravi Singh Kushwaha Kidney Int Reports
  We regret that there was a typographical error in the above abstract in which a single word ‘UNRELATED’ was omitted. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “Analysis and Management of Rituximab Resistance in PLA2R1-Associated Membranous Nephropathy” [Kidney International Reports Volume 6, Issue 4, April 2021, Pages 1183-1188] - Maxime Teisseyre, Sonia Boyer-Suavet, Marion Crémoni, Vesna Brglez, Vincent Esnault, Barbara Seitz-Polski Kidney Int Reports
  The authors regret that the dosage of obinutuzumab reported in cases 1 and 2 was incorrect. The correct dosage of obinutuzumab is 100 mg intravenously on day 1, 900 mg intravenously on day 2, and 1 g intravenously on days 8 and 15. (Kidney International Reports (2024))

21 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Thrombotic Microangiopathy in Pregnancy: Current Understanding and Management Strategies - Manuel Urra, Shannon Lyons, Corina Gabriela Teodosiu, Richard Burwick, Anuja Java Kidney Int Reports
  Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by microvascular thrombosis and end-organ damage. Pregnancy-associated thrombotic microangiopathy (p-TMA) has emerged as a distinct clinical entity with unique diagnostic challenges. Identifying the (…) (Kidney International Reports (2024))
• 00:00
  Economic Evaluation of an Integrated Care Program Compared to Conventional Care for Patients With Chronic Kidney Disease in Rural Communities of Thailand - Molly Paffett, Jeerath Phannajit, Kinanti Khansa Chavarina, Tanainan Chuanchaiyakul, Teerayuth Jiamjariyapon, Teerawat Thanachayanont, Methee Chanpitakkul, Salyaveth Lekagul, Yot Teerawattananon, Kriang Tungsanga Kidney Int Reports
  An integrated care program for chronic kidney disease (CKD) in Thailand has shown its effectiveness in delaying the decline in kidney function, as evidenced by the Effectiveness of Integrated Care on Delaying Progression of Stages 3 to 4 CKD in Rural Communities of Thailand (ESCORT-1) randomized (…) (Kidney International Reports (2024))

18 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Perspectives in Immunosuppression Management Following Renal Graft Failure: A Portuguese National Survey - Rita Leal, João Venda, Helena Oliveira Sá, Arnaldo Figueiredo, Rui Alves Kidney Int Reports
  Advances in kidney transplantation and immunosuppression have resulted in significant improvements in short-term kidney allograft survival, but long-term graft survival remains suboptimal. This has led to an increased prevalence of patients with graft loss returning to dialysis and relisted to a (…) (Kidney International Reports (2024))
• 00:00
  Elevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression - Jonathan P. Troost, Jennifer D’Souza, Miatta Buxton, Abhijit V. Kshirsagar, Lawrence S. Engel, Cassandra R. O’Lenick, William E. Smoyer, Jon Klein, Wenjun Ju, Sean Eddy, Margaret Helmuth, Laura H. Mariani, Matthias Kretzler, Howard Trachtman Kidney Int Reports
  Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies. (Kidney International Reports (2024))

17 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Fully Understanding Sex/Gender Disparities in Kidney Care Requires End-to-End, National Data Collection - Darren Stewart, Priyadarshini John Kidney Int Reports
  Sex (reflecting biological, reproductive differences between males and females) and gender (reflecting social and cultural differences between men and women) inequities exist in numerous societal and medical contexts, including in kidney care. Adequate kidney care requires awareness of kidney (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1105 PHARMACOGENETIC RISK FACTORS FOR TENOFOVIR-INDUCED KIDNEY TUBULAR DYSFUNCTION AMONG HIV-POSITIVE ADULT NIGERIANS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S339] - Muzamil Hassan, Raquel Duarte, Victor Mabayoje, Therese Dix-Peek, Caroline Dickens, Akeem Lasisi, Saraladevi Naicker, Muzamil Hassan, Raquel Duarte, Victor Mabayoje, Therese Dix-Peek, Caroline Dickens, Akeem Lasisi, Saraladevi Naicker Kidney Int Reports
  We regret that the above abstract text was incomplete, and the author affiliations were incorrect. This is now corrected below. We apologize for any inconvenience caused. (Kidney International Reports (2024))

15 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Renal and Extrarenal Phenotypes in Patients With HNF1B Variants and Chromosome 17q12 Microdeletions - Bénédicte Buffin-Meyer, Juliette Richard, Vincent Guigonis, Stefanie Weber, Jens König, Laurence Heidet, Nabila Moussaoui, Jeanne-Pierrette Vu, Stanislas Faguer, Audrey Casemayou, Richa Prakash, Véronique Baudouin, Julien Hogan, Demi Alexandrou, Detlef Bockenhauer, Justine Bacchetta, Bruno Ranchin, Stepanka Pruhova, Jakub Zieg, Annie Lahoche, Christine Okorn, Violetta Antal-Kónya, Denis Morin, Francesca Becherucci, Sandra Habbig, Max C. Liebau, Mathilde Mauras, Tom Nijenhuis, Brigitte Llanas, Djalila Mekahli, Julia Thumfart, Burkhard Tönshoff, Laura Massella, Philippe Eckart, Sylvie (…) Kidney Int Reports
  Hepatocyte nuclear factor 1-beta (HNF1B) gene variants or the chromosome 17q12 deletion (17q12del) represent the most common monogenic cause of developmental kidney disease. Although neurodevelopmental disorders have been associated with the 17q12del, specific genotype-phenotype associations (…) (Kidney International Reports (2024))
• 00:00
  Donor Perceptions and Preferences of Telemedicine and In-Person Visits for Living Kidney Donor Evaluation - Ellie Kim, Hannah C. Sung, Katya Kaplow, Victoria Bendersky, Carolyn Sidoti, Abimereki D. Muzaale, Jasmine Akhtar, Macey Levan, Suad Esayed, Amir Khan, Christina Mejia, Fawaz Al Ammary Kidney Int Reports
  Living kidney donor evaluation is a lengthy and complex process requiring in-person visits. Access to transplant centers, travel costs, lost wages, and dependent care arrangements are barriers to willing donors initiating evaluation. Telemedicine can help streamline and epedite the evaluation (…) (Kidney International Reports (2024))
• 00:00
  Clinical Characteristics of Nephrin Autoantibody-Positive Minimal Change Disease in Older Adults - Yoko Fujita, Andrew J.B. Watts, Daisuke Ichikawa, Yugo Shibagaki, Tomo Suzuki, Keith H. Keller, Astrid Weins, Naoka Murakami Kidney Int Reports
  Minimal change disease (MCD) is a major cause of the adult-onset nephrotic syndrome, particularly in Japan where it affects 40% of patients compared with 15% of patients worldwide.1 Its incidence is particularly high among the elderly and both the disease and corticosteroid therapy can be a (…) (Kidney International Reports (2024))

14 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  The Role of Mitochondrial Dysfunction in CKD-Related Vascular Calcification: From Mechanisms to Therapeutics - Junmin Huang, Junfeng Hao, Peng Wang, Yongzhi Xu Kidney Int Reports
  Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) and is closely associated with cardiovascular events. The transdifferentiation of vascular smooth muscles (VSMCs) into an osteogenic phenotype is hypothesized to be the primary cause underlying VC. However, (…) (Kidney International Reports (2024))
• 00:00
  Pregnancy Among Women Receiving Chronic Dialysis in France (2006–2020) - Hayet Baouche, Cécile Couchoud, Henri Boulanger, Salima Ahriz-Saksi, Imene Mansouri, Abdelaziz Hamani, Pierre Taupin, Xavier Ferreira, Marine Panaye, Julien Stirnemann, Olivier Moranne, Jean-Philippe Jais, REIN registry Kidney Int Reports
  In women receiving chronic dialysis, fertility is impaired. The objectives of this study were to estimate the incidence rate of pregnancies among women of childbearing age (15–50 years) receiving chronic dialysis from 2006 to 2020 in France, to describe the pregnancy outcomes and renal (…) (Kidney International Reports (2024))
• 00:00
  Derivation and Validation of an Optimal Neutrophil Gelatinase-Associated Lipocalin Cutoff to Predict Stage 2/3 Acute Kidney Injury (AKI) in Critically Ill Children - Stuart L. Goldstein, Ayse Akcan-Arikan, Natasha Afonso, David J. Askenazi, Abby M. Basalely, Rajit K. Basu, Hostensia Beng, Julie C. Fitzgerald, Katja Gist, Sarah Kizilbash, David Kwiatkowski, Christopher W. Mastropietro, Shina Menon, Megan SooHoo, Avram Z. Traum, Christopher A. Bird Kidney Int Reports
  Acute kidney injury (AKI) defined by changes in serum creatinine (SCr), or oliguria is associated with increased morbidity and mortality in children who are critically ill. We derived and validated a clinical cutoff value for urine neutrophil gelatinase-associated lipocalin (NGAL), in a (…) (Kidney International Reports (2024))
• 00:00
  Clinicopathologic Features of IgG4-Related Kidney Disease - Alessia Buglioni, Sarah M. Jenkins, Samih H. Nasr, Pingchuan Zhang, Ian W. Gibson, Mariam P. Alexander, Loren P. Herrera Hernandez, Mary E. Fidler, Naoki Takahashi, Marie C. Hogan, Lynn D. Cornell Kidney Int Reports
  IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that can involve nearly any organ. IgG4-RD can affect the kidney in different disease patterns, collectively referred to as IgG4-related kidney disease (IgG4-RKD). (Kidney International Reports (2024))

13 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Patiromer to Reduce Albuminuria through Increased Renin Angiotensin Aldosterone System Inhibition in Patients With CKD-A Feasibility Trial - Frederik H. Mårup, Christian D. Peters, Steffen F. Nielsen, Louis Nygaard, Bo Madsen, Frank H. Mose, Henrik Birn Kidney Int Reports
  We tested the feasibility of adding a potassium binder to enable increased renin angiotensin aldosterone system inhibition (RAASi) and reduce albuminuria in patients with chronic kidney disease (CKD). In a controlled trial design, a potassium binder was introduced exclusively in patients (…) (Kidney International Reports (2024))

12 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Obinutuzumab as Initial or Second-line Therapy in Patients With Primary Membranous Nephropathy - Xiaole Su, Binxin Wu, Xuan Tie, Xiaojiao Guo, Rongrong Feng, Xi Qiao, Lihua Wang Kidney Int Reports
  B-cell lymphocytes have been demonstrated to play a key role in the pathogenesis underlying membranous nephropathy (MN). The aim of this study was to evaluate the therapeutic efficacy and safety of Obinutuzumab, a glycoengineered type II anti-CD20 monoclonal antibody in individuals with MN. (Kidney International Reports (2024))

8 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Voclosporin Induces Systemic Lipidomic Alterations: Implications for Lupus Nephritis Remission - Farsad Afshinnia, Thekkelnaycke M. Rajendiran, Jaeman Byun, Manikanta Swamy Arnipalli, Linda M. Rehaume, Jennifer L. Cross, Robert B. Huizinga, Subramaniam Pennathur Kidney Int Reports
  Lupus nephritis (LN) is a major cause of morbidity and mortality with a lifetime incidence of up to 60% in systemic lupus erythematosus.1 Cardiovascular diseases (CVDs) are also the leading cause of death in patients with systemic lupus erythematosus.2 LN is an independent risk factor for CVD, (…) (Kidney International Reports (2024))
• 00:00
  Description and Cross-Sectional Analyses of 25,880 Adults and Children in the UK National Registry of Rare Kidney Diseases Cohort - Katie Wong, David Pitcher, Fiona Braddon, Lewis Downward, Retha Steenkamp, Sherry Masoud, Nicholas Annear, Jonathan Barratt, Coralie Bingham, Richard J. Coward, Tina Chrysochou, David Game, Sian Griffin, Matt Hall, Sally Johnson, Durga Kanigicherla, Fiona Karet Frankl, David Kavanagh, Larissa Kerecuk, Eamonn R. Maher, Shabbir Moochhala, Jenny Pinney, John A. Sayer, Roslyn Simms, Smeeta Sinha, Shalabh Srivastava, Frederick W.K. Tam, Kay Thomas, A. Neil Turner, Stephen B. Walsh, Aoife Waters, Patricia Wilson, Edwin Wong, Karla Therese L. Sy, Kui Huang, Jamie Ye, Dorothea Nitsch, Moin Saleem, (…) Kidney Int Reports
  The National Registry of Rare Kidney Diseases (RaDaR) collects data from people living with rare kidney diseases across the UK, and is the world’s largest, rare kidney disease registry. We present the clinical demographics and renal function of 25,880 prevalent patients and sought evidence of (…) (Kidney International Reports (2024))
• 00:00
  Implementation and Evaluation of a National Multidisciplinary Kidney Genetics Clinic Network Over 10 Years - Kushani Jayasinghe, Erik Biros, Trudie Harris, Alasdair Wood, Rosie O’Shea, Lauren Hill, Lindsay Fowles, Louise Wardrop, Carolyn Shalhoub, Deirdre Hahn, Gopala Rangan, Lucy Kevin, Michel Tchan, Paul Snelling, Rhiannon Sandow, Madhivan Sundaram, Swasti Chaturvedi, Peter Trnka, Randall Faull, Nicola K. Poplawski, Vanessa Huntley, Denisse Garza, Mathew Wallis, Matthew Jose, Anna Leaver, Alison H. Trainer, Ella J. Wilkins, Sue White, Yoni Elbaum, Yael Prawer, Emma Krzesinski, Giulia Valente, Ingrid Winship, Jessica Ryan, John Whitlam, Kathy Nicholls, Kirsty West, Liz Donaldson, Lilian (…) Kidney Int Reports
  Diagnostic genomic sequencing is the emerging standard of care in nephrology. There is a growing need to scale up the implementation of genomic diagnostics nationally to improve patient outcomes. (Kidney International Reports (2024))

7 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Structures, Organization, and Delivery of Kidney Care to Children Living in Low-Resource Settings - Nivedita Kamath, Robin L. Erickson, Sangeeta Hingorani, Nilzete Bresolin, Ali Duzova, Adrian Lungu, Erica C. Bjornstad, Risky Prasetyo, Sampson Antwi, Hesham Safouh, Giovanni Montini, Melvin Bonilla-Félix Kidney Int Reports
  There is a disparity in the availability of health care for children in resource-constrained countries. The International Pediatric Nephrology Association (IPNA) commissioned an initiative exploring the challenges in the care of children with kidney disease in low- or middle-income countries (…) (Kidney International Reports (2024))
• 00:00
  Allogeneic CD4 T Cells Sustain Effective BK Polyomavirus-Specific CD8 T Cell Response in Kidney Transplant Recipients - Manon Dekeyser, Marie-Ghislaine de Goër de Herve, Houria Hendel-Chavez, Romain Lhotte, Ivan Scriabine, Karen Bargiel, Emmanuelle Boutin, Florence Herr, Jean-Luc Taupin, Yassine Taoufik, Antoine Durrbach Kidney Int Reports
  BK polyomavirus-associated nephropathy (BKPyVAN) is a significant complication in kidney transplant recipients (KTRs), associated with a higher level of plasmatic BK polyomavirus (BKPyV) replication and leading to poor graft survival. (Kidney International Reports (2024))
• 00:00
  Safety and Efficacy of Cinacalcet in Children Aged Under 3 Years on Maintenance Dialysis - Julie Bernardor, Sacha Flammier, Ilona Zagozdzon, Alexander D. Lalayiannis, Linda Koster-Kamphuis, Enrico Verrina, Eiske Dorresteijn, Isabella Guzzo, Dieter Haffner, Rukshana Shroff, Claus P. Schmitt, Justine Bacchetta Kidney Int Reports
  Secondary hyperparathyroidism (sHPT) is particularly severe in rapidly growing infants in dialysis. Although cinacalcet is effective and licensed in dialysis in children aged >3 years, its efficacy and safety for children aged (Kidney International Reports (2024))
• 00:00
  Difficult-to-treat Nephrotic Syndrome in Childhood–Global Depletion of B-cells - Lutz T. Weber, Sandra Habbig, Agnes Hackl Kidney Int Reports
  Idiopathic nephrotic syndrome (iNS) is the most common glomerular disease in childhood and there are clear and generally accepted treatment strategies for initial and follow-up treatment. In general, pediatric nephrologists feel confident about the diagnosis and treatment of iNS. (Kidney International Reports (2024))

6 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Can Future Value-Based Care Models in Nephrology Promote Kidney Transplantation? - Gaurav Jain, Abhijit V. Kshirsagar Kidney Int Reports
  Value-based care (VBC) has taken center stage in nephrology with goals of providing high quality coordinated care for patients with advanced chronic kidney disease (CKD), performance assessment for providers, and lower costs for payers. A lack of emphasis on kidney transplantation was a concern (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Birth History and the Risk for Development of Hypertension in Adolescence - Roshan P. George, Joseph T. Flynn Kidney Int Reports
  A 16-year-old is referred to you for evaluation of hypertension noted in the primary care provider’s office. Office blood pressure (BP) averages were 138/78 mm Hg; 24-hour ambulatory BP monitoring shows a mean wake BP of 136/82, and mean sleep BP of 112/64 mm Hg. The patient has a normal body (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Chronic Hypotension and Transplant Outcomes–the Known Unknowns - Divya Bajpai, Chethan M. Puttarajappa Kidney Int Reports
  Kidney transplantation (KT) is the preferred treatment for patients with end-stage kidney disease; however, KT outcomes are highly dependent on several donor and recipient variables. Although donor quality and ischemia times mainly drive early and long-term graft outcomes, several recipient (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Kidney Disease in the Caribbean-APOL1 Risk Alleles and Emerging Environmental Stressors - Joseph Myrie, Adedamola Soyibo, David Friedman, Shuchi Anand, Lori-Ann Fisher Kidney Int Reports
  The English-Speaking Caribbean comprises of 8 million persons predominantly of African descent, unified by a shared history of European (mainly British) colonization spanning centuries. Although most individual countries are now designated as high-income and middle-income sociodemographic index, (…) (Kidney International Reports (2024))
• 00:00
  P2Y12 Inhibitors Refill Gap Predicts Death in Medicare Beneficiaries on Chronic Dialysis - Rafia S. Rasu, Milind A. Phadnis, Christy Xavier, Junqiang Dai, Suzanne L. Hunt, Nishank Jain Kidney Int Reports
  Oral P2Y12 inhibitors (P2Y12-I) are commonly used antiplatelet drugs in patients with end-stage kidney disease (ESKD) on chronic dialysis. Although gaps in prescription refills are quite common in patients with ESKD, it remains unclear whether P2Y12-I prescription refill patterns are associated (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “The Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Population” [Kidney International Reports Volume 8, Issue 9, September 2023, Pages 1831-1840] - Erikka W. Bystad, Vidar T.N. Stefansson, Bjørn O. Eriksen, Toralf Melsom Kidney Int Reports
  The authors regret that there was a small error in the calculation of iohexol clearance (mGFR) in the third round of the Renal Iohexol Clearance Survey (RENIS-3). (Kidney International Reports (2024))
• 00:00
  Corrigendum to “Nitric Oxide Precursors and Dimethylarginines as Risk Markers for Accelerated Measured GFR Decline in the General Population” [Kidney International Reports Volume 8, Issue 4, April 2023, Pages 818-826] - Nikoline B. Rinde, Inger Therese Enoksen, Toralf Melsom, Ole Martin Fuskevåg, Bjørn Odvar Eriksen, Jon Viljar Norvik Kidney Int Reports
  The authors regret that there was a small error in the calculation of iohexol clearance (mGFR) in the third round of the Renal Iohexol Clearance Survey (RENIS-3). (Kidney International Reports (2024))

4 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  The Interaction Between Coagulation and Complement Cascades in the Management of Thrombotic Microangiopathies Related to Postpartum Hemorrhage - Michele Orsi, Manuela Wally Ossola, Irene Cetin, Gianluigi Ardissino Kidney Int Reports
  We read with great interest the report by Kaufeld et al.1 who studied the impact of short-term complement inhibition in patients with thrombotic microangiopathy associated with postpartum hemorrhage.1 We agree with the authors regarding the need to propose a pragmatic management model by (…) (Kidney International Reports (2024))

3 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Choice of Estimated GFR Concept and Implications for Cystatin C to Creatinine Ratio Among Hospitalized Older Adults - Esben Iversen, Louise Westberg Strejby Christensen, Aino Leegaard Andersen, Rikke Lundsgaard Nielsen, Morten Damgaard, Trine Meldgaard Lund, Mads Hornum, Ove Andersen, Morten Baltzer Houlind Kidney Int Reports
  Older adults (age ?65 years) account for nearly half of all hospitalizations in both Europe and the United States.1 Hospitalized older adults are uniquely vulnerable to inaccurate creatinine-based estimates of glomerular filtration rate (eGFRcre) due to nonrenal factors such as sarcopenia2 and (…) (Kidney International Reports (2024))
• 00:00
  A Cell-Based Assay to Measure the Activity of the Complement Convertases - Ma?gorzata Stasi?oj?, Grzegorz Stasi?oj?, Alicja Ku?niewska, Santiago Rodriguez de Córdoba, Marcin Okrój Kidney Int Reports
  The complement system serves as a crucial defense mechanism against invading pathogens; however, dysregulation of this system can result in harmful consequences. Central to the complement cascade are the classical pathway (CP) or lectin pathway (LP) and the alternative pathway (AP) convertases. (…) (Kidney International Reports (2024))
• 00:00
  Torque Teno Virus-Guided Immunosuppression in Kidney Transplantation: Expanding the Application - Farsad Eskandary, Gregor Bond, Krithika Mohan Kidney Int Reports
  Posttransplant care of kidney transplant recipients faces 2 major challenges that are associated with inadequate immunosuppression: alloimmune processes and infectious complications.1 In contrast, no novel immunosuppressive drugs that were specifically developed for maintenance use in solid (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Relevance of the Banff Human Organ Transplant Consensus Gene Panel for Detecting Antibody and T-Cell–Mediated Rejection of Kidney Allografts - Alessia Giarraputo, Valentin Goutaudier, Blaise Robin, Annalisa Angelini, Marta Sablik, Olivier Aubert, Ivy A. Rosales, Rex N. Smith, Candice Roufosse, Benjamin Adam, Mark Haas, Robert B. Colvin, Carmen Lefaucheur, Michael Mengel, Dina Zielinski, Alexandre Loupy Kidney Int Reports
  Tissue-based gene expression profiling can detect disease before it is visible from histology; more precisely capture disease activity, stage, and degree of injury; and has been shown to improve histology-based diagnosis of antibody-mediated rejection (AMR) and T-cell-mediated rejection (TCMR) (…) (Kidney International Reports (2024))
• 00:00
  Response to “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition”: Still a Long Way to Go - Cédric Rafat, Laurent Mesnard, Yosu Luque Kidney Int Reports
  We read with interest the work entitled “Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition.”1 The authors contend that postpartum patients presenting with thrombotic microangiopathy may benefit from short-term C5 inhibition. (…) (Kidney International Reports (2024))
• 00:00
  A Multinational, Multicenter Study Mapping Models of Kidney Supportive Care Practice - Seren Marsh, Amanda Varghese, Charlotte M. Snead, Barnaby D. Hole, Daniel V. O’Hara, Neeru Agarwal, Elizabeth Stallworthy, Fergus J. Caskey, Brendan J. Smyth, Kathryn Ducharlet Kidney Int Reports
  Kidney supportive care (KSC) integrates kidney and palliative care to improve quality of life for people with chronic kidney disease (CKD). Despite increasing interest and global advocacy to integrate KSC into kidney care, evidence to guide optimal care delivery is limited. (Kidney International Reports (2024))

2 mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis - Jeremy Puthumana, Nicolas Chong Lugon, Yunshan Xu, Yanhong Deng, Pramod K. Mistry, Chirag R. Parikh, TRIBE-AKI Consortium Kidney Int Reports
  Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis and is associated with significant mortality.1-3 The most common causes of AKI in these patients are prerenal azotemia, acute tubular necrosis (ATN), and hepatorenal syndrome (HRS), and accurate (…) (Kidney International Reports (2024))

1er mai

Kidney Int Reports http://www.kireports.org/

• 00:00
  Endothelial Dysfunction Biomarkers and CKD Incidence in the REGARDS Cohort - Samuel A.P. Short, Katherine Wilkinson, D. Leann Long, Deidra C. Crews, Orlando M. Gutierrez, Marguerite R. Irvin, Marsha Wheeler, Mary Cushman, Katharine L. Cheung Kidney Int Reports
  Chronic kidney disease (CKD) is only partly caused by traditional risk factors. Endothelial dysfunction is common in CKD and may contribute to CKD incidence. We studied the association of circulating biomarkers reflecting endothelial dysfunction with incident CKD. (Kidney International Reports (2024))

30 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Spectrum of Kidney Biopsy Findings Associated With Methamphetamine Use - Hae Yoon Grace Choung, Cynthia C. Nast, Mark Haas, Mercury Lin, Michifumi Yamashita, Jean Hou Kidney Int Reports
  Methamphetamine (METH) is one of the most used drugs of abuse worldwide. However, there are few reports and series examining the toxic kidney effects of METH, and associated histopathological changes are not well-described. (Kidney International Reports (2024))

29 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Corrigendum to “WCN24-1897 MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE AND MONOCLONAL IMMUNOGLOBULIN RELATED KIDNEY DAMAGE IN B-CELL MALIGNANCIES: THE REAL CLINICAL PRACTICE” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S624-S625] - Elena Zakharova, Anastasia Zykova, Ekaterina Stolyarevich, Olga Vorobyeva Kidney Int Reports
  The authors regret that the figures published in the above abstract were incorrect. The figures and legends are correctly listed here. (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1267 EMPAGLIFLOZIN IMPROVES VITALITY AND PROTECT FROM ADVANCED GLYCATION END PRODUCTS IN ENDOTHELIAL CELLS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S637] - Pietro Iulianiello, Davide Viggiano, Margherita Borriello, Rashmi Joshi, Alessandra Perna, Diego Ingrosso, Angela Vastante Kidney Int Reports
  The authors regret that the names of the authors were published in the wrong sequence. The correct sequence is listed below. In addition, the corresponding author should have been Davide Viggiano. (Kidney International Reports (2024))

26 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Glomerular Hypertrophy and Initial Dip in Estimated Glomerular Filtration Rate Following Dapagliflozin Administration - Akihiro Shimizu, Nobuo Tsuboi, Takaya Sasaki, Kotaro Haruhara, Kei Matsumoto, Hiroyuki Ueda, Shinya Yokote, Masahiro Okabe, Saeko Hatanaka, Masato Ikeda, Takashi Yokoo Kidney Int Reports
  The renoprotective effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, independent of their hypoglycemic actions, have attracted considerable attention in recent years.1-4 Treatment with SGLT-2 inhibitors is accompanied by an acute reduction in the estimated glomerular filtration rate (…) (Kidney International Reports (2024))
• 00:00
  Living with Atypical Hemolytic Uremic Syndrome in the Netherlands: Patient and Family Perspective - Romy N. Bouwmeester, Leonie J. Engel, Wim Altena, Caroline Renette, Clim van Daelen, Evy van Kempen, Renée de Wildt, Nicole C.A.J. van de Kar Kidney Int Reports
  Atypical hemolytic uremic syndrome (aHUS) poses a significant health challenge due to its rarity and severity within the spectrum of thrombotic microangiopathy. Despite efforts to optimize and personalize health care for patients with aHUS, understanding the individual experiences, needs, and (…) (Kidney International Reports (2024))
• 00:00
  Efficacy and Safety of Lumasiran in Patients With Primary Hyperoxaluria Type 1: Results from a Phase III Clinical Trial - Jeffrey M. Saland, John C. Lieske, Jaap W. Groothoff, Yaacov Frishberg, Hadas Shasha-Lavsky, Daniella Magen, Shabbir H. Moochhala, Eva Simkova, Martin Coenen, Wesley Hayes, Julien Hogan, Anne-Laure Sellier-Leclerc, Richard Willey, John M. Gansner, Sally-Anne Hulton Kidney Int Reports
  Patients with primary hyperoxaluria type 1 (PH1), a genetic disorder associated with hepatic oxalate overproduction, frequently experience recurrent kidney stones and worsening kidney function. Lumasiran is indicated for the treatment of PH1 to lower urinary and plasma oxalate (POx). (Kidney International Reports (2024))

25 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Social Deprivation and Incidence of Pediatric Kidney Failure in France - Bénédicte Driollet, Cécile Couchoud, Justine Bacchetta, Olivia Boyer, Julien Hogan, Denis Morin, François Nobili, Michel Tsimaratos, Etienne Bérard, Florian Bayer, Ludivine Launay, Karen Leffondré, Jérôme Harambat Kidney Int Reports
  Approximately 8 per million children and young adults aged < 20 years initiate kidney replacement therapy (KRT) per year in France. We hypothesize that social deprivation could be a determinant of childhood-onset kidney failure. The objective of this study was to estimate the incidence of (…) (Kidney International Reports (2024))
• 00:00
  Exploring Potential Gender-Based Disparities in Referral for Transplant, Activation on the Waitlist and Kidney Transplantation in a Canadian Cohort - Amanda J. Vinson, Aran Thanamayooran, Karthik K. Tennankore, Bethany J. Foster Kidney Int Reports
  In the United States, women are less likely to be referred, activated on the waitlist, or undergo kidney transplant (KT) than men; contemporary Canadian data regarding access to transplant for women are lacking. (Kidney International Reports (2024))

24 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Prognostication After Dialysis Withdrawal - Sarah So, Kelly Chen Lei Li Kidney Int Reports
  Dialysis withdrawal represents an increasingly common cause of death in patients receiving kidney replacement therapy internationally. Prognostic information about stopping dialysis guides clinicians counseling patients and families regarding end-of-life care. However, few studies examine (…) (Kidney International Reports (2024))
• 00:00
  Infectious Disease Prophylaxis During and After Immunosuppressive Therapy - Lorne Schweitzer, Benjamin A. Miko, Marcus R. Pereira Kidney Int Reports
  Immune-mediated renal diseases are a diverse group of disorders caused by antibody, complement, or cell-mediated autosensitization. Although these diseases predispose to infection on their own, a growing array of traditional and newer, more targeted immunosuppressant medications are used to (…) (Kidney International Reports (2024))
• 00:00
  Donor-Derived Hereditary Renal Hypouricemia - Shabna Sulaiman, Satish Balan, K.N. Gopika, Benil Hafeeq, Raja Ramachandran, Feroz Aziz, M. Nisha, Ranjit Narayanan, Jyotish Gopinathan, Arvind Krishnakumar, Shafeeque Rahman Kidney Int Reports
  Renal hypouricemia (RHUC) results from disease causing variations in urate transporter genes, notably URAT1/SLC22A12 and GLUT9 /SLC2A9, impairing tubular uric acid transport.1 Although mostly asymptomatic, 10% of patients are susceptible to exercise-induced acute kidney injury and/or (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Clinicopathologic Features of Kidney Disease in Patients With Cystic Fibrosis - Tiffany N. Caza, Patrick D. Walker Kidney Int Reports
  Extrapulmonary complications of cystic fibrosis (CF) occur in nearly all adults living with the disease and renal manifestations are no exception. Data from the Cystic Fibrosis Foundation registry showed that chronic kidney disease increases with age in patients with CF, nearly doubling every (…) (Kidney International Reports (2024))

23 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Myeloperoxidase-Associated Membranous Nephropathy in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis - Kenta Tominaga, Etsuko Toda, Kazuhiro Takeuchi, Shoichiro Takakuma, Emi Sakamoto, Hideaki Kuno, Yusuke Kajimoto, Yasuhiro Terasaki, Shinobu Kunugi, Mika Terasaki, Hiroyasu Goto, Toshihiko Imakiire, Naoki Oshima, Akira Shimizu Kidney Int Reports
  Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) is characterized by pauci-immune crescentic GN. Myeloperoxidase ANCA-associated GN (MPO-ANCA GN) with membranous nephropathy (MN), where bright granular capillary MPO and IgG staining along the glomerular basement (…) (Kidney International Reports (2024))

18 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Corrigendum to “WCN24-1675 ACUTE NECROTIZING ULCERATIVE GENGIVITIS IN KIDNEY TRANSPLANTATION: A CASE REPORT” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S473] - KLEBSON FELLIPE FEIJÓ DE MELO, MARCLEBIO DOURADO, DIOGO CABRAL, LARISSA ANDRADE, GILBERTO FILHO Kidney Int Reports
  DOI of original article: https://doi.org/10.1016/j.ekir.2024.02.994 (Kidney International Reports 9, 6 (2024))

17 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Derangement in Nicotinamide Adenine Dinucleotide Metabolism is Observed During Acute Kidney Injury Among Male Agricultural Workers at Risk for Mesoamerican Nephropathy - Nathan H. Raines, Dominic A. Leone, Juan Jose Amador, Damaris Lopez-Pilarte, Oriana Ramírez-Rubio, Iris S. Delgado, Lauren J. Francey, Jessica H. Leibler, John M. Asara, Madeleine K. Scammell, Samir M. Parikh, Daniel R. Brooks, David J. Friedman Kidney Int Reports
  Mesoamerican nephropathy (MeN) is a chronic kidney disease (CKD) which may be caused by recurrent acute kidney injury (AKI). We investigated urinary quinolinate-to-tryptophan ratio (Q/T), a validated marker of nicotinamide adenine dinucleotide (NAD+) biosynthesis that is elevated during ischemic (…) (Kidney International Reports (2024))
• 00:00
  Corrigendum to “WCN24-1065 QUALITY INDICATORS IN PERITONEAL DIALYSIS IN A CLINIC FROM FLORIANÓPOLIS, SANTA CATARINA, BRAZIL” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S586] - Joeci A. Jacobowski, Jocelaine B. Rodrigues, Leonora Ramlow Leodoro da Silva, João Antônio Ramlow Leodoro da Silva Kidney Int Reports
  DOI of original article: https://doi.org/10.1016/j.ekir.2024.02.1230 (Kidney International Reports 9, 6 (2024))
• 00:00
  Erratum to “WCN24-966 THE EFFECT OF HOME-BASED TELE-EXERCISE ON ANEMIA IN PERITONEAL DIALYSIS PATIENTS: A RANDOMIZED CONTROLLED TRIAL” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S584] - Mohammad Ali Tabibi, Nasrin Salimian, Farzad Nazemi, Mahsa Soleymany, Saghar Ahmadi Kidney Int Reports
  DOI of original article: https://doi.org/10.1016/j.ekir.2024.02.1225 (Kidney International Reports 9, 6 (2024))
• 00:00
  Corrigendum to “WCN24-319 EFFICACY OF THERAPY WITH DOUBLE PLASMA MOLECULAR ADSORPTION SYSTEM IN SEVERE ACUTE LIVER INJURY SECONDARY TO CYTOMEGALOVIRUS: CASE REPORT” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S523-S524] - MAIKOALEJANDRO MAIKO ALEJANDRO, ANNIA AGUILAR LOAYZA, JUAN FERNANDOMAMANI OCHOA, GILKA ELIZABETH VARGAS LOPEZ Kidney Int Reports
  DOI of original article: https://doi.org/10.1016/j.ekir.2024.02.1095 (Kidney International Reports 9, 6 (2024))
• 00:00
  Corrigendum to “WCN24-2216 Clinical-surgical parameters in patients with arteriovenous fistulas failure in SERMESA’S nephrological centers during 2022” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S411] - Yorwell Alberto Baltodano Caldera, Pablo Lorío Kidney Int Reports
  DOI of original article: https://doi.org/10.1016/j.ekir.2024.02.858 (Kidney International Reports 9, 6 (2024))
• 00:00
  Corrigendum to “WCN24-843 ULTRAPROCESSED FOODS: DETERMINANTS AND RELATIONSHIP WITH BIOCHEMICAL PARAMETERS IN CHRONIC HEMODIALYSIS PATIENTS” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S371] - FABIANA NERBASS, ANDREA SCZIP, JYANA MORAIS, ADAIANE CALEGARI, TATIANA KRUGER, JORGIANE OLIVEIRA, NATÁLIA SCATONE, RAFAELA DOS SANTOS, FELLYPE BARRETO Kidney Int Reports
  DOI of original article: https://doi.org/10.1016/j.ekir.2024.02.776 (Kidney International Reports 9, 6 (2024))
• 00:00
  Corrigendum to “WCN24-2221 NEPHROCALCINOSIS AND LOWER LIMBS TISSUE NECROSIS DUE TO CALCIUM OXALATE DEPOSITS IN A 24-YEAR-OLD PATIENT WITH STAGE 5 CHRONIC KIDNEY DISEASE” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Pages S656-S657] - Sofia Angulo, Luis Ivan Garcia Gutierrez Kidney Int Reports
  We regret that the above abstract case report text was incomplete. This is now listed below. We apologize for any inconvenience caused. (Kidney International Reports 9, 6 (2024))

16 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Ex vivo C5b-9 Deposition Test to Monitor Complement Activity in Clinical and Subclinical Atypical Hemolytic Uremic Syndrome and in Transplantation-Associated Thrombotic Microangiopathy - Maria Martin, Carmen Llorens-Cebria, Juan León-Román, Janire Perurena-Prieto, Víctor Perez-Beltran, Silvia Saumell, Irina B. Torres, Irene Agraz, Joana Sellarès, Natàlia Ramos, Oriol Bestard, Mercedes López, Francesc Moreso, Gema Ariceta, Maria José Soler, Manuel Hernandez-Gonzalez, Conxita Jacobs-Cachá Kidney Int Reports
  Atypical hemolytic uremic syndrome (aHUS) is a complement system (CS)–mediated ultrarare disease that manifests as thrombotic microangiopathy (TMA) with preferential small kidney vessels involvement. Transient CS activation is also observed in secondary TMA or in patients at risk of developing (…) (Kidney International Reports (2024))
• 00:00
  Emerging Therapies for Familial Lecithin-Cholesterol Acyltransferase Deficiency: A Role for Plasma Exchange - Aruni Ratnayake, Marta Turri, Laura Calabresi, Chiara Pavanello, Adam McLean, Anisha Tanna, Jaimini Cegla, Ben Jones, Neill Duncan Kidney Int Reports
  Familial lecithin-cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare disorder of lipid metabolism causing decreased maturation of high density lipoprotein particles and impaired cholesterol esterification.1 Patients with FLD develop corneal opacification, hemolytic anemia, (…) (Kidney International Reports (2024))

15 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Randomized Controlled Trial of Intradialytic Cognitive and Physical Training to Enhance Functional Capacity - Špela Bogataj, Maja Pajek, Aljaž Kren, Katja Kurnik Mesari?, Jernej Pajek Kidney Int Reports
  Hemodialysis (HD) patients frequently experience cognitive and physical impairments due to various factors, including age, comorbidities, and the demanding nature of the treatment. This study explores the impact of a 12 week integrated cognitive and physical training program on the functional (…) (Kidney International Reports (2024))
• 00:00
  A Novel Monoallelic ALG5 Variant Causing Late-onset ADPKD and Tubulointerstitial Fibrosis - Elhussein A.E. Elhassan, Tereza Kmochová, Katherine A. Benson, Neil K. Fennelly, Veronika Barešová, Kendrah Kidd, Brendan Doyle, Anthony Dorman, Martina M. Morrin, Niamh C. Kyne, Petr Vyle?al, Hana Hartmannová, Kate?ina Hoda?ová, Jana Sovová, Dita Mušálková, Alena Vrbacká, Anna P?istoupilová, Jan Živný, Klára Svojšová, Martin Radina, Viktor Stránecký, Dmitry Loginov, Petr Pompach, Petr Novák, Zdislava Vaní?ková, Hana Hansíková, Silvie Rajnochová-Bloudí?ková, Ond?ej Viklický, Helena H?lková, Gianpiero L. Cavalleri, Aleš Hnízda, Anthony J. Bleyer, Stanislav Kmoch, Peter J. Conlon, Martina Živná Kidney Int Reports
  Monoallelic variants in the ALG5 gene encoding asparagine-linked glycosylation protein 5 homolog (ALG5) have been recently shown to disrupt polycystin-1 (PC1) maturation and trafficking via underglycosylation, causing an autosomal dominant polycystic kidney disease-like (ADPKD-like) phenotype (…) (Kidney International Reports (2024))
• 00:00
  The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study - Weiwei Kong, Xiaoying Wu, Zhuowei Shen, Meifang Wang, Xinyu Liu, Xiaoli Lin, Yingyin Qiu, Hong Jiang, Jianghua Chen, Yan Lou, Hongfeng Huang Kidney Int Reports
  Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor, can stimulate erythropoiesis. Our objective was to evaluate the efficacy and safety of roxadustat for the treatment of posttransplantation anemia (PTA). (Kidney International Reports 9, 6 (2024))
• 00:00
  Sex/Gender Disparities in Preemptive Referrals for Kidney Transplantation - Jessica L. Harding, Annika Gompers, Mengyu Di, Kelsey Drewery, Stephen Pastan, Ana Rossi, Derek DuBay, Jennifer C. Gander, Rachel E. Patzer Kidney Int Reports
  Sex/gender inequities persist in access to kidney transplantation. Whether differences in preemptive referral (i.e., referral before dialysis start) explain this inequity remains unknown. (Kidney International Reports (2024))
• 00:00
  Outcomes of Early Versus Delayed Anemia Treatment in Nondialysis-Dependent CKD - Kouji Kawai, Manabu Ishii, Yoshimasa Kokado, Takashi Horikawa, Junichi Hoshino Kidney Int Reports
  The association of hemoglobin level at treatment initiation with renal and cardiovascular outcomes in patients with anemia in nondialysis-dependent (NDD) chronic kidney disease (CKD) is unclear. (Kidney International Reports (2024))

13 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Thrombotic Microangiopathy as an Emerging Complication of Viral Vector–Based Gene Therapy - Nora Schwotzer, Carine El Sissy, Isabelle Desguerre, Véronique Frémeaux-Bacchi, Laurent Servais, Fadi Fakhouri Kidney Int Reports
  Gene therapy has brought tremendous hope for patients with severe life-threatening monogenic diseases. Although studies have shown the efficacy of gene therapy, serious adverse events have also emerged, including thrombotic microangiopathy (TMA) following viral vector–based gene therapy. In this (…) (Kidney International Reports (2024))
• 00:00
  Rethinking Blood Pressure Management in Children Receiving Maintenance Hemodialysis - Edward Nehus, Mark Mitsnefes Kidney Int Reports
  Hypertension is a well-known complication of children on maintenance dialysis. Reports over the past 3 decades demonstrate a prevalence of hypertension at 50% to 75%. Similarly, the prevalence of left ventricular hypertrophy (LVH), the most common cardiac abnormality in children on maintenance (…) (Kidney International Reports 9, 6 (2024))

11 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Enhancing Disaster Preparedness in Peritoneal Dialysis Care - Tuncay Sahutoglu, Rumeyza Kazancioglu Kidney Int Reports
  Earthquakes, as capricious acts of nature, pose substantial threats to both human life and infrastructure.1 The recent twin earthquakes that struck southern Turkey in 2023 serve as stark reminders of the devastating potential of such events.2 Their aftermath extends well beyond immediate (…) (Kidney International Reports (2024))
• 00:00
  Hypoxia-Inducible Factor Stabilizers: an Evolving Role in Post-Transplant Anemia - Steven Fishbane, Ross Jude Cimagala, Volker H. Haase Kidney Int Reports
  In this edition of the journal, Kong et al.1 report on a study of the hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), roxadustat, for the treatment of post-transplant anemia. After kidney transplantation, anemia is common, although the incidence varies in relation to clinical (…) (Kidney International Reports 9, 6 (2024))

7 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Response to Letter to the Editor From Bouwmeester RN et al.: “Eculizumab in Postransplant TMA: Unproven Benefit.” - Federica Maritati, Gaetano La Manna, Giorgia Comai Kidney Int Reports
  We would like to thank Dr. Bouwmeester and colleagues for their critical analysis of our article titled “Eculizumab first” in the Management of Posttransplant Thrombotic Microangiopathy.1 In their letter, authors affirm that eculizumab does not appear instrumental in the improvement of graft (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Eculizumab in Posttransplant TMA: Unproven Benefit - Romy N. Bouwmeester, Jack F.M. Wetzels, Nicole C.A.J. van de Kar Kidney Int Reports
  In their retrospective study, Maritati et al.1 advocate “eculizumab first” in patients with posttransplant thrombotic microangiopathy (PT-TMA). A critical analysis indicates that the data do not provide evidence to suggest that the use of eculizumab was instrumental in the improvement of graft (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation - Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçac?o?lu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, European Society for Paediatric Nephrology Transplantation and CKD-MBD working groups and the Cooperative European Paediatric Renal Transplant Initiative Research Network Kidney Int Reports
  We investigated the relationship between metabolic acidosis over time and allograft outcome in pediatric kidney transplantation (KTx). (Kidney International Reports 9, 6 (2024))

6 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Corrigendum to “An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD” [Kidney International Reports Volume 9, Issue 2, February 2024, Pages 249-256] - Jonathan Taylor, Richard Thomas, Peter Metherall, Marieke van Gastel, Emilie Cornec-Le Gall, Anna Caroli, Monica Furlano, Nathalie Demoulin, Olivier Devuyst, Jean Winterbottom, Roser Torra, Norberto Perico, Yannick Le Meur, Sebastian Schoenherr, Lukas Forer, Ron T. Gansevoort, Roslyn J. Simms, Albert C.M. Ong Kidney Int Reports
  The authors regret that there was an error in co-author name Marieke van Gastel, which should have been published as Maatje D.A. van Gastel. (Kidney International Reports 9, 6 (2024))

5 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Four Cases of Kidney Transplants With Donor HCV-Derived Immune Complex Glomerulonephritis - Jae-Hyung Chang, Satoru Kudose, Sami Droubi, Hector A. Verduzco, Jeremy Awori, Lloyd E. Ratner, Sumit Mohan Kidney Int Reports
  Although outcomes from hepatitis C virus (HCV)-positive and HCV-negative donor kidneys are comparable in the short term, questions remain about the clinical consequences of preexisting HCV-related kidney injury, which may go undetected at the time of organ procurement.1-5 We previously reported (…) (Kidney International Reports 9, 6 (2024))

4 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Renal Response Criteria for Clinical Trials in Amyloid Light Chain Amyloidosis - Nelson Leung, Raymond Comenzo, Julian Gillmore, Andrea Havasi, Efstathios Kastritis, Spencer Guthrie, James Signorovitch, Dena Heath, Isabelle Lousada, Amyloidosis Forum Working Group Participants Kidney Int Reports
  Immunoglobin light chain (AL) amyloidosis is a rare disease characterized by organ deposition of amyloid fibrils, most commonly in the heart and kidney. Disease heterogeneity necessitates organ-specific assessment to determine prognosis and response or progression. To facilitate development of (…) (Kidney International Reports (2024))
• 00:00
  NephroConnect: Patterns, Preferences, Barriers, and Potentials in the Global Nephrology Community’s Social Media Landscape - Sibel G. Bek, Sabine Karam, Daniel P. Murphy, José A. Moura-Neto, Sibel Balc?, Mohammed A. Gawad, Rolando Claure-Del Granado, Namrata Parikh, Basu Gopal, Manju Yadla, Elliot Tannor, Yannick Nlandu, Didem Turgut, Xavier V. Parada, Ahmed Akl, Augusto Cesar Soares dos Santos Junior, Fernanda Arce-Amare, Urmila Anandh, Edgar Lerma, Jyoti Baharani Kidney Int Reports
  In today’s world, the internet has undoubtedly transformed the world into a small village with nearly 66% of its population having access to the World Wide Web.1 In the past few years, social media platforms have assumed an important role, representing a major reason for which the global (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Toolkit on Creating a Young Nephrologists Committee: An ISN Young Nephrologists Committee Project to Empower Young Nephrologists Worldwide - Nikolay Bulanov, Iman Alshamsi, Alexandra Cambier, Jonathan S. Chávez-Iñiguez, Miguel Gallardo, Charu Malik, Ahad Qayyum, Anim Shah, Marina Wainstein, Aldjia Hocine, Marco Montomoli, Ailish Nimmo, Matthew Rowlandson, Elliot K. Tannor, Khalida Soki, Bianca Davidson, Sabine Karam Kidney Int Reports
  Young nephrologists constitute a significant proportion of the nephrology workforce worldwide and represent the future of our battle to mitigate the annually growing burden of kidney disease.1 Unfortunately, they often face challenges related to unmet needs of the early-career nephrologists in (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Combined Rituximab and Daratumumab Treatment in Difficult-to-Treat Nephrotic Syndrome Cases - Andrea Angeletti, Sofia Bin, Xhuliana Kajana, Sonia Spinelli, Carolina Bigatti, Gianluca Caridi, Giovanni Candiano, Francesca Lugani, Enrico E. Verrina, Edoardo La Porta, Alberto Magnasco, Maurizio Bruschi, Paolo Cravedi, Gian Marco Ghiggeri Kidney Int Reports
  Idiopathic nephrotic syndrome (NS) is characterized by severe proteinuria, hypoalbuminemia, and/or edema and affects about 1 to 3 per 100,000 children and young adults.1 Corticosteroids represent the first line therapy for primary NS, leading to disease remission in 70% to 80% of cases.2 (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Deep Learning–Based Automated Imaging Classification of ADPKD - Youngwoo Kim, Seonah Bu, Cheng Tao, Kyongtae T. Bae, HALT Polycystic Kidney Disease Study Group Kidney Int Reports
  The Mayo imaging classification model (MICM) requires a prestep qualitative assessment to determine whether a patient is in class 1 (typical) or class 2 (atypical), where patients assigned to class 2 are excluded from the MICM application. (Kidney International Reports 9, 6 (2024))

3 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem - Michael Eder, Tarek A. Schrag, Ella F. Havel, Alexander Kainz, Haris Omic, Konstantin Doberer, Nicolas Kozakowski, Günther F. Körmöczi, Marlies Schönbacher, Gottfried Fischer, Robert Strassl, Monika Breuer, Lukas Weseslindtner, Frederik Haupenthal, Georg A. Böhmig, Elisabeth Puchhammer-Stöckl, Gregor Bond, Irene Görzer, Farsad Eskandary Kidney Int Reports
  Earlier reports suggest that patients after ABO-incompatible kidney transplantation (ABOi) are at enhanced risk of developing BK-virus (BKV, also known as BK polyomavirus [BKPyV]) nephropathy (BKPyVAN). It remains elusive whether this is a result of more intense immunosuppression or an (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  The Effect of Randomized Beta-Carotene Supplementation on CKD in Men - Api Chewcharat, Pol Chewcharat, Kathryn M. Rexrode, Robert J. Glynn, Julie E. Buring, John Michael Gaziano, Howard D. Sesso Kidney Int Reports
  Beta-carotene (BC) protects the body against free radicals that may damage the kidney and lead to the development of acute kidney injury and chronic kidney disease (CKD). Previous studies in animal models have demonstrated a potential protective effect of 30 mg/kg BC supplementation on renal (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Global Validation of a Model to Predict Reduced Estimated GFR in People With Type 2 Diabetes Without Diagnosis of CKD - Camilla Sammut-Powell, Rose Sisk, Estefania Vazquez-Mendez, Hardik Vasnawala, Susana Goncalves, Mark Edge, Rory Cameron Kidney Int Reports
  A minimal-resource model for predicting reduced kidney function among people with type 2 diabetes and no diagnosis of chronic kidney disease (CKD) stages 3 to 5 was previously developed in a UK population to pre-screen for undiagnosed CKD. This study aims to evaluate the performance of the model (…) (Kidney International Reports (2024))
• 00:00
  Diagnostic Yield of APOL1 p.N264K Variant Screening in Daily Practice - Céline Narjoz, Vinh-Hoang-Lan Julie Tran, Marion Rabant, Alexandre Karras, Nicolas Pallet Kidney Int Reports
  Large American cohorts of individuals of African ancestry have demonstrated a strong protective effect of the p.N264K variant of APOL1 on the risk of chronic kidney disease, focal segmental glomerulosclerosis, and end-stage kidney disease.1,2 This variant is only effective in the presence of the (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Etelcalcetide use During Maintenance Hemodialysis and Incidence of Parathyroidectomy After Kidney Transplantation - Philippe Delaey, Arnaud Devresse, Johann Morelle, Danai Faitatzidou, Miren Iriarte, Nada Kanaan, Antoine Buemi, Michel Mourad, Tom Darius, Eric Goffin, Michel Jadoul, Laura Labriola, CUSL Kidney Transplantation Network Collaborators Kidney Int Reports
  Etelcalcetide is an i.v. calcimimetic agent, effectively reducing parathyroid hormone levels in patients on maintenance hemodialysis (HD). The clinical impact of discontinuing etelcalcetide at the time of kidney transplantation is unknown. (Kidney International Reports (2024))

2 avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy - Dana Kim, Jicheng Lv, Michelle Hladunewich, Vivekanand Jha, Lai Seong Hooi, Helen Monaghan, Sana Shan, Heather N. Reich, Sean Barbour, Laurent Billot, Hong Zhang, Vlado Perkovic, Muh Geot Wong, TESTING trial steering committee Kidney Int Reports
  The therapeutic effects of steroids in immunoglobulin A nephropathy (IgAN) global (TESTING) study reported that methylprednisolone reduces the risk of major kidney events in individuals with IgAN at high risk of disease progression compared to supportive care alone but is associated with (…) (Kidney International Reports (2024))
• 00:00
  Advances of Iron and Ferroptosis in Diabetic Kidney Disease - Jiayi Chu, Kewu Wang, Lulu Lu, Hui Zhao, Jibo Hu, Wenbo Xiao, Qian Wu Kidney Int Reports
  Diabetes mellitus presents a significant threat to human health because it disrupts energy metabolism and gives rise to various complications, including diabetic kidney disease (DKD). Metabolic adaptations occurring in the kidney in response to diabetes contribute to the pathogenesis of DKD. (…) (Kidney International Reports (2024))

1er avril

Kidney Int Reports http://www.kireports.org/

• 00:00
  The Lectin Pathway–A Dominant Pattern of the Complement System Activation in Primary Focal Segmental Glomerulosclerosis? - Nikola Zagorec, Ivica Horvati?, Petar Šenjug, Slavica Sovi?, Krešimir Galeši?, Danica Galeši? Ljubanovi? Kidney Int Reports
  We read with a big interest article by Cambier et al.1 reporting significantly elevated urine levels of C5b-C9 and C5a in individuals with focal segmental glomerulosclerosis (FSGS), indicating the role of the complement system activation in disease pathogenesis. We can not only confirm the role (…) (Kidney International Reports 9, 6 (2024))

29 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Unraveling the Role of Complement in Focal Segmental Glomerulosclerosis Pathogenesis: Insights and Challenges - Alexandra Cambier, Natacha Patey, Virginie Royal, François Gougeon, Dominique S. Genest, Soumeya Brachemi, Guillaume Bollée, Clémence Merlen, Arnaud Bonnefoy, Anne-Laure Lapeyraque, Stéphan Troyanov Kidney Int Reports
  We thank Dr Zagorec et al. for their interest in our study and for adding additional patient data supporting a plausible role for complement activation in the pathogenesis of focal segmental glomerulosclerosis (FSGS). Immunofluorescence and immunohistochemistry are invaluable in assessing (…) (Kidney International Reports 9, 6 (2024))

28 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Challenging the Restrictive Approach: Reconsidering Sodium-Glucose Transport Protein 2 Inhibitor Use in CKD - Ozant Helvaci, Emre Yasar, Bur?ak Helvaci Kidney Int Reports
  We have read with interest the review by Tarun et al.1 titled “updates on new therapies for patients with chronic kidney disease (CKD),” which provides a comprehensive discussion of new treatment options for CKD. Although we appreciate the thoroughness of the authors' work, we wish to raise some (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Letter to the editor about: “Eculizumab First” in the Management of Posttransplant Thrombotic Microangiopathy - Simon Ville, Leo Drapeau, Jean Paraire, Mehdi Maanaoui, Marie Frimat Kidney Int Reports
  We read with interest the article by Maritati et al.1 describing their experience with eculizumab in the treatment of very early posttransplant thrombotic microangiopathy. The reported incidence of almost 10% is remarkably high and prompted us to look more closely. Diagnosing thrombotic (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Townes-Brocks Syndrome Revealed by Kidney Gene Panel Testing - Quinn Stein, Anna Vostrizansky, Yelena Magay, Sara Jandeska, Maggie Westemeyer, Emily Hendricks, Tessa Pitman, Meg M. Hager, Akash Anand, Kathryn Curry, Michelle Bloom, Nour Al Haj Baddar, Hossein Tabriziani, Melisa Harrington, Sumit Punj Kidney Int Reports
  Townes-Brocks syndrome (TBS), a rare autosomal dominant genetic condition associated with SALL1 (Spalt like Transcription Factor 1), is reported to be present in 1:238,000 individuals in the general population. TBS is characterized by the triad of anorectal malformations, dysplastic ears, with (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Best Practice of Peritoneal Dialysis-Associated Gram-Negative Peritonitis in Children: Insights From the International Pediatric Peritoneal Dialysis Network Registry - Dagmara Borzych-Du?a?ka, Rebeca Same, Alicia Neu, Hui Kim Yap, Enrico Verrina, Sevcan A. Bakkaloglu, Francisco Cano, Hiren Patel, Maria Szczepa?ska, ?ukasz Obrycki, Ana Paula Spizzirri, Lisa Sartz, Karel Vondrak, Anabella Rebori, Gordana Milosevski-Lomic, Eugene Yu-hin Chan, Biswanath Basu, Andrea Lazcano Pezo, Ariane Zaloszyc, Vimal Chadha, Franz Schaefer, Bradley A. Warady Kidney Int Reports
  Gram-negative peritonitis (GNP) is associated with significant morbidity in children receiving long-term peritoneal dialysis (PD) and current treatment recommendations are based on limited data. (Kidney International Reports 9, 6 (2024))
• 00:00
  The Promise of Metabolomics and Exposomics in CKDu - Nathan H. Raines, Enrique Ivan Rodriguez Garcia Kidney Int Reports
  Chronic kidney disease of unknown cause (CKDu, also called Mesoamerican nephropathy) is a form of nondiabetic, nonhypertensive CKD most often described in impoverished agricultural communities. The strongest evidence to date indicates that heat stress is an important factor in the pathogenesis (...) (Kidney International Reports 9, 5 (2024))

27 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Response to [Challenging the Restrictive Approach: Reconsidering SGLT-2 Inhibitor Use in CKD] - Tushar Tarun, Otis M. Davis, Sai N. Ghanta, Nishank Jain Kidney Int Reports
  Dear editors, we would like to respond to the questions raised by Helvaci et al.1 regarding the beneficial effects of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in the absence of renin-angiotensin-aldosterone system inhibitors (RAASi) and in the absence of albuminuria when estimated (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Response to Letter to the Editor From Ville S. et al. About: “Eculizumab First” in the Management of Posttransplant Thrombotic Microangiopathy - Federica Maritati, Gaetano La Manna, Giorgia Comai Kidney Int Reports
  We would like to thank Ville et al. for showing interest in our article1 titled “Eculizumab First” in the management of posttransplant thrombotic microangiopathy (TMA), by allowing us to better clarify more findings from our experience. (Kidney International Reports 9, 6 (2024))

26 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Indoxyl Sulfate Contributes to Impaired Height Velocity in (Pre)School Children - Evelien Snauwaert, Stefanie De Buyser, Wim Van Biesen, Ann Raes, Griet Glorieux, Laure Collard, Koen Van Hoeck, Maria Van Dyck, Nathalie Godefroid, Johan Vande Walle, Sunny Eloot Kidney Int Reports
  Growth failure is considered the most important clinical outcome parameter in childhood chronic kidney disease (CKD). Central to the pathophysiology of growth failure is the presence of a chronic proinflammatory state, presumed to be partly driven by the accumulation of uremic toxins. In this (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Association of Calcium Channel Blocker Use With Intradialytic Hypotension in Maintenance Hemodialysis - Armida Lefranc Torres, Simon Correa, Finnian R. Mc Causland Kidney Int Reports
  Calcium channel blockers (CCBs) are common antihypertensive agents among patients receiving hemodialysis (HD). Despite this, the association of CCBs with intradialytic hypotension (IDH), an important adverse outcome that is associated with cardiovascular morbidity and mortality, remains largely (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Prospective Study of Change in Skin Autofluorescence Over Time and Mortality in People Receiving Hemodialysis - Daniela Viramontes-Hörner, Nicholas M. Selby, Maarten W. Taal Kidney Int Reports
  Elevated skin autofluorescence (SAF), a measure of tissue accumulation of advanced glycation end products (AGEs), is a strong predictor of all-cause and cardiovascular mortality in the hemodialysis population. However, prospective studies investigating the association between changes in SAF over (…) (Kidney International Reports (2024))
• 00:00
  Real-World Experience With Avacopan in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis - Reza Zonozi, Faten Aqeel, Dustin Le, Frank B. Cortazar, Jugal Thaker, Maria Jose Zabala Ramirez, Sebastian Eduardo Sattui Cortes, Rose Mary Attieh, Madeline Chung, David H. Bulbin, Aisha Shaikh, Karina Guaman, Julia Ford, Colin Diffie, Ora Gewurz-Singer, Gabriel Sauvage, Anushya Jeyabalan, Abdallah Geara, Isabelle Ayoub, Andrew Bomback, Lara L. Khoury, Jason C. George, Kenar D. Jhaveri, Vimal Kumar Derebail, John L. Niles, Duvuru Geetha Kidney Int Reports
  Postmarketing data on outcomes of avacopan use in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) are lacking. (Kidney International Reports 9, 6 (2024))

25 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Citrate-Buffered, Magnesium-Enriched Dialysate on Calcification Propensity in Hemodialysis Patients – The CitMag Study - Daniel Cejka, Ursula Thiem, Eric Blinzler, Jennifer Machacek, Jakob Voelkl, Edward R. Smith, Andreas Pasch, Maria C. Haller Kidney Int Reports
  Serum calcification propensity (T50 time) is associated with mortality in patients on dialysis. Several solitary interventions improve T50. However, whether a combination of interventions yields further increases in T50 is unknown. We hypothesized that a combination of 2 interventions, namely (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Ironing Out the Details: How to Manage Anemia in Pregnancy in Women Living With CKD - Cristina Popa, Giorgina B. Piccoli Kidney Int Reports
  Chronic kidney disease (CKD) affects approximately 3% of pregnant women in high-income countries, and its prevalence is expected to increase due to rising maternal age, and the increasing prevalence of obesity and diabetes.1 In low and middle-income countries the prevalence of CKD is likely (...) (Kidney International Reports 9, 5 (2024))

18 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Kidney Transplantation Outcomes of Patients With Chronic Hypotension in Dialysis - Pilar Auñón, Teresa Cavero, Ana García, Jorge González, Amado Andrés Kidney Int Reports
  Persistent chronic hypotension affects 5–10% of dialysis patients. It seems to be reversible after receiving a functioning graft, but data regarding its influence on transplant outcomes are scarce. We analyze the evolution of patients with chronic hypotension in dialysis who undergo kidney (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Performance Evaluation of an Automated Peritoneal Dialysis Solution Generation System in Patients Using Automated Peritoneal Dialysis - Shuchita Sharma, Osama E. Shamy, Alyssa Wilmington, Brad Keller, Nabeel Aslam, Ha Tran, Peter Rutherford, Jaime Uribarri Kidney Int Reports
  Most patients on peritoneal dialysis (PD) in the United States are on automated PD (APD) utilizing several liters of PD solution daily for their treatment. The ordering, delivery, and storage of PD solutions can be challenging and is an important factor that can dissuade patients from doing PD. (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Inhibition of Interleukin-33 to Reduce Glomerular Endothelial Inflammation in Diabetic Kidney Disease - Alexis Hofherr, Elena Liarte Marin, Barbara Musial, Asha Seth, Tim Slidel, James Conway, David Baker, Pernille B.L. Hansen, Benjamin Challis, Stefano Bartesaghi, Maria Bhat, Roberto Pecoits-Filho, Xiao Tu, Viknesh Selvarajah, Kevin Woollard, Hiddo J.L. Heerspink Kidney Int Reports
  Inflammation is a significant contributor to cardiorenal morbidity and mortality in diabetic kidney disease (DKD). The pathophysiological mechanisms linking systemic, subacute inflammation and local, kidney injury-initiated immune maladaptation is partially understood. (Kidney International Reports 9, 6 (2024))
• 00:00
  Prospective Study of Modifiable Risk Factors of Arterial Hypertension and Left Ventricular Hypertrophy in Pediatric Patients on Hemodialysis - Dagmara Borzych-Du?a?ka, Rukshana Shroff, Bruno Ranchin, Yihui Zhai, Fabio Paglialonga, Jameela A. Kari, Yo H. Ahn, Hazem S. Awad, Reyner Loza, Nakysa Hooman, Robin Ericson, Dorota Dro?dz, Amrit Kaur, Sevcan A. Bakkaloglu, Charlotte Samaille, Marsha Lee, Stephanie Tellier, Julia Thumfart, Marc Fila, Bradley A. Warady, Franz Schaefer, Claus P. Schmitt Kidney Int Reports
  Fluid and salt overload in patients on dialysis result in high blood pressure (BP), left ventricular hypertrophy (LVH) and hemodynamic instability, resulting in cardiovascular morbidity. (Kidney International Reports 9, 6 (2024))
• 00:00
  Systematic Review of Kidney Injury Biomarkers for the Evaluation of CKD of Uncertain Etiology - Sophie E. Claudel, Sushrut S. Waikar, Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium Kidney Int Reports
  Chronic kidney disease of uncertain etiology (CKDu) is an incompletely defined phenotype of chronic kidney disease (CKD) affecting young individuals mostly in agricultural communities in Central America and South Asia. CKDu is a diagnosis of exclusion made in individuals from endemic regions. (Kidney International Reports 9, 6 (2024))

13 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Combining Patient Care and Environmental Protection: A Pilot Program Recycling Polyvinyl Chloride From Automated Peritoneal Dialysis Waste - Nathan Berman-Parks, Ilana Berman-Parks, Ismael A. Gómez-Ruíz, Juan M. Ardavin-Ituarte, Giorgina B. Piccoli Kidney Int Reports
  Dialysis produces large amounts of plastic waste, much of which is potentially recyclable, but recycling is seldom performed.1-3 This stagnant situation is expected to change, because by the end of 2024, 175 United Nations members have agreed to develop a legally binding agreement on plastic (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Risk Factors for Severe Hypertension and Proteinuria After Treatment With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors Among Patients With Cancer - Paul E. Hanna, Rajesh K. Anumolu, Shveta S. Motwani, Kevin L. Chen, Nurit Katz-Agranov, Olivia Green-Lingren, Osman A. Yilmam, Kenar D. Jhaveri, Abhijat Kitchlu, Jaya Kala, Meghan E. Sise, Shruti Gupta Kidney Int Reports
  Vascular endothelial growth factor signaling pathway inhibitors (VSPIs) treat numerous types of cancers by blocking tumor angiogenesis;1 however, they are associated with both hypertension and proteinuria. Hypertension has been reported in 20% to 90% of patients.2,3 The onset of hypertension can (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Association Between Disturbed Serum Phosphorus Levels and QT Interval Prolongation - Sho Sasaki, Kiichiro Fujisaki, Masato Nishimura, Toshiaki Nakano, Masanori Abe, Norio Hanafusa, Nobuhiko Joki Kidney Int Reports
  QT interval prolongation is a risk factor for fatal arrhythmias and other cardiovascular complications. QT interval prolongation in patients on hemodialysis (HD) is not well understood. Hypocalcemia is a suspected, but poorly verified etiology in these patients, and the association between serum (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Prospective Multicenter Study on Early Proximal Tubular Injury in COVID-19–Related Acute Respiratory Distress Syndrome - Mickaël Bobot, Xavier Heim, Howard Max, José Boucraut, Pierre Simeone, Claire Stein, Lionel Velly, Nicolas Bruder, Jean-Marie Forel, Sami Hraiech, Christophe Guervilly, Julien Carvelli, Marc Gainnier, Jean-Louis Mège, Sophie Chopinet, Noémie Jourde-Chiche, Laurent Papazian, Stéphane Burtey Kidney Int Reports
  During COVID-19, renal impairment is associated with poor prognosis in intensive care unit (ICU). We aimed to assess the existence and incidence of early renal dysfunction and its prognostic value in patients with COVID-19–related acute respiratory distress syndrome (ARDS). (Kidney International Reports 9, 6 (2024))
• 00:00
  Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure - Mahboube Ganji-Arjenaki, Zoha Kamali, International Consortium of Blood Pressure, Soroush Sardari, Martin de Borst, Harold Snieder, Ahmad Vaez Kidney Int Reports
  Blood pressure (BP) is a highly heritable trait with over 2000 underlying genomic loci identified to date. Although the kidney plays a key role, little is known about specific cell types involved in the genetic regulation of BP. (Kidney International Reports 9, 6 (2024))
• 00:00
  Longitudinal Changes in Kidney Solute Clearance in a Prospective Cohort of Patients Initiating Chronic Hemodialysis - Tammy L. Sirich, Zijian Tan, Benjamin R. Highland, Zhidong Lin, Gregory B. Russell, Mariana Murea Kidney Int Reports
  Longitudinal changes in residual kidney function have not been well-examined in patients starting chronic hemodialysis (HD). (Kidney International Reports 9, 6 (2024))
• 00:00
  Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis - Ioannis Parodis, Julius Lindblom, Daniel Toro-Domínguez, Lorenzo Beretta, Maria O. Borghi, Jessica Castillo, Elena Carnero-Montoro, Yvonne Enman, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Dionysis Nikolopoulos, PRECISESADS Clinical Consortium Kidney Int Reports
  Current therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% of patients, highlighting the urgent need for additional options. (Kidney International Reports 9, 6 (2024))
• 00:00
  Outcomes in LD70s Redefining the Limits of Kidney Donation: Insights From Living Donors Aged 70 Years and Older - Arpita Basu, Renz Michael F. Pasilan Kidney Int Reports
  Kidney transplantation has been established as the standard treatment for people with advanced kidney disease, offering superior survival benefit over remaining on dialysis. Globally, significant mismatch between those awaiting transplantation and available cadaveric organs has resulted in (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Preventing Relapses in Childhood Nephrotic Syndrome - Anna Francis, Francesco Emma Kidney Int Reports
  The majority of children with steroid-sensitive idiopathic nephrotic syndrome (SSNS) will eventually attain complete remission. Treatment balances side effects of different immunosuppressants while we await disease resolution. Rituximab decreases the risk of relapses in children with (...) (Kidney International Reports 9, 5 (2024))

9 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Evaluation of Torque Teno Virus DNA Load as a Predictive Biomarker in Kidney Transplant Recipients Converted from Calcineurin Inhibitors to Belatacept - Lara Cabezas, Aurelie Truffot, Raphaele Germi, Mathilde Bugnazet, Paolo Malvezzi, Manon Gnesotto, Lionel Rostaing, Thomas Jouve, Johan Noble Kidney Int Reports
  Belatacept is a relevant alternative to calcineurin inhibitors (CNIs) after kidney transplantation (KT). Circulating Torque Teno virus (TTV) DNA load is correlated to infections and rejection risks post-KT in patients treated with CNIs. The aim of this study was to assess the TTV DNA load (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Multiomics Assessment of the Gut Microbiome in Rare Hyperoxaluric Conditions - Nadim Zaidan, Chan Wang, Ze Chen, John C. Lieske, Dawn Milliner, Barbara Seide, Melody Ho, Huilin Li, Kelly V. Ruggles, Frank Modersitzki, David S. Goldfarb, Martin Blaser, Lama Nazzal Kidney Int Reports
  Hyperoxaluria is a risk factor for kidney stone formation and chronic kidney disease progression. The microbiome is an important protective factor against oxalate accumulation through the activity of its oxalate-degrading enzymes (ODEs). In this cross-sectional study, we leverage multiomics to (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Sex-Specific Association of Ambient Temperature With Urine Biomarkers in Southwest Coastal Bangladesh - Hoimonty Mazumder, Momenul Haque Mondol, Mahbubur Rahman, Rizwana Khan, Solaiman Doza, Leanne Unicomb, Farjana Jahan, Ayesha Mukhopadhyay, Konstantinos C. Makris, Alberto Caban-Martinez, Romaina Iqbal, Faruk Ahmed, Lota Creencia, Mohammad Shamsudduha, Fawaz Mzayek, Chunrong Jia, Hongmei Zhang, Anwar Musah, Lora E. Fleming, Xichen Mou, Csaba P. Kovesdy, Matthew O. Gribble, Abu Mohd Naser Kidney Int Reports
  Men are vulnerable to ambient heat-related kidney disease burden; however, limited evidence exists on how vulnerable women are when exposed to high ambient heat. We evaluated the sex-specific association between ambient temperature and urine electrolytes, and 24-hour urine total protein, and volume. (Kidney International Reports 9, 6 (2024))

8 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Role of Iron in Children With Immunoglobulin A Nephropathy and Macrohematuria-Induced Acute Kidney Injury - Shingo Ishimori, Tomoko Horinouchi, Tomohiko Yamamura, Junya Fujimura, Naohiro Kamiyoshi, Hiroshi Kaito, Yuriko Tanaka, Hiroyoshi Matsukura, Wataru Shimabukuro, Yuko Shima, Azusa Kawaguchi, Yoshinori Araki, Koichi Nakanishi, Shigeo Hara, Kandai Nozu Kidney Int Reports
  The role of iron in, and the prognosis of, pediatric Immunoglobulin A nephropathy (IgAN) with macrohematuria (MH)-induced acute kidney injury (AKI) (MH-AKI) have not been evaluated. Thirty percent of adults with MH-AKI, and especially those who are older, show progression to chronic kidney disease. (Kidney International Reports 9, 6 (2024))

6 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Pregnancy and Family Planning in Women With Kidney Disease - Joy Eskandar, Anika Lucas, Angelina Dixon, Jessica Kendrick Kidney Int Reports
  Females with kidney disease are at increased risk for pregnancy complications. Few studies have examined pregnancy perspectives of people with kidney disease. Our objective was to examine kidney patients’ perspectives on family planning. (Kidney International Reports 9, 5 (2024))
• 00:00
  Predictive Factors of Renal Recovery and Progression to End-Stage Kidney Disease in Patients With Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis With Severe Kidney Disease - Marta Casal Moura, Dalia Zubidat, Marc Patricio Liebana, Sanjeev Sethi, Maria Jose Soler, Ladan Zand, Fernanda G. dos Santos, Luca Nardelli, Juan Leon-Roman, Ciria Sousa, Kenneth J. Warrington, Ulrich Specks, Fernando C. Fervenza Kidney Int Reports
  A significant number of patients with antineutrophil cytoplasmic antibodies (ANCA)- associated vasculitis (AAV) with glomerulonephritis (AAV-GN) still progress to end-stage kidney disease (ESKD, estimated glomerular filtration rate [eGFR] (Kidney International Reports 9, 5 (2024))

4 mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Nedosiran Safety and Efficacy in PH1: Interim Analysis of PHYOX3 - Jaap Groothoff, Anne-Laure Sellier-Leclerc, Lisa Deesker, Justine Bacchetta, Gesa Schalk, Burkhard Tönshoff, Graham Lipkin, Sandrine Lemoine, Thomas Bowman, Jing Zhou, Bernd Hoppe Kidney Int Reports
  Primary hyperoxaluria (PH) is a rare genetic disorder of hepatic glyoxylate metabolism. Nedosiran is an RNA interference (RNAi) therapeutic that the US Food and Drug Administration has approved for treatment of PH1. PHYOX3 is a trial evaluating monthly nedosiran in patients with PH. (Kidney International Reports 9, 5 (2024))

1er mars

Kidney Int Reports http://www.kireports.org/

• 00:00
  Narrative Review of Immunomodulatory and Anti-inflammatory Effects of Sodium-Glucose Cotransporter 2 Inhibitors: Unveiling Novel Therapeutic Frontiers - Sul A. Lee, Leonardo V. Riella Kidney Int Reports
  Sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors) have evolved from their initial role as antidiabetic drugs to garner recognition for their remarkable cardio-protective and reno-protective attributes. They have become a crucial component of therapeutic guidelines for congestive heart (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  The Conversion From Mycophenolic Acid to Mammalian Target of Rapamycin Inhibitor Reduces the Incidence of Cytomegalovirus Replication in Belatacept-Treated Kidney-Transplant Recipients - Arnaud Del Bello, Joseph Cachoux, Florence Abravanel, Thomas Prudhomme, Nassim Kamar Kidney Int Reports
  A better long-term graft survival, kidney function, and metabolic profile are observed in de novo kidney-transplant patients given belatacept associated with mycophenolic acid (MPA) than those receiving calcineurin-based immunosuppression.1 Similarly, kidney function is better in (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Be Aware of the Dog: Tacrolimus Usage and Chronic Hepatitis E Virus Infections - Mara Klöhn, Subashri Mohanasundaram, Eike Steinmann Kidney Int Reports
  Tacrolimus is an immunosuppressive drug that is used to prevent and treat organ rejection in liver, heart, and kidney transplant recipients.1–3 As a macrolide calcineurin inhibitor, it specifically disrupts T cell signal transduction and activation by inhibiting the transcription and release (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Associations Between Prematurity, Birthweight, and Adolescence Blood Pressure in a Nationwide Cohort - Shimrit Tzvi-Behr, Lucy B. Greenstein, Efrat Ben-Shalom, Yaacov Frishberg, Sharon O. Cohen Kidney Int Reports
  Prematurity is associated with incomplete nephrogenesis and an increased incidence of acute kidney injury, that may increase the risk of future kidney disease, including hypertension, proteinuria and reduced glomerular filtration rate. The aim of this study was to evaluate the risk of (...) (Kidney International Reports 9, 5 (2024))

29 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  A Caution Against the Use of C5b-9 Endothelial Assay to Support Eculizumab Therapy: A response to Maritati et al.: “Eculizumab first” in the management of posttransplant thrombotic microangiopathy - Caroline Duineveld, Nicole C.A.J. van de Kar, Jack F.M. Wetzels Kidney Int Reports
  In their recent study, Maritati and colleagues reported 45 patients with early onset thrombotic microangiopathy (TMA) after kidney transplantation.1 Using serum of these patients, an increased C5b-9 deposition on endothelial cells was observed in 84%. The authors suggest that these positive (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Response to “A Caution Against the Use of C5B-9 Endothelial Assay to Support Eculizumab Therapy” - Federica Maritati, Gaetano La Manna, Giorgia Comai Kidney Int Reports
  We would like to thank Dr. Duineveld and colleagues for showing interest in our article titled “Eculizumab first” in the management of posttransplant thrombotic microangiopathy,1 by highlighting the role of the ex vivo C5b-9 assay in the evaluation of disease activity. (Kidney International Reports 9, 5 (2024))

23 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Clinical Remission and Reduction of Circulating Nephritic Factors by Combining Rituximab With Belimumab in a Case of Complement Factor 3 Glomerulopathy - Mieke van Schaik, Aiko P.J. de Vries, Frederike J. Bemelman, Ton J. Rabelink, Leendert A. Trouw, Cees van Kooten, Yoe Kie Onno Teng Kidney Int Reports
  Complement factor 3 glomerulopathy (C3G) is caused by dysregulation of the alternative complement pathway (AP), resulting in either dense deposit disease or complement factor 3 (C3) glomerulonephritis. Both diseases are characterized by a distinct pattern of glomerular C3 deposition in the (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy - Suruthy Narayanasami, Niranjan Anitha Vijayakumar, Mayuri Trivedi, Aravind Sekar, Shabna Sulaiman, Saurabh Nayak, Neeraj Inamdar, Sourabh Sharma, Rajeevalochana Parthasarathy, Vidya Kadam, Vaibhav Keskar, Sahil Bagai, Ashwani Kumar, Bajinder Reen, Anila Abraham Kurien, Alok Sharma, Dinesh Khullar, Benil Hafeeq, Arvind Krishnakumar, Shafeeque Rahman KV, Ismail NA, Sanjeev Nair, Smita Divyaveer, Manish Rathi, Harbir Singh Kohli, Ritambhra Nada, Raja Ramachandran Kidney Int Reports
  Among patients with primary membranous nephropathy (PMN), neural epidermal growth factor-like 1 protein (NELL1)-associated membranous nephropathy (MN) is the second most common antigen, following phospholipase A2 receptor (PLA2R).1 (Kidney International Reports 9, 5 (2024))
• 00:00
  Fournier's Gangrene in a Patient With CKD Without Diabetes Possibly Related to Sodium-Glucose Cotransporter 2 Inhibitor Therapy - Isabel Heidegger, Marit Zwierzina, Jan Boeckhaus, Vera Krane, Oliver Gross Kidney Int Reports
  Sodium-glucose cotransporter 2 (SGLT2)-inhibitors reduce the risk of adverse cardiovascular and kidney outcomes in patients with diabetes mellitus, chronic heart failure, or chronic kidney disease (CKD).1,2 Beneficial effects were proven in ample randomized controlled trials (RCTs) in patients (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Characteristics and Outcomes of NELL1 Membranous Nephropathy in Lipoic Acid Users and Nonusers - Rupali S. Avasare, Samantha Clark, Rebecca I. Spain, Raghav Wusirika, Robert Rope, Susan Gurley, Madison Stanaway, Miroslav Sekulic, Dominick Santoriello, Andrew S. Bomback, Pietro Canetta, Sitalakshmi J. Iyer, Vanderlene Kung, Vivek Charu, Megan L. Troxell, Satoru Kudose, Nicole K. Andeen Kidney Int Reports
  Neural epidermal growth factor like 1 membranous nephropathy (NELL1 MN) is associated with various secondary etiologies. However, previous studies on the frequency of these associations and their impact on outcomes are limited. We report a large multiinstitutional series of patients with NELL1 (...) (Kidney International Reports 9, 5 (2024))

22 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Pilot Study of sC5b-9 and Bb Fragment Plasma Levels in Crescentic Immunoglobulin A Nephropathy - Gabriella Guzzo, Salima Sadallah, Valentin Rousson, Francisco Herrera-Gómez, Giuseppe Pantaleo, Manuel Pascual, Daniel Teta Kidney Int Reports
  Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide and an important cause of end-stage kidney disease.1 The hallmark is the mesangial deposition of IgA1 immunoglobulins with an aberrant glycosylation that triggers mesangial cell hyperplasia with the release of (...) (Kidney International Reports 9, 5 (2024))

21 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia - Rosa Rodríguez-Rodríguez, Mads Hornum, Ana Elena Rodríguez Rodríguez, Sebastjan Bevc, Francesco Trevisani, Gema Fernández, Radovan Hojs, Beatriz Fernández-Fernández, Clara María Cases Corona, Josep María Cruzado, María Quero, Maruja Navarro Díaz, Arianna Bettiga, Francisco Moreso, Clara García Carro, Khaled Khazim, Fedaa Ghanem, Meritxell Ibernón, Ivo Laranjinhia, Luís Mendonça, Miguel Bigotte Vieira, Bo Feldt-Rasmussen, Alberto Ortiz, Per Bagi, Cristian Acosta Sorensen, Enrique Morales, Esteban Porrini, DIABESITY working group of the European Renal Association Kidney Int Reports
  The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. We evaluated renal histology in subjects with MS and those without MS, who are participants in (...) (Kidney International Reports 9, 5 (2024))

18 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Utility of Routine Post Kidney Transplant Anti-HLA Antibody Screening - Sofiane Salhi, Nicolas Congy-Jolivet, Anne-Laure Hebral, Laure Esposito, Guillaume Vieu, Jean Milhès, Nassim Kamar, Arnaud Del Bello Kidney Int Reports
  De novo donor-specific antibody (dnDSA) is a strong biomarker associated with the development of antibody-mediated rejection (AMR) and graft loss after kidney transplantation. This procedure is expensive; however, systematic annual screening was recommended by some national organ transplant (...) (Kidney International Reports 9, 5 (2024))

17 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Longitudinal Trajectories of Biomarkers of Kidney Tubular Function in Type 1 Diabetes - Christine P. Limonte, Xiaoyu Gao, Ionut Bebu, Jesse C. Seegmiller, Gayle M. Lorenzi, Bruce A. Perkins, Amy B. Karger, Valerie L. Arends, Andrew Paterson, Mark E. Molitch, Ian H. de Boer, DCCT/EDIC Research Group Kidney Int Reports
  Tubular biomarkers may shed insight into progression of kidney tubulointerstitial pathology complementary to traditional measures of glomerular function and damage. (Kidney International Reports 9, 5 (2024))

16 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Update Thiazide Diuretic Evidence Review for CARI Guidelines Kidney Stones Recommendations - David J. Tunnicliffe, Andrew Mallett, Brydee Cashmore, Adam Mullan, Lyn Lloyd, Adela Yip, Ieuan Wickham, Hicham Hassan, Matthew Jose, Caring for Australians and New Zealanders with kidney Impairment (CARI) Guidelines Kidney Stones Working Group Kidney Int Reports
  Recently, a double-blind randomized controlled trial (RCT) NOSTONE compared hydrochlorothiazide (12.5 mg/d, 25 mg/d, 50 mg/d) to placebo in adults with at least 2 episodes of kidney stones (at least 50% calcium oxalate, calcium phosphate, or a mixture of both) within 10 years from 12 centers (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Clinical Presentation, Pathological Spectrum, and Outcomes of Alcoholic Cirrhosis-Related Immunoglobulin A Nephropathy - Charles Ronsin, Pierre Braud, Christine Kandel-Aznar, Amaury Dujardin, Clémence Petit, David Larmet, Claire Garandeau, Clément Deltombe, Alice Le Clech, Claire Leman, Gilles Blancho, Juliet Schurder, Grégoire Couvrat-Desvergnes, Simon Ville Kidney Int Reports
  Immunoglobulin A nephropathy (IgAN) associated with cirrhosis is frequent but often overlooked because it is largely considered silent. Until now, little has been known about their presentation and outcomes. (Kidney International Reports 9, 5 (2024))

15 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population - Arno R. Bourgonje, Martin F. Bourgonje, Sacha la Bastide-van Gemert, Tom Nilsen, Clara Hidden, Ron T. Gansevoort, Douwe J. Mulder, Jan-Luuk Hillebrands, Stephan J.L. Bakker, Robin P.F. Dullaart, Harry van Goor, Amaal E. Abdulle Kidney Int Reports
  Systemic inflammation has been associated with chronic kidney disease (CKD). In this study, we aimed to investigate a potential association between the plasma biomarker of inflammation calprotectin and new-onset CKD in a population-based cohort study. (Kidney International Reports 9, 5 (2024))
• 00:00
  Aversion to a High Salt Taste is Disturbed in Patients With CKD - Natsuko Okuno-Ozeki, Yusuke Kohama, Hiromu Taguchi, Yuka Kawate, Minato Umehara, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Itaru Nakamura, Kunihiro Nakai, Tomohiro Nakata, Yuhei Kirita, Takuya Taniguchi, Keiichi Tamagaki, Takashi Hirao, Satoaki Matoba, Tetsuro Kusaba Kidney Int Reports
  A reduced salt intake is a vital lifestyle modification in the management of hypertension. Initiatives aimed at decreasing the intake of salt are based on the preference by humans for a salt taste. Salt intake behavior appears to be affected by the balance between attraction to a low salt (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Early Rituximab as an Add-On Therapy in Children With the Initial Episode of Nephrotic Syndrome - Jialu Liu, Fang Deng, Xiaowen Wang, Cuihua Liu, Shuzhen Sun, Ruifeng Zhang, Aihua Zhang, Xiaoyun Jiang, Weili Yan, Yalan Dou, Yi Zhang, Li Xie, Biyun Qian, Qian Shen, Hong Xu Kidney Int Reports
  The approximately 70% 12-month relapse in children experiencing the initial episode of steroid-sensitive nephrotic syndrome (SSNS) is a significant concern, with over 50% developing frequent relapses or steroid-dependent nephrotic syndrome (FRNS/SDNS). There is a lack of strategies to reduce (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Immune Checkpoint Therapy–Induced Lupus Nephritis - Imran Humza Hanif, Saifudeen Abdelrahim, Majd Al Shaarani, Huifang Lu, Raisa Ahmad, Sangeeta Goswami, Ala Abudayyeh Kidney Int Reports
  Immune checkpoint therapy (ICT), an emerging transformative cancer treatment, targets inhibitory proteins in the immune system, such as programmed cell death protein 1 (PD-1) and its ligand (PD-L1), and cytotoxic T-lymphocyte–associated protein 4 (CTLA-4). This strategy has remarkably improved (...) (Kidney International Reports 9, 5 (2024))

14 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Associations With Baseline Blood Pressure Control in NURTuRE-CKD - Bethany J. Lucas, Paul Cockwell, Simon D.S. Fraser, Philip A. Kalra, David C. Wheeler, Maarten W. Taal Kidney Int Reports
  Hypertension is commonly associated with chronic kidney disease (CKD) and is a key mediator of progressive kidney damage and the associated increase in cardiovascular mortality.1 The importance of blood pressure (BP) control as a therapeutic intervention in CKD, both for reduction in mortality (...) (Kidney International Reports 9, 5 (2024))

13 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis - Gabriel C. Barsotti, Randy Luciano, Ashwani Kumar, Kristin Meliambro, Vijayakumar Kakade, Joji Tokita, Abhijit Naik, Jia Fu, Elizabeth Peck, John Pell, Anand Reghuvaran, E.M. Tanvir, Prashant Patel, Weijia Zhang, Fan Li, Gilbert Moeckel, Sudhir Perincheri, Lloyd Cantley, Dennis G. Moledina, F. Perry Wilson, John C. He, Madhav C. Menon Kidney Int Reports
  Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease leading to end-stage kidney disease (ESKD), is characterized by podocyte injury and depletion, whereas minimal change disease (MCD) has better outcomes despite podocyte injury. Identifying mechanisms capable (...) (Kidney International Reports 9, 5 (2024))

12 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Updating the Data: The Resource Consumption of Modern-Day Hemodialysis Systems - Katherine A. Barraclough, Steve Moller, Susan Blair, Richard Knight, John W. Agar, Scott McAlister, Anthea White, Matthew Sypek Kidney Int Reports
  Two decades ago, the kidney care community was first alerted to the extraordinarily high resource consumption of hemodialysis. Agar et al.1 identified that ?500 l of water were required for each 4-hour conventional treatment, with only one-third used for dialysis and two-thirds lost as reverse (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Randomized Trial on the Efficacy and Safety of Standard Versus Higher Bicarbonate Supplementation in CKD of Unknown Etiology - Swathy Raju, Karthikeyan Manoharan, Natarajan Ramachandran, Jayaprakash Sahoo, Balasubramanian Vairappan, Velkumary Subramaniyam, Sreejith Parameswaran, P.S. Priyamvada Kidney Int Reports
  A bicarbonate level of less than 22 mEq/l is associated with an increased risk for chronic kidney disease (CKD) progression, reduced bone mineral density, loss of muscle mass, and all-cause mortality.1 Many previous studies have shown that bicarbonate supplementation in the dose range of 0.3 (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  A Pilot Study on the Safety and Adequacy of a Novel Ecofriendly Hemodialysis Prescription–Green Nephrology - Dolphin Solomon, Venkatesh Arumugam, Ramanathan Sakthirajan, Tanuj Moses Lamech, Thanigachalam Dineshkumar, Paulpandiyan Vathsalyan, Guhan Senthilkumaran, Ravindran Krishna, Sajmi Shaji, Natarajan Gopalakrishnan Kidney Int Reports
  Hemodialysis (HD) units require large quantities of water. To reduce water consumption without compromising the adequacy and safety of dialysis, we studied a novel HD prescription with high temperature and low flow dialysate. (Kidney International Reports 9, 5 (2024))

9 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Aortic Dilatation in Children and Young People With ADPKD - Alexandra Savis, Emily Haseler, Hayley Beardsley, Phil J. Chowienczyk, John M. Simpson, Manish D. Sinha Kidney Int Reports
  Aortic root dilatation is a reported cardiovascular sequela seen in children and young people (CYP) with chronic kidney disease (CKD) but has yet to be described in those with autosomal dominant polycystic kidney disease (ADPKD). (Kidney International Reports 9, 5 (2024))
• 00:00
  Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in CKD Patients With COVID-19 - Franco Wing Tak Cheng, Vincent Ka Chun Yan, Eric Yuk Fai Wan, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Carlos King Ho Wong, Xue Li, Irene Ran Zhang, Sydney Chi Wai Tang, Ian Chi Kei Wong, Esther Wai Yin Chan Kidney Int Reports
  Even with effective vaccines, patients with CKD have a higher risk of hospitalization and death subsequent to COVID-19 infection than those without CKD. Molnupiravir and nirmatrelvir-ritonavir have been approved for emergency use, but their effectiveness for the CKD population is still (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Kidney Tissue Proteome Profiles in Short Versus Long Duration of Delayed Graft Function - A Pilot Study in Donation After Circulatory Death Donors - M. Letizia Lo Faro, Kaithlyn Rozenberg, Honglei Huang, Sergei Maslau, Sarah Bonham, Roman Fischer, Benedikt Kessler, Henri Leuvenink, Edward Sharples, Jan H. Lindeman, Rutger Ploeg Kidney Int Reports
  Delayed graft function (DGF) is often defined as the need for dialysis treatment in the first week after a kidney transplantation. This definition, though readily applicable, is generic and unable to distinguish between “types” of DGF or time needed to recover function that may also (...) (Kidney International Reports 9, 5 (2024))

8 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  A Transplant-Inclusive Value-Based Kidney Care Payment Model - Benjamin E. Hippen, George M. Hart, Franklin W. Maddux Kidney Int Reports
  In the United States, kidney care payment models are migrating toward value-based care (VBC) models incentivizing quality of care at lower cost. Current kidney VBC models will continue through 2026. We propose a future transplant-inclusive VBC (TIVBC) model designed to supplement current models (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Effect of Intravitreal Anti-Endothelial Growth Factor Agents on Renal Function in Patients With Diabetes Mellitus - Marta Rivero, María Fernández-Vidal, Justo Sandino, Raquel Berzal Rico, Candela Moliz, José Enrique Ruiz-Cabello, Lucía Cordero Garcia-Galán, Celia González-García, Paúl Hernández-Velasco, Julián Segura, Eduardo Gutiérrez, Enrique Morales Kidney Int Reports
  Intravitreal administration of vascular endothelial growth factor inhibitors (anti-VEGF) is the treatment of choice in retinal pathology associated with type 2 diabetes mellitus (DM2). We aimed to analyze the effect of intravitreal anti-VEGF administration on renal function in patients with DM2. (Kidney International Reports 9, 5 (2024))
• 00:00
  A Post Hoc Analysis of the CKD-FIX Study Analyzing the Association Between Metformin Usage and Estimated GFR Decline - Isabelle Kitty Stanley, Andrew J. Mallett, Andrea K. Viecelli, Carmel M. Hawley, Christine E. Staatz, David W. Johnson, Elasma Milanzi Kidney Int Reports
  Chronic kidney disease (CKD) poses an increasing burden on global health; however, there are few interventions available to manage the condition. It has been hypothesized that metformin, a commonly prescribed oral antidiabetic drug, may potentially be able to slow the progression of CKD.1 (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Effects of Medications on the in vitro Growth of Gut Bacteria Associated With Kidney Stones - Jing Bi Karchin, Dylan Curry, Elliot S. Friedman, Michelle Denburg, Gregory E. Tasian Kidney Int Reports
  Kidney stone disease (nephrolithiasis) is a disorder of mineral metabolism that is punctuated by painful, episodic events. The prevalence of kidney stone disease has doubled in 30 years with the greatest increases in incidence observed in adolescents and young women.1,2 Previous studies (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Modification of Dialysate Na+ Concentration but not Ultrafiltration or Dialysis Treatment Time Affects Tissue Na+ Deposition in Patients on Hemodialysis - Christoph Kopp, Lukas Kittler, Peter Linz, Dennis Kannenkeril, Stephan Horn, Charles Chazot, Mario Schiffer, Michael Uder, Armin M. Nagel, Anke Dahlmann Kidney Int Reports
  Tissue Na+ overload is present in patients receiving hemodialysis (HD) and is associated with cardiovascular mortality. Strategies to actively modify tissue Na+ amount in these patients by adjusting the HD regimen have not been evaluated. (Kidney International Reports 9, 5 (2024))

5 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E - Nancy León-Janampa, Natacha Boennec, Olivier Le Tilly, Simon Ereh, Gabriel Herbet, Alain Moreau, Philippe Gatault, Hélène Longuet, Christelle Barbet, Mathias Büchler, Christophe Baron, Catherine Gaudy-Graffin, Denys Brand, Julien Marlet Kidney Int Reports
  Hepatitis E virus (HEV) can cause chronic infection (?3 months) and cirrhosis in immunocompromised patients, especially kidney transplant recipients. Low alanine aminotransferase (ALT) levels and high HEV intrahost diversity have previously been associated with evolution toward chronicity in (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  Exposome and Metabolome Analysis of Sugarcane Workers Reveals Predictors of Kidney Injury - Arthur D. Stem, Stephen Brindley, Keegan L. Rogers, Adil Salih, Carlos A. Roncal-Jimenez, Richard J. Johnson, Lee S. Newman, Jaime Butler-Dawson, Lyndsay Krisher, Jared M. Brown Kidney Int Reports
  Sugarcane workers are exposed to potentially hazardous agrochemicals, including pesticides, heavy metals, and silica. Such occupational exposures present health risks and have been implicated in a high rate of kidney disease seen in these workers. (Kidney International Reports 9, 5 (2024))
• 00:00
  Uptake and Outcomes of Peritoneal Dialysis among Aboriginal and Torres Strait Islander People: Analysis of Registry Data - Ashik Hayat, Yeoungjee Cho, E.M. Pascoe, Rathika Krishnasamy, Monique Borlace, Jenny Chen, Neil Boudville, Kamal Sud, M. Varnfield, Ross Francis, Rochelle Pitt, Jaquelyne T. Hughes, David Wayne Johnson Kidney Int Reports
  Peritoneal dialysis (PD) enables people to use kidney replacement therapy (KRT) outside of healthcare-dependent settings, a strong priority of Aboriginal and Torres Strait Islander people. (Kidney International Reports 9, 5 (2024))
• 00:00
  Reclassification of Variants Following Renal Genetics Testing: Uncommon Yet Impactful for Diagnosis and Management - Euyn Lim, Chloe Borden, Seysha Mehta, Mary-Beth Roberts, Sarah Mazzola, Fang Zhao, Xiangling Wang Kidney Int Reports
  Genetic testing is increasingly utilized in nephrology practice, but limited real-world data exist on variant reclassification following renal genetics testing. (Kidney International Reports 9, 5 (2024))

4 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Modifiable Physical Factors That Influence Physical Function for People Receiving Peritoneal Dialysis - Brett Tarca, Shilpanjali Jesudason, Paul N. Bennett, Thomas P. Wycherley, Katia E. Ferrar Kidney Int Reports
  People receiving peritoneal dialysis experience physical function decline, impairing their ability to complete everyday activities, leading to poorer quality of life. Physical factors, including cardiorespiratory fitness, muscle strength, physical activity, and sedentary behavior are (...) (Kidney International Reports 9, 5 (2024))
• 00:00
  How Does ADPKD Severity Differ Between Family Members? - Klement C. Yeung, Elise Fryml, Matthew B. Lanktree Kidney Int Reports
  Thousands of pathogenic variants in more than 100 genes can cause kidney cysts with substantial variability in phenotype and risk of subsequent kidney failure. Despite an established genotype-phenotype correlation in cystic kidney diseases, incomplete penetrance and variable disease (...) (Kidney International Reports 9, 5 (2024))

2 février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Description of a New Simple and Cost-Effective Molecular Testing That Could Simplify MUC1 Variant Detection - Victor Fages, Florentin Bourre, Romain Larrue, Andrea Wenzel, Jean-Baptiste Gibier, Fabrice Bonte, Claire-Marie Dhaenens, Kendrah Kidd, Stanislav Kmoch, Anthony Bleyer, François Glowacki, Olivier Grunewald Kidney Int Reports
  Patients with autosomal dominant tubulointerstitial kidney disease (ADTKD) usually present with nonspecific progressive chronic kidney disease (CKD) with mild to negative proteinuria and a family history. ADTKD-MUC1 leads to the formation of a frameshift protein that accumulates in the (...) (Kidney International Reports 9, 5 (2024))

1er février

Kidney Int Reports http://www.kireports.org/

• 00:00
  Lithium-Associated Kidney Failure: Predictors and Outcomes - Emily Qian, Kamal Sud, Vincent Lee Kidney Int Reports
  Despite the widespread use of lithium for bipolar disorders and depression, little is known about the characteristics of patients with lithium-associated kidney failure receiving kidney replacement therapy (KRT). (Kidney International Reports 9, 5 (2024))
• 00:00
  Clinical Relevance of Anti-C3 and Anti-C4 Autoantibodies in Lupus Nephritis - Vasil Vasilev, Mikel Rezola Artero, Marijana Petkova, Galya Mihaylova, Marie-Agnes Dragon-Durey, Maria Radanova, Lubka T. Roumenina Kidney Int Reports
  Complement system overactivation is pivotal in lupus nephritis (LN) pathophysiology. Considering that anti-C3 autoantibodies play a significant role in LN pathophysiology, we explored them as disease activity biomarkers and compared them to the ones against the homologous protein, C4. (Kidney International Reports 9, 5 (2024))

31 janvier

Kidney Int Reports http://www.kireports.org/

• 00:00
  Competing Risks Analysis of Kidney Transplant Waitlist Outcomes: Two Important Statistical Perspectives - Jeffrey J. Gaynor, Giselle Guerra, Rodrigo Vianna, Marina M. Tabbara, Enric Lledo Graell, Gaetano Ciancio Kidney Int Reports
  Modern competing risks analysis has 2 primary goals in clinical epidemiology as follows: (i) to maximize the clinician’s knowledge of etiologic associations existing between potential predictor variables and various cause-specific outcomes via cause-specific hazard models, and (ii) to maximize (…) (Kidney International Reports 9, 6 (2024))
• 00:00
  Socioeconomic Position and Health Among Children and Adolescents With CKD Across the Life-Course - Anita van Zwieten, Siah Kim, Amanda Dominello, Chandana Guha, Jonathan C. Craig, Germaine Wong Kidney Int Reports
  Children and adolescents in families of lower socioeconomic position (SEP) experience an inequitable burden of reduced access to healthcare and poorer health. For children living with chronic kidney disease (CKD), disadvantaged SEP may exacerbate their considerable disease burden. Across the (...) (Kidney International Reports 9, 5 (2024))

30 janvier

Kidney Int Reports http://www.kireports.org/

• 00:00
  Impact of Age 70 years or Older on Donors for Living-Donor Kidney Transplantation - Takahisa Hiramitsu, Tomoki Himeno, Yuki Hasegawa, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai Kidney Int Reports
  Kidney transplantation (KT) involving elderly living kidney donors (LKDs) is becoming more frequent because of a profound organ shortage. The efficacy of KT involving grafts obtained from LKDs aged 70 years or older has been reported. However, the safety of donor nephrectomy in LKDs aged 70 (...) (Kidney International Reports 9, 5 (2024))

11 janvier

Kidney Int Reports http://www.kireports.org/

• 00:00
  Anemia in Pregnancy With CKD - Margriet F.C. de Jong, Elizabeta Nemeth, Pien Rawee, Kate Bramham, Michele F. Eisenga Kidney Int Reports
  Chronic kidney disease (CKD), anemia, and iron deficiency are global health issues affecting individuals in both high-income and low-income countries. In pregnancy, both CKD and iron deficiency anemia increase the risk of adverse maternal and neonatal outcomes, including increased maternal (...) (Kidney International Reports 9, 5 (2024))