1er juillet

Kidney Int http://www.kidney-international.org/

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  MRI findings of renal cortical hemosiderosis after cardiac valve surgery - Haijuan Lv, Hongwei Zhao Kidney Int
  A 74-year-old female patient, at 9 years post mitral and tricuspid valve repairs with C-shaped annuloplasty rings, presented with proteinuria (2+) and anemia (Hb 97 g/l), and elevated lactate dehydrogenase levels at 845 U/L (reference range: 120–250 U/L), indicative of intravascular hemolysis. (…) (Kidney International 106, 1 (2024))
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  Solitary kidney in a patient with Pallister-Hall syndrome - Ines Vanderheyden, Saskia Bulk, François Jouret Kidney Int
  A 58-year-old female patient was referred for solitary kidney management. She was born following a full-term pregnancy, with a weight of 2.2 kg. Her medical history included the following: (i) “Y-shaped metacarpals” and postaxial polydactyly (15 fingers in toto) bilaterally operated (Figure 1); (…) (Kidney International 106, 1 (2024))
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  Taking the amphoterism out of amphotericin: a wonder drug in the making - Andrew Beenken Kidney Int
  Invasive fungal infections number up to 1,000,000 cases per year,1 and an increasing number exhibit multidrug resistance. Amphotericin B has been an important tool in fighting these infections ever since the 1950s when it was first isolated from the soil of the Orinoco basin in Venezuela.2 (…) (Kidney International 106, 1 (2024))
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  Inflammasome activation: unraveling the link between chronic kidney disease and atrial fibrillation - Melis Sahinoz, T. Alp Ikizler Kidney Int
  Atrial fibrillation (AF) is the most common cardiac arrhythmia, currently affecting ?60 million people worldwide, and it is associated with significant morbidity and mortality.1 Chronic kidney disease (CKD) is an independent risk factor for incident and prevalent AF, with a stepwise increase in (…) (Kidney International 106, 1 (2024))
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  Corrigendum to “Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.” Kidney International 2023;103:115–133 - Jingyao Li, Xi’ang Sun, Ninghao Yang, Jiayun Ni, Hongyan Xie, Hengjiang Guo, Xin Wang, Li Zhou, Jun Liu, Sijia Chen, Xiaoxia Wang, Yingying Zhang, Chen Yu, Wei Zhang, Limin Lu Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2022.08.022 (Kidney International 106, 1 (2024))
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  Corrigendum to “Kidney involvement in Rosai-Dorfman disease.” Kidney International 2023;103:231–232 - Martina Mazzariol, Francesco Peyronel, Filippo Fagni, Andrea Minervini, Raffaella Santi, Simone Agostini, Augusto Vaglio Kidney Int
  DOI of original article: 10.1016/j.kint.2022.09.005 (Kidney International 106, 1 (2024))
• 00:00
  Foscarnet-induced nephropathy in a kidney transplant recipient - Ian P. Rios, Christian H.L. Nguyen, Suman S. Misra, Margaret S. Ryan, Sumi S. Nair, Hasan A. Khamash Kidney Int
  A 53-year-old man with type 2 diabetes–related kidney failure underwent cytomegalovirus (CMV)–mismatched (CMV positive to negative), deceased donor kidney transplant in July 2021. He was on a prophylactic dose of valganciclovir until September 2021 when he developed neutropenia, and (…) (Kidney International 106, 1 (2024))
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  The Case | Rapid onset of severe hyponatremia after a dental procedure - Laura Scholz, Max Schuller, Michael Kolland, Philipp Eller, Alexander H. Kirsch Kidney Int
  A 38-year-old woman presented at a peripheral hospital for progressive abdominal pain, nausea, and vomiting. Except for a 7-day course of antibiotic treatment following a dental procedure performed a few days before symptom onset, she had not been on any medication. Her medical history was not (…) (Kidney International 106, 1 (2024))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 106, 1 (2024))
• 00:00
  Erratum to “An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).” Kidney International 2023;105:1058–1076 - Zewu Zhu, Bryan Bo-Ran Ho, Alyssa Chen, James Amrhein, Andreea Apetrei, Thomas Oliver Carpenter, Marise Lazaretti-Castro, Juan Manuel Colazo, Kathryn McCrystal Dahir, Michaela Geßner, Evgenia Gurevich, Cathrine Alsaker Heier, Jill Hickman Simmons, Tracy Earl Hunley, Bernd Hoppe, Christina Jacobsen, Anne Kouri, Nina Ma, Sachin Majumdar, Arnaud Molin, Natalie Nokoff, Susan M. Ott, Helena Gil Peña, Fernando Santos, Peter Tebben, Lisa Swartz Topor, Yanhong Deng, Clemens Bergwitz Kidney Int
  The publisher regrets that the definition of het-post (post-treatment levels of het carriers) was not included in the legends of Figure 3 and Supplementary Figure S3, and that descriptions of upper limit (%UL) and/or z-score were not included in the legends of Supplementary Figures S2–S4, S6, (…) (Kidney International 106, 1 (2024))
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  Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? - Paulina X. Medina Rangel, Shuta Ishibe Kidney Int
  Glomerular issues and affected podocytes are at the origin of 80% of chronic kidney disease cases. Thus, acquiring a deeper understanding in this domain is necessary to halt progressive kidney damage. In this study, the authors investigated the harmful impact of podocyte-cleaved soluble retinoic (…) (Kidney International 106, 1 (2024))
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  Genomics in the kidney transplant clinic: the future standard of care? - Emilie Cornec-Le Gall, Andrew J. Mallett Kidney Int
  New evidence indicates potential benefit of genomics to illuminate nonkidney monogenic morbidity and mortality risk among kidney transplant recipients. This might be of direct relevance to an equivalent proportion of patients to those who harbor a monogenic kidney disease. Further evidence and (…) (Kidney International 106, 1 (2024))
• 00:00
  journal club Kidney Int
  Verma et al. (Ann Intern Med. 2024;177:467–475.) (Kidney International 106, 1 (2024))
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  in this issue Kidney Int
  Asowata and colleagues studied deceased donor transplant kidneys with impaired kidney function as a model of acute and chronic kidney injury using an integrated multi-omic approach. RNA sequencing demonstrated that T cell and macrophage tissue infiltration associated with changes in both donors’ (…) (Kidney International 106, 1 (2024))
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  Factor XI inhibition in hemodialysis patients: the safer anticoagulation? - Eleni Stamellou, Heidi Noels, Jürgen Floege Kidney Int
  Chronic hemodialysis patients exhibit an excessive cardiovascular risk and a marked increase in both thromboembolism and bleeding episodes. Factor XI inhibition may provide anticoagulation, with a low risk of bleeding, and several factor XI inhibitors, including fesomersen, an antisense (…) (Kidney International 106, 1 (2024))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 106, 1 (2024))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 106, 1 (2024))

18 juin

Kidney Int http://www.kidney-international.org/

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  A meta-analysis of randomized controlled clinical trials implications of acute treatment effects on glomerular filtration rate for long-term kidney protection. - Hiddo J.L. Heerspink, Devin Eddington, Juhi Chaudhari, Raymond Estacio, Enyu Imai, Marian Goicoechea, Thierry Hannedouche, Richard Haynes, Tazeen H. Jafar, David W. Johnson, Rob C.M. van Kruijsdijk, Julia B. Lewis, Philip K.T. Li, Brendon L. Neuen, Ronald D. Perrone, Piero Ruggenenti, Christoph Wanner, Mark Woodward, Di Xie, Tom Greene, Lesley A. Inker Kidney Int
  Pharmacologic interventions to slow chronic kidney disease progression, such as ACE-inhibitors, angiotensin receptor blockers, or sodium glucose co-transporter 2 inhibitors, often produce acute treatment effects on glomerular filtration rate (GFR) that differ from their long-term chronic (…) (Kidney International (2024))
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  Effects of microplastics on the kidneys: A narrative review - Rodrigo Bueno de Oliveira, Lauter E. Pelepenko, Daniela A. Masaro, Glauco M.M. M. Lustosa, Mariana Cassani, Noemí A.V. Roza, Marina A. Marciano, Luciene M. dos Reis, Saïd Kamel, Loïc Louvet, Talita Mazon. Kidney Int
  Micro- and nanoplastics (MPs) are small synthetic organic polymer particles ( (Kidney International (2024))
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  A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells. - Joseph C. Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Thitinee Vanichapol, Evan Streeter, Zainab Almuallim, Akira Oda, Takuto Chiba, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill, Haojia Wu, Katherine Pfister, Sara E. Howden, Simon C. Watkins, Melissa H. Little, Benjamin D. Humphreys, Samira Kiani, Alan Watson, Donna B. Stolz, Alan J. Davidson, Tom Carroll, Ondine Cleaver, Sunder Sims-Lucas, Mo R. Ebrahimkhani, Neil A. Hukriede Kidney Int
  Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation hinge on achieving robust vascularization of in vitro engineered organs. Here, focusing on human kidney organoids, we overcame this hurdle by (…) (Kidney International (2024))
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  Imaging Kidney Inflammation Using An Oxidatively Activated MRI Probe - Ivy A. Rosales, Iris Yuwen Zhou, Ilknur Ay, Mozhdeh Sojoodi, Meghan E. Sise, Eric M. Gale Kidney Int
  Imaging tools for kidney inflammation could improve care for patients suffering inflammatory kidney diseases by lessening reliance on percutaneous biopsy or biochemical tests alone. During kidney inflammation, infiltration of myeloid immune cells generates a kidney microenvironment that is (…) (Kidney International (2024))

4 juin

Kidney Int http://www.kidney-international.org/

• 00:00
  The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - Marina Vivarelli, Jonathan Barratt, Laurence H. Beck, Fadi Fakhouri, Daniel P. Gale, Elena Goicoechea de Jorge, Marta Mosca, Marina Noris, Matthew C. Pickering, Katalin Susztak, Joshua M. Thurman, Michael Cheung, Jennifer M. King, Michel Jadoul, Wolfgang C. Winkelmayer, Richard J.H. Smith, for Conference Participants Kidney Int
  Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. Although complement activation plays a causal role in atypical hemolytic uremic syndrome and C3 glomerulopathy, over the past decade, a rapidly accumulating body of evidence has shown a (…) (Kidney International (2024))

1er juin

Kidney Int http://www.kidney-international.org/

• 00:00
  Characterizing the cellular and molecular landscape of mineralocorticoid action and antagonism in the kidney - Verónica Miguel, Tilman B. Drueke Kidney Int
  The mineralocorticoid hormone aldosterone plays a major role in sodium and potassium homeostasis and blood volume regulation. Aldosterone binds to the mineralocorticoid receptor (MR) in the cytosol, and this complex translocates into the nucleus and binds to DNA, regulating target gene (…) (Kidney International 105, 6 (2024))
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  The tragedy of mitotic catastrophe in podocytes - Stuart J. Shankland, Behzad Najafian, Oliver Wessely Kidney Int
  In diabetic and nondiabetic glomerular disease, the magnitude of the reduction of podocyte numbers is a critical determinant in the development of glomerulosclerosis. Experimental studies show that a decline of podocyte numbers by 21%–40% leads to mild persistent proteinuria and focal segmental (…) (Kidney International 105, 6 (2024))
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  Renal artery microaneurysms in antineutrophil cytoplasmic antibody–associated vasculitis - Jiale Tang, Zhou Xiao, Liang Liu, Xiaozhao Li Kidney Int
  A 61-year-old man presented to the emergency department with a 1-week history of low back pain. Three years prior, he had been diagnosed with myeloperoxidase–antineutrophil cytoplasmic-associated vasculitis, with normal kidney function, and had received term treatment with prednisone and (…) (Kidney International 105, 6 (2024))
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  Diagnosis of pseudo-acute kidney injury: mesothelial cells in the urine - Satoshi Kurahashi, Naohiro Toda, Ryo Sato, Kyoka Fujita, Jun Takeoka, Akira Ishii, Masaaki Fujita, Toshiyuki Komiya Kidney Int
  A 79-year-old man with lung cancer treated with chemotherapy was admitted for acute kidney injury. One week before admission, the patient was aware of abdominal distension and difficulty urinating. Admission laboratory tests showed serum creatinine level of 8.92 mg/dl (baseline, 0.94 mg/dl), (…) (Kidney International 105, 6 (2024))
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  Not too much, not too little—just the right amount: the story of YAP in the podocyte - Caitríona M. McEvoy, Darren A. Yuen Kidney Int
  Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms’ tumor 1, and worsened podocyte injury in a (…) (Kidney International 105, 6 (2024))
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  Prognostic implications of unbiased molecular categorization in kidney disease - Michael T. Eadon Kidney Int
  In this commentary, a novel approach to the reclassification of chronic kidney disease is reviewed. In the revisited study, the investigators identify 4 distinct subtypes of kidney disease derived from an unbiased self-organizing map of transcriptomic data from kidney biopsy samples. These (…) (Kidney International 105, 6 (2024))
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  The authors reply - Boris Fehse, Nicola M. Tomas Kidney Int
  We thank Rovira et al.1 for their interest in our recent work.2 We fully agree that the use of chimeric autoantibody receptor (CAAR) cells, which specifically target pathogenic B-cell clones, represents a highly innovative therapeutic strategy for antibody-mediated diseases. In this direction, (…) (Kidney International 105, 6 (2024))
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  Chimeric autoantibody receptor cell therapy for the treatment of membranous nephropathy - Jordi Rovira, Carolt Arana, Ainhoa Garcia-Busquets, Ilse Gille, Luís F. Quintana, Mirjam H.M. Heemskerk, Sebastiaan Heidt, Eduard Palou, Fritz Diekmann Kidney Int
  We read with interest the research letter by Seifert et al.1 recently published in Kidney International. They demonstrated the basic efficacy of PLA2R1- and THSD7A-based chimeric autoantibody receptor (CAAR) natural killer (NK) and T cells for the antigen-specific elimination of (…) (Kidney International 105, 6 (2024))
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  The Case | An active injection drug user with a skin rash and kidney failure - Abraham W. Aron, Randy L. Luciano Kidney Int
  A 38-year-old man with active IV heroin use presented with progressive lethargy and an evolving rash on his extremities for 1 week. The patient was afebrile and hemodynamically stable. Examination revealed multiple, painful purpuric lesions on his fingertips with painful petechiae on his upper (…) (Kidney International 105, 6 (2024))
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  SGLT2 inhibitors act as metabolic transducers to restore healthy nutrient deprivation and surplus signaling in the kidney - Shinji Kume, Milton Packer Kidney Int
  In the healthy adult kidney, cellular homeostasis is maintained by the balance between nutrient surplus and nutrient deprivation signaling.1 The primary nutrient deprivation signals are sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK), which are activated by low intracellular (…) (Kidney International 105, 6 (2024))
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  Kidney protective mechanisms of SGLT2 inhibitors: evidence for a hemodynamic effect - Kevin Yau, David Z.I. Cherney, Daniël H. van Raalte, Britt E. Wever Kidney Int
  Sodium-glucose cotransporter-2 (SGLT2) inhibitors were introduced a decade ago for the treatment of type 2 diabetes (T2D) and have emerged as a key therapy for the treatment of chronic kidney disease (CKD). In trials with primary kidney end points, SGLT2 inhibitors reduced the composite of (…) (Kidney International 105, 6 (2024))
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  Podocyte injury as a potential therapeutic target in IgA nephropathy: should pathology guide us? - Mark Haas Kidney Int
  The Oxford histopathologic classification (MEST-C: scores for lesions indicating active glomerular inflammation, mesangial [M] and endocapillary [E] hypercellularity as well as cellular or fibrocellular crescents [C], and for segmental glomerulosclerosis [S] and interstitial fibrosis and/or (…) (Kidney International 105, 6 (2024))
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  Challenges in the development of novel methodologies for measuring glomerular filtration rate - Edward J. Johns Kidney Int
  Measurement of glomerular filtration rate (GFR) is crucial in assessing kidney function status. Estimating GFR using clearance methodologies is cumbersome, as plasma and urinary concentrations and timed urine collections are required. Recently, a transcutaneous sensor has been developed whereby (…) (Kidney International 105, 6 (2024))
• 00:00
  in this issue Kidney Int
  Lafayette et al. report on the progress of the ORIGIN trial (ClinicalTrials.gov: NCT04716231), a phase 2B study of atacicept for the treatment of IgA nephropathy (IgAN). Atacicept inhibits the B-cell survival factors B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). (…) (Kidney International 105, 6 (2024))
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  SGLT2 inhibitor: 2-way superstar in nephrology? - Masaomi Nangaku Kidney Int
  Shohei Ohtani became an amazing 2-way player in a modern-day game of baseball that basically never sees them, and he won his second American League most valuable player award unanimously in 2023. (Kidney International 105, 6 (2024))
• 00:00
  journal club Kidney Int
  Colombijn et al. (Representation of patients with chronic kidney disease in clinical trials of cardiovascular disease medications: a systematic review. JAMA Netw Open. 2024;7:e240427.) (Kidney International 105, 6 (2024))
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  Corrigendum to “Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look.” Kidney Int. 2024;105:675–678 - Chirag R. Parikh, Steven G. Coca Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2024.01.018 (Kidney International 105, 6 (2024))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 105, 6 (2024))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 105, 6 (2024))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 105, 6 (2024))

29 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis - Lilia Abbad, Maximin Détrait, Panagiotis Kavvadas, Dorian Bergonnier, Lisa Melis, Marion Laudette, Tiffany Migeon, Marie-Christine Verpont, Alexandre Lucas, Christos Chatziantoniou, Frank Lezoualc’h Kidney Int
  Unlike classical protein kinase A, with separate catalytic and regulatory subunits, EPACs are single chain multi-domain proteins containing both catalytic and regulatory elements. The importance of cAMP-Epac-signaling as an energy provider has emerged over the last years. However, little is (…) (Kidney International (2024))
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  Platelets, inflammation, and purinergic receptors in chronic kidney disease - Adam L. Corken, Vincz Ong, Rajshekhar Kore, Sai N. Ghanta, Oleg Karaduta, Rupak Pathak, Shannon Rose, Craig Porter, Nishank Jain Kidney Int
  Platelets are anucleated cells that circulate in the bloodstream. Historically, platelets were thought to perform a singular function—stop bleeding via clotting. Although platelets do play a key role in hemostasis and thrombosis, recent studies indicate that platelets also modulate inflammation, (…) (Kidney International (2024))
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  Identification of the gut microbial enzyme turning the urine yellow - Marianne Harvent, Olivier Devuyst Kidney Int
  For ages, the transparency, smell, color, and even taste of urine have been scrutinized by physicians and laypeople willing to understand disease and to make a diagnosis. Some of these associations have stood the test of time. The color of urine, in particular, is still considered as a valuable (…) (Kidney International (2024))

28 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function - Charlotte Reichardt, Sabine Brandt, Anja Bernhardt, Anna Krause, Jonathan A. Lindquist, Sönke Weinert, Robert Geffers, Tobias Franz, Sascha Kahlfuss, Anne Dudeck, Akash Mathew, Rajiv Rana, Berend Isermann, Peter R. Mertens Kidney Int
  DNA-binding protein-A (DbpA; gene: Ybx3) belongs to the cold shock protein family with known functions in cell cycling, transcription, translation, and tight junction communication. In chronic nephritis, DbpA is upregulated. However, its activities in acute injury models, such as kidney (…) (Kidney International (2024))

24 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging - Yoshihisa Wada, Kengo Kidokoro, Megumi Kondo, Atsuyuki Tokuyama, Hiroyuki Kadoya, Hajime Nagasu, Eiichiro Kanda, Tamaki Sasaki, David Z.I. Cherney, Naoki Kashihara Kidney Int
  The mechanisms responsible for glomerular hemodynamic regulation with sodium-glucose co-transporter 2 (SGLT2) inhibitors in kidney disease due to type 2 diabetes remain unclear. Therefore, we investigated changes in glomerular hemodynamic function using an animal model of type 2 diabetes, (…) (Kidney International (2024))
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  Genome-wide association study of hospitalized patients and acute kidney injury - E.D. Siew, J.N. Hellwege, A.M. Hung, B.C. Birkelo, A.J. Vincz, S.K. Parr, J. Denton, R.A. Greevy, C. Robinson-Cohen, H. Liu, K. Susztak, M.E. Matheny, D.R. Velez Edwards Kidney Int
  Acute kidney injury (AKI) is a common and devastating complication of hospitalization. Here, we identified genetic loci associated with AKI in patients hospitalized between 2002-2019 in the Million Veteran Program and data from Vanderbilt University Medical Center’s BioVU. AKI was defined as (…) (Kidney International (2024))
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  Environmental pollution to kidney disease: an updated review of current knowledge and future directions - Xiang Qian Lao, Yacong Bo, Dezhong Chen, Kai Zhang, Cheuk-Chun Szeto Kidney Int
  Environmental pollution significantly impacts global disease burden. However, the contribution of environmental pollution to kidney disease is often overlooked in nephrology. This review examines the growing body of research demonstrating the significant impacts of environmental pollutants, with (…) (Kidney International (2024))

23 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Dietary potassium loads call on intercalated cell PIEZO1 to go with the flow - Seth L. Alper, Fouad T. Chebib Kidney Int
  Adult humans in steady-state excrete ?90% of dietary K+ via the kidney’s connecting segment and cortical collecting duct. Baseline renal K+ secretion is mediated by the principal cell (PC) ROMK K+ channel in a manner sustained by active ENaC-mediated, amiloride-sensitive Na+ reabsorption (Figure (…) (Kidney International (2024))
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  A stepped wedge cluster randomized trial of graphical surveillance of kidney function data to reduce late presentation for kidney replacement therapy - Hugh Gallagher, Shona Methven, Anna Casula, Hugh Rayner, Erik Lenguerrand, Nicola Thomas, Anne Dawnay, David Kennedy, Lesley Woolnough, Michael Nation, Fergus J. Caskey Kidney Int
  Late presentation for kidney replacement therapy (KRT) is an important cause of avoidable morbidity and mortality. Here, we evaluated the effect of a complex intervention of graphical estimated glomerular filtration rate (eGFR) surveillance across 15% of the United Kingdom population on the rate (…) (Kidney International (2024))
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  ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging - Quan Jiang, Guiyu Song, Liying He, Xue Li, Bo Jiang, Qianxun Wang, Shaoxun Wang, Catherine Kim, Mahsa Nouri Barkestani, Roberto Lopez, Matthew Fan, Kujani Wanniarachchi, Maya Quaranta, Xuefei Tian, Arya Mani, Anjelica Gonzalez, Julie E. Goodwin, William C. Sessa, Shuta Ishibe, Dan Jane-wit Kidney Int
  ZFYVE21 is an ancient, endosome-associated protein that is highly expressed in endothelial cells (ECs) but whose function(s) in vivo are undefined. Here, we identified ZFYVE21 as an essential regulator of vascular barrier function in the aging kidney. ZFYVE21 levels significantly decline in ECs (…) (Kidney International (2024))

22 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Kidney macrophages keep the stones rolling - Maria B. Rodrigo, Christian Kurts Kidney Int
  The kidney tubulointerstitium is densely populated by mononuclear phagocytes (MNPs), including macrophages and dendritic cells.1 These immune cells develop from yolk sac–derived precursors in early life and are later gradually replaced by bone marrow–derived cells. They enter the kidney by using (…) (Kidney International (2024))
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  The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-?B family activation - Yating Wang, Hongyu Li, Simin Jiang, Dongying Fu, Xiaohui Lu, Miaoqing Lu, Yi Li, Dan Luo, Kefei Wu, Yiping Xu, Guanglan Li, Yi Zhou, Yiming Zhou, Wei Chen, Qinghua Liu, Haiping Mao Kidney Int
  Persistently elevated glycolysis in kidney has been demonstrated to promote chronic kidney disease (CKD). However, the underlying mechanism remains largely unclear. Here, we observed that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key glycolytic enzyme, was remarkably (…) (Kidney International (2024))

21 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Salvaging donated kidneys from prolonged warm ischemia during ex vivo hypothermic oxygenated perfusion - Peng Zhang, Chao Sun, Shuyong Mo, Chaoyu Hu, Yuxiang Ning, Han Liang, Zhongzhong Liu, Xiaoli Fan, Yanfeng Wang Kidney Int
  Prolonged warm ischemic is the main cause discarding donated organs after cardiac death. Here, we identified that prolonged warm ischemic time induced disseminated intravascular coagulation and severe capillary vasospasm after cardiac death of rat kidneys. Additionally, we found a significant (…) (Kidney International (2024))

20 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease - Julie Xia Zhou, Linda Xiaoyan Li, Hongbing Zhang, Ewud Agborbesong, Peter C. Harris, James P. Calvet, Xiaogang Li Kidney Int
  Alteration of DNA methylation leads to diverse diseases, and the dynamic changes of DNA methylation (DNAm) on sets of CpG dinucleotides in mammalian genomes are termed “DNAm age” and “epigenetic clocks” that can predict chronological age. However, whether and how dysregulation of DNA methylation (…) (Kidney International (2024))
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  Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation - Shuwen Yu, Xiangchen Gu, Qimin Zheng, Yunzi Liu, Teija Suhas, Wen Du, Lin Xie, Zhengying Fang, Yafei Zhao, Mingxin Yang, Jing Xu, Yimei Wang, Meei-Hua Lin, Xiaoxia Pan, Jeffrey H. Miner, Yuanmeng Jin, Jingyuan Xie Kidney Int
  COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and other genetic chronic kidney diseases. However, the underlying pathogenesis remains unclear, and specific treatments are lacking. Here, we constructed a transgenic Alport syndrome mouse model by generating a (…) (Kidney International (2024))

13 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  The innate immune cells at the heart of kidney allograft rejection - Griffith B. Perkins, James D. Zuiani, P. Toby Coates Kidney Int
  The pathogenic process underlying graft rejection traditionally is interpreted as being either T cell–mediated (TCMR) or antibody-mediated (ABMR), based on histology. However, mixed and paradoxical rejection phenotypes exist (e.g., ABMR-like microvascular inflammation in the absence of (…) (Kidney International (2024))
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  Variant upon variant: kidney-disease risk associated with APOL1 G2 genetic variants is abrogated by the APOL1 p.N264K variant - Sethu M. Madhavan, Johannes S. Schlöndorff Kidney Int
  Two variants in apolipoprotein L1 (APOL1) (coined G1 and G2), highly prevalent in populations of West African descent including African Americans, confer an increased risk of developing kidney disease.1,2 The variants likely were selected for positively on the African continent by mediating (…) (Kidney International (2024))

12 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Corrigendum to “KDIGO 2024 Clinical Practice Guideline for the Management of Antineutrophil Cytoplasmic Antibody (ANCA)–Associated Vasculitis.” Kidney International 2024;105(3S):S71–S116 - Kidney Disease: Improving Global Outcomes (KDIGO) ANCA Vasculitis Work Group Kidney Int
  DOI of original article: 10.1016/j.kint.2023.10.008 (Kidney International 106, 1 (2024))
• 00:00
  Corrigendum to “Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Management of ANCA–Associated Vasculitis.” Kidney International 2024;105(3):447–449 - Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Ethan M. Balk, Craig E. Gordon, Gaelen Adam, Marcello A. Tonelli, Michael Cheung, Amy Earley, Brad H. Rovin Kidney Int
  DOI of original article: 10.1016/j.kint.2023.10.009 (Kidney International 106, 1 (2024))

7 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Monoclonal immunoglobulin crystalline nephropathies - Samih H. Nasr, Christophe Sirac, Nelson Leung, Frank Bridoux Kidney Int
  Monoclonal Ig crystalline nephropathies are rare lesions resulting from precipitation of monoclonal Igs in the kidney as crystalline inclusions. They can be categorized into lesions with predominant intracellular crystals (light chain [LC] proximal tubulopathy, LC crystal-storing histiocytosis, (…) (Kidney International (2024))

3 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Frailty in patients on dialysis - Gordon Chun-Kau Chan, Kamyar Kalantar-Zadeh, Jack Kit-Chung Ng, Na Tian, Aine Burns, Kai-Ming Chow, Cheuk-Chun Szeto, Philip Kam-Tao Li Kidney Int
  Frailty is a condition that is frequently observed among patients undergoing dialysis. Frailty is characterized by a decline in both physiological state and cognitive state, leading to a combination of symptoms, such as weight loss, exhaustion, low physical activity level, weakness, and slow (…) (Kidney International 106, 1 (2024))

1er mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Seeing through the density of dense deposit disease - Charles E. Alpers Kidney Int
  Little is known about what constitutes the dense deposits of dense deposit disease (DDD), apart from components of the complement pathway. This study presents the novel finding that large accumulations of apolipoprotein E are present in the deposits of DDD, as revealed by mass spectroscopy and (...) (Kidney International 105, 5 (2024))
• 00:00
  The Ottawa Statement implementation guidance document for cluster randomized trials in the hemodialysis setting - Cory E. Goldstein, Monica Taljaard, Stuart G. Nicholls, Mary Beaucage, Jamie Brehaut, Charles L. Cook, Brenden B. Cote, Jonathan C. Craig, Stephanie N. Dixon, Jessica Du Toit, Catherine C.S. Du Val, Amit X. Garg, Jeremy M. Grimshaw, Shasikara Kalatharan, Scott Y.H. Kim, Austin Kinsella, Valerie Luyckx, Charles Weijer Kidney Int
  Research teams are increasingly interested in using cluster randomized trial (CRT) designs to generate practice-guiding evidence for in-center maintenance hemodialysis. However, CRTs raise complex ethical issues. The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized (...) (Kidney International 105, 5 (2024))
• 00:00
  A pig kidney supporting human physiology - Stuart J. Knechtle, Joseph M. Ladowski, Jean Kwun Kidney Int
  Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month’s issue of Kidney International assesses the kidney physiology of a (...) (Kidney International 105, 5 (2024))
• 00:00
  WIP1 inhibition as a new therapeutic strategy for collapsing glomerulopathy - Shreeram Akilesh Kidney Int
  Collapsing glomerulopathy (CG) is an aggressive variant of focal and segmental glomerulosclerosis. Understanding the diverse mechanisms that can drive CG promises to uncover new therapeutic strategies. In this issue, Duret et al. identify WIP1 phosphatase as a therapeutic target for CG. Using (...) (Kidney International 105, 5 (2024))
• 00:00
  Targeting immune cell glutamyl-prolyl-transfer RNA synthetase 1 (EPRS1) to prevent fibrosis after tubulointerstitial nephritis - Shishir Kumar Patel, Hamid Rabb Kidney Int
  Glutamyl-prolyl-transfer RNA synthetase 1 is an enzyme that connects glutamic acid and proline to transfer RNA during protein synthesis. In this issue, a study by Kang et al. examined the role of the immune cell glutamyl-prolyl-transfer RNA synthetase 1 in toxin-induced tubulointerstitial (...) (Kidney International 105, 5 (2024))
• 00:00
  Hereditary hypophosphatemic rickets with hypercalciuria (HHRH), a complex disorder in need of precision medicine - Thorsten Schinke, Ralf Oheim Kidney Int
  Hereditary hypophosphatemic rickets with hypercalciuria is an autosomal recessive phosphate-wasting disorder, associated with kidney and skeletal pathologies, which is caused by pathogenic variants of SLC34A3. In this issue, Zhu et al. describe a pooled analysis of 304 individuals carrying (...) (Kidney International 105, 5 (2024))
• 00:00
  Levamisole in childhood idiopathic nephrotic syndrome: new promises, and advocacy for global access - Eugene Yu-hin Chan, Olivia Boyer Kidney Int
  In the current issue of Kidney International, Sinha et al. present data from an open-label, noninferior, randomized controlled trial comparing 12-months of alternate-day prednisolone, given daily during infection, versus levamisole, in children with frequently relapsing or steroid-dependent (...) (Kidney International 105, 5 (2024))
• 00:00
  Deciphering interleukin 37's therapeutic potential: insights into alleviating inflammation in autosomal dominant polycystic kidney disease - Cheng Xue, Chenchen Zhou, Lijun Sun, Liming Zhang, Zhiguo Mao Kidney Int
  We were intrigued by the article “Modulating Inflammation with Interleukin 37 Treatment Ameliorates Murine Autosomal Dominant Polycystic Kidney Disease,” by Zylberberg et al.1 The study focused on the therapeutic potential of interleukin 37 (IL37) in autosomal dominant polycystic kidney (...) (Kidney International 105, 5 (2024))
• 00:00
  Endogenous adenine as a key player in diabetic kidney disease progression: an integrated multiomics approach - Yu Ah Hong, Masaomi Nangaku Kidney Int
  Adenine is 1 of the 2 nitrogenous bases that form purine nucleotides in nucleic acids. Under physiological conditions, exogenous adenine is absorbed through the intestines, metabolized into several adenine derivatives, and excreted as uric acid by the kidneys. High doses of exogenous adenine (...) (Kidney International 105, 5 (2024))
• 00:00
  B-cell lymphoma with intracellular crystals: a mimic of crystal-storing histiocytosis - Michael G. Daniel, Craig R. Soderquist, Satoru Kudose Kidney Int
  A 74-year-old man with chronic kidney disease and splenic marginal zone lymphoma, diagnosed 3 years ago, status post bendamustine and rituximab and now on zanubrutinib due to recurrence, presented with acute kidney injury and proteinuria. On admission, he had a serum creatinine level of 2.7 (...) (Kidney International 105, 5 (2024))
• 00:00
  Calprotectin, a misnomer for another player in vascular calcification - Tilman B. Drueke, Ziad A. Massy Kidney Int
  Chronic kidney disease (CKD) is an important risk factor for cardiovascular complications. Both traditional and disease-specific risk factors contribute to the increased risk of cardiovascular complications in patients with CKD.1 Vascular calcification is closely associated with increased (...) (Kidney International 105, 5 (2024))
• 00:00
  The Case | Acute kidney injury in a patient with systemic necrotizing lesions - Sébastien Kissling, Samuel Rotman, Fadi Fakhouri Kidney Int
  A 41-year-old male patient, who had been experiencing joint pain and weakness for the past 3 weeks, was admitted to the intensive care unit because of vasoplegic and cardiogenic shock, accompanied by multiorgan failure. Before the rapid deterioration of his clinical condition, his kidney (...) (Kidney International 105, 5 (2024))
• 00:00
  Bacillus Calmette-Guérin–induced kidney granulomas - Xueyan Zhang, Huixiu Lian, Xiaolei Song, Jun Li Kidney Int
  A 59-year-old woman presented with asymptomatic right kidney masses on surveillance computed tomography. She underwent transurethral resection of the bladder tumor for urothelial carcinoma 3 months prior and received regular intravesical Bacillus Calmette-Guérin therapy. Abdominal computed (...) (Kidney International 105, 5 (2024))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 105, 5 (2024))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 105, 5 (2024))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 105, 5 (2024))
• 00:00
  Acknowledgment of reviewers Kidney Int
  The quality of a journal depends on several components: the Authors and their work, the Editors and their efforts to attract the best authors and disseminate their work, and the peer review, which maintains scientific integrity, pushes authors to get the most out of their data, and ensures the (...) (Kidney International 105, 5 (2024))
• 00:00
  in this issue Kidney Int
  Gosselink et al. examined the effects of Alport syndrome (AS) on pregnancy outcomes and kidney function on a cohort of patients after the 20th week of gestation from the ALPART-Network (mAternaL and fetal PregnAncy outcomes of women with AlpoRT syndrome). Patients were stratified by the (...) (Kidney International 105, 5 (2024))
• 00:00
  journal club Kidney Int
  Ishikawa et al. (Bone marrow plasma cells require P2RX4 to sense extracellular ATP. Nature. 2024;626:1102–1107.) (Kidney International 105, 5 (2024))

30 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury - Ye Feng, Zeguo Sun, Jia Fu, Fang Zhong, Weijia Zhang, Chengguo Wei, Anqun Chen, Bi-Cheng Liu, John C. He, Kyung Lee Kidney Int
  Retinoic acid receptor responder protein-1 (RARRES1) is a podocyte-enriched transmembrane protein whose increased expression correlates with human glomerular disease progression. RARRES1 promotes podocytopenia and glomerulosclerosis via p53-mediated podocyte apoptosis. Importantly, the (…) (Kidney International 106, 1 (2024))
• 00:00
  Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV - Annegret Pelchen-Matthews, Amanda Mocroft, Lene Ryom, Michael J. Ross, Shweta Sharma, Steven Coca, Amit Achhra, Elaine Cornell, Russell Tracy, Andrew Phillips, Marta Montero Alonso, Giota Toulomi, Brian K. Agan, Nicholas Medland, Christina M. Wyatt, INSIGHT START Study Group Kidney Int
  People with human immunodeficiency virus (HIV) are at risk for chronic kidney disease (CKD) due to HIV and antiretroviral therapy (ART) nephrotoxicity. Immediate ART initiation reduces mortality and is now the standard of care, but the long-term impact of prolonged ART exposure on CKD is (…) (Kidney International 106, 1 (2024))

29 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  Assessment of biological organ age using molecular pathology in pre-transplant kidney biopsies - Roy Zhang, Patrick B. Trotter, James McCaffrey, Rory Fitzroy, Giorgio Trivioli, Benjamin J. Stewart, John R. Ferdinand, Kevin W. Loudon, Alexandra Riding, Jonathan West, Ashley Ferro, Menna R. Clatworthy Kidney Int
  Organ shortage is a major challenge in kidney transplantation but the use of older donors, often with co-morbidities, is hampered by inconsistent outcomes. Methods of accurately stratifying marginal donor organs by clinical and histological assessment are lacking. To better understand organ (…) (Kidney International (2024))

27 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients - Laura Donadeu, Thomas Jouve, Sofia Bin, Susan Hartzell, Elena Crespo, Alba Torija, Marta Jarque, Delphine Kevella, José Zúñiga, Weijia Zhang, Zeguo Sun, Alberto Verlato, Mónica Martínez-Gallo, Cristina Font-Miñarro, Maria Meneghini, Nestor Toapanta, Irina B. Torres, Joana Sellarés, Manel Perelló, Hannah Kaminski, Lionel Couzi, Alexandre Loupy, Gaetano La Manna, Francesc Moreso, Paolo Cravedi, Oriol Bestard Kidney Int
  Cytomegalovirus (CMV) infection is associated with poor kidney transplant outcomes. While innate and adaptive immune cells have been implicated in its prevention, an in-depth characterization of the in vivo kinetics of multiple cell subsets and their role in protecting against CMV infection has (…) (Kidney International (2024))

26 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  A cohort study of sodium-glucose cotransporter-2 inhibitors after acute kidney injury among Veterans with diabetic kidney disease - Daniel P. Murphy, Julian Wolfson, Scott Reule, Kirsten L. Johansen, Areef Ishani, Paul E. Drawz Kidney Int
  Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce the risk for several adverse outcomes among patients with diabetic kidney disease. Yet, optimal timing for SGLT2i after acute kidney injury (AKI) is uncertain, as are the providers responsible for post-AKI SGLT2i initiation. Using a (…) (Kidney International 106, 1 (2024))

11 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  NELL-1–associated membranous nephropathy linked to skin fairness cream use: insights from an Indian case series - Ranjit Narayanan, Sajeesh Sivadas, Anila Abraham Kurien Kidney Int
  Neural epidermal growth factor-like protein 1 (NELL-1) is an autoantigen associated with both primary and secondary membranous nephropathy (MN) and is described with malignancy, autoimmune diseases, lipoic acid, and traditional indigenous medicines.1–6 (Kidney International 105, 6 (2024))

10 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  The key role of altered tubule cell lipid metabolism in kidney disease development - Lauren E. Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak Kidney Int
  Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and (…) (Kidney International 106, 1 (2024))
• 00:00
  Unexpected metabolic effects of sodium-glucose cotransporter 2 inhibitors - Tilman B. Drueke, Ziad A. Massy Kidney Int
  The sodium-glucose cotransporter 2 (SGLT2) is exclusively expressed in the brush border of the proximal tubule of the kidney, where it effects glucose reabsorption. However, a recent study of young persons with type 2 diabetes (T2D) and early kidney injury showed that treatment with SGLT2 (…) (Kidney International 106, 1 (2024))
• 00:00
  Deciphering missense coding variants with AlphaMissense - Zhicheng Pan, Chandra L. Theesfeld Kidney Int
  Genetic diagnosis promises to guide treatment and manage expectations for patients and physicians. Yet even when a variant in a disease gene is identified, the assignment of pathogenic impact is not always possible.1 Of the 215 million possible substitutions in approximately 19,900 genes, 71 (…) (Kidney International (2024))

5 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  The authors reply - Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, World Kidney Day Joint Steering Committee Kidney Int
  Responding to the letter from Tantisattamo, we are grateful for the interest in our paper on improving kidney care through effective implementation of available scientific knowledge in real-world clinical practices. The author highlighted a framework to help clinicians systematically consider (…) (Kidney International 105, 6 (2024))
• 00:00
  Implementation science: a tool to narrow know-do gap and widen equity in kidney diseases and transplantation - Ekamol Tantisattamo Kidney Int
  I read the 2024 World Kidney Day editorial1 with interest and agree with the authors regarding the current situation where there is a lack of effective implementation of available scientific knowledge in real-world clinical practices. In addition to health behavioral changes to improve clinical (…) (Kidney International 105, 6 (2024))
• 00:00
  The authors reply - Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, writing team and the World Kidney Day Joint Steering Committee Kidney Int
  We thank the author for his interest and comments on this important topic on translating what we know into what we do in kidney care1 and for highlighting Thailand’s success in integrating dialysis and kidney care within its universal health coverage.2 We agreed that this may be a commendable (…) (Kidney International 105, 6 (2024))
• 00:00
  Bridging the knowledge–practice gap in kidney care: insights from a medical student in Thailand - Abhishet Varama Kidney Int
  As a medical student at King Chulalongkorn Memorial Hospital, Bangkok, I found the article “Mind the gap in kidney care: translating what we know into what we do” published in Kidney International1 deeply resonant with my observations in our dialysis unit. (Kidney International 105, 6 (2024))

3 avril

Kidney Int http://www.kidney-international.org/

• 00:00
  Time for action: recognizing chronic kidney disease as a major noncommunicable disease driver of premature mortality - Germaine Wong, Amélie Bernier-Jean, Brad Rovin, Pierre Ronco, Editors of Kidney International Kidney Int
  Chronic kidney disease (CKD) is now the seventh most common cause of death from noncommunicable disease (NCD) worldwide. Approximately 10% of the world’s population is affected by CKD, and many remain undiagnosed.1 Its prevalence has increased from 11% in the early 1990s to >15% in the past (…) (Kidney International 105, 6 (2024))

28 mars

Kidney Int http://www.kidney-international.org/

• 00:00
  Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy - Shubha S. Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian S.D. Roberts, Validation in IgA Nephropathy study group Kidney Int
  Evidence from the Oxford IgA nephropathy (IgAN) cohort supports the clinical value of subclassifying focal segmental glomerulosclerosis lesions (S1). Using the larger Validation in IgA (VALIGA) study cohort, we investigated the association between podocytopathic changes and higher proteinuria, (…) (Kidney International 105, 6 (2024))
• 00:00
  Single-cell lineage tracing approaches to track kidney cell development and maintenance - Baul Yoon, Hayoung Kim, Su Woong Jung, Jihwan Park Kidney Int
  The kidney is a complex organ consisting of various cell types. Previous studies have aimed to elucidate the cellular relationships among these cell types in developing and mature kidneys using Cre-loxP–based lineage tracing. However, this methodology falls short of fully capturing the (…) (Kidney International 105, 6 (2024))

27 mars

Kidney Int http://www.kidney-international.org/

• 00:00
  A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy - Richard Lafayette, Sean Barbour, Rubeen Israni, Xuelian Wei, Necmi Eren, Jürgen Floege, Vivekanand Jha, Sung Gyun Kim, Bart Maes, Richard K.S. Phoon, Harmeet Singh, Vladimír Tesa?, Celia J.F. Lin, Jonathan Barratt Kidney Int
  Atacicept is a first-in-class, dual anti-B-cell Activation Factor–A Proliferation-Inducing Ligand fusion protein in clinical evaluation for treatment of IgA nephropathy. To compare efficacy and safety of atacicept versus placebo in patients with IgAN, this randomized, double-blind, (…) (Kidney International 105, 6 (2024))

25 mars

Kidney Int http://www.kidney-international.org/

• 00:00
  A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis - Wolfgang C. Winkelmayer, Anthonie W.A. Lensing, Ravi I. Thadhani, Kenneth W. Mahaffey, Michael Walsh, Ákos F. Pap, Stefan Willmann, Kirstin Thelen, Sophie Hodge, Alexander Solms, Sheila J.M. Ingham, John Eikelboom, RE-THINC investigators Kidney Int
  Patients with kidney failure on hemodialysis (KF-HD) are at high risk for both atherothrombotic events and bleeding. This Phase IIb study evaluated the dose-response of fesomersen, an inhibitor of hepatic Factor XI expression, versus placebo, for bleeding and atherothrombosis in patients with (…) (Kidney International 106, 1 (2024))
• 00:00
  Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis - Yusho Ueda, Daigo Nakazawa, Saori Nishio, Satoka Shiratori-Aso, Takashi Kudo, Atsuko Miyoshi-Harashima, Kanako Watanabe-Kusunoki, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, Utano Tomaru, Yasuaki Aratani, Mamiko Yamamoto, Akihiro Ishizu, Tatsuya Atsumi Kidney Int
  Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease pathologically characterized by vascular necrosis with inflammation. During AAV development, activated neutrophils produce reactive oxygen species (ROS), leading to the aberrant formation of (…) (Kidney International 105, 6 (2024))

21 mars

Kidney Int http://www.kidney-international.org/

• 00:00
  Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis - Xiao Xiao, Wei Wang, Chunyuan Guo, Jiazhu Wu, Sheng Zhang, Huidong Shi, Sangho Kwon, Jiankang Chen, Zheng Dong Kidney Int
  Epigenetic regulations, including DNA methylation, are critical to the development and progression of kidney fibrosis, but the underlying mechanisms remain elusive. Here, we show that fibrosis of the mouse kidney was associated with the induction of DNA methyltransferases and increases in global (…) (Kidney International 106, 1 (2024))
• 00:00
  Developing a genetic testing panel for evaluation of morbidities in kidney transplant recipients - Becky M. Ma, Naama Elefant, Martina Tedesco, Kelsie Bogyo, Natalie Vena, Sarath K. Murthy, Shiraz A. Bheda, Sandy Yang, Nikita Tomar, Jun Y. Zhang, Syed Ali Husain, Sumit Mohan, Krzysztof Kiryluk, Hila Milo Rasouly, Ali G. Gharavi Kidney Int
  Cardiovascular disease, infection, malignancy, and thromboembolism are major causes of morbidity and mortality in kidney transplant recipients (KTR). Prospectively identifying monogenic conditions associated with post-transplant complications may enable personalized management. Therefore, we (…) (Kidney International 106, 1 (2024))

18 mars

Kidney Int http://www.kidney-international.org/

• 00:00
  Discrepancies between transcutaneous and estimated glomerular filtration rates in rats with chronic kidney disease - Tobias T. Pieters, Paul J. Besseling, Dominique M. Bovée, Maarten B. Rookmaaker, Marianne C. Verhaar, Benito Yard, Ewout J. Hoorn, Jaap A. Joles Kidney Int
  Accurate assessment of the glomerular filtration rate (GFR) is crucial for researching kidney disease in rats. Although validation of methods that assess GFR is crucial, large-scale comparisons between different methods are lacking. Both transcutaneous GFR (tGFR) and a newly developed estimated (…) (Kidney International 105, 6 (2024))
• 00:00
  Cutting back on low-value health care practices supports sustainable kidney care - Scott McAlister, Valerie A. Luyckx, Andrea K. Viecelli Kidney Int
  July 2023 marked the hottest month on record, underscoring the urgent need for action on climate change. The imperative to reduce carbon emissions extends to all sectors, including health care, with it being responsible for 5.5% of global emissions. In decarbonizing health care, although much (…) (Kidney International 105, 6 (2024))

6 mars

Kidney Int http://www.kidney-international.org/

• 00:00
  Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3-dimensional fast marching algorithm - Alexander M.C. Böhner, Alexander Effland, Alice M. Jacob, Karin A.M. Böhner, Zeinab Abdullah, Sebastian Brähler, Ulrike I. Attenberger, Martin Rumpf, Christian Kurts Kidney Int
  Three-dimensional (3D) imaging has advanced basic research and clinical medicine. However, limited resolution and imperfections of real-world 3D image material often preclude algorithmic image analysis. Here, we present a methodologic framework for such imaging and analysis for functional and (…) (Kidney International 105, 6 (2024))

29 février

Kidney Int http://www.kidney-international.org/

• 00:00
  Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function - Evans O. Asowata, Simone Romoli, Rebecca Sargeant, Jennifer Y. Tan, Scott Hoffmann, Margaret M. Huang, Krishnaa T. Mahbubani, Fynn N. Krause, Daniel Jachimowicz, Rasmus Agren, Albert Koulman, Benjamin Jenkins, Barbara Musial, Julian L. Griffin, Magnus Soderberg, Stephanie Ling, Pernille B.L. Hansen, Kourosh Saeb-Parsy, Kevin J. Woollard Kidney Int
  Despite the recent advances in our understanding of the role of lipids, metabolites, and related enzymes in mediating kidney injury, there is limited integrated multi-omics data identifying potential metabolic pathways driving impaired kidney function. The limited availability of kidney biopsies (…) (Kidney International 106, 1 (2024))
• 00:00
  Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition - Jeonghwan Lee, Jinhaeng Lee, Kyuhong Kim, Jiwon Lee, Youngae Jung, Jin Seong Hyeon, Areum Seo, Wencheng Jin, Boram Weon, Nayeon Shin, Sejoong Kim, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee, Geum-Sook Hwang, Seung Hee Yang Kidney Int
  Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of antibiotic-induced microbiota depletion (…) (Kidney International 105, 6 (2024))

28 février

Kidney Int http://www.kidney-international.org/

• 00:00
  Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis - Josep M. Cruzado, Anna Manonelles, Sandra Rayego-Mateos, Núria Doladé, Ana Amaya-Garrido, Cristian Varela, Roser Guiteras, Jose Luis Mosquera, Michaela Jung, Sergi Codina, Laura Martínez-Valenzuela, Juliana Draibe, Carlos Couceiro, Francesc Vigués, Álvaro Madrid, M. Carolina Florian, Marta Ruíz-Ortega, Anna Sola Kidney Int
  Parietal epithelial cells (PECs) are kidney progenitor cells with similarities to a bone marrow stem cell niche. In focal segmental glomerulosclerosis (FSGS) PECs become activated and contribute to extracellular matrix deposition. Colony stimulating factor-1 (CSF-1), a hematopoietic growth (…) (Kidney International 106, 1 (2024))

27 février

Kidney Int http://www.kidney-international.org/

• 00:00
  Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury - Jianchun Chen, Xiaoyong Wang, Qian He, Hai-Chun Yang, Agnes B. Fogo, Raymond C. Harris Kidney Int
  Podocyte injury and loss are hallmarks of diabetic nephropathy (DN). However, the molecular mechanisms underlying these phenomena remain poorly understood. YAP (Yes-associated protein) is an important transcriptional coactivator that binds with various other transcription factors, including the (…) (Kidney International 105, 6 (2024))

26 février

Kidney Int http://www.kidney-international.org/

• 00:00
  Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription - Yue Lu, Linlin Meng, Ruiqing Ren, Xinlu Wang, Wenhai Sui, Fei Xue, Lin Xie, Ang Chen, Yuxia Zhao, Jianmin Yang, Wencheng Zhang, Xiao Yu, Bo Xi, Feng Xu, Meng Zhang, Yun Zhang, Cheng Zhang Kidney Int
  Vascular calcification is a pathological process commonly associated with atherosclerosis, chronic kidney disease, and diabetes. Paraspeckle protein NONO is a multifunctional RNA/DNA binding protein involved in many nuclear biological processes but its role in vascular calcification remains (…) (Kidney International 105, 6 (2024))

26 janvier

Kidney Int http://www.kidney-international.org/

• 00:00
  Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine - Anna Reznichenko, Viji Nair, Sean Eddy, Damian Fermin, Mark Tomilo, Timothy Slidel, Wenjun Ju, Ian Henry, Shawn S. Badal, Johnna D. Wesley, John T. Liles, Sven Moosmang, Julie M. Williams, Carol Moreno Quinn, Markus Bitzer, Jeffrey B. Hodgin, Laura Barisoni, Anil Karihaloo, Matthew D. Breyer, Kevin L. Duffin, Uptal D. Patel, Maria Chiara Magnone, Ratan Bhat, Matthias Kretzler Kidney Int
  Current classification of chronic kidney disease (CKD) into stages using indirect systemic measures (estimated glomerular filtration rate (eGFR) and albuminuria) is agnostic to the heterogeneity of underlying molecular processes in the kidney thereby limiting precision medicine approaches. To (…) (Kidney International 105, 6 (2024))