11:00Rectifying METTL4-Mediated N6-Methyladenine Excess in Mitochondrial DNA Alleviates Heart Failure -
Fuyang Zhang Ling Zhang Guangyu Hu Xiyao Chen Hui Liu Congye Li Xiong Guo Chong Huang Fangfang Sun Tongzheng Li Zhe Cui Yongzhen Guo Wenjun Yan Yunlong Xia Zhiyuan Liu Zhen Lin Weixun Duan Linhe Lu Xinyi Wang Zhengyang Wang Shan Wang Ling Tao Departments of Cardiology (F.Z., L.Z., G.H., H.L., C.L., X.G., C.H., F.S., T.L., Z.C., Y.G., W.Y., Y.X., Z. Liu, Z. Lin, X.W., Z.W., S.W., L.T.), Xijing Hospital, Fourth Military Medical University, Xi’an, China. Geriatrics (X.C.), Xijing Hospital, Fourth Military Medical University, Xi’an, China. Cardiovascular Surgery (W.D., L.L.), Xijing Hospital, (…)
Circulation
Circulation, Ahead of Print. BACKGROUND:Myocardial mitochondrial dysfunction underpins the pathogenesis of heart failure (HF), yet therapeutic options to restore myocardial mitochondrial function are scarce. Epigenetic modifications of mitochondrial DNA (mtDNA), such as methylation, play a (…) (Circulation)
11:00Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease -
Huize Pan Sebastian E. Ho Chenyi Xue Jian Cui Quinian S. Johanson Nadja Sachs Leila S. Ross Fang Li Robert A. Solomon E. Sander Connolly Virendra I. Patel Lars Maegdefessel Hanrui Zhang Muredach P. Reilly Division of Cardiology, Department of Medicine (H.P., S.E.H., C.X., J.C., Q.S.J., L.S.R., F.L., H.Z., M.P.R.), Columbia University Irving Medical Center, New York, NY. Irving Institute for Clinical and Translational Research (M.P.R.), Columbia University Irving Medical Center, New York, NY. Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, (…)
Circulation
Circulation, Volume 149, Issue 24, Page 1885-1898, June 11, 2024. BACKGROUND:Atherosclerosis, a leading cause of cardiovascular disease, involves the pathological activation of various cell types, including immunocytes (eg, macrophages and T cells), smooth muscle cells (SMCs), and endothelial (…) (Circulation)