5 juin

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Personalized peritoneal dialysis prescription—beyond clinical or analytical values Clin Kidney J
  ABSTRACTTraditionally, dialysis adequacy has been assessed primarily by determining the clearance of a single small solute, urea. Nevertheless, it has become increasingly evident that numerous other factors play a crucial role in the overall well-being, outcomes and quality of life of dialysis (…)
• 02:00
  Towards a better uptake of home dialysis in Europe: understanding the present and looking to the future Clin Kidney J
  ABSTRACTUse of peritoneal dialysis and home haemodialysis remains low in Europe, with the highest use in Scandinavian countries and the lowest in Eastern and Central Europe despite the advantages for people on dialysis and economic advantages for healthcare systems. This is partly due to the (…)
• 02:00
  Integrated home dialysis model: facilitating home-to-home transition Clin Kidney J
  ABSTRACTPeritoneal dialysis (PD) and home hemodialysis (HHD) are the two home dialysis modalities offered to patients. They promote patient autonomy, enhance independence, and are generally associated with better quality of life compared to facility hemodialysis. PD offers some advantages (…)
• 02:00
  The integrated care model: facilitating initiation of or transition to home dialysis Clin Kidney J
  ABSTRACTA proportion of end-stage kidney disease (ESKD) patients require kidney replacement therapy to maintain clinical stability. Home dialysis therapies offer convenience, autonomy and potential quality of life improvements, all of which were heightened during the COVID-19 pandemic. While the (…)
• 02:00
  Use of eHealth and remote patient monitoring: a tool to support home dialysis patients, with an emphasis on peritoneal dialysis Clin Kidney J
  ABSTRACTImplementing eHealth requires technological advancement, universal broadband and internet access, and devices to conduct telemedicine and remote patient monitoring in end-stage kidney disease patients receiving home dialysis. Although eHealth was beginning to make inroads in this patient (…)
• 02:00
  Assisted peritoneal dialysis in Europe: a strategy to increase and maintain home dialysis Clin Kidney J
  ABSTRACTPeritoneal dialysis (PD) is a form of kidney replacement therapy with the major advantage that it can be performed at home. This has a positive impact on patients’ autonomy and quality of life. However, the dialysis population is ageing and physical and/or cognitive impairments are (…)
• 02:00
  Fostering a future of home dialysis: transforming kidney care in Europe Clin Kidney J
  Baxter Healthcare Corporation10.13039/100007658

24 mai

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Correction to: Moving on obesity treatment in CKD: inertia is unjustified Clin Kidney J

23 mai

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Sixty years of European Renal Association (ERA) Registry data on kidney disease: visualizing differences in clinical practice Clin Kidney J
  European Renal Association

25 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  The effect of COVID-19 vaccination on kidney function and HLA antibody formation in patients with end-stage kidney disease and on kidney replacement treatment Clin Kidney J
  Netherlands Organisation for Health Research and Development10.13039/50110000182610430072010002
• 02:00
  Effect of absolute blood volume measurement–guided fluid management on the incidence of intradialytic hypotension-associated events: a randomised controlled trial Clin Kidney J
  AbstractBackgroundUltrafiltration to target weight during haemodialysis is complicated by intradialytic hypotension-associated adverse events (IHAAEs) in 10–30% of dialysis treatments. IHAAEs are caused by critical reductions in absolute blood volume (ABV), due to the interaction of (...)
• 02:00
  Risk of first peritonitis episode in continuous ambulatory peritoneal dialysis and automated peritoneal dialysis: a population-based study Clin Kidney J

23 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Prevalence of chronic kidney disease in France: methodological considerations and pitfalls with the use of Health claims databases Clin Kidney J
  ABSTRACTBackgroundHealth policy-making require careful assessment of chronic kidney disease (CKD) epidemiology to develop efficient and cost-effective care strategies. The aim of the present study was to use the RENALGO-EXPERT algorithm to estimate the global prevalence of CKD in (...)

22 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Factor XI antagonists: the discovery of the philosopher's stone? Clin Kidney J

18 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Arteriovenous fistula for haemodialysis as a predictor of de novo heart failure in kidney transplant recipients Clin Kidney J
  ABSTRACTBackgroundThe haemodynamic effects of a functioning haemodialysis arteriovenous fistula (AVF) can cause or exacerbate heart failure (HF). We investigated whether the presence of an AVF at the time of kidney transplant (KT) is associated with de novo HF.MethodsThis was an observational (...)
• 02:00
  Prediction of incident chronic kidney disease in community-based electronic health records: a systematic review and meta-analysis Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD) is a major global health problem and its early identification would allow timely intervention to reduce complications. We performed a systematic review and meta-analysis of multivariable prediction models derived and/or validated in (...)

17 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Genome editing and kidney health Clin Kidney J
  ABSTRACTGenome editing technologies, clustered regularly interspaced short palindromic repeats (CRISPR)-Cas in particular, have revolutionized the field of genetic engineering, providing promising avenues for treating various genetic diseases. Chronic kidney disease (CKD), a significant health (...)

16 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Deciphering three predominant biopsy-proven phenotypes of IgG4-associated kidney disease: a retrospective study Clin Kidney J
  ABSTRACTBackgroundIgG4-associated kidney disease (IgG4-RKD) encompasses a spectrum of disorders, predominantly featuring tubulointerstitial nephritis (TIN) and membranous glomerulonephropathy (MGN). The limited understanding of the co-occurrence of IgG4-RD-TIN with anti-neutrophil cytoplasmic (...)
• 02:00
  The efficacy and safety of tacrolimus in treating refractory IgA vasculitis nephritis: a single-center retrospective study on 16 cases Clin Kidney J
  ABSTRACTBackgroundThis study aimed to observe the efficacy and safety of tacrolimus in the treatment of refractory immunoglobulin A vasculitis nephritis (IgAVN).MethodsSixteen patients with IgAVN who had been previously treated with cyclophosphamide shock therapy at least five times, some of (...)

15 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Acute kidney injury and point-of-care ultrasound in liver cirrhosis: redefining hepatorenal syndrome Clin Kidney J
  AbstractAcute kidney injury (AKI) in patients with cirrhosis is a diagnostic challenge due to multiple and sometimes overlapping possible etiologies. Many times, diagnosis cannot be made based on case history, physical examination or laboratory data, especially when the nephrologist is faced (...)
• 02:00
  Outcomes of primary membranous nephropathy refractory to immunosuppressants Clin Kidney J

13 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey Clin Kidney J
  ABSTRACTBackground and hypothesisThere seems to be a lack of consensus on the necessity and the modality of psychological and specifically cognitive assessment of candidates for kidney transplantation. Both points are often delegated to individual hospitals/centres, whereas international (...)
• 02:00
  Effects of Kt/Vurea on outcomes according to age in patients on maintenance hemodialysis Clin Kidney J
  ABSTRACTBackgroundThe guidelines recommended target and minimum single-pool Kt/Vurea are 1.4 and 1.2, respectively, in hemodialysis patients. However, the optimal hemodialysis dose remains controversial. We investigated the effects of Kt/Vurea on patient outcomes according to age, with a focus (...)

11 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Rationale and design of the Innsbruck Diabetic Kidney Disease Cohort (IDKDC)—a prospective study investigating etiology and progression of early-stage chronic kidney disease in type 2 diabetes Clin Kidney J
  ABSTRACTBackgroundThe development of chronic kidney disease (CKD) in about 20%–40% of patients with type 2 diabetes (T2D) aggravates cardiovascular morbidity and mortality. Pathophysiology is of increasing relevance for individual management and prognosis, though it is largely unknown among (...)

8 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  A clinical score to predict recovery in end-stage kidney disease due to acute kidney injury Clin Kidney J
  ABSTRACTBackgroundAcute kidney injury (AKI) is a major contributor to end-stage kidney disease (ESKD). About one-third of patients with ESKD due to AKI recover kidney function. However, the inability to accurately predict recovery leads to improper triage of clinical monitoring and impacts the (...)
• 02:00
  31P-MRS, molecular level imaging for assessing muscular mitochondrial dysfunction in chronic kidney disease Clin Kidney J

3 avril

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Primary hyperoxaluria in adults and children: a nationwide cohort highlights a persistent diagnostic delay Clin Kidney J
  ABSTRACTBackgroundPrimary hyperoxalurias (PH) are extremely rare genetic disorders characterized by clinical heterogeneity. Delay in diagnosing these conditions can have detrimental effects on patient outcomes. The primary objective of this study is to assess the current diagnostic delay for (...)

30 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Single-patient trial of dietary protein restriction in kidney disease: a patient-centred opportunity Clin Kidney J

28 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Lumasiran treatment in pediatric patients with PH1: real-world data within a compassionate use program in Italy Clin Kidney J
  ABSTRACTBackgroundPrimary hyperoxaluria (PH) is a rare, severe genetic disorder, characterized by increased urinary excretion of calcium oxalate, which is responsible for kidney damage and systemic clinical manifestations. Since the year 2020, a new molecule, lumasiran, based on RNA (...)

27 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Non-surgical interventions to control bleeding from arteriovenous fistulas and grafts inside and outside the hemodialysis unit: a scoping review Clin Kidney J
  ABSTRACTBackgroundProlonged bleeding from arteriovenous fistulas (AVF) and arteriovenous grafts (AVG) associates with worse outcomes; Within the hemodialysis unit these outcomes include anemia and quality of life disruptions, and outside the hemodialysis unit includes fatal hemorrhage. (...)
• 01:00
  Comparison of ?-blocker agents and mortality in maintenance hemodialysis patients: an international cohort study Clin Kidney J
  ABSTRACTBackgroundDespite a lack of clinical trial data, ?-blockers are widely prescribed to dialysis patients. Whether specific ?-blocker agents are associated with improved long-term outcomes compared with alternative ?-blocker agents in the dialysis population remains uncertain.MethodsWe (...)
• 01:00
  Performances of acute kidney injury biomarkers vary according to sex Clin Kidney J
  ABSTRACTBackgroundBefore implementing individualized strategies to treat acute kidney injury (AKI), identifying clusters of patients with divergent pathophysiological mechanisms, diagnosis criteria or outcomes is of the utmost importance. Here we studied sex-related molecular mechanisms in (...)

25 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Maintained renin–angiotensin–aldosterone system inhibitor therapy with sodium zirconium cyclosilicate following a hyperkalaemia episode: a multicountry cohort study Clin Kidney J
  ABSTRACTBackgroundThis observational cohort study compared the likelihood of maintained (stabilized/up-titrated) renin–angiotensin–aldosterone system inhibitor (RAASi) therapy at 6 months following hyperkalaemia in patients with chronic kidney disease (CKD) and/or heart failure (HF) from the (...)

22 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Pre-gestational counselling for women living with CKD: starting from the bright side Clin Kidney J
  ABSTRACTPregnancy in women living with chronic kidney disease (CKD) was often discouraged due to the risk of adverse maternal–fetal outcomes and the progression of kidney disease. This negative attitude has changed in recent years, with greater emphasis on patient empowerment than on the (...)
• 01:00
  A 20-year follow-up study of identical twin sisters with immunoglobulin A nephropathy Clin Kidney J
  ABSTRACTImmunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney histopathology and proteinuria and a lower (...)
• 01:00
  Artificial intelligence in medicine and nephrology: hope, hype, and reality Clin Kidney J
• 01:00
  Time for a relook? An update on primary membranous nephropathy incidence in a large UK cohort Clin Kidney J

20 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Decreased life expectancy: a health outcome not corrected by kidney replacement therapy that emphasizes the need for primary prevention of CKD Clin Kidney J
  FEDER10.13039/501100002924PI22/00469PI22/00050PI21/00251ERA-PerMed-JTC2022AC22/00027Comunidad de Madrid en BiomedicinaP2022/BMD-7223European Union10.13039/501100000780
• 01:00
  Fractional excretion of total protein predicts renal prognosis in Japanese patients with primary membranous nephropathy Clin Kidney J
  ABSTRACTBackgroundPrimary membranous nephropathy (pMN) is one of the most common types of glomerulonephritis, with a third of patients progressing to renal insufficiency. Various prognostic factors have been reported, of which urinary protein and renal function are the most critical (...)

19 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Endothelin receptor antagonists in diabetic and non-diabetic chronic kidney disease Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) is one of the major causes of morbidity and mortality, affecting >800 million persons globally. While we still lack efficient, targeted therapies addressing the major underlying pathophysiologic processes in CKD, findings of several recent trials have (...)

15 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Associations of MRI-derived kidney volume, kidney function, body composition and physical performance in ?38 000 UK Biobank participants: a population-based observational study Clin Kidney J
  ABSTRACTBackgroundKidney volume is used as a predictive and therapeutic marker for several clinical conditions. However, there is a lack of large-scale studies examining the relationship between kidney volume and various clinicodemographic factors, including kidney function, body composition (...)

14 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Baxter Physioneal, Extraneal, Nutrineal (PEN) and Dianeal solution bags can be accidentally connected to Fresenius peritoneal dialysis catheter extensions in a non-sterile manner Clin Kidney J
  Dr Werner Jacksta?dt Foundation
• 01:00
  Associations of urinary fetuin-A with histopathology and kidney events in biopsy-proven kidney disease Clin Kidney J
  ABSTRACTBackgroundFetuin-A is implicated in the pathogenesis of vascular calcification in chronic kidney disease (CKD); however, the relationship between fetuin-A, histopathologic lesions and long-term kidney outcomes in patients with various types of kidney disease remains unclear.MethodsWe (...)

13 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Differences in drug removal between standard high-flux and medium cut-off dialyzers in a case of severe vancomycin toxicity Clin Kidney J
  ABSTRACTVancomycin is a widely used glycopeptide antibiotic with the need for therapeutic drug monitoring to avoid renal toxicity. We report a case of severe vancomycin-associated anuric acute kidney injury managed with successful drug-removal by hemodialysis (HD) using different types of (...)
• 01:00
  Denosumab-induced hypocalcemia in patients treated with dialysis: an avoidable complication? Clin Kidney J

12 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Meet and greet but avoid the heat: a reflection on the carbon footprint of congresses prompted by ERA2023 Clin Kidney J
• 01:00
  Continuous surveillance for kidney transplant rejection: ready for clinical trials? Clin Kidney J

9 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Fine-tuning tumor- and allo-immunity: advances in the use of immune checkpoint inhibitors in kidney transplant recipients Clin Kidney J
  ABSTRACTCancer is a common complication after kidney transplantation. Kidney transplant recipients (KTR) have a 2- to 4-fold higher risk of developing cancer compared to the general population and post-transplant malignancy is the third most common cause of death in KTR. Moreover, it is well (...)
• 01:00
  Generalize the use of the kidney failure risk equation (KFRE) for better vascular access planning Clin Kidney J
• 01:00
  Kidney involvement in Wilson's disease: a review of the literature Clin Kidney J
  ABSTRACTWilson's disease (WD) is a rare inherited disease due to the mutation of the ATP7B gene, resulting in impaired hepatic copper excretion and its pathological accumulation in various organs such as the liver, the nervous system, or the kidneys. Whereas liver failure and neuropsychiatric (...)

7 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Plain language summary of a study looking at the effect of empagliflozin treatment in patients with chronic kidney disease Clin Kidney J
  Video Abstract10.1093/ckj/sfae057Video Abstract Watch the video of this contribution at https://academic.oup.com/ckj/pages/author_videossfae057Media16351880631112
• 01:00
  Estimating glomerular filtration rate with cystatin C: a systematic comparison of the new EKFC and the CKD-EPI equation Clin Kidney J
• 01:00
  Association between diabetic status and risk of all-cause and cause-specific mortality on dialysis following first kidney allograft loss Clin Kidney J
  ABSTRACTBackgroundDiabetes mellitus (DM) is associated with a greater risk of mortality in kidney transplant patients, primarily driven by a greater risk of cardiovascular disease (CVD)-related mortality. However, the associations between diabetes status at time of first allograft loss and (...)

6 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Switching from immediate- to extended-release cysteamine in patients with nephropathic cystinosis: from clinical trials to clinical practice Clin Kidney J
  ABSTRACTBackgroundThe purpose of this study is to evaluate the effectiveness and safety of switching from immediate-release (IR) to extended-release (ER) cysteamine in patients with nephropathic cystinosis (NC) in Spain.MethodsWe conducted an observational, retrospective, multicentre study in (...)
• 01:00
  Validation of the Klinrisk chronic kidney disease progression model in the FIDELITY population Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD) affects >800 million individuals worldwide and is often underrecognized. Early detection, identification and treatment can delay disease progression. Klinrisk is a proprietary CKD progression risk prediction model based on common laboratory data (...)

4 mars

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review Clin Kidney J
  ABSTRACTAcute interstitial nephritis (AIN) is a significant contributor to acute kidney injury and can be attributed to a variety of factors, including but not limited to allergens or drugs, infections, autoimmune or systemic diseases, and idiopathic forms of the disease. In some cases, AIN (...)

29 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Differential associations of fetuin-A and calcification propensity with cardiovascular events and subsequent mortality in patients undergoing hemodialysis Clin Kidney J
  ABSTRACTBackgroundFetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter T50 levels were (...)

28 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Recovery from kidney failure associated with chronic thromboembolic pulmonary hypertension following pulmonary thomboendarterectomy Clin Kidney J
  ABSTRACTThe occurrence of renal failure in pulmonary hypertension (PH) is an ominous sign and implies excessive adverse hemodynamic factors. Pharmacologic agents to treat the PH are the mainstay of management, whereas diuretics assist in management of fluid overload. However, when such (...)

23 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Ionized and total magnesium levels in patients with chronic kidney disease: associated factors and outcomes Clin Kidney J
  ABSTRACTBackgroundThe association between hypo- and/or hypermagnesaemia and cardiovascular (CV) outcomes or mortality has shown conflicting results in chronic kidney disease (CKD) and has been conducted on total magnesium (tMg) levels. Thus, the objectives of the present study were to (i) (...)

21 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Are we ready for an adipocentric approach in people living with type 2 diabetes and chronic kidney disease? Clin Kidney J
  ABSTRACTWe are entering a new era in the management of adiposity-based chronic disease (ABCD) with type 2 diabetes (T2D) and related chronic kidney disease (CKD). ABCD, T2D and CKD can affect almost every major organ system and have a particularly strong impact on the incidence of (...)
• 01:00
  Exploring the impact and utility of genomic sequencing in established CKD Clin Kidney J
  ABSTRACTClinical genetics is increasingly recognized as an important area within nephrology care. Clinicians require awareness of genetic kidney disease to recognize clinical phenotypes, consider use of genomics to aid diagnosis, and inform treatment decisions. Understanding the broad spectrum (...)
• 01:00
  Risk of incident chronic kidney disease among patients with urolithiasis: a nationwide longitudinal cohort study Clin Kidney J
  ABSTRACTBackgroundUrolithiasis has been infrequently implicated to have a causal association with chronic kidney disease (CKD). Recently, several studies have demonstrated the relationship between urolithiasis and CKD. However, the generalizability of their results is limited. This study aimed (...)

20 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Transient acute kidney injury after chimeric antigen receptor T-cell therapy in patients with hematological malignancies Clin Kidney J
  ABSTRACTBackgroundAcute kidney injury (AKI) occurs in 30% of patients infused with chimeric antigen receptor (CAR) T-cells. The purpose of this study was to identify risk factors and long-term outcomes after AKI in patients who received CAR T-cell therapy.MethodsMedical records of 115 adult (...)
• 01:00
  Making the invisible visible: imaging techniques for assessing muscle mass and muscle quality in chronic kidney disease Clin Kidney J
  ABSTRACTMuscle wasting and low muscle mass are prominent features of protein energy wasting (PEW), sarcopenia and sarcopenic obesity in patients with chronic kidney disease (CKD). In addition, muscle wasting is associated with low muscle strength, impaired muscle function and adverse clinical (...)
• 01:00
  Mortality and hyperkalaemia-associated hospitalisation in patients with chronic kidney disease: comparison of sodium zirconium cyclosilicate and sodium/calcium polystyrene sulfonate Clin Kidney J
  ABSTRACTBackgroundSodium zirconium cyclosilicate (SZC), a novel drug used for treating hyperkalaemia, is effective in reducing serum potassium levels. The effects of potassium adsorbents on the mortality and hyperkalaemia-associated hospitalisation rates remain unclear. We aimed to examine how (...)

15 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Monoallelic pathogenic IFT140 variants are a common cause of autosomal dominant polycystic kidney disease–spectrum phenotype Clin Kidney J
  ABSTRACTBackgroundAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, characterized by development and enlargement of kidney cysts, eventually leading to end-stage kidney disease (ESKD). Pathogenic variants in the PKD1 and PKD2 genes are the major (...)

14 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Characterization of glomerular basement membrane components within pediatric glomerular diseases Clin Kidney J
  ABSTRACTBackgroundDisruptions in gene expression associated with the glomerular basement membrane (GBM) could precipitate glomerular dysfunction. Nevertheless, a comprehensive understanding of the characterization of GBM components within pediatric glomerular diseases and their potential (...)

12 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Single-nephron assessment of urate excretion in patients with IgA nephropathy Clin Kidney J
  JSPS10.13039/501100001691JP 21K08238

9 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Loin pain haematuria syndrome 1967–2020: a review Clin Kidney J
  ABSTRACTThe purpose of this retrospective review is to question the validity of the condition ‘loin pain haematuria syndrome’ (LPHS). We highlight the possibility that most patients regarded as having LPHS have a psychiatric/psychological basis for their symptoms, particularly loin pain. (...)
• 01:00
  Association between beta-blocker utilization and heart failure mortality in the peritoneal dialysis population: a cohort study Clin Kidney J
  ABSTRACTBackgroundThe prognostic significance of beta(?)-blocker therapy in patients at end-stage renal disease, specifically those receiving peritoneal dialysis (PD) and presenting with heart failure, remains inadequately elucidated due to limited research conducted thus far.MethodsA (...)
• 01:00
  Renal function alters the association of lipoprotein(a) with cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a prospective cohort study Clin Kidney J
  ABSTRACTBackground and hypothesisLipoprotein(a) [Lp(a)] and renal dysfunction are both independent risk factors for cardiovascular disease. However, it remains unclear whether renal function mediates the association between Lp(a) and cardiovascular outcomes in patients undergoing percutaneous (...)
• 01:00
  Dapagliflozin in chronic kidney disease: cost-effectiveness beyond the DAPA-CKD trial Clin Kidney J
  ABSTRACTBackgroundThe Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial enrolled patients with estimated glomerular filtration rate 25–75 mL/min/1.73 m2 and urine albumin-to-creatinine ratio >200 mg/g. The Dapagliflozin Effect on CardiovascuLAR Events-Thrombolysis in (...)

8 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  The Young Nephrologists’ Platform: the gateway to the future of nephrology Clin Kidney J

7 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Correction to: A deep learning system for retinal vessel calibre improves cardiovascular risk prediction in Asians with chronic kidney disease Clin Kidney J

5 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Incremental dialysis: two complementary views Clin Kidney J
  ABSTRACTFranco Casino and Mariana Murea discuss today's knowledge about the ‘incremental dialysis’ concept. Franco Casino frames the problem by saying that, in the presence of substantial residual kidney function, kidney replacement therapy can begin with low doses and/or frequencies, to be (...)
• 01:00
  Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise Clin Kidney J
  ABSTRACTChronic changes on kidney biopsy specimens include increasing amounts of arteriosclerosis, glomerulosclerosis, interstitial fibrosis and tubular atrophy, enlarged nephron size, and reduced nephron number. These chronic changes are difficult to accurately assess by visual inspection but (...)

2 février

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Membranous nephropathy in primary antiphospholipid syndrome Clin Kidney J
• 01:00
  Recognition of intraglomerular histological features with deep learning in protocol transplant biopsies and their association with kidney function and prognosis Clin Kidney J
  ABSTRACTBackgroundThe Banff Classification may not adequately address protocol transplant biopsies categorized as normal in patients experiencing unexplained graft function deterioration. This study seeks to employ convolutional neural networks to automate the segmentation of glomerular cells (...)

31 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  The risk of CKD progression remains high in patients treated with ACE inhibitors and ARBs, MRAs and SGLT2 inhibitors. Have we already achieved the therapeutic ceiling in CKD? (The CON part) Clin Kidney J
  ABSTRACTRenin-Angiotensin-System (RAS) inhibitors remained the only effective nephro-protective treatments until recent landmark trials showed that sodium-glucose co-transporter 2 (SGLT2) inhibitors and non-steroid mineral receptor antagonists added-on RAS inhibitor therapy dramatically slowed (...)
• 01:00
  Moderator's view: after SGLT2i and MRA antagonists, where do we go? Clin Kidney J
• 01:00
  Use of ACEi/ARBs, SGLT2 inhibitors and MRAs can help us reach the therapeutic ceiling in CKD Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) is increasing in prevalence worldwide, posing major implications for public health such as kidney failure requiring dialysis, and increased risk of cardiovascular and all-cause mortality. Diabetic and hypertensive kidney disease represent the two most (...)
• 01:00
  The utility of surveillance peritoneal dialysis effluent cultures following completion of PD peritonitis treatment: a quality improvement report Clin Kidney J

24 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Microangiopathy associated with poor outcome of immunoglobulin A nephropathy: a cohort study and meta-analysis Clin Kidney J
  ABSTRACTBackgroundMicroangiopathy (MA) lesions are not rare in immunoglobulin A nephropathy (IgAN) and have been suggested to have a potential role in increasing risk in renal function decline. However, this suggestion has not been universally accepted. We aimed to investigate its role in our (...)

19 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Comparison of three creatinine-based equations to predict adverse outcome in a cardiovascular high-risk cohort: an investigation using the SPRINT research materials Clin Kidney J
  ABSTRACTBackgroundNovel creatinine-based equations have recently been proposed but their predictive performance for cardiovascular outcomes in participants at high cardiovascular risk in comparison to the established CKD-EPI 2009 equation is unknown.MethodIn 9361 participants from the United (...)
• 01:00
  Potentially modifiable factors associated with health-related quality of life among people with chronic kidney disease: baseline findings from the National Unified Renal Translational Research Enterprise CKD (NURTuRE-CKD) cohort Clin Kidney J
  ABSTRACTBackgroundMany non-modifiable factors are associated with poorer health-related quality of life (HRQoL) experienced by people with chronic kidney disease (CKD). We hypothesize that potentially modifiable factors for poor HRQoL can be identified among CKD patients, providing potential (...)
• 01:00
  Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study Clin Kidney J
  ABSTRACTBackgroundPost-operative acute kidney injury (PO-AKI) is a common surgical complication consistently associated with subsequent morbidity and mortality. Prior kidney dysfunction is a major risk factor for PO-AKI, however it is unclear whether serum creatinine, the conventional kidney (...)

12 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  An increase in albuminuria is associated with a higher incidence of malignancies Clin Kidney J
  ABSTRACTBackgroundA single albuminuria measurement is reported to be an independent predictor of cancer risk. Whether change in albuminuria is also independently associated with cancer is not known.MethodsWe included 64 303 subjects of the Stockholm CREAtinine Measurements (SCREAM) project (...)

11 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Kidney Failure Risk Equation in vascular access planning: a population-based study supporting value in decision making Clin Kidney J
  ABSTRACTBackgroundThe Kidney Failure Risk Equation (KFRE) can play a better role in vascular access (VA) planning in patients with chronic kidney disease (CKD) requiring hemodialysis (HD). We described the VA creation and utilization pattern under existing estimated glomerular filtration rate (...)

8 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Hospitalizations for fluid overload and heart failure among individuals with diabetes: healthcare utilization and guideline-directed medical therapy Clin Kidney J
• 01:00
  The spectrum of thrombotic microangiopathy related to monoclonal gammopathy Clin Kidney J
  ABSTRACTBackgroundRecent studies showed a high prevalence of monoclonal gammopathy (MG) in patients with thrombotic microangiopathy (TMA) aged over 50 years and suggested that complement dysregulation is pivotal for the disease to develop. Here, we studied this premise in seven patients with (...)

4 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  The prevalence of chronic kidney disease–associated pruritus and its impact on quality of life in hemodialysis patients: a commentary from experts from two countries Clin Kidney J
• 01:00
  eGFR slope as a primary endpoint for clinical trials of CKD progression: one size fits all? Clin Kidney J

3 janvier

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Elimination and penetration of amikacin into urine in patients with decreased glomerular filtration rate Clin Kidney J
  ABSTRACTBackgroundAmikacin monotherapy is recommended for urinary tract infection (UTI) treatment with multi-resistant pathogens. Even though amikacin efficacy in the treatment of UTIs is dependent on its urinary concentration, there are no robust data proving that sufficiently high urinary (...)
• 01:00
  Sex disparities in the utilization of nurse-assisted peritoneal dialysis: a mediation analysis using data from the REIN registry Clin Kidney J
  ABSTRACTBackgroundThis study was carried out to evaluate the association between patient sex and the proportion of nurse-assisted peritoneal dialysis (PD) at dialysis initiation and to explore whether sex disparities in nurse-assisted PD utilization was explained by predialysis care and/or by (...)

28 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Comparative analysis of hospitalizations among patients treated with hemodialysis and peritoneal dialysis in European pediatric nephrology centers: results from a prospective EPDWG/ESPN Dialysis Working Group study Clin Kidney J
  ABSTRACTBackground and hypothesisHospital admissions in pediatric dialysis patients need to be better studied, and most existing studies are retrospective and based on registry data. This study aimed to analyse and compare hospital admission rates, causes, length of stay (LOS), and outcomes in (...)

27 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  How primary care physicians view kidney supportive care Clin Kidney J

21 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Ambient temperature and the occurrence of intradialytic hypotension in patients receiving hemodialysis Clin Kidney J
  ABSTRACTBackgroundIntradialytic hypotension (IDH) is a common hemodialysis complication causing adverse outcomes. Despite the well-documented associations of ambient temperatures with fluid removal and pre-dialysis blood pressure (BP), the relationship between ambient temperature and IDH has (...)

13 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Gut-immune axis and cardiovascular risk in chronic kidney disease Clin Kidney J
  ABSTRACTPatients with chronic kidney disease (CKD) suffer from marked cardiovascular morbidity and mortality, so lowering the cardiovascular risk is paramount to improve quality of life and survival in CKD. Manifold mechanisms are hold accountable for the development of cardiovascular disease (...)

12 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database Clin Kidney J
  ABSTRACTBackground and hypothesisProteinuria is associated with an increased risk of kidney function deterioration, cardiovascular disease, or cancer. Previous reports suggesting an association between kidney dysfunction and bone fracture may be confounded by concomitant proteinuria and were (...)

11 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Novel biomarkers and pathophysiology of membranous nephropathy: PLA2R and beyond Clin Kidney J
  ABSTRACTResearch on membranous nephropathy truly exploded in the last 15 years. This happened because of the application of new techniques (laser capture microdissection, mass spectrometry, protein G immunoprecipitation, arrays) to the study of its pathogenesis. After the discovery of PLA2R as (...)

9 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Cost-effectiveness of screening for chronic kidney disease: existing evidence and knowledge gaps Clin Kidney J
  ABSTRACTIt is well known that the worldwide prevalence of chronic kidney disease (CKD) has risen to over 10% of the general population during the past decades. Patients with CKD are at increased risk of both kidney failure and cardiovascular disease (CVD), posing a substantial health (...)
• 01:00
  Mediators of the association between albuminuria and incident cancer: the PREVEND study Clin Kidney J
  Dutch Kidney Foundation10.13039/501100002997E.033Dutch Heart Foundation10.13039/5011000029962001.005National Institutes of Health10.13039/100000002University Medical Center Groningen10.13039/501100005075China Scholarship Council10.13039/501100004543202008440376European Research (...)

8 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Utilizing artificial intelligence and next-generation sequencing to facilitate the diagnosis of rare diseases Clin Kidney J
• 01:00
  Nephrology Partnership for Advancing Technology in Healthcare (N-PATH) program: the teachers’ perspective Clin Kidney J
  ABSTRACTThe N-PATH (Nephrology Partnership for Advancing Technology in Healthcare) program concluded with the 60th European Renal Association 2023 Congress in Milan, Italy. This collaborative initiative aimed to provide advanced training in interventional nephrology to young European (...)

7 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Comparison of outcomes on hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in anaemia associated with chronic kidney disease: network meta-analyses in dialysis and non-dialysis dependent populations Clin Kidney J
  ABSTRACTBackgroundHypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are oral alternatives to current standard-of-care treatments for anaemia in chronic kidney disease (CKD). We conducted network meta-analyses to indirectly compare clinical outcomes for three HIF-PHIs in (...)

5 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Changes in cardiac troponins during hemodialysis depend on hemodialysis membrane and modality: a randomized crossover trial Clin Kidney J

4 décembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Differentiating primary and secondary FSGS using non-invasive urine biomarkers Clin Kidney J
  ABSTRACTBackgroundFocal segmental glomerulosclerosis (FSGS) is divided into genetic, primary (p), uncertain cause, and secondary (s) forms. The subclasses differ in management and prognosis with differentiation often being challenging. We aimed to identify specific urine proteins/peptides (...)
• 01:00
  Ethnicity and IgA nephropathy: worldwide differences in epidemiology, timing of diagnosis, clinical manifestations, management and prognosis Clin Kidney J
  ABSTRACTImmunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis, is one of the major causes of end-stage renal disease. Significant variances in epidemiology, clinical manifestation, timing of diagnosis, management and renal prognosis of IgAN have been reported (...)
• 01:00
  Understanding patient needs and predicting outcomes in IgA nephropathy using data analytics and artificial intelligence: a narrative review Clin Kidney J
  ABSTRACTThis narrative review explores two case scenarios related to immunoglobulin A nephropathy (IgAN) and the application of predictive monitoring, big data analysis and artificial intelligence (AI) in improving treatment outcomes. The first scenario discusses how online service providers (...)
• 01:00
  Expanding options of supportive care in IgA nephropathy Clin Kidney J
  ABSTRACTImmunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, with a potentially serious prognosis. At present, management of IgAN is primarily based on therapeutic lifestyle changes, and excellent blood pressure control and maximized supportive treatment (...)
• 01:00
  Systemic and targeted steroids for the treatment of IgA nephropathy Clin Kidney J
  ABSTRACTImmunoglobulin A nephropathy (IgAN) is a common glomerulonephritis partially correlated with mucosal immune system dysfunction. Progressive renal failure occurs in many patients, with about 30–50% of the patients with IgAN developing end-stage kidney disease (ESKD). Many treatments (...)
• 01:00
  Targeting complement in IgA nephropathy Clin Kidney J
  ABSTRACTImmunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Recent years have witnessed significant improvements in the understanding of the pathogenesis of IgAN and particularly, the pathogenic role of complement activation. The alternative complement (...)
• 01:00
  Microscopic hematuria as a risk factor for IgAN progression: considering this biomarker in selecting and monitoring patients Clin Kidney J
  ABSTRACTHematuria—either macroscopic hematuria or asymptomatic microscopic hematuria—is a clinical feature typical but not specific for immunoglobulin A nephropathy (IgAN). The only biomarker supported by the Kidney Disease: Improving Global Outcomes group as a predictor of progression, (...)
• 01:00
  The contribution of a proliferation-inducing ligand (APRIL) and other TNF superfamily members in pathogenesis and progression of IgA nephropathy Clin Kidney J
  ABSTRACTAdvances in our understanding of the pathogenesis of immunoglobulin A nephropathy (IgAN) have led to the identification of novel therapeutic targets and potential disease-specific treatments. Specifically, a proliferation-inducing ligand (APRIL) has been implicated in the pathogenesis (...)

29 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Real-world usage of Chronic Kidney Disease – Mineral Bone Disorder (CKD–MBD) biomarkers in nephrology practices Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease mineral bone disorder (CKD-MBD) is a condition characterized by alterations of calcium, phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF-23) metabolism that in turn promote bone disorders, vascular calcifications, and increase (...)

28 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Risk factors for COVID-19 hospitalization and mortality in patients with chronic kidney disease: a nationwide cohort study Clin Kidney J
  ABSTRACTBackgroundSeveral studies have demonstrated an increased risk of severe coronavirus disease 2019 (COVID-19) in chronic kidney disease (CKD) patients. However, few have investigated the impact of CKD stage and dialysis modality. The primary aim of this study was to investigate the (...)
• 01:00
  All-cause and immune checkpoint inhibitor–associated acute kidney injury in immune checkpoint inhibitor users: a meta-analysis of occurrence rate, risk factors and mortality Clin Kidney J
  ABSTRACTBackgroundImmune checkpoint inhibitors (ICIs) have been associated with acute kidney injury (AKI). However, the occurrence rate of ICI-related AKI has not been systematically examined. Additionally, exposure to proton pump inhibitors (PPIs) and non-steroidal anti-inflammatory drugs (...)

27 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Protocolized polyoma BK viral load monitoring and high-dose immunoglobulin treatment in children after kidney transplant Clin Kidney J
  ABSTRACTBackgroundBKPyV virus nephropathy (BKPyVAN) is diagnosed in 5%–16% of pediatric renal transplant recipients (PRTR) and preceded by BKPyV-viruria and DNAemia. Despite the risk of irreversible transplant damage associated with BKPyVAN, evidence-based consensus guidelines for BKPyVAN (...)
• 01:00
  Clinicopathological prognostic stratification for proteinuria and kidney survival in IgA nephropathy: a Japanese prospective cohort study Clin Kidney J
  ABSTRACTBackgroundWe require a clinicopathological risk stratification method for immunoglobulin A nephropathy (IgAN) to predict kidney outcomes. We examined a renal failure risk group (RF-RG) classification system created following a prior multicentre, retrospective study to determine if (...)

23 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Early growth response 1 as a podocyte injury marker in human glomerular diseases Clin Kidney J
  ABSTRACTBackgroundIn human glomerular diseases, visualizing podocyte injury is desirable since podocytes do not regenerate and podocyte injury leads to podocyte loss. Herein, we investigated the utility of immunostaining for early growth response 1 (EGR1), which is expressed in injured (...)

22 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Moving on obesity treatment in CKD: inertia is unjustified Clin Kidney J

21 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Bone mineral density after exercise training in patients with chronic kidney disease stages 3 to 5: a sub-study of RENEXC—a randomized controlled trial Clin Kidney J
  AbstractBackgroundWe evaluated the effects of 12 months of exercise training on bone mineral density (BMD) in patients with chronic kidney disease (CKD) stages 3–5 not on kidney replacement therapy (KRT).MethodsA total of 151 patients were randomized to 12 months of either balance or strength (...)

20 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Direct oral anticoagulants: the safer choice in chronic kidney disease? Clin Kidney J
• 01:00
  Unmasking the CONVINCE trial: is hemodiafiltration ready to steal the spotlight in real-world practice? Clin Kidney J

17 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Blood pressure reduction after renal denervation in patients with or without chronic kidney disease Clin Kidney J
  ABSTRACTBackgroundRenal denervation (RDN) has emerged as an adjacent option for the treatment of hypertension. This analysis of the Erlanger registry aimed to compare the blood pressure (BP)-lowering effects and safety of RDN in patients with and without chronic kidney disease (CKD).MethodsIn (...)

16 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Role of leukapheresis in the management of acute kidney injury associated with hyperleukocytosis of acute myeloid leukemia Clin Kidney J
• 01:00
  Optimization of guideline-directed medical therapies in patients with diabetes and chronic kidney disease Clin Kidney J
  ABSTRACTDiabetes is the leading cause of chronic kidney disease (CKD) and kidney failure worldwide. CKD frequently coexists with heart failure and atherosclerotic cardiovascular disease in the broader context of cardio-kidney-metabolic syndrome. Diabetes and CKD are associated with increased (...)
• 01:00
  Circulating metabolites associated with kidney function decline and incident CKD: a multi-platform population-based study Clin Kidney J
  ABSTRACTBackgroundInvestigation of circulating metabolites associated with kidney function and chronic kidney disease (CKD) risk could enhance our understanding of underlying pathways and identify new biomarkers for kidney function.MethodsWe selected participants from the population-based (...)

15 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  The ERA Registry Annual Report 2021: a summary Clin Kidney J
  ABSTRACTBackgroundThe European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities.MethodsData was (...)

14 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Sleep apnoea syndrome prevalence in chronic kidney disease and end-stage kidney disease patients: a systematic review and meta-analysis Clin Kidney J
  ABSTRACTBackgroundSeveral studies have examined the frequency of sleep apnoea (SA) in patients with chronic kidney disease (CKD), reporting different prevalence rates. Our systematic review and meta-analysis aimed to define the clinical penetrance of SA in CKD and end-stage kidney disease (...)

13 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Mechanisms and treatment of obesity-related hypertension—Part 1: Mechanisms Clin Kidney J
  AbstractThe prevalence of obesity has tripled over the past five decades. Obesity, especially visceral obesity, is closely related to hypertension, increasing the risk of primary (essential) hypertension by 65%–75%. Hypertension is a major risk factor for cardiovascular disease, the leading (...)
• 01:00
  Twenty years of the French Renal Epidemiology and Information Network Clin Kidney J
  ABSTRACTBackgroundThe French Renal Epidemiology and Information Network (REIN) is 20 years old. It is not just a national data registry, but rather an epidemiological and informational network serving patients with chronic kidney disease, nephrology teams and health services.MethodsThe past (...)

9 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Podocyte puzzle: ANCA vasculitis Clin Kidney J
• 01:00
  Replacing a kidney biopsy by exome sequencing in undetermined kidney diseases—not yet ready for prime time! Clin Kidney J
  Fundació la Marató de TV310.13039/100008666202036-30Instituto de Salud Carlos III10.13039/501100004587PI 22/0031
• 01:00
  Kidney and urine cell transcriptomics in IgA nephropathy and lupus nephritis: a narrative review Clin Kidney J
  ABSTRACTThis narrative review sheds light on the use of transcriptomics in the analysis of kidney biopsies and urinary cell samples from patients with immunoglobulin A nephropathy or lupus nephritis. The conventional methods of examining kidney biopsy through light microscopy, (...)

8 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Single-cell transcriptomes of kidneys in a 6-month-old boy with Denys-Drash syndrome reveal stromal cell heterogeneity in the tumor microenvironment Clin Kidney J
  ABSTRACTBackgroundDenys-Drash syndrome (DDS) is a rare disease characterized with pseudohermaphroditism, nephroblastoma (also known as Wilms tumor), and diffuse mesangial sclerosis. The therapy for DDS is largely supportive, i.e. surgery and chemotherapy for Wilms tumor and renal replacement (...)
• 01:00
  Incremental versus conventional haemodialysis in end-stage kidney disease: a systematic review and meta-analysis Clin Kidney J
  ABSTRACTBackgroundAppropriate dialysis prescription in the transitional setting from chronic kidney disease to end-stage kidney disease is still challenging. Conventional thrice-weekly haemodialysis (HD) might be associated with rapid loss of residual kidney function (RKF) and high mortality. (...)

7 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Ketogenic metabolic therapy for chronic kidney disease – the pro part Clin Kidney J
  ABSTRACTKetogenic metabolic therapy (KMT) is a medical nutrition therapy to address certain health and disease conditions. It is increasingly used for many non-communicable diseases that are rooted in abnormal metabolic health. Since chronic kidney disease (CKD) is commonly caused by (...)
• 01:00
  Risks of the ketogenic diet in CKD – the con part Clin Kidney J
  ABSTRACTThe ketogenic diet is a very low carbohydrate diet that has received a lot of attention for its role in the treatment of type 2 diabetes and obesity. For patients with chronic kidney disease, there is limited evidence on the risks and/or benefits of this diet. However, from the limited (...)

3 novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease—a comprehensive review from the ERA CKD-MBD working group Clin Kidney J
  ABSTRACTKlotho, a multifunctional protein, acts as a co-receptor in fibroblast growth factor 23 and exerts its impact through various molecular pathways, including Wnt, hypoxia-inducible factor and insulin-like growth factor 1 pathways. The physiological significance of Klotho is the (...)

1er novembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Serum sclerostin is associated with recurrent kidney stone formation independent of hypercalciuria Clin Kidney J
  ABSTRACTBackgroundKidney stones are frequent in industrialized countries with a lifetime risk of 10 to 15%. A high percentage of individuals experience recurrence. Calcium-containing stones account for more than 80% of kidney stones. Diet, environmental factors, behavior, and genetic variants (...)

26 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Should we enlarge the indication for kidney biopsy in diabetics? The con part Clin Kidney J
  ABSTRACTDiabetes is the most common cause of chronic kidney disease (CKD), a condition found in 850 million persons and projected to become the fifth global cause of death by 2040. Research is needed that examines kidney tissue to characterize distinct phenotypes in patients with diabetes (...)
• 02:00
  Should we enlarge the indication for kidney biopsy in patients with diabetes? The pro part Clin Kidney J
  ABSTRACTDiabetic nephropathy (DN) and non-diabetic renal diseases (NDRD) represent intricate challenges in diagnosis and treatment within the context of the global diabetes epidemic. As the prevalence of diabetes continues to escalate, effective management of renal complications becomes (...)
• 02:00
  Kidney biopsy in diabetic kidney disease. Yes, but in very selected cases Clin Kidney J
  ABSTRACTThe debate on kidney biopsy in diabetic kidney disease (DKD) is multifaceted. Loreto Gesualdo and colleagues argue for its broader application, claiming that biopsies can offer precise diagnostic data and guide personalized treatment plans. On the other hand, Alberto Ortiz opposes (...)

25 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Molecular characteristics of circulating B cells and kidney cells at the single-cell level in special types of primary membranous nephropathy Clin Kidney J
  ABSTRACTBackgroundAlthough primary membranous nephropathy (pMN) associated with podocyte autoantibodies (POS) is becoming well-known, the molecular characteristics of the specific type of pMN that is negative for podocyte autoantibodies (NEG) is still unclear.MethodsWe performed single-cell (...)

23 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  SGLT2 inhibitors and finerenone in non-diabetic CKD: a step into the (near) future? Clin Kidney J

19 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Prophylactic ultra-low dose rituximab to maintain remission in relapsing adult minimal change disease Clin Kidney J
• 02:00
  The need for better donor engagement and outreach with legacy living kidney donors Clin Kidney J

17 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Genetic and clinical characterization of familial renal glucosuria Clin Kidney J
  ABSTRACTBackgroundFamilial renal glucosuria (FRG) is a hereditary disorder caused by variants in SLC5A2 encoding sodium-glucose cotransporter 2 (SGLT2). In this study, we aimed to characterize proximal tubule solute transport, glucagon secretion and the genotype–phenotype relationship in FRG (...)
• 02:00
  Factors that influence the selection of conservative management for end-stage renal disease – a systematic review Clin Kidney J
  AbstractBackgroundMost patients with end-stage renal disease (ESRD) are managed with dialysis and less commonly kidney transplantation. However, not all are suitable for or desire either of these renal replacement therapies. Conservative management (CM) is an option. However, the selection of (...)

16 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Age- and time-dependent increases in incident anti-glomerular basement membrane disease: a nationwide cohort study Clin Kidney J
  ABSTRACTBackgroundEpidemiologic assessments of anti-glomerular basement membrane (GBM) disease have been challenging due to its rare occurrence. We examined changes in the incidence and outcomes from 1998 to 2018 using nationwide healthcare registries.MethodsAll patients with incident anti-GBM (...)
• 02:00
  Tubulo-interstitial inflammation increases the risk of graft loss after the recurrence of IgA nephropathy Clin Kidney J
  ABSTRACTBackgroundImmunoglobulin A nephropathy (IgAN) is the most frequent recurrent disease in kidney transplant recipients and its recurrence contributes to reducing graft survival. Several variables at the time of recurrence have been associated with a higher risk of graft loss. The (...)

14 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Vitamin K supplementation impact in dialysis patients: a systematic review and meta-analysis of randomized trials Clin Kidney J
  ABSTRACTVitamin K supplementation has been considered recently as a potential treatment for addressing vascular calcification in chronic kidney disease patients.We conducted a systematic review and meta-analysis to summarize the impact of vitamin K supplementation in dialysis patients. (...)

13 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Reconsidering the role of the IL-23/IL-17 immune axis in idiopathic nephrotic syndrome pathogenesis Clin Kidney J
• 02:00
  DKK3 as a potential novel biomarker in patients with autosomal polycystic kidney disease Clin Kidney J
  ABSTRACTBackgoundAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, and leads to a steady loss of kidney function in adulthood. The variable course of the disease makes it necessary to identify the patients with rapid disease progression who will (...)
• 02:00
  Personalizing electrolytes in the dialysis prescription: what, why and how? Clin Kidney J
  ABSTRACTMaintenance hemodialysis patients suffer from multiple comorbidities and treatment-related complications. A personalized approach to hemodialysis prescription could reduce some of these burdens by preventing complications such as excessive changes in blood pressure, arrhythmias, (...)
• 02:00
  Meta-analysis on the efficacy and safety of rituximab versus tacrolimus for nephrotic syndrome in the paediatric age group Clin Kidney J
• 02:00
  Mechanisms of pathogenicity and the quest for genetic modifiers of kidney disease in branchiootorenal syndrome Clin Kidney J
  ABSTRACTBackgoundBranchiootorenal (BOR) syndrome is an autosomal dominant disorder caused by pathogenic EYA1 variants and clinically characterized by auricular malformations with hearing loss, branchial arch anomalies, and congenital anomalies of the kidney and urinary tract. BOR phenotypes (...)

11 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Tenapanor in Chinese ESRD patients with hyperphosphatemia on haemodialysis: a randomised, phase 3 trial Clin Kidney J
  ABSTRACTBackgroundThe efficacy and safety of tenapanor has not been confirmed in Chinese end-stage renal disease (ESRD) patients with hyperphosphatemia on haemodialysis (HD).MethodsThis was a randomised, double blind, phase 3 trial conducted at 26 dialysis facilities in China (...)
• 02:00
  Will another trial CONVINCE nephrologists to adopt high-dose haemodiafiltration over conventional haemodialysis? Clin Kidney J

10 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD) is associated with increased atherosclerotic burden and higher risk for cardiovascular events (CVE). Atherosclerosis has a significant genetic component and, in CKD, it is influenced by mineral metabolism alterations. Therefore, genetic (...)

9 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Gender-specific risk factors and outcomes of hyperkalemia in CKD patients: smoking as a driver of hyperkalemia in men Clin Kidney J
  ABSTRACTBackgroundHyperkalemia is common among patients with chronic kidney disease (CKD) but there is scarce information on differential risk factors and outcomes for men and women. For instance, smoking has been suggested to be a risk factor for hyperkalemia, but specific analysis of the (...)

6 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Effect of music therapy intervention on anxiety and pain during percutaneous renal biopsy: a randomized controlled trial Clin Kidney J
  ABSTRACTBackgroundPercutaneous renal biopsy (PRB) may subject patients to emotional distress and pain before and during the biopsy. The aim of this study was to evaluate the effects of complementary/non-pharmacological interventions such as music therapy (MT) on anxiety, pain and satisfaction (...)

3 octobre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Oral anticoagulant treatment and risk of kidney disease—a nationwide, population-based cohort study Clin Kidney J
  ABSTRACTBackgroundDirect oral anticoagulants (DOACs) are recommended as first-line treatment of atrial fibrillation. Whether DOAC use is associated with lower risks of kidney complications compared with vitamin K antagonists (VKAs) remains unclear. We examined this association in a nationwide, (...)
• 02:00
  Cardiovascular disease in older women with CKD Clin Kidney J

29 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Causal effects of rheumatoid arthritis or ankylosing spondylitis on membranous nephropathy: a two-sample Mendelian randomization study Clin Kidney J
  ABSTRACTBackgroundMembranous nephropathy (MN) is the leading cause of adult-onset nephrotic syndrome, with primary MN of unclear cause accounting for 80% of cases. Retrospective clinical research reported that MN occurring in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients (...)
• 02:00
  Welcome from the new CKJ Editor-in-Chief Clin Kidney J

28 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Study of the association between serum levels of kynurenine and cardiovascular outcomes and overall mortality in chronic kidney disease Clin Kidney J
  ABSTRACTBackgroundKynurenine is a protein-bound uremic toxin. Its circulating levels are increased in chronic kidney disease (CKD). Experimental studies showed that it exerted deleterious cardiovascular effects. We sought to evaluate an association between serum kynurenine levels and adverse (...)
• 02:00
  Performance of the race-free CKD-EPI creatinine-based eGFR equation in a Danish cohort with measured GFR Clin Kidney J
  ABSTRACTBackgroundIn 2021, an updated Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimated glomerular filtration rate (eGFR) without a coefficient for race (CKD-EPI21) was developed. The performance of this new equation has yet to be examined among specific (...)

27 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  New trials in resistant hypertension: mixed blessing stories Clin Kidney J
  ABSTRACTResistant hypertension (RH) is linked to an increased risk of cardiovascular and renal complications. Treatment options include non-pharmacological interventions, such as lifestyle modifications, and the use of specific antihypertensive drug combinations, including diuretics. Renal (...)
• 02:00
  Klotho and lean mass as novel cardiovascular risk factors in hemodialysis patients Clin Kidney J
  ABSTRACTBackgroundPatients with chronic kidney disease (CKD) present a higher risk of cardiovascular (CV) morbidity and mortality compared with the general population. While there are several well-established traditional CV risk factors, few studies have addressed novel potential risk factors (...)

26 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Additive effects of dapagliflozin and finerenone on albuminuria in non-diabetic CKD: an open-label randomized clinical trial Clin Kidney J
  ABSTRACTBackgroundDapagliflozin and finerenone reduce albuminuria and slow CKD progression, but additive effects remain unstudied. We compared their individual and combined efficacy and safety in patients with non-diabetic CKD.MethodsIn an open-label, randomized clinical trial, we included (...)

20 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Plasma activin A rises with declining kidney function and is independently associated with mortality in patients with chronic kidney disease Clin Kidney J
  ABSTRACTBackgroundPlasma (p-)activin A is elevated in chronic kidney disease–mineral and bone disorder (CKD-MBD). Activin A inhibition ameliorates CKD-MBD complications (vascular calcification and bone disease) in rodent CKD models. We examined whether p-activin A was associated with major (...)
• 02:00
  Late outcomes of renal denervation are more favourable than early ones: facts or fancies? Clin Kidney J
  ABSTRACTFollowing second-generation randomized trials, there is evidence that renal denervation (RDN) decreases blood pressure (BP), although to a lesser extent than suggested in the initial controlled and observational studies. The recent publication of the 36-month follow-up of the (...)

19 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  A deep learning system for retinal vessel calibre improves cardiovascular risk prediction in Asians with chronic kidney disease Clin Kidney J
  ABSTRACTBackgraundCardiovascular disease (CVD) and mortality is elevated in chronic kidney disease (CKD). Retinal vessel calibre in retinal photographs is associated with cardiovascular risk and automated measurements may aid CVD risk prediction.MethodsRetrospective cohort study of 860 (...)

18 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor Clin Kidney J
  ABSTRACTPeople living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting in cognitive impairment as a potentially modifiable risk factor in CKD (...)
• 02:00
  Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients Clin Kidney J
  ABSTRACTThere is growing evidence that chronic kidney disease (CKD) is an independent risk factor for cognitive impairment, especially due to vascular damage, blood–brain barrier disruption and uremic toxins. Given the presence of multiple comorbidities, the medication regimen of CKD patients (...)

14 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Urine MMP7 as a kidney injury biomarker Clin Kidney J
  ABSTRACTMatrix metalloproteinase 7 (MMP-7) is a secreted endopeptidase involved in the degradation of extracellular matrix components and the activation of cytokines and growth factors. The regulation of MMP-7 can be transcriptionally regulated by AP-1 or Wnt/?-catenin or post-translationally (...)
• 02:00
  Urinary markers of the alternative and lectin complement pathway are increased in IgA vasculitis nephritis Clin Kidney J
  ABSTRACTBackgroundIgA vasculitis (IgAV) is the most common form of childhood vasculitis. Nephritis (IgAVN) occurs in 50% of patients and 1–2% progress to chronic kidney disease stage 5. The pathophysiology of nephritis remains largely unknown, but recent evidence suggests that the complement (...)

13 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Decision aids to assist patients and professionals in choosing the right treatment for kidney failure Clin Kidney J
  ABSTRACTBackgroundKidney services vary in the way they involve people with kidney failure (PwKF) in treatment decisions as management needs change. We discuss how decision-science applications support proactively PwKF to make informed decisions between treatment options with kidney (...)
• 02:00
  A learning process to deliver virtual staff training involving patients in shared haemodialysis care Clin Kidney J
  ABSTRACTShared haemodialysis (HD) care (SHC) is a person-centred approach delivering a flexible choice of options for centre-based HD patients to become more involved in their treatment. To support this, a 4-day course was developed to provide healthcare professionals with the confidence and (...)
• 02:00
  An update on absolute and relative indications for dialysis treatment modalities Clin Kidney J
  ABSTRACTBackgroundChoosing a dialysis modality is an important decision for people to make as their kidney failure progresses. In doing so, their options should be informed by any absolute or relative indications that may favour one modality over another.MethodsIn creating this update, we (...)
• 02:00
  The role of low health literacy in shared treatment decision-making in patients with kidney failure Clin Kidney J
  ABSTRACTThe classic paternalist medicine in nephrology has been modified to a shared decision-making model that clearly offers a benefit in patients with kidney disease. One of the cornerstones of shared treatment decision in patients with kidney failure is the understanding of kidney disease. (...)
• 02:00
  Involving patients in treatment decisions, disease management and research for end-stage kidney disease Clin Kidney J
• 02:00
  Partnering with patients and caregivers to enrich research and care in kidney disease: values and strategies Clin Kidney J
  ABSTRACTPatient and caregiver involvement broadens the scope of new knowledge generated from research and can enhance the relevance, quality and impact of research on clinical practice and health outcomes. Incorporating the perspectives of people with lived experience of chronic kidney disease (...)
• 02:00
  Shared decision making: a personal view from two kidney doctors and a patient Clin Kidney J
  ABSTRACTShared decision making (SDM) combines the clinician's expertise in the treatment of disease with the patient's expertise in their lived experience and what is important to them. All decisions made in the care of patients with kidney disease can potentially be explored through SDM. (...)

11 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Hypoxia inducible factor prolyl hydroxylase inhibitors: what a meta-analysis could tell us Clin Kidney J
  ABSTRACTMeta-analyses offer an estimate of the overall effect size and help address the inconsistency in findings across studies. The risk is the overemphasis on statistical significance while underrepresenting or misinterpreting clinical significance. There's also a lack of standardized (...)

7 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Associations of calcium, phosphate and intact parathyroid hormone levels with mortality, residual kidney function and technical failure among patients on peritoneal dialysis Clin Kidney J
  ABSTRACTBackgroundAssociations of calcium, phosphate and intact parathyroid hormone (iPTH) levels with outcomes may be different between patients on peritoneal dialysis (PD) and hemodialysis (HD). The aim of the study is to evaluate these associations among PD patients.MethodsIn this (...)

6 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Associations between maternal chronic diseases and congenital anomalies of the kidney and urinary tract in offspring: a population-based cohort study Clin Kidney J
  ABSTRACTBackgroundThe relationship between maternal chronic diseases and congenital anomalies of the kidneys and urinary tract (CAKUT) in offspring still needs elucidation. This study aimed to comprehensively evaluate the associations between maternal chronic disease and CAKUT in their (...)

5 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Increased expression of SCARF genes favoring SARS-CoV-2 infection in key target organs in CKD Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD), especially diabetic CKD, is the condition that most increases the risk of lethal coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the underlying molecular mechanisms are unclear. (...)

4 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Kidney function estimators for drug dose adjustment of direct oral anticoagulants in older adults with atrial fibrillation Clin Kidney J
  ABSTRACTBackgroundThe Cockcroft–Gault equation (CrClC-G) is recommended for dose adjustment of direct oral anticoagulant drugs (DOACs) to kidney function. We aimed to assess whether defining DOAC dose appropriateness according to various kidney function estimators changed the associations (...)
• 02:00
  Phase 2 study of upacicalcet in Japanese haemodialysis patients with secondary hyperparathyroidism: an intraindividual dose-adjustment study Clin Kidney J
  ABSTRACTBackgroundUpacicalcet is a novel small-molecule calcimimetic agent developed for intravenous injection. Here, we evaluated the long-term efficacy and safety of upacicalcet treatment via intraindividual dose adjustment in haemodialysis patients with secondary hyperparathyroidism (...)
• 02:00
  Long-term safety and efficacy of left atrial appendage occlusion in dialysis patients with atrial fibrillation: a multi-center, prospective, open label, observational study Clin Kidney J
  ABSTRACTBackgroundThe prevalence of atrial fibrillation (AF) in end stage kidney disease (ESKD) patients undergoing dialysis is high, however, the high risk of bleeding often hampers with a correct anticoagulation in ESKD patients with AF, despite high thromboembolic risk. Left atrial (...)
• 02:00
  Contemporary secondary prevention in survivors of ST-elevation myocardial infarction with and without chronic kidney disease: a retrospective analysis Clin Kidney J
  ABSTRACTBackgroundSurvivors of myocardial infarction have an elevated risk of long-term mortality. We sought to evaluate guideline-directed medical treatment and its impact on long-term mortality in survivors of ST-elevation myocardial infarction (STEMI) according to their chronic kidney (...)
• 02:00
  European chronic kidney disease registries for children not on kidney replacement therapy: tools for improving health systems and patient-centred outcomes Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) in children, from birth to late adolescence, is a unique and highly challenging condition that requires epidemiological research and large-scale, prospective cohort studies. Since its first launch in 2007, the European Society for Paediatric (...)

2 septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Urinary peptidome analysis in CKD and IgA nephropathy Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD) has emerged as a significant challenge to human health and economic stability in aging societies worldwide. Current clinical practice strategies remain insufficient for the early identification of kidney dysfunction, and the differential diagnosis (...)

1er septembre

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Contrast-associated acute kidney injury and cardiovascular events: a secondary analysis of the PRESERVE cohort Clin Kidney J
  ABSTRACTBackgroundContrast-associated acute kidney injury (CA-AKI) has been associated with a higher risk of cardiovascular (CV) events. We studied the risk of CV events in chronic kidney disease (CKD) patients undergoing angiography and whether biomarkers can predict such events. We also (...)
• 02:00
  Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease—prospective data from the German Chronic Kidney Disease cohort Clin Kidney J
  ABSTRACTBackgroundDiabetes mellitus (DM) and chronic kidney disease (CKD) are well-known cardiovascular and mortality risk factors. To what extent they act in an additive manner and whether the etiology of CKD modifies the risk is uncertain.MethodsThe multicenter, prospective, observational (...)
• 02:00
  Proton pump inhibitors and adverse kidney outcomes during immune checkpoint blockade: time to sound the alarm? Clin Kidney J
  AbstractImmune checkpoint inhibitors (ICIs) have significantly altered the treatment landscape for cancer in the last decade. However, their benefits are often offset by therapy-limiting immune-related adverse events (irAEs). Acute interstitial nephritis (AIN) is the most common renal irAE, (...)
• 02:00
  Venous bicarbonate and CKD progression: a longitudinal analysis by the group-based trajectory model Clin Kidney J
  ABSTRACTBackgroundMetabolic acidosis accelerates chronic kidney disease (CKD) progression towards kidney failure in animal models. Clinical trials testing the effect of bicarbonate on kidney outcomes are underpowered and/or of suboptimal quality. On the other hand, observational studies (...)

29 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in patients on kidney replacement therapy: observational study using the OpenSAFELY-UKRR and SRR databases Clin Kidney J
  ABSTRACTBackgroundDue to limited inclusion of patients on kidney replacement therapy (KRT) in clinical trials, the effectiveness of coronavirus disease 2019 (COVID-19) therapies in this population remains unclear. We sought to address this by comparing the effectiveness of sotrovimab against (...)

25 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Trunk muscle quality and quantity are associated with renal volume in nondiabetic people Clin Kidney J
  ABSTRACTBackgroundRenal disease is a major problem in terms of community health and the economy. Skeletal muscle is involved in crosstalk with the kidney. We therefore investigated the relationship between muscle quality and quantity, and renal parenchymal volume (RPV).MethodsThe association (...)
• 02:00
  Clinical and pathological characteristics in elderly patients with IgA nephropathy Clin Kidney J
  ABSTRACTBackgroundImmunoglobulin A nephropathy (IgAN) is the most common cause of primary glomerulonephritis, with highly variable manifestations. Although the peak incidence of IgAN is in young adults, the diagnosis among elderly people is increasing. Here we explored the effect of aging on (...)
• 02:00
  Incidence and prognosis of acute kidney injury versus acute kidney disease among 71 041 inpatients Clin Kidney J
  ABSTRACTBackgroundAcute kidney disease (AKD) defines patients with acute kidney injury (AKI) or subacute loss of kidney function lasting for >7 days. Little is known about the prognosis of AKD in hospitalized patients. The aim of this study was to investigate the risk factors and prognosis of (...)

21 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  The centre-calculated cutoff value is better for identifying fast peritoneal solute transfer of patients on peritoneal dialysis than the traditional value: a retrospective cohort study Clin Kidney J
  ABSTRACTBackgroundThe mean 4-h dialysate to plasma ratio of creatinine (4-h D/Pcr) is a vital cutoff value for recognizing the fast peritoneal solute transfer rate (PSTR) in patients on peritoneal dialysis (PD); however, it shows a noticeable centre effect. We aimed to investigate our (...)

17 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  mRNA as a medicine in nephrology: the future is now Clin Kidney J
  ABSTRACTThe successful employment of messenger RNA (mRNA) as vaccine therapy for the prevention of COVID-19 infection has spotlighted the attention of scientific community onto the potential clinical application of these molecules as innovative and alternative therapeutic approaches in (...)

16 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Are there sex differences in cardiovascular outcomes in non-dialysis CKD patients? Clin Kidney J
  ABSTRACTBackgroundSex differences for cardiovascular (CV) risk and outcomes in chronic kidney disease (CKD) patients not on dialysis have been scarcely or never investigated. We therefore studied this important aspect in a cohort of CKD stage 2–5 in the south of Italy.MethodsWe tested the (...)

12 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Management of hypertension in patients with cancer: challenges and considerations Clin Kidney J
  ABSTRACTThe survival rates of many cancers have significantly improved due to recent advancements in cancer screening and therapeutics. Although better cancer outcomes are encouraging, additional health challenges have surfaced, the utmost of which is the burden imposed by various (...)

10 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  A new methodological series in CKJ: from basic-level methodology to artificial intelligence in medicine Clin Kidney J
• 02:00
  Epidemiology and predictors of hyponatremia in a contemporary cohort of patients with malignancy: a retrospective cohort study Clin Kidney J
  ABSTRACTBackgroundHyponatremia is associated with worse outcomes among patients with malignancy. However, contemporary cohort data on epidemiology and risk factors are lacking.MethodsIn this single-centre, retrospective cohort study, patients who received intravenous antineoplastic agents from (...)
• 02:00
  The long-term benefits of early intensive therapy in chronic diseases—the legacy effect Clin Kidney J
  ABSTRACTThe ‘legacy effect’ refers to the long-term benefits of intensive therapy that are observed long after the end of clinical trials and trial interventions in chronic diseases such as diabetes, hyperlipidaemia and hypertension. It emphasizes the importance of intensive treatment to (...)
• 02:00
  Genetic testing in focal segmental glomerulosclerosis: in whom and when? Clin Kidney J
  ABSTRACTBackgroundGenetic causes are increasingly recognized in patients with focal segmental glomerulosclerosis (FSGS), but it remains unclear which patients should undergo genetic study. Our objective was to determine the frequency and distribution of genetic variants in steroid-resistant (...)

9 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Measurement of urinary exosomal phospholipase A2 receptor is a sensitive method for diagnosis of PLA2R-associated membranous nephropathy Clin Kidney J
  ABSTRACTBackgroundThe discovery of phospholipase A2 receptor (PLA2R) and its antibody (aPLA2Rab) has paved the way for diagnosing PLA2R-associated membranous nephropathy (PLA2R-MN) with a high specificity of 98%. However, the sensitivity was only 40% to 83.9%, and there is ongoing discussion (...)
• 02:00
  Cystatin C–based estimated glomerular filtration rate and risk of stroke in the general population: a prospective cohort study Clin Kidney J
  ABSTRACTBackgroundPrevious results on the association between the estimated glomerular filtration rate (eGFR) and stroke are mixed. Most studies derived the eGFR from serum creatinine, which is affected by non-kidney determinants and thus has possibly biased the association with stroke (...)
• 02:00
  Association of oral iron replacement therapy with kidney failure and mortality in CKD patients Clin Kidney J
  ABSTRACTBackgroundOral iron is the predominant route of iron replacement (IRT) but its benefits and safety are unclear in patients with chronic kidney disease (CKD).MethodsWe examined the association of oral IRT vs no IRT with end-stage kidney disease (ESKD) and mortality in a national cohort (...)
• 02:00
  Examining the safety and effectiveness of a 4-week supervised exercise intervention in the treatment of frailty in patients with chronic kidney disease Clin Kidney J
  ABSTRACTBackgroundThe optimal duration of antifrailty interventions and how best to deliver them to patients with chronic kidney disease (CKD) is unknown. The aim of this study was to examine the safety, feasibility and preliminary efficacy of a 4-week supervised exercise intervention on (...)

8 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Why do we keep ignoring sex in kidney disease? Clin Kidney J
  ABSTRACTThroughout the history of nephrology, little attention has been paid to the sex and gender differences in kidney disease. This lack of awareness prevents optimal diagnosis and management of kidney disease. In today's world of precision medicine, it is imperative to appreciate the (...)
• 02:00
  Automating kidney transplant rejection diagnosis: a simple solution for a complex problem? Clin Kidney J

3 août

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Effect of serum creatinine difference between the Jaffe and the enzymatic method on kidney disease detection and staging Clin Kidney J
  ABSTRACTBackgroundSerum creatinine (SCr), mainly determined by the Jaffe or an enzymatic method, is the central marker to assess kidney function. Deviations between these two methods may affect the diagnosis and staging of acute kidney injury (AKI) and chronic kidney disease (CKD).MethodsThe (...)

29 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Artificial intelligence: a new field of knowledge for nephrologists? Clin Kidney J
  ABSTRACTArtificial intelligence (AI) is a science that involves creating machines that can imitate human intelligence and learn. AI is ubiquitous in our daily lives, from search engines like Google to home assistants like Alexa and, more recently, OpenAI with its chatbot. AI can improve (...)

26 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Fibroblast growth factor 23 but not copeptin is independently associated with kidney failure and mortality in patients with chronic kidney disease Clin Kidney J
  ABSTRACTBackgroundCopeptin and intact fibroblast growth factor 23 (iFGF23) increase early during chronic kidney disease (CKD) and may be predictive of unfavourable outcomes. The aim of this study was to evaluate their respective associations with renal and vital outcomes in CKD (...)

20 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Prevalence of pericardial effusion in autosomal dominant polycystic kidney disease Clin Kidney J
  ABSTRACTBackgroundAutosomal dominant polycystic kidney disease (ADPKD) has numerous extrarenal manifestations. Pericardial effusion (PE) may be an underrecognized complication with a reported prevalence of up to 35%. Our study is the first to systematically evaluate the prevalence of PE and (...)

19 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  The potential association between influenza vaccination and lower incidence of renal cell carcinoma Clin Kidney J
  ABSTRACTIt is well-established that kidney cancer or renal cell carcinoma (RCC) occurs more commonly in chronic kidney disease (CKD) than in the general population, although the underlying mechanisms are incompletely understood. Beyond hereditary RCC syndromes; smoking, obesity and (...)
• 02:00
  Diastolic function in chronic kidney disease Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) is characterized by clustered age-independent concentric left ventricular (LV) geometry, geometry-independent systolic dysfunction and age and heart rate–independent diastolic dysfunction. Concentric LV geometry is always associated with echocardiographic (...)
• 02:00
  Development of a multimodal kidney age prediction based on automatic segmentation CT image in patients with normal renal function Clin Kidney J
  ABSTRACTBackground For decades, description of renal function has been of interest to clinicians and researchers. Serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) are familiar but also limited in many circumstances. Meanwhile, the physiological volumes of the kidney (...)
• 02:00
  Plasma A?42:A?40 ratio as a biomarker for cognitive impairment in haemodialysis patients: a multicentre study Clin Kidney J
  ABSTRACTBackgroundMild cognitive impairment (MCI) and dementia are more prevalent in patients undergoing haemodialysis (HD). Although the cerebrospinal fluid amyloid beta (A?) and tau (?) have proven to be valid biomarkers for the diagnosis of Alzheimer's disease (AD) in the general (...)

18 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Development of a multiple convolutional neural network–facilitated diagnostic screening program for immunofluorescence images of IgA nephropathy and idiopathic membranous nephropathy Clin Kidney J
  ABSTRACTBackgroundImmunoglobulin A nephropathy (IgAN) and idiopathic membranous nephropathy (IMN) are the most common glomerular diseases. Immunofluorescence (IF) tests of renal tissues are crucial for the diagnosis. We developed a multiple convolutional neural network (CNN)-facilitated (...)
• 02:00
  The effect of a ketogenic diet on weight loss in CKD: a randomized controlled trial in obese stage G1–3a CKD patients Clin Kidney J
  ABSTRACTThis study describes a multicentre randomized controlled trial comparing the effects of a ketogenic diet with a low-energy standard diet containing 0.8 g/kg/day on weight loss and metabolic alterations in adult patients with mild-to-moderate non-diabetic chronic kidney disease (CKD) (...)
• 02:00
  Measurement properties of performance-based measures to assess physical function in chronic kidney disease: recommendations from a COSMIN systematic review Clin Kidney J
  ABSTRACTBackgroundThere is wide heterogeneity in physical function tests available for clinical and research use, hindering our ability to synthesize evidence. The aim of this review was to identify and evaluate physical function measures that could be recommended for standardized use in (...)

14 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Something old, something new: Na+/K+/ATPase as a mechanism of intrarenal B cells viability in lupus nephritis Clin Kidney J
  GSK10.13039/100004330Otsuka10.13039/100019120Alexion10.13039/100006396Novartis10.13039/100004336Vifor Pharma10.13039/501100006484

13 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Oral glucocorticoids with intravenous cyclophosphamide or oral glucocorticoids alone in the treatment of IgA nephropathy present with nephrotic syndrome and mesangioproliferative glomerulonephritis Clin Kidney J
  ABSTRACTBackgroundFew studies have evaluated the treatment of immunoglobulin A nephropathy (IgAN) patients with nephrotic syndrome (NS) and mesangioproliferative glomerulonephritis (MPGN). The aim of this study was to compare the therapeutic effects of oral glucocorticoids (GCS) combined with (...)
• 02:00
  Multidisciplinary approach to patients with heart failure and kidney disease: preliminary experience of an integrated cardiorenal unit Clin Kidney J
  ABSTRACTBackgroundCardiorenal programs have emerged to improve the management of cardiorenal disease (CRD). Evidence about the benefits of these programs is still scarce. This work aims to evaluate the performance of a novel cardiorenal program and describe the clinical profile and outcomes of (...)
• 02:00
  From electronic health records to clinical management systems: how the digital transformation can support healthcare services Clin Kidney J
  ABSTRACTHealthcare systems worldwide are currently undergoing significant transformations in response to increasing costs, a shortage of healthcare professionals and the growing complexity of medical needs among the population. Value-based healthcare reimbursement systems are emerging as an (...)

11 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Leukopenia in autosomal dominant polycystic kidney disease: a single-center cohort of kidney transplant candidates with post-transplantation follow-up Clin Kidney J
  ABSTRACTBackgroundAutosomal dominant polycystic kidney disease (ADPKD) has occasionally been associated with lower peripheral white blood cell (WBC) counts. This study aimed to investigate the peripheral blood cell counts in a large cohort of kidney transplant recipients before and after (...)

7 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Association between dietary vitamin E intake and chronic kidney disease events in US adults: a cross-sectional study from NHANES 2009–2016 Clin Kidney J
  ABSTRACTBackgroundThe relationship between vitamin E supplementation and the prevalence of chronic kidney disease (CKD) is unclear. We discussed the relationship between vitamin E intake and CKD prevalence and further investigated the effect on different CKD risk strata.MethodsWe ultimately (...)
• 02:00
  Shedding a light on sex disparity in clinical trials in CKD patients Clin Kidney J
  ABSTRACTClinical studies do not include an adequate proportion of female participants, and research data on drug efficacy and safety are generally collected from studies including a majority of men and extrapolated to women. This article describes the imbalance of male and female distribution (...)

5 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data Clin Kidney J
  ABSTRACTBackgroundNephrotoxic drugs frequently cause acute kidney injury (AKI) in adult intensive care unit (ICU) patients. However, there is a lack of large pharmaco-epidemiological studies investigating the associations between drugs and AKI. Importantly, AKI risk factors may also be (...)
• 02:00
  Standardized 4-point scoring scale of [18F]-FDG PET/CT imaging helps in the diagnosis of renal and hepatic cyst infections in patients with autosomal dominant polycystic kidney disease: a validation cohort Clin Kidney J
  ABSTRACTBackgroundAutosomal dominant polycystic kidney disease (ADPKD) is prone to multiple complications, including cyst infection (CyI). 2-Deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography ([18F]-FDG PET/CT) imaging has proved useful in the diagnosis of renal and (...)

4 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Adding 6-month parameters for the prediction of kidney prognosis in ANCA-associated glomerulonephritis Clin Kidney J
  ABSTRACTBackgroundAntineutrophil-cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with kidney involvement (AAV-GN) frequently evolves to end-stage kidney disease (ESKD) despite aggressive immunosuppressive treatment. Several risk scores have been used to assess renal prognosis. We aimed (...)

3 juillet

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Impact of peritoneal dialysis strategy on technique and patient survival Clin Kidney J
  ABSTRACTBackgroundThe aim of this study was to evaluate the impact of peritoneal dialysis (PD) strategy on technique and patient survival.MethodsThis was a retrospective, single-center study conducted on consecutive patients with chronic kidney disease who underwent PD between January 2009 and (...)

29 juin

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Risk of chronic kidney disease in patients with acute kidney injury following a major surgery: a US claims database analysis Clin Kidney J
  ABSTRACTBackgroundAcute kidney injury (AKI) is a common complication after major surgery. This study assessed the risk of developing or worsening of chronic kidney disease (CKD) and other clinical outcomes in patients experiencing AKI after major surgery.MethodsThis retrospective observational (...)
• 02:00
  Long-term follow-up of IgA nephropathy: clinicopathological features and predictors of outcomes Clin Kidney J
  ABSTRACTBackgroundThe establishment of the Oxford classification and newly developed prediction models have improved the prognostic information for immunoglobulin A nephropathy (IgAN). Considering new treatment options, optimizing prognostic information and improving existing prediction models (...)
• 02:00
  Opportunities to improve the management of anemia in peritoneal dialysis patients: lessons from a national study in routine clinical practice Clin Kidney J
  ABSTRACTBackgroundCurrent guidelines establish the same hemoglobin (Hb) and iron biomarkers targets for hemodialysis (HD) and peritoneal dialysis (PD) in patients receiving erythropoiesis-stimulating agents (ESAs) even though patients having PD are usually younger, more active and less (...)
• 02:00
  Inferior vena cava ultrasound and other techniques for assessment of intravascular and extravascular volume: an update Clin Kidney J
  ABSTRACTGoals of volume management are to accurately assess intravascular and extravascular volume and predict response to volume administration, vasopressor support or volume removal.Data are reviewed that support the following:(i) Dynamic parameters reliably guide volume administration and (...)
• 02:00
  What is central to renal nutrition: protein or sodium intake? Clin Kidney J
  ABSTRACTHistorically, nutrition intervention has been primarily focused on limiting kidney injury, reducing generation of uraemic metabolites, as well as maintaining nutrition status and preventing protein-energy wasting in patients with chronic kidney disease (CKD). This forms an important (...)

28 juin

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Prior cancer history and suitability for kidney transplantation Clin Kidney J
  ABSTRACTKidney transplantation is the optimal treatment for most patients with kidney failure. For patients with a prior history of treated cancers, listing and transplant eligibility decisions are complex. Patients and health professionals are obliged to consider the time-periods between (...)