255 articles
30 mai
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1er mai
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Background: Visit-to-visit blood pressure (BP) variability associates with an increased risk of cardiovascular events. We investigated the role of seasonal BP modifications on the magnitude of BP variability and its impact on cardiovascular risk. Methods: In 25 390 patients included in the (…) -- ORIGINAL ARTICLES
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Beta-blocker bashing and downgrading in hypertension management: a fashionable trend representing a matter of concern -
Kreutz, Reinhold; Brunström, Mattias; Burnier, Michel; Grassi, Guido; Januszewicz, Andrzej; Kjeldsen, Sverre E.; Muiesan, Maria L.; Thomopoulos, Costas; Tsioufis, Konstantinos; Mancia, Giuseppe
J Hypertens
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22 avril
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Objectives: Heterogeneous are the results of the published studies aimed at determining the long-term effects of habitual coffee consumption on blood pressure (BP). Specifically, no data are available on the longitudinal association between habitual coffee consumption and office, home and 24 h (...) -- ORIGINAL ARTICLES
12 avril
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This systematic review and meta-analysis was conducted to assess the randomized controlled trial (RCT) evidence available for renal denervation (RDN) in uncontrolled arterial hypertension. Twenty-five RCTs met the eligibility criteria for the systematic review, and 16 RCTs were included in the (…) -- REVIEW
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Originally, the beta-blockers were equally ranked alongside the other antihypertensive drug classes. Things changed when two major long-term randomized controlled trials, ASCOT-BPLA and LIFE showed that the patients receiving the beta-blockers based regimes suffered 25–30% more strokes than (...) -- REVIEW
11 avril
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Management of hypertensive disorders in pregnancy: a Position Statement of the European Society of Hypertension Working Group ‘Hypertension in Women’ -
Thomopoulos, Costas; Hitij, Jana Brguljan; De Backer, Tine; Gkaliagkousi, Eugenia; Kreutz, Reinhold; Lopez-Sublet, Marilucy; Marketou, Maria; Mihailidou, Anastasia S.; Olszanecka, Agnieszka; Pechère-Bertschi, Antoinette; Pérez, Mariana Paula; Persu, Alexandre; Piani, Federica; Socrates, Thenral; Stolarz-Skrzypek, Katarzyna; Cífková, Renata
J Hypertens
Hypertensive disorders in pregnancy (HDP), remain the leading cause of adverse maternal, fetal, and neonatal outcomes. Epidemiological factors, comorbidities, assisted reproduction techniques, placental disorders, and genetic predisposition determine the burden of the disease. The (…) -- CONSENSUS DOCUMENT
4 avril
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In memoriam: Michel Emile Safar 1937–2024 -
Blacher, Jacques; Benetos, Athanase; Protogerou, Athanase; Boudier, Harry Struijker; Levy, Bernard; for Michel Safar's students; colleagues and friends of the Paris Vascular School; for Michel Safar's students; colleagues and friends of the Paris Vascular School
J Hypertens
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3 avril
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Isolated nocturnal hypertension (INHT), defined as nighttime elevated blood pressure (BP) with normal daytime BP assessed by ambulatory BP monitoring, is associated with higher cardiovascular morbidity and mortality. We hypothesized that an alteration in the circulating renin-angiotensin (...) -- SHORT REPORT
2 avril
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Association between time-of-day for eating, exercise, and sleep with blood pressure in adults with elevated blood pressure or hypertension: a systematic review -
Keiser, Thomas; Katz, Sarah; Robson, Shannon M.; Greaney, Jody L.; Healy, Sean; Malone, Susan K.; Farrahi, Vahid; Patterson, Freda
J Hypertens
The purpose of this review is to synthesize results from studies examining the association between time-of-day for eating, exercise, and sleep with blood pressure (BP) in adults with elevated BP or hypertension. Six databases were searched for relevant publications from which 789 were (...) -- REVIEW
26 mars
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Objectives: ?? T-lymphocytes play a role in angiotensin II (AngII)-induced hypertension, vascular injury and T-cell infiltration in perivascular adipose tissue (PVAT) in mice. Mesenteric arteries of hypertensive mice and subcutaneous arteries from obese humans present similar remodeling. We (…) -- ORIGINAL ARTICLES
23 mars
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Objective: Adrenal venous sampling (AVS) is key for primary aldosteronism subtype identification. However, the value of adrenocorticotropic hormone (ACTH) stimulation in AVS is still controversial. Methods: In this prospective study, we investigated the role of continuous ACTH infusion on the (...) -- ORIGINAL ARTICLES
22 mars
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Background: Adherence to antihypertensives is key for blood pressure control. Most people with hypertension have several comorbidities and require multiple medicines, leading to complex care pathways. Strategies for coordinating medicine use can improve adherence, but cumulative benefits of (…) -- ORIGINAL ARTICLES
18 mars
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Background: Soluble P-selectin (sP-selectin) and high-sensitivity C-reactive protein (hsCRP) have previously been associated with hypertension, but the relation with out-of-office blood pressure (BP) and coronary artery calcification score is unknown. We aimed to examine the relationship between (…) -- ORIGINAL ARTICLES
13 mars
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There is little quantitative clinical data available to support blood pressure measurement accuracy during cuff inflation. In this study of 35 male and 5 female lightly anaesthetized subjects aged 64.1 ± 9.6 years, we evaluate and compare the performance of both the oscillometric ratio and (…) -- ORIGINAL ARTICLES
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Most non-invasive blood pressure (BP) measurements are carried out using instruments which implement either the Ratio or the Maximum Gradient oscillometric method, mostly during cuff deflation, but more rarely during cuff inflation. Yet, there is little published literature on the relative (...) -- ORIGINAL ARTICLES
11 mars
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Objective: Hypertension affects 50–90% of kidney transplant recipients and is associated with cardiovascular disease and graft loss. We aimed to evaluate the comparative benefits and harms of blood pressure lowering agents in people with a functioning kidney transplant. Methods: We conducted a (...) -- ORIGINAL ARTICLES
8 mars
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Combined vaccines against angiotensin II receptor type 1 and alpha 1D-adrenergic receptor for hypertension -
Wu, Jiacheng; Wu, Zhijie; Kuang, Wenlong; Shi, Dingyang; Yang, Yulu; Li, Xin; Huang, Jianwu; Li, Xuehan; Liao, Yuhua; Zhou, Zihua; Qiu, Zhihua
J Hypertens
Purpose: Compared with monotherapy, combination therapy with multiple antihypertensive drugs has demonstrated superior efficacy in the management of hypertension. The aim of this study was to explore the efficacy of multitarget combined vaccines in achieving simultaneous antihypertensive and (…) -- ORIGINAL ARTICLES
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Association between blood pressure variability and risk of kidney function decline in hypertensive patients without chronic kidney disease: a post hoc analysis of Systolic Blood Pressure Intervention Trial study -
Wang, Zhiyan; Li, Wenjie; Jiang, Chao; Wang, Jue; Hua, Chang; Tang, Yangyang; Zhang, Hao; Liu, Xinru; Wang, Yufeng; Gao, Mingyang; Lv, Qiang; Dong, Jianzeng; Ma, Changsheng; Du, Xin
J Hypertens
Background: Blood pressure variability (BPV) is a risk factor for poor kidney function independent of blood pressure (BP) in chronic kidney disease (CKD). Little is known about the association between kidney function decline and BPV in hypertensive patients without CKD. Methods: A post-hoc (…) -- ORIGINAL ARTICLES
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Background: Resistant hypertension is a severe phenotype in hypertension that may be driven by interactions between genetic and environmental factors. Specific changes in gut microbiota and metabolites have been shown to influence cardiovascular disease progression. However, microbial and (…) -- ORIGINAL ARTICLES
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Complete remission with histamine blocker in a patient with intractable hyperadrenergic postural orthostatic tachycardia syndrome secondary to long coronavirus disease syndrome -
González-Alvarez, Felipe; Estañol, Bruno; González-Hermosillo, Jesús Antonio; Gómez-Pérez, Francisco Javier; Tamez-Torres, Karla Maria; Peña, Eduardo; Cantú, Carlos; Chiquete, Erwin; Sifuentes-Osornio, José; Alba-Lorenzo, Maria del Carmen; Celestino-Montelongo, Dulce Andrea; Salazar-Calderón, Guadalupe E.; Aceves Buendia, Jose de Jesus
J Hypertens
The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has emerged as a global public health concern and its sequels have barely started to outcrop. A good percentage of patients who suffered from COVID-19 are prone to develop long-COVID or (...) -- CASE REPORT
5 mars
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Objective: It has been suggested that a blunted nocturnal blood pressure (BP) decline is associated with a poor prognosis. Nevertheless, it remains unclear if an abnormal dipping is deleterious per se or it merely reflects an elevated BP during sleep. We aimed to assess the prognostic value of (…) -- ORIGINAL ARTICLES
1er mars
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Protein disulfide isomerase-mediated transcriptional upregulation of Nox1 contributes to vascular dysfunction in hypertension -
Camargo, Livia De Lucca; Trevelin, Silvia Cellone; da Silva, Guilherme Henrique Gatti; dos Santos Dias, Ana Alice; Oliveira, Maria Aparecida; Mikhaylichenko, Olga; Androwiki, Aline C.D.; dos Santos, Celio Xavier; Holbrook, Lisa-Marie; Ceravolo, Graziela Scalianti; Denadai-Souza, Alexandre; Ribeiro, Izabela Martina Ramos; Sartoretto, Simone; Laurindo, Francisco Rafael Martins; Coltri, Patricia Pereira; Antunes, Vagner Roberto; Touyz, Rhian; Miller, Francis J. Jr; Shah, Ajay M.; Lopes, Lucia Rossetti
J Hypertens
Nox1 signaling is a causal key element in arterial hypertension. Recently, we identified protein disulfide isomerase A1 (PDI) as a novel regulatory protein that regulates Nox1 signaling in VSMCs. Spontaneously hypertensive rats (SHR) have increased levels of PDI in mesenteric resistance (...) -- ORIGINAL ARTICLES
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Assessment and management of exaggerated blood pressure response to standing and orthostatic hypertension: consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability -
Palatini, Paolo; Kollias, Anastasios; Saladini, Francesca; Asmar, Roland; Bilo, Grzegorz; Kyriakoulis, Konstantinos G.; Parati, Gianfranco; Stergiou, George S.; Grassi, Guido; Kreutz, Reinhold; Mancia, Giuseppe; Jordan, Jens; Biaggioni, Italo; de la Sierra, Alejandro
J Hypertens
Recent evidence suggests that an exaggerated blood pressure (BP) response to standing (ERTS) is associated with an increased risk of adverse outcomes, both in young and old individuals. In addition, ERTS has been shown to be an independent predictor of masked hypertension. In the vast majority (...) -- CONSENSUS DOCUMENT
29 février
28 février
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Background: Early-life programming due to prematurity and very low birth weight (VLBW, -- ORIGINAL ARTICLES
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Ambulatory blood pressure after 12 weeks of quadruple combination of quarter doses of blood pressure medication vs. standard medication -
Nolde, Janis M.; Atkins, Emily; Marschner, Simone; Hillis, Graham S.; Chalmers, John; Billiot, Laurent; Nelson, Mark R.; Reid, Christopher M.; Hay, Peter; Burke, Michael; Jansen, Shirley; Usherwood, Tim; Rodgers, Anthony; Chow, Clara K.; Schlaich, Markus P.
J Hypertens
Background: A combination of four ultra-low-dose blood pressure (BP) medications lowered office BP more effectively than initial monotherapy in the QUARTET trial. The effects on average ambulatory BP changes at 12 weeks have not yet been reported in detail. Methods: Adults with hypertension (...) -- ORIGINAL ARTICLES
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Objective: Reno-renal reflexes are disturbed in cardiovascular and hypertensive conditions when elevated levels of pro-inflammatory mediators/cytokines are present within the kidney. We hypothesised that exogenously administered inflammatory cytokines tumour necrosis factor alpha (TNF-?) and (...) -- ORIGINAL ARTICLES
27 février
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Retinal artery to vein ratio is associated with cerebral microbleeds in individuals with type 1 diabetes -
Tarkkonen, Aleksi; Fickweiler, Ward; Eriksson, Marika; Sun, Jennifer K.; Thorn, Lena M.; Summanen, Paula; Groop, Per-Henrik; Putaala, Jukka; Martola, Juha; Gordin, Daniel; the FinnDiane Study Group
J Hypertens
Objectives: A third of asymptomatic individuals with type 1 diabetes (T1D) show signs of cerebrovascular disease in brain MRI. These signs associate with advanced stages of diabetic retinal disease, but not in mild or moderate retinopathy. We aimed to evaluate a wider spectrum of retinal (...) -- ORIGINAL ARTICLES
26 février
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Blood pressure (BP) reduction occurs after a single bout of exercise, referred to as postexercise hypotension (PEH). The clinical importance of PEH has been advocated owing to its potential contribution to chronic BP lowering, and as a predictor of responders to exercise training as an (...) -- REVIEW
23 février
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Background : Circular RNAs (circRNAs) have been shown to be extensively involved in preeclampsia progression. At present, the role of circ_0007445 in preeclampsia progression is not clear. Methods: A total of 30 preeclampsia patients and 30 normal pregnant women were recruited in our study. The (…) -- ORIGINAL ARTICLES
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Background: Diets high in sodium are associated with adverse cardiovascular outcomes. We aimed to quantify the burden of cardiovascular disease (CVD) attributable to high dietary sodium consumption in the Australian population. Methods: Using data from the Global Burden of Disease (GBD) 2019, we (…) -- ORIGINAL ARTICLES
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Effectiveness of a two-component nutritional strategy for blood pressure control in individuals with hypertension users of a public health system: a randomized controlled clinical trial -
Bersch-Ferreira, Angela C.; Machado, Rachel H.V.; de Oliveira, Júlia S.; Santos, Renato H.N.; da Silva, Lucas R.; Mota, Luis G.S.; Pagano, Raira; Sady, Erica R.R.; Miyada, Débora H.K.; Valeis, Nanci; Martins, Pedro N.; de Almeida, Jussara C.; Marchioni, Dirce M.L.; Lara, Enilda M.S.; Gherardi-Donato, Edilaine C.S.; Quinhoneiro, Driele; Carvalho, Ana Paula P.F.; Machado, Malaine M.A.; Gedda, Lana P.F.; Ferro, Camila M.B.; Carvalho, Ana Clara M.S.; Feoli, Ana Maria P.; Walker, Marthina S.; Pinto, Sônia L.; Silva, Kellen C.; Bruscato, Neide M.; Moriguchi, Emilio H.; Penafort, Andreza M.; (…)
J Hypertens
Objective: To evaluate the effectiveness of a nutritional strategy based on two components and adapted for the public health system on blood pressure, cardiometabolic features, self-care, qualify of life and diet quality in individuals with hypertension. Methods: NUPRESS was an open-label, (…) -- ORIGINAL ARTICLES
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21 février
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Background: The correlation between systolic blood pressure (SBP) and mortality in hypertensive patients with different phenotypes of heart failure (HF) has not been adequately studied, and optimal blood pressure control targets remain controversial. To explore the link between SBP and (...) -- ORIGINAL ARTICLES
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Volume overload is a major characteristic in primary aldosteronism: a 3-year follow-up study -
Kokko, Eeva; Choudhary, Manoj Kumar; Mutanen, Aapo; Honkonen, Milja; Tikkakoski, Antti; Koskela, Jenni K.; Hämäläinen, Mari; Moilanen, Eeva; Viukari, Marianna; Matikainen, Niina; Nevalainen, Pasi I.; Pörsti, Ilkka
J Hypertens
Objectives: We examined haemodynamics, focusing on volume balance and forward and backward wave amplitudes, before and after 2.8 years of targeted treatment of primary aldosteronism. Patients with essential hypertension and normotensive individuals were examined for comparison (n = 40 in each (...) -- ORIGINAL ARTICLES
20 février
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NOS3 prevents MMP-9, and MMP-13 induced extracellular matrix proteolytic degradation through specific microRNA-targeted expression of extracellular matrix metalloproteinase inducer in hypertension-related atherosclerosis -
Ramírez-Carracedo, Rafael; Hernández, Ignacio; Moreno-Gómez-Toledano, Rafael; Díez-Mata, Javier; Tesoro, Laura; González-Cucharero, Claudia; Jiménez-Guirado, Beatriz; Alcharani, Nunzio; Botana, Laura; Saura, Marta; Zamorano, Jose L.; Zaragoza, Carlos
J Hypertens
Background: Endothelial nitric oxide synthase (NOS3) elicits atheroprotection by preventing extracellular matrix (ECM) proteolytic degradation through inhibition of extracellular matrix metalloproteinase inducer (EMMPRIN) and collagenase MMP-13 by still unknown mechanisms. Methods: C57BL/6 (...) -- ORIGINAL ARTICLES
19 février
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Objective: The evidence regarding the associations of circulating metabolic biomarkers with hypertension risk is scarce. We aimed to examine the associations between circulating metabolites and risk of hypertension. Methods: We included 49 422 individuals free of hypertension at baseline with (...) -- ORIGINAL ARTICLES
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Background: Sleep apnea is associated with hypertension. Metaanalyses indicate that treatment of sleep apnea by continuous positive airway pressure (CPAP) reduces blood pressure (BP) by a mean of 3 mmHg. To date, predictors of BP response to CPAP remain incompletely understood. We hypothesized (...) -- ORIGINAL ARTICLES
14 février
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The relationship of blood volume (BV) to systemic blood pressure (BP) is not well defined in resistant hypertension (RH). The goal of this study was to examine the extent to which systemic BP stratified by patient sex would impact BV phenotypes. A retrospective analysis of clinical and (...) -- ORIGINAL ARTICLES
12 février
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Background: Hypertension can be classified into different phenotypes according to systolic and diastolic blood pressure (BP). In younger adults, these phenotypical differences have different prognostic value for men and women. However, little is known about sex differences in the natural (...) -- ORIGINAL ARTICLES
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Background: It remained unclear whether central blood pressures (BP) was more closely associated with cardiovascular disease (CVD) than brachial BP in different age groups. Objectives: To investigate the age-stratified association of CVD with brachial and central BPs, and to evaluate (...) -- ORIGINAL ARTICLES
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Previous studies have investigated the effects of different combined training programs involving traditional resistance training and aerobic exercise on hemodynamic parameters and arterial stiffness in older adults. However, little is known about the impact of power training combined with (...) -- ORIGINAL ARTICLES
9 février
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Prevalence and factors associated with masked hypertension in chronic kidney disease -
Legrand, Frédéric; Motiejunaite, Justina; Arnoult, Florence; Lahens, Alexandre; Tabibzadeh, Nahid; Robert-Mercier, Tiphaine; Rouzet, François; De Pinho, Natalia Alencar; Vrtovsnik, François; Flamant, Martin; Vidal-Petiot, Emmanuelle
J Hypertens
Objectives: Optimal blood pressure (BP) control is key to prevent cardiovascular complications in patients with chronic kidney disease (CKD). We described the prevalence and factors associated with masked hypertension in CKD. Methods: We analyzed 1113 ambulatory 24-h BP monitoring (ABPM) (...) -- ORIGINAL ARTICLES
7 février
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The polypill strategy, which combines several medicines that simultaneously control different risk factors/diseases in a single pill, is one of the approaches used in cardiovascular therapy. In different guidelines, this one-pill combination therapy is suggested as first-line step in disease (...) -- SHORT REPORT
1er février
30 janvier
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The association of hypertension and diabetes mellitus is extremely common, increasing the mortality risk of patients, mainly by cardiovascular causes. Regarding the blood pressure (BP) targets to be achieved, most guidelines suggest levels of 130 mmHg for SBP and of 80 mmHg for DBP. Dietary (...) -- REVIEW
25 janvier
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Objective: Enalapril has shown satisfactory potential in controlling increased and sustained blood pressure (BP). However, multiple dysregulated mechanisms that interact with each other and are involved in the pathophysiology of arterial hypertension may not be affected, contributing to the (...) -- ORIGINAL ARTICLES
24 janvier
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Objective: We investigated the interrelationship between hyperglycemia and hypertension on cardiovascular mortality in the middle-aged and elderly people. Methods: In this retrospective cohort study that used data from the Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases, we (...) -- ORIGINAL ARTICLES
23 janvier
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Objective: There is an increasing number of cuffless blood pressure (BP) measurement (BPM) devices. Despite promising results when comparing single measurements, the ability of these devices to track changes in BP levels over 24 h related to an initial calibration BP (CalibBP) is unknown. Our (...) -- ORIGINAL ARTICLES
17 janvier
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Background: We investigated seasonal variation in ambulatory blood pressure control in hypertensive patients on clinic blood pressure-guided antihypertensive treatment. Methods: The study participants were hypertensive patients enrolled in an 8-week therapeutic study. Antihypertensive (...) -- ORIGINAL ARTICLES
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Objective: Statins appear to have greater antihypertensive effects in observational studies than in randomized controlled trials. This study assessed whether more frequent treatment of hypertension contributed to better blood pressure (BP, mmHg) control in statin-treated than statin-eligible (...) -- ORIGINAL ARTICLES
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Hypertension is the leading cardiovascular risk factor worldwide. However, in Japan, only 30% of patients have their blood pressure controlled under 140/90 mmHg, and nonadherence to antihypertensives is thought to be a reason for the poor control of hypertension. We therefore sought to assess (...) -- ORIGINAL ARTICLES
16 janvier
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Objectives: Several recent guidelines have proposed the gradual reduction of antihypertensive drugs for patients with well controlled blood pressure (BP). However, no studies have examined alterations in BP variability (BPV) during the down-titration of antihypertensives. This study aims to (...) -- ORIGINAL ARTICLES
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Dietary patterns associated with hypertension among stroke-free indigenous Africans: insights from the Stroke Investigative Research and Educational Network study -
Okekunle, Akinkunmi Paul; Asowata, Osahon Jeffery; Akpa, Onoja Matthew; Fakunle, Adekunle Gregory; Bodunde, Ifeoluwa; Komolafe, Morenikeji; Arulogun, Oyedunni; Sarfo, Fred Stephen; Obiako, Reginald; Osaigbovo, Godwin; Ogbole, Godwin; Bello, Abiodun; Adeniyi, Sunday; Calys-Tagoe, Benedict; Appiah, Lambert; Jenkins, Carolyn; Oyinloye, Olalekan; Dambatta, Hamisu; Balogun, Olayemi; Singh, Arti; Olalere, Abimbola; Mensah, Yaw; Ogah, Okechukwu S.; Ibinaiye, Philip; Adebayo, Oladimeji; Adebajo, Olayinka; Adebayo, Philip; Chukwuonye, Ijezie; Akinyemi, Rufus; Ovbiagele, Bruce; Owolabi, Mayowa; (…)
J Hypertens
Background: The dietary factors associated with the high burden of hypertension among indigenous Africans remain poorly understood. We assessed the relationship between dietary patterns and hypertension among indigenous Africans. Method: In this study, 1550 participants with hypertension (...) -- ORIGINAL ARTICLES
15 janvier
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Conventional sphygmomanometry with cuff deflation is used to calibrate all noninvasive BP (NIBP) instruments and the International Standard makes no mention of calibrating methods specifically for NIBP instruments, which estimate systolic and diastolic pressure during cuff inflation rather (...) -- ORIGINAL ARTICLES
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Objective: Pressure wave reflection predicts cardiovascular events in the general population. Obesity is negatively associated with pressure wave reflection. Muscular arterial diameter (responsible for pressure wave reflection) increases with obesity, and obesity-dependent dilation of muscular (...) -- ORIGINAL ARTICLES
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Introduction: Mounting evidence has indicated that maternal dyslipidemia is associated with adverse obstetric outcomes, and the actions of lipid-lowering drugs in pregnant women remain controversial. Hence, this study aimed to appraise the causal relationship of lipid-lowering drugs (...) -- ORIGINAL ARTICLES
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Prediction of preeclampsia from retinal fundus images via deep learning in singleton pregnancies: a prospective cohort study -
Zhou, Tianfan; Gu, Shengyi; Shao, Feixue; Li, Ping; Wu, Yuelin; Xiong, Jianhao; Wang, Bin; Zhou, Chenchen; Gao, Peng; Hua, Xiaolin
J Hypertens
Introduction: Early prediction of preeclampsia (PE) is of universal importance in controlling the disease process. Our study aimed to assess the feasibility of using retinal fundus images to predict preeclampsia via deep learning in singleton pregnancies. Methods: This prospective cohort study (...) -- ORIGINAL ARTICLES
12 janvier
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Objective: This study aimed to investigate the impact of dietary salt intake during normal pregnancy on maternal microvascular and macrovascular endothelium-dependent reactivity and oxidative stress level. Materials and methods: In this cross-sectional study, based on their 24-h urinary sodium (...) -- ORIGINAL ARTICLES
10 janvier
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Salt sensitivity risk derived from nocturnal dipping and 24-h heart rate predicts long-term blood pressure reduction following renal denervation -
Sesa-Ashton, Gianni; Carnagarin, Revathy; Nolde, Janis M.; Muente, Ida; Lee, Rebecca; Macefield, Vaughan G.; Dawood, Tye; Sata, Yusuke; Lambert, Elisabeth A.; Lambert, Gavin W.; Walton, Antony; Kiuchi, Marcio G.; Esler, Murray D.; Schlaich, Markus P.
J Hypertens
Background: Renal denervation (RDN) has been consistently shown in recent sham-controlled clinical trials to reduce blood pressure (BP). Salt sensitivity is a critical factor in hypertension pathogenesis, but cumbersome to assess by gold-standard methodology. Twenty-four-hour average heart (...) -- ORIGINAL ARTICLES
8 janvier
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Cardiovascular disease is the number 1 cause of death globally, with elevated blood pressure (BP) being the single largest risk factor. Hence, BP is an important physiological parameter used as an indicator of cardiovascular health. Noninvasive cuff-based automated monitoring is now the (...) -- ORIGINAL ARTICLES
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Objective: Although anxiety is known to be associated with elevated blood pressure and hypertension in adults, this has not been studied in children. The aim of this study was to determine the association between anxiety and elevated blood pressures in adolescents. Methods: Adolescents, aged (...) -- ORIGINAL ARTICLES
4 janvier
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3 janvier
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Effect of 12-week high-intensity interval training on hemodynamic variables at rest and during exercise in patients with obstructive sleep apnoea -
Lins-Filho, Ozeas; Germano-Soares, Antonio H.; Aguiar, José Lucas Porto; de Almedia, José Ricardo Vieira; Felinto, Elton Carlos; Lyra, Maria Julia; Leite, Danielle Batista; Drager, Luciano Ferreira; Farah, Breno Quintella; Pedrosa, Rodrigo Pinto
J Hypertens
This study aimed to investigate the impact of 12 weeks of high-intensity interval training (HIIT) on hemodynamic variables at rest and during exercise in patients with obstructive sleep apnoea. Twenty-six obese adults with moderate-to-severe OSA (AHI = 42 ± 22.9 e/h) were randomly assigned to (...) -- SHORT REPORT
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A potential antifibrotic mechanism in pathological myocardial remodeling is the recruitment of beneficial functional subpopulations of macrophages or the transformation of their phenotype. Macrophages are required to activate molecular cascades that regulate fibroblast behavior. Identifying (...) -- ORIGINAL ARTICLES
2 janvier
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Comparing the severity of second preeclampsia with first preeclampsia: a multicenter retrospective longitudinal cohort study -
Zhang, Lizi; Bi, Shilei; Gong, Jingjin; Wang, Xinghe; Liang, Jingying; Gu, Shifeng; Su, Minglian; Wang, Weiwei; Sun, Manna; Chen, Jingsi; Zheng, Weitan; Wu, Junwei; Wang, Zhijian; Liu, Jianmeng; Li, Hong-tian; Chen, Dunjin; Du, Lili
J Hypertens
Objective: Compare the clinical severity of second preeclampsia with the first preeclampsia. Methods: This retrospective longitudinal cohort study was conducted in three teaching hospitals in Guangzhou, where there were a total of 296 405 deliveries between 2010 and 2021. Two consecutive (...) -- ORIGINAL ARTICLES
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Objectives: Ambulatory (ABP) and self-home blood pressure (HBP) measurements are known to be superior to office blood pressure (OBP) measurements in predicting cardiovascular events. Whether ABP has superior prognostic ability than HBP, or the reverse, has not been adequately investigated. (...) -- REVIEW
29 décembre
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Background: Preeclampsia (PE) is one of the leading causes of maternal mortality and placental trophoblastic disorders. Recent studies reported that circular RNAs (circRNAs) were involved in PE pathogenesis. However, the role of circ_0001861 in PE progression is largely unknown. Methods: The (...) -- ORIGINAL ARTICLES
21 décembre
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Nerve growth factor (Ngf) gene-driven semaphorin 3a (Sema3a) expression exacerbates thoracic aortic aneurysm dissection in mice -
Wu, Li-Fei; Zhou, Ying; Wang, De-Ping; Zhang, Jiao-Jiao; Zheng, Zhi-Fa; Guo, Jia; Shen, Jing; Shi, Jian-Yun; Liu, Qing-Hua; Wang, Xue-Ning; Wang, Hai-Xiong; Du, Wen-Jing; Li, Miao-Ling; Cao, Ji-Min
J Hypertens
Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening disease and currently there is no pharmacological therapy. Sympathetic nerve overactivity plays an important role in the development of TAAD. Sympathetic innervation is mainly controlled by nerve growth factor (NGF, a key (...) -- ORIGINAL ARTICLES
20 décembre
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Adipose c-Jun NH2-terminal kinase promotes angiotensin II-induced and deoxycorticosterone acetate salt-induced hypertension and vascular dysfunction by inhibition of adiponectin production and activation of SGK1 in mice -
Gan, Jing; Shi, Yaru; Zhao, Ruyi; Li, Dan; Jin, Hua; Wu, Maolan; Liu, Zhen; Li, Xiaokun; Xu, Aimin; Li, Yulin; Lin, Zhuofeng; Wu, Fan
J Hypertens
Background: Adipose c-Jun NH2-terminal kinase 1/2 (JNK1/2) is a central mediator involved in the development of obesity and its complications. However, the roles of adipose JNK1/2 in hypertension remain elusive. Here we explored the role of adipose JNK1/2 in hypertension. Methods and results: (...) -- ORIGINAL ARTICLES
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07:00
Ten-year follow-up of very-high risk hypertensive patients undergoing renal sympathetic denervation -
Wang, Li; Li, Chao; Li, Zhuqing; Li, Qi; Liu, Chunlei; Sun, Xiaoqiang; He, Qiang; Xia, Da-sheng; Xia, Dachuan; Lu, Chengzhi
J Hypertens
Objectives: Renal denervation (RDN) has been proven to be effective in lowering blood pressure (BP) in patients, but previous studies have had short follow-ups and have not examined the effects of RDN on major cardiovascular outcomes. This study aimed to demonstrate the effectiveness and (...) -- ORIGINAL ARTICLES
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07:00
Relationship of calcium and magnesium intakes with the dietary approaches to stop hypertension score and blood pressure: the International Study of Macro/micronutrients and Blood Pressure -
Gibson, Rachel; Aljuraiban, Ghadeer S.; Oude Griep, Linda M.; Vu, Thanh-Huyen; Steffen, Lyn M.; Appel, Lawrence J.; Rodriguez, Beatriz L.; Daviglus, Martha L.; Elliott, Paul; Van Horn, Linda; Chan, Queenie
J Hypertens
Objective: Research investigating calcium and magnesium intakes from the Dietary Approaches to Stop Hypertension (DASH) pattern and other sources in association with blood pressure is limited. We aimed to characterize sources/intake levels of calcium and magnesium in relation to overall diet (...) -- ORIGINAL ARTICLES
18 décembre
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07:00
In the present study, we aimed to conduct a literature review and meta-analysis to assess the effect of Vitamin D supplementation on SBP and DBP levels in individuals with hypertension and hypovitaminosis D. PubMed, Scopus, Web of Science, and SciELO were systematically searched for relevant (...) -- REVIEW
15 décembre
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07:00
Standardized treatment protocols for hypertension: global availability, characteristics, and alignment with the hypertension guideline recommendations -
Satheesh, Gautam; Dhurjati, Rupasvi; Huffman, Mark D.; Rosende, Andres; Rodgers, Anthony; Prabhakaran, Dorairaj; Ordunez, Pedro; Jha, Vivekanand; Salam, Abdul
J Hypertens
Background: Hypertension control is suboptimal globally. Implementing evidence-based, simple, standardized treatment protocols (STPs) has been instrumental in effectively and efficiently improving treatment and control of hypertension. We aimed to identify, characterize, and critically (...) -- ORIGINAL ARTICLES
14 décembre
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07:00
Objectives: Mineralocorticoid receptor antagonist (MRA) treatment is kidney protective but not recommended to patients with advanced renal failure due to the risk of hyperkalemia and death. This study aimed to examine the impact of MRA treatment in patients with chronic kidney disease on risk (...) -- ORIGINAL ARTICLES
13 décembre
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07:00
Our study aimed to examine the effect of testosterone replacement therapy (TRT) on blood pressure in opioid-treated men with relative hypogonadism, and whether the effect of TRT on blood pressure was modified by body composition, red blood cell levels, or carotid intima media thickness. Men (...) -- DE-NOVO SUBMISSION
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07:00
Objective: To assess the rate of gastric emptying in spontaneously hypertensive rats (SHR) and to evaluate rapid gastric emptying as a possible predisposing factor for hypertension. Rapid gastric emptying of carbohydrates, known to elevate postprandial serum glucose, has been reported to occur (...) -- ORIGINAL ARTICLES
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07:00
Application of deep neural survival networks to the development of risk prediction models for diabetes mellitus, hypertension, and dyslipidemia -
Sasagawa, Yoshinori; Inoue, Yosuke; Futagami, Katsuya; Nakamura, Tomohiro; Maeda, Kiyohiro; Aoki, Tomohiro; Fukubayashi, Naoko; Kimoto, Mayumi; Mizoue, Tetsuya; Hoshina, Gakuse
J Hypertens
Objectives : Although numerous risk prediction models have been proposed, few such models have been developed using neural network-based survival analysis. We developed risk prediction models for three cardiovascular disease risk factors (diabetes mellitus, hypertension, and dyslipidemia) (...) -- ORIGINAL ARTICLES
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07:00
Early vascular damage in retinal microcirculation in arterial hypertension: the Czech post-MONICA study -
Cífková, Renata; Harazny, Joanna M.; Bruthans, Jan; Wohlfahrt, Peter; Kraj?oviechová, Alena Hrubeš; Lánská, V?ra; Gelžinský, Július; Mate?ánková, Markéta; Mareš, Št?pán; Filipovský, Jan; Mayer, Otto Jr.; Schmieder, Roland E.
J Hypertens
Retinal microcirculation reflects retinal perfusion abnormalities and retinal arterial structural changes at relatively early stages of various cardiovascular diseases. Wall-to-lumen ratio (WLR) may represent the earliest step in hypertension-mediated organ damage. Our objective was to compare (...) -- ORIGINAL ARTICLES
8 décembre
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07:00
Combining renin-angiotensin system blockade and sodium-glucose cotransporter-2 inhibition in experimental diabetes results in synergistic beneficial effects -
Cruz-López, Edwyn O.; Ye, Dien; Stolk, Daniel G.; Clahsen-van Groningen, Marian C.; van Veghel, Richard; Garrelds, Ingrid M.; Poglitsch, Marko; Domenig, Oliver; Alipour Symakani, Rahi S.; Merkus, Daphne; Verdonk, Koen; Jan Danser, A.H.
J Hypertens
Background: Sodium-glucose cotransporter-2 (SGLT2) inhibition exerts cardioprotective and renoprotective effects, often on top of renin-angiotensin system (RAS) blockade. We investigated this in diabetic hypertensive (mREN2)27 rats. Methods: Rats were made diabetic with streptozotocin and (...) -- ORIGINAL ARTICLES
7 décembre
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07:00
Factors influencing the continuation of home blood pressure measurement in community-dwelling older adults: the NOSE study -
Wada, Arisa; Kabayama, Mai; Godai, Kayo; Kido, Michiko; Ohata, Yuka; Murakami, Naoko; Nakamura, Yuko; Yoshida, Hiroko; Hashimoto, Sumiyo; Higashi, Makiko; Hatanaka, Hiromi; Kikuchi, Takeshi; Terauchi, Keiji; Nagayoshi, Sho; Matsuno, Fumie; Shinomiya, Noboru; Asayama, Kei; Ohkubo, Takayoshi; Rakugi, Hiromi; Tabara, Yasuharu; Kamide, Kei
J Hypertens
Objective: This study aimed to identify the factors influencing home blood pressure measurement (HBPM) continuation in community-dwelling older adults. Methods: A longitudinal analysis used the NOSE study intervention group datasets. The participants were encouraged HBPM with self-monitoring (...) -- ORIGINAL ARTICLES
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07:00
Reversal of arterial stiffness in medically and surgically treated unilateral primary aldosteronism -
Chen, Zheng-Wei; Liao, Che-Wei; Pan, Chien-Ting; Tsai, Cheng-Hsuan; Chang, Yi-Yao; Chang, Chin-Chen; Lee, Bo-Ching; Chiu, Yu-Wei; Huang, Wei-Chieh; Lai, Tai-Shuan; Lu, Ching-Chu; Chueh, Jeff S.; Wu, Vin-Cent; Hung, Chi-Sheng; Lin, Yen-Hung; the TAIPAI Study Group
J Hypertens
Objective: Hyperaldosteronism has adverse effects on cardiovascular structure and function. Laparoscopic adrenalectomy is the gold standard for patients with unilateral primary aldosteronism. For unilateral primary aldosteronism patients unable or unwilling to undergo surgery, the effects of (...) -- ORIGINAL ARTICLES
6 décembre
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07:00
Objective: Arterial hypertension is one of the common treatment goals in today's medicine. 24-h ambulatory blood pressure measurement (ABPM) performed by oscillometric cuff-based devices is considered as the gold standard in hypertension diagnostics. This study aims at examining the (...) -- ORIGINAL ARTICLES
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07:00
Hypertension in the first blood pressure reading and the risk of cardiovascular disease mortality in the general population: findings from the prospective KORA study -
Atasoy, Seryan; Henningsen, Peter; Johar, Hamimatunnisa; Middeke, Martin; Sattel, Heribert; Linkohr, Birgit; Rückert-Eheberg, Ina-Maria; Heier, Margit; Peters, Annette; Ladwig, Karl-Heinz
J Hypertens
Background: The risk of cardiovascular disease (CVD) mortality in individuals with an alerting reaction, assessed by hypertension in the first blood pressure (BP) reading but normal BP in further readings, remains unknown in the general population. Methods and Results: In a sample of 11 146 (...) -- ORIGINAL ARTICLES
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07:00
The association of time-updated ambulatory blood pressure and renal progression in hypertensive patients with chronic kidney disease: post hoc analysis of ACCURATE study -
Kim, Yunmi; Kim, Jayoun; Kang, Eunjeong; Im, Dha Woon; Kim, Taehee; Huh, Hyuk; Kim, Yeong Hoon; Lee, Hyanglim; Kim, Ji Hye; Oh, Kook-Hwan
J Hypertens
Objectives : This study aimed to evaluate the effect of time-updated ambulatory blood pressure on chronic kidney disease (CKD) progression in patients with hypertension. Methods : Among patients with hypertension and CKD stages 3 and 4, enrolled in a clinical trial in which hypertension was (...) -- ORIGINAL ARTICLES
4 décembre
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07:00
Objectives: Advanced glycation end product (AGE) is an established risk marker for diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in middle-aged and older individuals. The relationship between AGEs and aortic stiffness (...) -- ORIGINAL ARTICLES
30 novembre
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07:00
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07:00
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07:00
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07:00
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07:00
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07:00
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07:00
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07:00
No abstract available -- ERRATA
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07:00
No abstract available -- ERRATA
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07:00
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07:00
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07:00
27 novembre
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07:00
Objective: Although hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anemia, their effects on cardiac and renal dysfunction remain unknown. We previously reported on Dahl salt-sensitive rats, in a rat model of salt-sensitive (...) -- ORIGINAL ARTICLES
23 novembre
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07:00
Dose–response association between physical activity and blood pressure among Chinese adults: a nationwide cross-sectional study -
Guan, Tianjia; Cao, Man; Zheng, Congyi; Zhou, Haoqi; Wang, Xin; Chen, Zuo; Zhang, Linfeng; Cao, Xue; Tian, Yixin; Guo, Jian; Han, Xueyan; Wang, Zengwu
J Hypertens
Objectives: The aim of this study was to examine the dose–response associations of physical activity with blood pressure (BP) and hypertension risk among Chinese adults. Methods: Derived from the national community-based China Hypertension Survey database during 2012--2015, a total of 203 108 (...) -- ORIGINAL ARTICLES
22 novembre
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07:00
Objective: The G-allele of FOXO3 SNP rs2802292, which is associated with human resilience and longevity, has been shown to attenuate the impact of hypertension on the risk of intracerebral hemorrhage (ICH). We sought to determine whether the FOXO3 G-allele similarly attenuates the impact of (...) -- ORIGINAL ARTICLES
20 novembre
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07:00
Long-term blood pressure variability and frailty risk in older adults -
Fravel, Michelle A.; Ernst, Michael E.; Woods, Robyn L.; Beilin, Lawrence; Zhou, Zhen; Orchard, Suzanne G.; Chowdhury, Enayet; Reid, Christopher M.; Saifuddin Ekram, ARM; Espinoza, Sara E.; Nelson, Mark R.; Stocks, Nigel; Polkinghorne, Kevan R.; Wolfe, Rory; Ryan, Joanne
J Hypertens
Introduction: In healthy older adults, the relationship between long-term, visit-to-visit variability in blood pressure (BP) and frailty is uncertain. Methods: Secondary analysis of blood pressure variability (BPV) and incident frailty in >13 000 participants ?65–70 years enrolled in the (...) -- ORIGINAL ARTICLES
16 novembre
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07:00
Lactobacillus induced by irbesartan on spontaneously hypertensive rat contribute to its antihypertensive effect -
Xiong, Yanling; He, Yanping; Chen, Zhi; Wu, Tianyuan; Xiong, Yalan; Peng, Yilei; Yang, Xuechun; Liu, Yujie; Zhou, Jian; Zhou, Honghao; Zhang, Wei; Shu, Yan; Li, Xiong; Li, Qing
J Hypertens
Objective: Hypertension is linked to gut dysbiosis. Here, the impact of the angiotensin receptor antagonist irbesartan on the gut microbiota of spontaneously hypertensive rats (SHR) were investigated. In addition, we assessed their contribution to its antihypertensive effect. Methods: (...) -- ORIGINAL ARTICLES
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07:00
Objectives: A knowledge gap exists around the costs and budget impact of specialist hypertension clinics. This study reports on the cost of providing care in a multidisciplinary hypertension clinic staffed by nephrologist, endocrinologist and cardiologist, which manages patients with suspected (...) -- ORIGINAL ARTICLES
15 novembre
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07:00
Objectives: To estimate the national prevalence of chlorthalidone and hydrochlorothiazide use among adults diagnosed with hypertension by sociodemographic subgroup, healthcare access status, and clinical factors. Methods: Data was extracted from the National Health and Nutrition Examination (...) -- ORIGINAL ARTICLES
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07:00
Objectives: Stress, and particularly job strain, has been found to associate with ambulatory blood pressure (BP). Moreover, BP is known to vary between days. One potential over-looked factor underlying this day-to-day BP variation could be work-related psychosocial factors. Thus, we aimed to (...) -- ORIGINAL ARTICLES
14 novembre
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07:00
Introduction: Management of midlife blood pressure and hypertension status may provide a window of intervention to mitigate cognitive decline with advancing age. The aim of this review was to investigate the relationship between midlife hypertension and cognition in midlife and later life. (...) -- REVIEWS
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07:00
Objective: In the growing population of older patients with hypertension, limited evidence supports an association between lowering systolic blood pressure (SBP) and decreased adverse events. We aimed to investigate cardiovascular outcomes according to on-treatment SBP in older hypertensive (...) -- ORIGINAL ARTICLES
8 novembre
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07:00
Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway -
Wei, Cheng; Zhang, Jishou; Peng, Shanshan; Liu, Jianfang; Xu, Yao; Zhao, Mengmeng; Xu, Shuwan; Pan, Wei; Yin, Zheng; Zheng, Zihui; Qin, Juan-Juan; Wan, Jun; Wang, Menglong
J Hypertens
The proliferation, migration and phenotypic transformation of vascular smooth muscle cells contribute to vascular remodeling and hypertension. Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator that has been shown to have anti-inflammatory effects and can protect against (...) -- ORIGINAL ARTICLES
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07:00
Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study -
Budzy?, Magdalena; Gryszczy?ska, Bogna; Begier-Krasi?ska, Beata; Kaja, El?bieta; Miko?ajczak, Przemys?aw; Kujawski, Rados?aw; Grupi?ska, Joanna; Iskra, Maria; Tykarski, Andrzej; Kaczmarek, Mariusz
J Hypertens
Background: Low-grade chronic inflammation is recognized to contribute to the physiopathology of arterial hypertension. Therefore, this study aimed to assess the pro-inflammatory phenotype of peripheral monocytes of hypertensive patients by analyzing Toll-like receptor 4 (TLR4) and CD11b/CD18 (...) -- ORIGINAL ARTICLES
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07:00
Background: Hypertension is a cardiovascular risk factor that predisposes to cardiac structural alterations namely increased left ventricular (LV) wall thickness, reduced LV compliance and diastolic dysfunction, with consequent left atrial (LA) dilation and functional impairment. In this (...) -- ORIGINAL ARTICLES
2 novembre
1er novembre
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06:00
Treatment decision based on unilateral index from nonadrenocorticotropic hormone-stimulated and adrenocorticotropic hormone-stimulated adrenal vein sampling in primary aldosteronism -
Zhang, Xizi; Shu, Xiaoyu; Wu, Feifei; Yang, Jun; Cheng, Qingfeng; Du, Zhipeng; Song, Ying; Yang, Yi; Hu, Jinbo; Wang, Yue; Li, Qifu; Yang, Shumin; the Chongqing Primary Aldosteronism Study (CONPASS) Group†
J Hypertens
Objective: Adrenal venous sampling (AVS) is recommended for identifying the subtype of primary aldosteronism before making a surgical treatment decision, but failed cannulation of one adrenal vein is common. To evaluate whether using results of one adrenal vein during AVS could accurately (...) -- ORIGINAL ARTICLES
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06:00
Objectives: Little evidence regarding the associations of longitudinal trajectories of depressive symptoms and incident hypertension and cardiovascular diseases (CVDs). This study aimed to evaluate the relationships between trajectories of depressive symptoms and new-onset hypertension and (...) -- ORIGINAL ARTICLES
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06:00
Objectives: The role of hypercholesterolemia in arterial stiffness, which usually reflects the progression of atherosclerosis has not been fully investigated. To clarify the meaning of arterial stiffness in hypercholesterolemia, we evaluated arterial stiffness in myocardial infarction-prone (...) -- ORIGINAL ARTICLES
26 octobre
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07:00
Orthostatic hypotension, orthostatic hypertension, and ambulatory blood pressure in patients with chronic kidney disease in CRIC -
Ghazi, Lama; Cohen, Jordana B.; Townsend, Raymond R.; Drawz, Paul E.; Rahman, Mahboob; Pradhan, Nishigandha; Cohen, Debbie L.; Weir, Matthew R.; Rincon-Choles, Hernan; Juraschek, Stephen P.
J Hypertens
Background: Orthostatic changes in blood pressure (BP), either orthostatic hypotension or orthostatic hypertension (OHTN), are common among patients with chronic kidney disease. Whether they are associated with unique out-of-office BP phenotypes is unknown. Methods: CRIC is a prospective, (...) -- ORIGINAL ARTICLES
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07:00
Background: Myocardial ischemia causes the release of bradykinin, which stimulates cardiac afferents, causing sympathetic excitation and chest pain. Glutamatergic activation of the paraventricular hypothalamic nucleus (PVN) in the spontaneously hypertensive rat (SHR) drives elevated basal (...) -- ORIGINAL ARTICLES
25 octobre
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07:00
Objective: Blood pressure (BP), cardiorespiratory fitness (CRF), and body composition are independently associated with health outcomes, yet the relationship between these variables has not been explored among airline pilots. The aim of this study was to evaluate the relationship between CRF (...) -- ORIGINAL ARTICLES
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07:00
Objective: We report data regarding systolic BP monitoring in children aged -- ORIGINAL ARTICLES
20 octobre
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07:00
Persistently elevated sFlt-1 and recovery of reduced ADAMTS13 activity in malignant hypertension -
Ma, Hongkun; Wang, Chongjian; Jiang, Mengdi; Jin, Kexin; Xu, Tingting; Wang, Zhiyu; Xu, Jing; Ni, Liyan; Shi, Hao; Shen, Pingyan; Chen, Yongxi; Feng, Xiaobei; Zhang, Wen
J Hypertens
Background and objectives: Malignant hypertension (MHT) characterized by acute hypertension with retinopathy or multiorgan damage, is a severe form of hypertensive emergency and associated with target organ involvement and poor kidney outcome. However, the underlying mechanisms are unclear. (...) -- ORIGINAL ARTICLES
19 octobre
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07:00
Purpose: Prior studies have shown that treatment intensification for patients presenting with uncontrolled hypertension (HTN) rarely occurs, even during visits to the patient's own primary care physicians (PCPs). In this article, we identified predictors of treatment intensification for (...) -- ORIGINAL ARTICLES
18 octobre
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07:00
Background: Neuropeptide Y (NPY) is a neurotransmitter expressed in both the central and peripheral nervous systems, which is involved in regulating a multitude of physiological processes ranging from arterial pressure, energy balance, the immune response and inflammation and renal electrolyte (...) -- ORIGINAL ARTICLES
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07:00
Antihypertensive drug concentration measurement combined with personalized feedback in resistant hypertension: a randomized controlled trial -
Peeters, Laura E.J.; Kappers, M.H.W.; Hesselink, D.A.; van der Net, J.B.; Hartong, S.C.C.; van de Laar, R.; Ezzahti, M.; van de Ven, P.J.G.; van der Meer, I.M.; de Bruijne, E.L.E.; Kroon, A.A.; Indhirajanti-Tomasoa, S.; van der Linde, N.A.J.; Bahmany, S.; Boersma, E.; Massey, E. K.; van Dijk, L.; van Gelder, T.; Koch, Birgit C.P.; Versmissen, Jorie
J Hypertens
Background: Adherence to antihypertensive drugs (AHDs) is crucial for controlling blood pressure (BP). We aimed to determine the effectiveness of measuring AHD concentrations using a dried blood spot (DBS) sampling method to identify nonadherence, combined with personalized feedback, in (...) -- ORIGINAL ARTICLES
11 octobre
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07:00
The acute and long-term benefits of exercise on cardiovascular health are well established, yet the optimal mode of exercise training that improves arterial stiffness in women with high blood pressure remains unclear. The aim of this systematic review and meta-analysis was to assess the (...) -- REVIEWS
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07:00
Objective: This study aimed to investigate the relationship between serum uric acid (SUA) levels and hypertension in the middle-aged and elderly populations. Methods: The cross-sectional analysis included 13 349 middle-aged and elderly general health checkup examinees without cardiovascular (...) -- ORIGINAL ARTICLES
10 octobre
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07:00
Risk factors for intraoperative hypertensive crisis in patients with pheochromocytomas and sympathetic paragangliomas -
Araujo-Castro, Marta; García Sanz, Iñigo; Mínguez Ojeda, César; Hanzu, Felicia; Mora, Mireia; Vicente, Almudena; Blanco Carrera, Concepción; Miguel Novoa, Paz de; López García, María del Carmen; Lamas, Cristina; Manjón-Miguélez, Laura; del Castillo Tous, María; Rodríguez de Vera, Pablo; Barahona San Millán, Rebeca; Recasens, Mónica; Fernández-Ladreda, Mariana Tomé; Valdés, Nuria; Gracia Gimeno, Paola; Robles Lazaro, Cristina; Michalopoulou, Theodora; Álvarez Escolá, Cristina; García Centeno, Rogelio; Calatayud, María
J Hypertens
Purpose: To identify presurgical and surgical risk factors for intraoperative hypertensive crisis in patients with pheochromocytomas and sympathetic paragangliomas (PGLs) (PPGLs). Methods: Retrospective multicenter cohort study of patients with PPGLs from 18 tertiary hospitals. Intraoperative (...) -- ORIGINAL ARTICLES
9 octobre
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07:00
Background: Observational studies have found associations between hypertensive disorders of pregnancy and an increased risk of cognitive dysfunction and reduced brain volume. However, the results of observational studies may have been influenced by confounding factors. This study applied (...) -- ORIGINAL ARTICLES
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07:00
Background and purpose: Reducing hypertensive myocardial fibrosis is the fundamental approach to preventing hypertensive ventricular remodelling. C1q/TNF-related protein-3 (CTRP3) is closely associated with hypertension. However, the role and mechanism of CTRP3 in hypertensive myocardial (...) -- ORIGINAL ARTICLES
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07:00
Objectives: In any treated hypertensive patient office blood pressure (BP) values may differ between visits and this variability (V) has an adverse prognostic impact. However, little information is available on visit-to-visit 24-h BPV. Methods: In 1114 hypertensives of the ELSA and PHYLLIS (...) -- ORIGINAL ARTICLES
5 octobre
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07:00
Objective: Glycometabolic changes are associated with hypercortisolism in Cushing's syndrome. Because impaired glucose tolerance (IGT) and insulin resistance are frequently detected in patients with essential hypertension, we hypothesized that in these patients, early glycometabolic (...) -- ORIGINAL ARTICLES
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07:00
Effects of adding exercise to usual care on blood pressure in patients with hypertension, type 2 diabetes, or cardiovascular disease: a systematic review with meta-analysis and trial sequential analysis -
Rijal, Anupa; Adhikari, Tara Ballav; Dhakal, Sarmila; Maagaard, Mathias; Piri, Reza; Nielsen, Emil Eik; Neupane, Dinesh; Jakobsen, Janus Christian; Olsen, Michael Hecht
J Hypertens
Introduction: Exercise is the most recommended lifestyle intervention in managing hypertension, type 2 diabetes, and/or cardiovascular disease; however, evidence in lowering blood pressure is still inconsistent and often underpowered. Method: We conducted a systematic review with meta-analysis (...) -- REVIEWS
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07:00
No abstract available -- ERRATA
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07:00
No abstract available -- ERRATA
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07:00
No abstract available -- ERRATA
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07:00
No abstract available -- ERRATA
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07:00
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07:00
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07:00
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07:00
No abstract available -- ERRATA
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07:00
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07:00
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07:00
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07:00
3 octobre
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07:00
Prevalence and correlates of frailty in older hypertensive outpatients according to different tools: the HYPER-FRAIL pilot study -
Rivasi, Giulia; Ceolin, Ludovica; Turrin, Giada; Tortu’, Virginia; D’Andria, Maria Flora; Testa, Giuseppe Dario; Montali, Sara; Tonarelli, Francesco; Brunetti, Enrico; Bo, Mario; Romero-Ortuno, Roman; Mossello, Enrico; Ungar, Andrea
J Hypertens
Objectives: To date, few studies have investigated frailty in hypertensive individuals. This study aimed at identifying the prevalence of frailty in a sample of hypertensive older outpatients using six different identification tools. Clinical correlates of frailty and agreement between (...) -- ORIGINAL ARTICLES
1er octobre
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07:00
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07:00
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07:00
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07:00
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07:00
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07:00
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07:00
Task sharing in the management of hypertension: highlights of the African hypertension school for nonphysicians health workers -
Akintunde, Abiodun A.; Mutagaywa, Reuben; Manmak, Manven; Oguntade, Ayodipupo S.; Adejumo, Oluseyi A.; Isiguzo, Godsent; Beheiry, Hind; Doku, Alfred; Dzudie, Anaestase; Damasceno, Albertino; Onwubere, B.J.C.; Odili, Augustine; Adeoye, Abiodun; Mbulaje, Lucia; Lamin, E.S.; Akumiah, Florence; Avorkliya, Loius; Ogola, Elijah; Ayoola, Yekeen; Marwa, Sebastian; Exon, A.; Amaechi, Uzochukwu M.; Okereke, Chinonso J.; Nwude, Ifeanyi E.
J Hypertens
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07:00
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07:00
29 septembre
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07:00
Objective: Hypertension is a leading preventable cause of mortality, yet high rates of undiagnosed and uncontrolled hypertension continue. The burden falls most heavily on some ethnic minorities and the socially deprived, with the COVID-19 pandemic having further widened inequalities. We (...) -- ORIGINAL ARTICLES
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07:00
Aim: Leg blood pressure (BP) measurement is needed when arm BP evaluation is not feasible, and calf BP, especially when measured in standing position, may have greater association with cardiovascular remodeling than arm BP. This study evaluated the relationship between calf and arm BP, and (...) -- ORIGINAL ARTICLES
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07:00
Development, validation, and clinical utility of a risk prediction model for recurrent preeclampsia -
Zhang, Lizi; Wang, Weiwei; Gong, Jingjin; Wang, Xinghe; Liang, Jingying; Gu, Shifeng; Su, Minglian; Bi, Shilei; Sun, Manna; Chen, Jingsi; Zheng, Weitan; Wu, Junwei; Wang, Zhijian; Liu, Jianmeng; Li, Hongtian; Chen, Dunjin; Du, Lili
J Hypertens
Objectives: We aim to establish a predictive model for recurrent preeclampsia. Methods: A retrospective review of medical records from three hospitals between 2010 and 2021 was conducted. The study included women who had two consecutive singleton deliveries at the same hospital, with the first (...) -- ORIGINAL ARTICLES
26 septembre
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07:00
Background and aims: Whether bedtime versus morning administration of antihypertensive therapy is beneficial on outcomes is controversial. We evaluated the risk of total and cardiovascular mortality in a very large observational cohort of treated hypertensive patients, according to the timing (...) -- ORIGINAL ARTICLES
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07:00
Objective: The association of childhood blood pressure (BP) and heart rate (HR) with intermediate markers of cardiovascular disease several decades later has been shown, but studies on more short-term outcomes are scarce. Using population-based data, this study investigates the association of (...) -- ORIGINAL ARTICLES
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07:00
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA) -
Mancia, Giuseppe; Kreutz, Reinhold; Brunström, Mattias; Burnier, Michel; Grassi, Guido; Januszewicz, Andrzej; Muiesan, Maria Lorenza; Tsioufis, Konstantinos; Agabiti-Rosei, Enrico; Algharably, Engi Abd Elhady; Azizi, Michel; Benetos, Athanase; Borghi, Claudio; Hitij, Jana Brguljan; Cifkova, Renata; Coca, Antonio; Cornelissen, Veronique; Cruickshank, J. Kennedy; Cunha, Pedro G.; Danser, A.H. Jan; Pinho, Rosa Maria de; Delles, Christian; Dominiczak, Anna F.; Dorobantu, Maria; Doumas, Michalis; Fernández-Alfonso, María S.; Halimi, Jean-Michel; Járai, Zoltán; Jelakovi?, Bojan; Jordan, Jens; (…)
J Hypertens
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis (Greece), Dorota (...) -- ESH GUIDELINES
21 septembre
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07:00
A nomogram for predicting the risk of preeclampsia in women with intrahepatic cholestasis of pregnancy based on prenatal monitoring time: a multicenter retrospective cohort study -
Cai, Qin-Yu; Li, Zhuo-Hang; Deng, Bei-Ning; Luo, Xin; Lan, Xia; Chen, Ya; Liang, Li-Fang; Liu, Chen-Yang; Liu, Tai-Hang; Wang, Ying-Xiong; Wang, Lan
J Hypertens
Background and aims: Intrahepatic cholestasis of pregnancy (ICP) is a special liver disease during pregnancy, characterized by abnormal bile acid metabolism. However, there is no consensus on how to group women with ICP based on the time of diagnosis worldwide. This study aimed to adopt a new (...) -- ORIGINAL ARTICLES
20 septembre
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07:00
Objectives: The subendocardial viability ratio (SEVR) reflects the balance of myocardial oxygen supply and demand. Low SEVR indicates a reduced subendocardial perfusion and has been shown to predict mortality in patients with kidney disease and diabetes. The aim of this study is to investigate (...) -- ORIGINAL ARTICLES
19 septembre
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07:00
Objective: Prepregnancy optimization of cardiovascular function may reduce the risk of pre-eclampsia. We aimed to assess the feasibility and effect of preconception cardiovascular monitoring, exercise, and beetroot juice on cardiovascular parameters in women planning to conceive. Design and (...) -- ORIGINAL ARTICLES
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07:00
Objectives: This analysis compared adherence, cardiovascular (CV) events and all-cause mortality incidence, and healthcare costs among hypertensive patients treated with perindopril (PER)/indapamide (IND)/amlodipine (AML) in single-pill combination (SPC) vs. multiple-pill combination, in a (...) -- ORIGINAL ARTICLES
18 septembre
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07:00
Background: High blood pressure (BP) increases carotid intima–media thickness (CIMT). On the other hand, it is not clear whether the vascular abnormalities reflected in high CIMT may predict incident hypertension. The present study aims to investigate the association between CIMT and incident (...) -- ORIGINAL ARTICLES
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07:00
Endoplasmic reticulum stress impairs trophoblast syncytialization through upregulation of HtrA4 and causes early-onset preeclampsia -
Yuan, Xi; Liu, Xiyao; Zhu, Fangyu; Huang, Biao; Lin, Li; Huang, Jiayu; Wen, Li; Kilby, Mark D.; Baker, Philip N.; Fu, Yong; Wu, Weiwei; Qi, Hongbo; Tang, Jing; Tong, Chao
J Hypertens
Objective: Syncytiotrophoblasts form via mononuclear cytotrophoblast fusion during placentation and play a critical role in maternal–fetal communication. Impaired syncytialization inevitably leads to pregnancy-associated complications, including preeclampsia. Endoplasmic reticulum stress (ERS) (...) -- ORIGINAL ARTICLES
14 septembre
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07:00
Objectives: Hypertension is the key modifiable cardiovascular risk factor but is underdiagnosed, and its scale in South Asian and African-Caribbean communities is unknown. Left ventricular hypertrophy (LVH) is a measure of target organ damage in uncontrolled hypertension. The study assesses (...) -- ORIGINAL ARTICLES
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07:00
Aim: Gender-based evidence on the association between serum uric acid (SUA) and left ventricular hypertrophy (LVH), as assessed by echocardiography, is still based on single studies. Thus, we performed a systematic meta-analysis of echocardiographic studies in order to provide an updated and (...) -- ORIGINAL ARTICLES
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07:00
Background: The stroke-prone spontaneously hypertensive rat (SHRSP) is a genetic model for cerebral stroke. Although a recent study on a congenic SHRSP suggested that a nonsense mutation in stromal interaction molecule 1 (Stim1) encoding a major component of store-operated Ca2+ entry was a (...) -- ORIGINAL ARTICLES
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07:00
Objectives: The lower limit of autoregulation (LLA) of cerebral blood flow was previously shown to vary directly with the Ambulatory Arterial Stiffness Index (AASI) redefined as 1-regression slope of DBP-versus-SBP readings invasively measured from the radial artery before the bypass. We aimed (...) -- ORIGINAL ARTICLES
13 septembre
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07:00
Objective: The aim of this work was to systematically review the level of evidence based on prospective cohort studies investigating the role of 24-h ambulatory blood pressure measurement (ABPM) and home blood pressure measurement (HBPM) on cardiovascular disease (CVD) risk prediction. (...) -- REVIEWS
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07:00
A randomized, placebo-controlled, trial to assess the photosensitizing, phototoxic and carcinogenic potential of hydrochlorothiazide in healthy volunteers -
Götzinger, Felix; Hohl, Mathias; Lauder, Lucas; Millenaar, Dominic; Kunz, Michael; Meyer, Markus R.; Ukena, Christian; Lerche, Catharina M.; Philipsen, Peter A.; Reichrath, Jörg; Böhm, Michael; Mahfoud, Felix
J Hypertens
Background and aims: Pharmacovigilance reports, associating hydrochlorothiazide (HCT) with skin cancer, resulted in a significant decrease of HCT prescriptions for hypertension and heart failure. Whether HCT exhibits phototoxic properties thereby causing skin cancer remains unknown. This study (...) -- ORIGINAL ARTICLES
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07:00
Background: Various sequelae have been described after nonsevere coronavirus disease 2019 (COVID-19), but knowledge on postacute effects on blood pressure is limited. Methods: This is a cross-sectional analysis of blood pressure profiles in individuals after nonsevere COVID-19 compared with (...) -- ORIGINAL ARTICLES
12 septembre
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07:00
This case report aims to alert physicians to neuropsychological features and chromosomal variants that may underly resistant hypertension. We present a 35-year-old female patient with hypertensive crisis (BP 260/160 mmHg), initially treated with a combination of calcium antagonists, beta (...) -- CASE REPORT
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07:00
Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension -
Charchar, Fadi J.; Prestes, Priscilla R.; Mills, Charlotte; Ching, Siew Mooi; Neupane, Dinesh; Marques, Francine Z.; Sharman, James E.; Vogt, Liffert; Burrell, Louise M.; Korostovtseva, Lyudmila; Zec, Manja; Patil, Mansi; Schultz, Martin G.; Wallen, Matthew P.; Renna, Nicolás F.; Islam, Sheikh Mohammed Shariful; Hiremath, Swapnil; Gyeltshen, Tshewang; Chia, Yook-Chin; Gupta, Abhinav; Schutte, Aletta E.; Klein, Britt; Borghi, Claudio; Browning, Colette J.; Czesnikiewicz-Guzik, Marta; Lee, Hae-Young; Itoh, Hiroshi; Miura, Katsuyuki; Brunström, Mattias; Campbell, Norm R.C.; Akinnibossun, (…)
J Hypertens
Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of (...) -- ISH PAPER
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07:00
Background and aims: Research reports on the relationship between systemic immune-inflammation index (SII) and hypertension are limited. We aim to evaluate the possible relationship between SII and hypertension. Methods and results: We conducted a cross-sectional analysis of adults from the (...) -- ORIGINAL ARTICLES
11 septembre
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07:00
Effect of 24-h blood pressure dysregulations and reduced ocular perfusion pressure in open-angle glaucoma progression -
Melgarejo, Jesus D.; Eijgen, Jan V.; Wei, Dongmei; Maestre, Gladys E.; Al-Aswad, Lama A.; Liao, Chia-Te; Mena, Luis J.; Vanassche, Thomas; Janssens, Stefan; Verhamme, Peter; Zhang, Zhen-Yu; Keer, Karel V.; Stalmans, Ingeborg
J Hypertens
Background: Low ocular perfusion pressure (OPP), which depends on the mean arterial pressure (MAP) and intraocular pressure (IOP), is associated with glaucoma. We studied 24-h MAP dysregulations and OPP in relation to the progression of glaucoma damage. Methods: We retrospectively analyzed 155 (...) -- ORIGINAL ARTICLES
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07:00
Maternal cardiovascular diseases, including hypertension and cardiac conditions, are associated with poor fetal outcomes. A range of adrenergic antihypertensive and cardioprotective medications are often prescribed to pregnant women to reduce major maternal complications during pregnancy. (...) -- REVIEWS
7 septembre
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07:00
Megalin is involved in angiotensinogen-induced, angiotensin II-mediated ERK1/2 signaling to activate Na+-H+ exchanger 3 in proximal tubules -
Goto, Sawako; Yoshida, Yutaka; Hosojima, Michihiro; Kuwahara, Shoji; Kabasawa, Hideyuki; Aoki, Hiroyuki; Iida, Tomomichi; Sawada, Ryuhei; Ugamura, Daisuke; Yoshizawa, Yuta; Takemoto, Kazuya; Komochi, Koichi; Kobayashi, Ryota; Kaseda, Ryohei; Yaoita, Eishin; Nagatoishi, Satoru; Narita, Ichiei; Tsumoto, Kouhei; Saito, Akihiko
J Hypertens
Background: Kidney angiotensin (Ang) II is produced mainly from liver-derived, glomerular-filtered angiotensinogen (AGT). Podocyte injury has been reported to increase the kidney Ang II content and induce Na+ retention depending on the function of megalin, a proximal tubular endocytosis (...) -- ORIGINAL ARTICLES
6 septembre
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07:00
Background: Wide brachial pulse pressure (PP) has been associated with cardiovascular events, while its population distribution and association with body composition were poorly characterized in large populations. Methods: We evaluated the age and sex distributions of PP and its associations (...) -- ORIGINAL ARTICLES
5 septembre
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07:00
Objectives: The primary objective of this study is to examine the secular trends in blood pressure levels from 2012 to 2022 in eastern China. Additionally, to compare two standards [International Blood Pressure Reference for Children and Adolescents (ICBP) and the National Blood Pressure (...) -- ORIGINAL ARTICLES
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07:00
Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank -
Feng, Li; Ye, Zhenyao; Mo, Chen; Wang, Jingtao; Liu, Song; Gao, Si; Ke, Hongjie; Canida, Travis A.; Pan, Yezhi; Greevenbroek, Marleen M.J. van; Houben, Alfons J.H.M.; Wang, Kai; Hatch, Kathryn S.; Ma, Yizhou; Lei, David K.Y.; Chen, Chixiang; Mitchell, Braxton D.; Hong, L. Elliot; Kochunov, Peter; Chen, Shuo; Ma, Tianzhou
J Hypertens
Background: Elevated blood pressure (BP) is a modifiable risk factor associated with cognitive impairment and cerebrovascular diseases. However, the causal effect of BP on white matter brain aging remains unclear. Methods: In this study, we focused on N = 228 473 individuals of European (...) -- ORIGINAL ARTICLES
4 septembre
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07:00
The present study aims to examine the effects of nonpharmacological, pharmacological and devices-based treatment on hypertension-related sympathetic overactivity. This will be done by analyzing the results of different published studies, in which sympathetic activity has been assessed via (...) -- REVIEWS
1er septembre
23 août
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07:00
Objectives: The aim of this study was to assess the changes in salt intake and concomitant changes in blood pressure (BP) and cardiovascular disease (CVD) mortality in England from 2003 to 2018. Methods: National surveys and death registration data were used for the analysis of salt intake as (...) -- ORIGINAL ARTICLES
21 août
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07:00
Background: Growing evidence has implicated sedentary behavior is associated with cardiovascular and all-cause mortality, independent of moderate to vigorous physical activity (MVPA). Contrary to national physical activity guidelines, reductions in sedentary behavior are not promoted as a (...) -- ORIGINAL ARTICLES
18 août
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07:00
Objectives: Renal diseases caused by primary hypertension (HTN) are often asymptomatic without sensitive markers for early diagnosis and prediction, easily progressing to severe and irreversible renal damage in patients with clinical manifestations. This study explored whether a set of urinary (...) -- ORIGINAL ARTICLES
17 août
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07:00
Objective: Cough caused by angiotensin-converting enzyme inhibitors (ACEIs) limits their clinical application and cardiovascular benefits. This randomized trial investigated whether genotype-guided perindopril use could reduce drug-related cough in 20 to 79-year-old individuals with (...) -- ORIGINAL ARTICLES
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07:00
Obesity dominates early effects on cardiac structure and arterial stiffness in people with type 2 diabetes -
Abushamat, Layla A.; Enge, Daniel; Fujiwara, Takashi; Schäfer, Michal; Clark, Ethan W.; Englund, Erin K.; Scalzo, Rebecca L.; Johnston, Aspen; Rafferty, Deirdre; Schauer, Irene E.; Whipple, Mary O.; Hunter, Kendall; Huebschmann, Amy G.; Nadeau, Kristen J.; Jarvis, Kelly; Barker, Alex J.; Regensteiner, Judith G.; Reusch, Jane E.B.
J Hypertens
Objective: Type 2 diabetes (T2D) and obesity are global epidemics leading to excess cardiovascular disease (CVD). This study investigates standard and novel cardiac MRI parameters to detect subclinical cardiac and central vascular dysfunction in inactive people with and without T2D. Methods: (...) -- ORIGINAL ARTICLES
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07:00
Background: The differentiation between preeclampsia and similarly presenting kidney disease in pregnancy is a diagnostic challenge. Although some laboratory tests have been utilized, globally validated tools are yet needed, particularly in resource-limited settings. Congophilic proteins are (...) -- ORIGINAL ARTICLES
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07:00
Clinical characteristics of pediatric hypertension: a multicenter study in China -
Chen, Yijun; Ye, Peiyu; Dong, Hongbo; Xu, Xin; Shi, Lin; Li, Bin; Dong, Jie; Lv, Aiting; Su, Zhe; Zhang, Yong; Zhou, Yunguo; Wang, Juanli; Feng, Guoshuang; Zeng, Yueping; Ni, Xin; Mi, Jie
J Hypertens
Objectives: Hypertension in children has attracted increasing attention. However, clinical-based studies investigating characteristics and secular trends of pediatric hypertension remain limited. This study aimed to investigate the clinical characteristics and secular trends of different types (...) -- ORIGINAL ARTICLES
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07:00
Background: Orthostatic hypotension (OH), an impaired blood pressure (BP) response to postural change, has been associated with cognitive decline and dementia, possibly through cerebral small vessel disease (CSVD). We hypothesized that longer duration of BP drop and a larger BP drop is (...) -- ORIGINAL ARTICLES
13 août
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07:00
Objective: Compared with placebo, olmesartan has been linked to numerical imbalances in cardiovascular mortality. There is a paucity of contemporary real-world evidence on this agent for different study populations. This study investigated the clinical outcomes of olmesartan and other (...) -- ORIGINAL ARTICLES
9 août
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07:00
Background and aim: Essential arterial hypertension is a risk factor for stroke, myocardial infarction, heart failure, and arterial aneurysm, which are related to the activation of platelets. Purinergic signaling has a central role in platelet aggregation. Although ATP and ADP can act as a (...) -- ORIGINAL ARTICLES
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07:00
Background and objective: Antihypertensive drugs are one of the most effective strategies to prevent disability and mortality; however, there have been contradictory findings about the best dosing time for antihypertensive drugs. Therefore, we aim to evaluate the effect of bedtime versus (...) -- ORIGINAL ARTICLES
3 août
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07:00
Objectives: The relationships between stress hormones and oxidative DNA damage have not yet been explored in human hypertension. We investigated the associations of urinary levels of cortisol or catecholamines with those of 8-hydroxy-2?-deoxyguanosine, a marker of oxidative DNA damage in (...) -- ORIGINAL ARTICLES
2 août
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07:00
Blood pressure control and antihypertensive medication use after discharge and prognosis of ischemic stroke -
Shi, Mengyao; Liu, Yang; Wang, Shuyao; Wang, Ruirui; Yang, Pinni; Peng, Yanbo; Peng, Hao; Wang, Aili; Xu, Tan; Chen, Jing; Zhang, Yonghong; He, Jiang
J Hypertens
Objective: To investigate the effect of consistently blood pressure (BP) control status after discharge on adverse clinical outcomes among ischemic stroke (IS) patients. Methods: Three thousand, four hundred and six acute IS patients were included and followed up at 3 months, 12 months, and 24 (...) -- ORIGINAL ARTICLES
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07:00
Proximal aorta dilatation in hypertension -
Zuo, Xianghao; Liu, Lu; Liu, Kai; Zhang, Xin; Ye, Runyu; Yang, Changqiang; Ma, Jun; Jia, Shanshan; Yang, Xiangyu; Liu, Xueting; Sun, Lirong; Huo, Xingwei; Chen, Xiaoping
J Hypertens
Dilation of the proximal aorta is a common clinical manifestation in hypertensive patients. Although it is straightforward to link hypertension with proximal aortic dilation, previous studies on their interrelation have yielded controversial results. Cross-sectional design, methodology of (...) -- REVIEWS
27 juillet
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07:00
P2RX7 gene knockout or antagonism reduces angiotensin II-induced hypertension, vascular injury and immune cell activation -
Shokoples, Brandon G.; Berillo, Olga; Comeau, Kevin; Chen, Hao Yu; Higaki, Akinori; Caillon, Antoine; Ferreira, Nathanne S.; Engert, James C.; Thanassoulis, George; Paradis, Pierre; Schiffrin, Ernesto L.
J Hypertens
Objective: Extracellular ATP is elevated in hypertensive mice and humans and may trigger immune activation through the purinergic receptor P2X7 (P2RX7) causing interleukin-1? production and T-cell activation and memory T-cell development. Furthermore, P2RX7 single nucleotide polymorphisms (...) -- ORIGINAL ARTICLES
26 juillet
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07:00
99mTc-HFAPi imaging identifies early myocardial fibrosis in the hypertensive heart -
Xie, Boqia; Li, Lina; Lin, Mingming; Nanna, Michele; Su, Yao; Hua, Cuncun; Leng, Chenlei; Gan, Qianqian; Xi, Xiao-Ying; Wang, Yidan; Yao, Dandan; Wang, Li; Yu, Liping; Zhao, Lei; Zhang, Ye-ping; Dou, Kefei; Su, Pixiong; Lv, Xiuzhang; Jia, Bing; Yang, Min-Fu
J Hypertens
Background: This study aimed to explore whether 99mTc-radiolabeled fibroblast activation protein inhibitor (99mTc-HFAPi) imaging can detect early myocardial fibrosis in the hypertensive heart. Methods: In the experimental model, spontaneously hypertensive rats (SHRs) and age-matched Wistar (...) -- ORIGINAL ARTICLES
20 juillet
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07:00
The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation -
Mengozzi, Alessandro; de Ciuceis, Carolina; Dell’oro, Raffaella; Georgiopoulos, Georgios; Lazaridis, Antonios; Nosalski, Ryszard; Pavlidis, George; Tual-Chalot, Simon; Agabiti-Rosei, Claudia; Anyfanti, Panagiota; Camargo, Livia L.; D?browska, Edyta; Quarti-Trevano, Fosca; Hellmann, Marcin; Masi, Stefano; Mavraganis, Georgios; Montezano, Augusto C.; Rios, Francesco J.; Winklewski, Pawel J.; Wolf, Jacek; Costantino, Sarah; Gkaliagkousi, Eugenia; Grassi, Guido; Guzik, Tomasz J.; Ikonomidis, Ignatios; Narkiewicz, Krzysztof; Paneni, Francesco; Rizzoni, Damiano; Stamatelopoulos, Kimon; Stellos, (…)
J Hypertens
Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and (...) -- ESH PAPER
18 juillet
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07:00
Background: A growing body of evidence suggests that oxidative stress plays a role in the pathophysiology of hypertension. However, the involvement of the reactive oxygen species (ROS) in the commissural nucleus of the solitary tract (commNTS) in development the of hypertension remains (...) -- ORIGINAL ARTICLES
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07:00
Cost-effectiveness of screening for primary aldosteronism in hypertensive patients in Australia: a Markov modelling analysis -
Woode, Maame Esi; Wong, Kristina; Reid, Christopher M.; Stowasser, Michael; Russell, Grant; Gwini, StellaMay; Young, Morag J.; Fuller, Peter J.; Yang, Jun; Chen, Gang
J Hypertens
Background: Primary aldosteronism affects 3–14% of hypertensive patients in the primary care setting and up to 30% in the hypertensive referral units. Although primary aldosteronism screening is recommended in patients with treatment-resistant hypertension, diagnosis at an earlier stage of (...) -- ORIGINAL ARTICLES
17 juillet
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07:00
Background: Left ventricular (LV) global longitudinal strain (GLS) has been proposed as an early imaging biomarker of cardiac mechanical dysfunction. Objective: To assess the impact of angiotensin-converting enzyme (ACE) inhibitor treatment of hypertensive heart disease on LV GLS and (...) -- ORIGINAL ARTICLES
13 juillet
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07:00
Background: Homocysteine (Hcy) is an independent risk factor for cardiovascular diseases, and elevated plasma Hcy levels could aggravate vascular injury in hypertension. Hyperhomocysteinemia can change the methylation status of global DNA and specific genes. In the present study, we aim to (...) -- ORIGINAL ARTICLES
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07:00
Cardiovascular and health cost impacts of cuff blood pressure underestimation and overestimation of invasive aortic systolic blood pressure -
Fonseca, Ricardo; Palmer, Andrew J.; Picone, Dean S.; Cox, Ingrid A.; Schultz, Martin G.; Black, J. Andrew; Bos, Willem J.W.; Cheng, Hao-min; Chen, Chen-Huan; Cremer, Antoine; Dwyer, Nathan; Hughes, Alun D.; Lacy, Peter; Omboni, Stefano; Ott, Christian; Pereira, Telmo; Pucci, Giacomo; Schmieder, Roland; Wang, Ji-Guang; Weber, Thomas; Westerhof, Berend E.; Williams, Bryan; Sharman, James E.
J Hypertens
Objective: Hypertension management is directed by cuff blood pressure (BP), but this may be inaccurate, potentially influencing cardiovascular disease (CVD) events and health costs. This study aimed to determine the impact on CVD events and related costs of the differences between cuff and (...) -- ORIGINAL ARTICLES
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02:36
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02:36
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02:36
12 juillet
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07:00
Objective: To investigate the association between sex hormone-binding globulin (SHBG) levels, change in blood pressure and development of hypertension. Methods: In a community-based study, we examined 2816 middle-aged participants with focus on cardiometabolic risk factors in 2002–2005. A (...) -- ORIGINAL ARTICLES
6 juillet
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07:00
Objectives: We aimed to study vascular function in healthy men with a parental history of hypertension compared to those without. Acute effect of various dosages of sugar ingestion on vascular function was also investigated in both groups. Methods: Thirty-two healthy men were recruited and (...) -- ORIGINAL ARTICLES
5 juillet
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07:00
Objective: Endogenous ouabain (EO) increases in some patients with hypertension and in rats with volume-dependent hypertension. When ouabain binds to Na+K+-ATPase, cSrc is activated, which leads to multieffector signaling activation and high blood pressure (BP). In mesenteric resistance (...) -- ORIGINAL ARTICLES
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07:00
The optimal management of hypertension in individuals aged 80 years or older with frailty remains uncertain due to multiple gaps in evidence. Complex health issues, polypharmacy, and limited physiological reserve make responding to antihypertensive treatments unpredictable. Patients in this (...) -- REVIEWS
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07:00
Objective: Saline infusion test (SIT) requires 2 l of isotonic saline for intravenous infusion over 4 h to suppress plasma aldosterone concentration (PAC). To shorten the procedure time and minimize the volume load, we study the performance of SIT at 1, 2 and 4 h for diagnosing primary (...) -- ORIGINAL ARTICLES
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07:00
Background: Altered baroreflex function is well documented in hypertension; however, the female sex remains far less studied compared with males. We have previously demonstrated a left-sided dominance in the expression of aortic baroreflex function in male spontaneously hypertensive rats (...) -- ORIGINAL ARTICLES
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07:00
Objective: To compare adherence to antihypertensive treatment between patients prescribed a three-drug single-pill combination (SPC) of perindopril/amlodipine/indapamide (P/A/I) vs. the combination of an angiotensin-converting enzyme inhibitor (ACEI), a calcium-channel blocker (CCB), and a (...) -- ORIGINAL ARTICLES
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07:00
Introduction: Hypertensive disorders of pregnancy are associated with adverse feto-maternal outcomes. Existing evidence is mostly limited to observational studies, which are liable to confounding and bias. This study investigated the causal relevance of component hypertensive indices on (...) -- ORIGINAL ARTICLES
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07:00
Background: Contrary to North America and Europe, the prevalence of hypertension is rising in West Africa. Although diet is implicated as a contributor to this trend, nutritional guidelines in West Africa are not tailored to address this concern. This study aimed to address this limitation by (...) -- REVIEWS
26 juin
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07:00
Objective: The aim of this study was to explore whether antiphosphatidylserine (aPS) antibodies play roles in the early prediction of pregnancy-induced hypertension (PIH). Methods: The serum levels of different isotypes of aPS antibodies were compared in women diagnosed with PIH (PIH group, n (...) -- ORIGINAL ARTICLES
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