18 juin

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Advancing Access to Cell and Gene Therapies in Medicaid J Am Med Assoc (JAMA)
  This Viewpoint presents the components of the payment model and the implementation challenges among the Center for Medicare and Medicaid Innovation, state Medicaid agencies, patients, and manufacturers.
• 02:00
  FTC Oversight of the Pharmaceutical Industry J Am Med Assoc (JAMA)
  High drug prices in the US are a serious problem for both patients and the health care system. Prices of branded drugs are driven higher by monopoly dynamics: patents and other exclusive marketing rights allow companies to increase prices and restrict supply. Firms earn extraordinary profits (…)
• 02:00
  Krill Oil for Knee Osteoarthritis J Am Med Assoc (JAMA)
  This randomized clinical trial assesses the effect of krill oil supplementation vs placebo on knee pain improvement in patients with knee osteoarthritis, significant knee pain, and effusion-synovitis.
• 02:00
  A Good Prognosis J Am Med Assoc (JAMA)
  These are not the final few months of my life, not the last bowl of salad I add a few spoons of tuna and mayo to. I’m not going to die on a date printed in the calendar that hangs on my fridge with cheesy pictures of Yosemite and captions like Bike to Work Day. I can sit here at the kitchen (…)
• 02:00
  Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke—Reply J Am Med Assoc (JAMA)
  In Reply We thank Drs Sedghi and Siepmann for their comments. Indeed, all trials included in our individual participant meta-analysis enrolled only patients directly presenting at thrombectomy-capable stroke centers. Hence, the data presented in our study are applicable only to this exact (…)
• 02:00
  Chronic Chagas Disease in the US J Am Med Assoc (JAMA)
  This JAMA Insights provides recommendations for Chagas disease screening, diagnosis, and management in the US
• 02:00
  Dispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020-2023 J Am Med Assoc (JAMA)
  This study uses data from US retail pharmacies to assess national GLP-1RA dispensing to adolescents and young adults from 2020-2023.
• 02:00
  Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke J Am Med Assoc (JAMA)
  To the Editor A recent individual patient data meta-analysis of 6 randomized trials found that the beneficial effect of intravenous thrombolysis (IVT) before thrombectomy in patients with anterior-circulation large-vessel occlusion diminished with time from onset of stroke symptoms to (…)
• 02:00
  Social Isolation and Loneliness in Older Adults J Am Med Assoc (JAMA)
  This JAMA Patient Page discusses social isolation and loneliness as important public health concerns, especially among older adults.
• 02:00
  The Other Side of the Curtain J Am Med Assoc (JAMA)
  In this narrative medicine essay, a newly minted pediatric critical care physician learns firsthand what holistic medical care is from the love and attention she received during a hospitalization for mediastinal lymphoma.
• 02:00
  Heard but Excluded: A Language Manifesto J Am Med Assoc (JAMA)
  This Viewpoint discusses dismantling language barriers via multipronged approaches grounded in innovation, human-centered design, and systems thinking in 3 key areas.
• 02:00
  Phoenix Criteria for Pediatric Sepsis and Septic Shock J Am Med Assoc (JAMA)
  To the Editor We read Dr Sanchez-Pinto and colleagues’ study with interest, but we are concerned that the final Phoenix 4-organ model does not include acute kidney injury (AKI) assessment. Additionally, the Phoenix 8-organ model used only a single serum creatinine threshold. Despite inclusion of (…)
• 02:00
  Phoenix Criteria for Pediatric Sepsis and Septic Shock—Reply J Am Med Assoc (JAMA)
  In Reply We are grateful to Dr Thadani and colleagues for their interest in our work and applaud their efforts to improve outcomes from AKI around the world. We agree that AKI is important to assess and treat in children with sepsis in any environment and that children in some less-resourced (…)
• 02:00
  Shingles Vaccination in Medicare Part D After Inflation Reduction Act Elimination of Cost Sharing J Am Med Assoc (JAMA)
  This cross-sectional study uses data from retail pharmacies to examine shingles vaccine uptake among Medicare Part D beneficiaries following an IRA policy to eliminate cost sharing.
• 02:00
  How AI Will Augment Radiologists J Am Med Assoc (JAMA)
  This Medical News article is an interview with Saurabh Jha, a cardiothoracic radiologist and an associate professor of radiology at the University of Pennsylvania, and JAMA Editor in Chief Kirsten Bibbins-Domingo.
• 02:00
  Public Health Preparedness and Response to Avian Influenza A(H5N1) Viruses J Am Med Assoc (JAMA)
  US public health preparedness and response to highly pathogenic avian influenza A(H5N1) viruses are assessed in this survey study conducted by the CDC.
• 02:00
  Congress, the Doctor J Am Med Assoc (JAMA)
  Without a dissenting vote, the House of Delegates of the American Medical Association adopted last week a resolution calling on the Board of Trustees to use its best endeavors to have repealed such sections of the national prohibition acts as may interfere with the proper relation between the (…)
• 02:00
  Monoclonal Antibody Protected Majority of Children From Malaria J Am Med Assoc (JAMA)
  Current strategies to protect children from malaria—administration of new RTS,S/AS01 or R21/Matrix-M vaccines as well as seasonal medications—require about 20 health care visits by the time a child reaches age 5 years. However, an approach involving the annual administration of a monoclonal (…)
• 02:00
  HHS Commits Millions to Improving Maternal, Infant Health J Am Med Assoc (JAMA)
  The proportion of people who die while pregnant or within 42 days after their pregnancy ends has been steadily increasing in the US. Now, updated numbers from the National Vital Statistics System indicate promising trends in maternal mortality rates. About 22 people per 100 000 live births died (…)
• 02:00
  Lower Dose of Mpox Vaccine Was Safe, Effective J Am Med Assoc (JAMA)
  Intradermal injections that were one-fifth of the standard mpox vaccine dose generated antibody responses equivalent to those of subcutaneous injections of the standard dose at 6 weeks, based on results from 225 US adults aged 18 to 50 years. No participants experienced serious adverse events (…)
• 02:00
  New Drug for UTIs Gets the Greenlight J Am Med Assoc (JAMA)
  The US Food and Drug Administration recently approved pivmecillinam, sold as Pivya, for uncomplicated urinary tract infections (UTIs) in females aged 18 years or older with no structural abnormalities of their urinary tract. UTIs affect about 50% of females at some point during their life, the (…)
• 02:00
  Progress in Heart Failure Deaths Reversed Over Past Decade J Am Med Assoc (JAMA)
  Although heart failure mortality rates fell between 1999 and 2012, the proportion of people dying from the condition in the US has increased in recent years, according to a study published in JAMA Cardiology. By 2021, the heart failure mortality rate was higher than in 1999, signaling that (…)
• 02:00
  Federal Trade Commission Bans Noncompete Clauses J Am Med Assoc (JAMA)
  Up to 45% of physicians are subject to noncompete clauses, contractual requirements that can prevent them from changing jobs, which can limit competition and access to care, according to the American Medical Association. However, employers will no longer be allowed to enforce noncompete clauses (…)
• 02:00
  Blood Pressure Drugs Linked to More Fractures, Falls in VA Nursing Homes J Am Med Assoc (JAMA)
  Long-term Veterans Health Administration (VA) nursing home residents who started new medications to treat high blood pressure were more than twice as likely to experience a fracture than those who did not, according to a cohort study involving more than 29 600 VA participants, almost all male, (…)
• 02:00
  Monoclonal Antibody Authorized to Protect At-Risk People From COVID-19 J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) granted emergency use authorization to pemivibart, marketed as Pemgarda, to protect people who are immunocompromised from COVID-19. Pemivibart is the only long-acting monoclonal antibody available in the US for preexposure prophylaxis after the FDA (…)
• 02:00
  Microneedle Vaccine Patches Generated Immune Response in Children J Am Med Assoc (JAMA)
  People who received a microneedle patch that delivered a measles and rubella vaccine mounted immune responses that were equivalent to those vaccinated via subcutaneous injection, according to data from a randomized clinical trial involving 285 participants from The Gambia, including 240 toddlers (…)
• 02:00
  Maintenance of Certification’s Value to Patients and Physicians—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the Letter by Drs Stern and Hafferty about our recent Viewpoint, which gave priority to highlighting the large and growing body of evidence that patients of physicians who demonstrate more medical knowledge have better prognoses on a host of important outcomes. In doing (…)
• 02:00
  Federal Trade Commission Actions on Prescription Drugs, 2000-2022 J Am Med Assoc (JAMA)
  This Special Communication examines the Federal Trade Commission’s policy and legal actions related to alleged misconduct, consolidation, and anticompetitive behavior in the pharmaceutical market between 2000 and 2022.
• 02:00
  Blood Testing for Phosphatidylethanol J Am Med Assoc (JAMA)
  A 36-year-old man with obesity and dyslipidemia presented with elevated liver enzymes following a liver transplant to treat acute-on-chronic liver failure due to alcohol-associated hepatitis. What would you do next?
• 02:00
  Risks of Harm in Alzheimer Disease by Amyloid Lowering J Am Med Assoc (JAMA)
  This Viewpoint discusses how data gaps in published research impede clinicians’ ability to clearly discuss the risks and benefits of amyloid-lowering drugs for treating Alzheimer disease.
• 02:00
  Harnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing J Am Med Assoc (JAMA)
  Approximately half of hospitalized adults in the US receive antibiotics, with pneumonia and urinary tract infection (UTI) being the 2 most frequent indications. Estimates suggest about 30% of all antibiotics prescribed in US hospitals are either unnecessary or suboptimal, and extended-spectrum (…)
• 02:00
  Stewardship Prompts to Improve Antibiotic Selection for Pneumonia J Am Med Assoc (JAMA)
  This clinical trial examines the effect of an antibiotic stewardship bundle (education, feedback, and real-time multidrug-resistant organism risk-based CPOE prompts) vs routine stewardship on antibiotic selection during the first 3 hospital days in adults with pneumonia.
• 02:00
  Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection J Am Med Assoc (JAMA)
  This clinical trial evaluates whether computerized provider order entry prompts providing patient- and pathogen-specific multidrug-resistant organism risk estimates could reduce use of empiric extended-spectrum antibiotics for treatment of urinary tract infections.
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Maintenance of Certification’s Value to Patients and Physicians J Am Med Assoc (JAMA)
  To The Editor The American Board of Internal Medicine (ABIM) has an outsized influence as the arbiter of internal medicine physician quality, given the alternatives of minimal state regulations, spotty insurance-based estimates, and random patient-based ratings. A recent Viewpoint responded to (…)

11 juin

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Toward More Equitable Breast Cancer Outcomes J Am Med Assoc (JAMA)
  In its revised Recommendation Statement, the US Preventive Services Task Force (USPSTF) now recommends that all women undergo routine breast cancer screening every other year beginning at age 40 years. This is an adjustment from the 2016 recommendation for all women to start at age 50 and for (…)
• 02:00
  USPSTF Report: Collaborative Modeling to Compare Breast Cancer Screening Strategies J Am Med Assoc (JAMA)
  This modeling study uses Cancer Intervention and Surveillance Modeling Network models and national data on breast cancer incidence, mammography performance, treatment effects, and other-cause mortality in US women without previous cancer diagnoses to estimate outcomes of various mammography (…)
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke J Am Med Assoc (JAMA)
  To the Editor A recent clinical trial demonstrated that apixaban did not significantly reduce recurrent stroke risk compared with aspirin in patients with cryptogenic stroke and evidence of atrial cardiopathy without atrial fibrillation. However, we had some concerns about this study. First, it (…)
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke J Am Med Assoc (JAMA)
  To the Editor The recent Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial did not demonstrate superiority of apixaban over aspirin for secondary prevention in patients with cryptogenic stroke and atrial cardiopathy. In this study, atrial (…)
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke—Reply J Am Med Assoc (JAMA)
  In Reply In response to our recent article, Dr Chi and colleagues raise an important point regarding uncertainty about optimal biomarkers of atrial cardiopathy. Compared with ARCADIA patients who qualified for enrollment in our study only by the NT-proBNP criterion, those who qualified by only (…)
• 02:00
  Poetry and the Meaning of Care J Am Med Assoc (JAMA)
  Health care is becoming more and more distanced. Clinicians must overcome not just mountains of data, burdensome electronic health records, and ever-increasing numbers of machines that separate us from patients, but more recently also navigate telemedicine and AI-driven chatbots. (…)
• 02:00
  Can Cardiovascular Risk Assessment Be Improved in the 21st Century? J Am Med Assoc (JAMA)
  Cardiovascular risk assessment has become an essential part of preventive strategies designed to target risk factor interventions and has contributed to dramatic reductions in cardiovascular disease mortality during the past 60 years in the US and other countries. Beginning in the 1960s, (…)
• 02:00
  Autoantibody Profile Emerged Years Before Multiple Sclerosis Diagnosis J Am Med Assoc (JAMA)
  About 10% of people with multiple sclerosis (MS) had an autoantibody signature that was present at least 5 years before symptoms, according to an analysis of blood samples from 500 military service members. Researchers collected the first sample an average of 5 years before some participants (…)
• 02:00
  Patients Treated by Female Physicians Had Better Mortality Rates J Am Med Assoc (JAMA)
  Hospitalized patients in the US tended to have a lower chance of dying or being readmitted within 30 days when they were treated by female physicians rather than male clinicians, a recent study published in Annals of Internal Medicine found. The difference in outcomes for patients examined by (…)
• 02:00
  The Challenge of the Computer J Am Med Assoc (JAMA)
  The average physician is unlikely to build a computer in his basement from a kit. But the principles of computer analysis are not difficult to master. Evidence of the growing importance of these complex electronic machines is found in the announcement that the potential of the computer in (…)
• 02:00
  AI-Generated Clinical Summaries J Am Med Assoc (JAMA)
  To the Editor In their recent Viewpoint, Dr Goodman and colleagues examined artificial intelligence (AI)–generated clinical summaries and identified concerns regarding variability, bias, and single-word errors in their AI summaries generated through the ChatGPT model. However, it must be noted (…)
• 02:00
  AI-Generated Clinical Summaries—Reply J Am Med Assoc (JAMA)
  In Reply We thank Ms Chen and Dr Thornton for their interest in our Viewpoint examining potential benefits and challenges of AI-generated clinical summaries. We fully agree that future studies should evaluate how AI summaries influence physician decision-making and clinical outcomes. We (…)
• 02:00
  Antipsychotics for Dementia Tied to More Serious Harms Than Expected J Am Med Assoc (JAMA)
  Prior research has suggested that antipsychotic drugs might be overprescribed for people with dementia, despite known risks of stroke and sudden cardiac death. Now, findings from a new study in The BMJ indicate that the range of serious adverse outcomes associated with antipsychotics in these (…)
• 02:00
  WHO Updates Terminology for Pathogens That Spread Through the Air J Am Med Assoc (JAMA)
  A multiyear global collaboration among public health agencies has led to new terminology for pathogens such as SARS-CoV-2 that can spread through the air, the World Health Organization (WHO) announced. The report by the WHO and partners, including the US Centers for Disease Control and (…)
• 02:00
  Pregnancy Complications Tied to Higher Risk of Death Decades Later J Am Med Assoc (JAMA)
  Pregnant people who experienced adverse pregnancy outcomes had up to a 50% increased risk of dying from any cause up to 46 years after giving birth, according to data from a cohort study involving about 2.2 million participants from Sweden who gave birth between 1973 and 2015. Cardiovascular and (…)
• 02:00
  New HHS Rule Strengthens Privacy Around US Reproductive Care J Am Med Assoc (JAMA)
  The US Department of Health and Human Services (HHS) recently announced a final rule that increases privacy protections for people seeking legal reproductive care, such as an abortion, either in their home state or by traveling to another one. The modification to the Health Insurance Portability (…)
• 02:00
  Changes to Medicare, Medicaid Coverage Could Cause Thousands of Deaths J Am Med Assoc (JAMA)
  Some policymakers have suggested increasing the eligibility age for Medicare and implementing work requirements for Medicaid coverage to reduce US health care costs. However, a recent analysis involving data projections from the Census Bureau suggests that the proposed changes would cost (…)
• 02:00
  CMS Finalizes Staffing Minimum Requirements for Nursing Homes J Am Med Assoc (JAMA)
  The US Centers for Medicare & Medicaid Services (CMS) recently finalized a rule establishing the first minimum staffing requirements for nursing homes after an earlier version was proposed last September. The new rule will “hold nursing homes accountable for providing safe and (…)
• 02:00
  Late-Stage Cancer End Points to Speed Cancer Screening Clinical Trials—Not So Fast J Am Med Assoc (JAMA)
  In this issue of JAMA, Feng et al studied whether late-stage cancer (ie, stage III or stage IV cancer), rather than cancer-specific mortality, was an acceptable alternative end point in clinical trials of cancer screening. The authors analyzed 41 clinical trials conducted in Europe, North (…)
• 02:00
  USPSTF Recommendation: Screening for Breast Cancer J Am Med Assoc (JAMA)
  This 2024 Recommendation Statement from the US Preventive Services Task Force recommends biennial screening mammography for women aged 40 to 74 years (B recommendation) and concludes that evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 (…)
• 02:00
  Screening for Breast Cancer J Am Med Assoc (JAMA)
  In this JAMA Patient Page, the US Preventive Services Task Force provides a guide to screening for breast cancer.
• 02:00
  USPSTF Review: Screening for Breast Cancer J Am Med Assoc (JAMA)
  This systematic review to support a 2024 US Preventive Services Task Force Recommendation Statement summarizes published evidence on the benefits and harms of screening for breast cancer in adult females.
• 02:00
  The State of State Biomarker Testing Insurance Coverage Laws J Am Med Assoc (JAMA)
  This Viewpoint discusses laws mandating insurance coverage of biomarker testing to broaden access to care for patients with cancer.
• 02:00
  When Is It Best to Begin Mammograms, and How Often? J Am Med Assoc (JAMA)
  This Medical News story discusses new USPSTF recommendations about the timing of screening mammograms.
• 02:00
  Prognostic Value of Cardiovascular Biomarkers in the Population J Am Med Assoc (JAMA)
  This study evaluates the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors in the identification of individuals at high risk for atherosclerotic cardiovascular disease.
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke J Am Med Assoc (JAMA)
  To the Editor We have several concerns about the recent trial that examined apixaban for prevention of recurrence after cryptogenic stroke in patients with atrial cardiopathy.
• 02:00
  Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024 J Am Med Assoc (JAMA)
  This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023.
• 02:00
  Even Joy J Am Med Assoc (JAMA)
  Since her birth with half a brain The doctors have been kind, So awed by her determination they loan a private Room for the transient child to be and Show the worth of being Even if
• 02:00
  Fosamax Fractures J Am Med Assoc (JAMA)
  This Viewpoint discusses the ongoing lawsuit between plaintiffs who had been affected by atypical femoral fractures while receiving alendronate and the drug manufacturer.
• 02:00
  Cancer Stage Compared With Mortality as End Points in Randomized Clinical Trials of Cancer Screening J Am Med Assoc (JAMA)
  This meta-analysis of 41 randomized clinical trials of cancer screening compares cancer-specific mortality with stage III-IV cancer as end points.
• 02:00
  I Kept Crying J Am Med Assoc (JAMA)
  In this narrative medicine essay, a second-year pediatric resident bears the scars from the terror that descended the moment of her son’s birth at 31 weeks’ gestation, terror relived even after he has come home healthy.
• 02:00
  Combined COVID-19 and Flu Vaccines Could Be Available Next Year J Am Med Assoc (JAMA)
  This Medical News story discusses the development of experimental combination vaccines for adults.
• 02:00
  “Inoculation” to Resist Misinformation J Am Med Assoc (JAMA)
  This JAMA Insights in the Communicating Medicine series explores the concept of “prebunking,” a psychological inoculation technique that could help prevent the spread of misinformation.
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Urine-Based Test Could Help Identify Aggressive Prostate Cancer J Am Med Assoc (JAMA)
  A urine-based test involving 18 genes was more accurate at diagnosing high-grade prostate cancer than existing biomarker tests such as blood levels of prostate-specific antigen (PSA), according to a recent study published in JAMA Oncology.

4 juin

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Non–HDL-C Levels From Childhood to Adulthood and CVD Events J Am Med Assoc (JAMA)
  This study of individual participant data from 6 pooled cohorts assesses whether resolution of elevated childhood non–high-density lipoprotein cholesterol (non–HDL-C) by adulthood is associated with reduced risk of clinical cardiovascular disease (CVD) events.
• 02:00
  Assessing the Real-World Effectiveness of Immunizations for Respiratory Syncytial Virus J Am Med Assoc (JAMA)
  This Viewpoint discusses recommendations from the US Centers for Disease Control and Prevention for newly licensed immunizations for respiratory syncytial virus in infants, children with high-risk conditions, and older adults.
• 02:00
  A Review of Thyroid Cancer—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate letters about our Review on thyroid cancer. In response to the comments by Drs Beheshtirouy and Shayanfar, the causal association between GLP-1 RA use and thyroid cancer is complex and requires careful consideration of factors that directly or indirectly influence (...)
• 02:00
  A Review of Thyroid Cancer J Am Med Assoc (JAMA)
  To the Editor A recent Review discussed the complexity of thyroid cancer. First, we would like to highlight the importance of distinguishing between benign and malignant thyroid nodules preoperatively.
• 02:00
  A Review of Thyroid Cancer J Am Med Assoc (JAMA)
  To the Editor A recent Review discussed exposure to ionizing radiation as a common risk factor for thyroid cancer. However, it is important to consider additional risk factors for thyroid cancer.
• 02:00
  Substances in Counterfeit Prescription Pills Seized by Law Enforcement, 2017-2022 J Am Med Assoc (JAMA)
  This study examines substances identified during testing of counterfeit prescription pills seized by law enforcement in Rhode Island from 2017 to 2022.
• 02:00
  Thomas, Unsainted J Am Med Assoc (JAMA)
  Again left fingers enter the chest
• 02:00
  Safeguarding Research Using Federal Health Insurance Data J Am Med Assoc (JAMA)
  This Viewpoint discusses the importance of researcher access to federal health care data following a CMS decision to limit the use of physical data and proposes solutions to maintain access and security.
• 02:00
  Fritz Kahn and the Centenary of the Doctor of the Future J Am Med Assoc (JAMA)
  This JAMA Arts and Medicine feature describes ways in which Fritz Kahn shared a prescient and nuanced vision of technology’s role in the patient-physician interaction, a topic of continued interest and relevance today, through his illustrations.
• 02:00
  Denosumab-Associated Severe Hypocalcemia in Dialysis-Dependent Patients—Reply J Am Med Assoc (JAMA)
  In Reply We thank Drs Schoenmakers and Fraser for their comments on our study. We reported the US experience with denosumab administration among dialysis-dependent patients, finding the weighted cumulative incidence of severe hypocalcemia (ie, <7.5 mg/dL or emergent care) at 12 weeks to (...)
• 02:00
  Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults J Am Med Assoc (JAMA)
  This cross-sectional study assesses the prevalence and temporal evolution of cardiovascular-kidney-metabolic syndrome stages.
• 02:00
  Denosumab-Associated Severe Hypocalcemia in Dialysis-Dependent Patients J Am Med Assoc (JAMA)
  To the Editor We have some concerns about the recent retrospective public health surveillance study of older female dialysis-dependent patients who were treated with denosumab for osteoporosis.
• 02:00
  Best Versions of Ourselves J Am Med Assoc (JAMA)
  In this narrative medicine essay, a lecturer in narrative medicine strives to accept her best self by surmounting the barriers of itchy skin and unsightly red patches caused by chronic atopic dermatitis.
• 02:00
  A 3-Year-Old With Gingival Hemorrhage and Musculoskeletal Pain J Am Med Assoc (JAMA)
  A 3-year-old had spontaneous gingival hemorrhage and bilateral limb weakness with inability to bear weight. He had no preceding oral trauma or recent infection, took no regular medications, and had no recent use of aspirin or nonsteroidal anti-inflammatory drugs; his diet was limited to (...)
• 02:00
  Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive ALL J Am Med Assoc (JAMA)
  This randomized trial assesses the effect of ponatinib vs imatinib combined with low-intensity chemotherapy on disease remission in adults with newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL).
• 02:00
  The “Day of Rest” and Human Efficiency J Am Med Assoc (JAMA)
  The refreshing influence of the weekly recurring “day of rest” on a person subjected to the strenuous routine of a busy life is a feature which he himself can duly appreciate in terms of his “feelings” and “spirits.” If it is desired to demonstrate the need of such relaxation and the benefits (...)
• 02:00
  PhALLCON Soars to New Heights—Faster, Stronger, but Better? J Am Med Assoc (JAMA)
  In this issue of JAMA, Jabbour and colleagues report results from the interim analysis of the PhALLCON randomized trial with ponatinib vs imatinib, combined with reduced-intensity chemotherapy. They found ponatinib to have superior efficacy and a comparable safety profile for frontline (...)
• 02:00
  Service Animals in Health Care Settings J Am Med Assoc (JAMA)
  This JAMA Insights article reviews Americans with Disabilities Act (ADA) rules for patients, visitors, and other members of the public bringing service animals into health care settings.
• 02:00
  Why the Bird Flu Outbreak in Dairy Cows Matters J Am Med Assoc (JAMA)
  This Medical News article discusses the current H5N1 avian influenza outbreak in US dairy cattle and its implications for occupational and public health.
• 02:00
  Patient Information: Poison Ivy, Poison Oak, and Poison Sumac J Am Med Assoc (JAMA)
  This JAMA Patient Page describes allergic skin reactions from contact with poison ivy, poison oak, and poison sumac plants, and how to treat rashes caused by these plants.
• 02:00
  Causal Inference and Effects of Interventions From Observational Studies in Medical Journals J Am Med Assoc (JAMA)
  This Special Communication examines drawing causal inferences about the effects of interventions from observational studies in medical journals.
• 02:00
  College Athlete Deaths by Suicide Have Doubled J Am Med Assoc (JAMA)
  This Medical News story discusses an analysis of deaths by suicide among NCAA athletes over the past 20 years.
• 02:00
  Meaning of Proposed Causal Inference Framework for the JAMA Network J Am Med Assoc (JAMA)
  The Special Communication “Causal Inferences About the Effects of Interventions From Observational Studies in Medical Journals,” published in this issue of JAMA, provides a rationale and framework for considering causal inference from observational studies published by medical journals. Our (...)
• 02:00
  Imaging Approach Tracked Subtle Changes Linked With Mild Brain Injury J Am Med Assoc (JAMA)
  Currently, there are few reliable tools for diagnosing mild traumatic brain injuries or predicting their likely course, which can include poor neuropsychiatric outcomes. But results published in JAMA Network Open show that an advanced form of magnetic resonance imaging picked up changes in the (...)
• 02:00
  Exercise Might Lower Heart Disease Risk in Part By Decreasing Stress in the Brain J Am Med Assoc (JAMA)
  Physical activity might reduce the risk of cardiovascular disease partly by decreasing activity in parts of the brain related to stress, a study in the Journal of the American College of Cardiology suggests. Researchers looked at data from more than 50 300 adults in Massachusetts who completed (...)
• 02:00
  Study: Stigma in Medical Records Tied to Diagnostic Errors J Am Med Assoc (JAMA)
  Patients who were affected by diagnostic errors were more likely to have stigmatizing language in their medical records, according to a new analysis in JAMA Internal Medicine. The cohort study involved more than 2300 hospital admissions during which patients died or were transferred to the (...)
• 02:00
  Permanent Procedures to Prevent Pregnancy in US Jumped After Dobbs J Am Med Assoc (JAMA)
  The number of young people who sought permanent contraception—such as tubal ligations or vasectomies—rose immediately after the US Supreme Court’s decision in Dobbs v Jackson Women’s Health Organization, researchers reported in JAMA Health Forum. The data came from US patients aged 18 to 30 years.
• 02:00
  Deprescribing Program Tied to Reductions in PPI Use in US J Am Med Assoc (JAMA)
  Previous studies have suggested that many people who use proton pump inhibitors (PPIs) might not have a clinical indication for doing so, which is concerning because PPIs have been associated with chronic kidney disease and infection in some observational studies. Now, recent results published (...)
• 02:00
  Five-in-One Meningitis Vaccine Rolls Out J Am Med Assoc (JAMA)
  Nigeria will be the first country in the world to vaccinate residents aged 1 through 29 years with Men5CV, a novel 1-dose vaccine that protects people from 5 major strains of the meningococcus bacteria (Neisseria meningitidis), the World Health Organization (WHO) announced. The news comes amid (...)
• 02:00
  Two-Thirds of Unhoused People Have Mental Health Disorders J Am Med Assoc (JAMA)
  The majority of people who are currently unhoused—67%—have mental health disorders, according to a systematic review and meta-analysis of 85 studies mainly from Canada, Germany, and the US involving more than 48 400 participants. The lifetime prevalence of mental health disorders among people (...)
• 02:00
  Clinicians Underprescribe Newer Antibiotics for Drug-Resistant Disease J Am Med Assoc (JAMA)
  About 42% of patients with infections caused by pathogens that were resistant to all first-line antibiotics received only older antibiotics rather than newer ones more recently approved by the US Food and Drug Administration, a new study found. The results were based on data from 619 US (...)
• 02:00
  National Academies Report: COVID-19 Vaccines Don’t Cause Many Potential Harms J Am Med Assoc (JAMA)
  The COVID-19 vaccines made by Pfizer-BioNTech and Moderna do not cause such conditions as female infertility, myocardial infarction, Bell palsy, or Guillain-Barré syndrome in adults, according to a report by the National Academies of Sciences, Engineering, and Medicine that reviewed evidence (...)
• 02:00
  Heart Failure in African American Individuals, Version 2.0 J Am Med Assoc (JAMA)
  An antecedent body of work established nearly 20 years ago benchmarked the nuanced distinctions of heart failure affecting African American people. Summative statements established a nearly 2-fold higher incidence, earlier onset, greater severity at the time of diagnosis, a more likely (...)
• 02:00
  Cardiovascular Burden of V142I Transthyretin Variant J Am Med Assoc (JAMA)
  This study used data on Black participants in 4 large observational studies to better define the natural history of disease in V142I variant carriers across mid to late life, assess variant modifiers, and estimate cardiovascular burden to the US population.
• 02:00
  Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger J Am Med Assoc (JAMA)
  There has been a transformational change in understanding heart failure due to transthyretin cardiac amyloidosis (ATTR-CA). Previously considered a rare condition, the widespread adaptation of nuclear imaging to establish the diagnosis has led to the recognition that ATTR-CA is commonly (...)
• 02:00
  Error in the Exclusion of Participants From Analysis in the ACTIV-6 Platform Randomized Clinical Trial J Am Med Assoc (JAMA)
  To the Editor On behalf of my coauthors, I write to explain errors that we identified in the Original Investigation “Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial,” published online on February 20, (...)
• 02:00
  Errors in Results From Erroneous Exclusion of Participants in Analysis J Am Med Assoc (JAMA)
  The Original Investigation titled “Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial,” published in the March 21, 2023, issue of JAMA, was corrected to fix an error in which 226 participants were (...)
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)

28 mai

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Urgent Need for Regulatory Oversight of Human Cellular/Tissue–Based Products J Am Med Assoc (JAMA)
  This Viewpoint discusses the death of a patient caused by unregulated biological products and efforts to encourage federal government oversight of such products.
• 02:00
  My Digital Refuge J Am Med Assoc (JAMA)
  In this narrative medicine essay, a medical ethicist discusses the complexity of juggling the interests of members in online forums dedicated to rare diseases after being blocked upon disclosing her affiliation with a medical school, thus barring her from the support and information she needed (...)
• 02:00
  Varenicline or Nicotine Replacement After Initial Treatment Failure J Am Med Assoc (JAMA)
  This sequential, multiple assignment randomized trial compares treatment strategies and dosages after abstinence from smoking was not achieved after 6 weeks of first-line therapies.
• 02:00
  Patient Information: Strep Throat J Am Med Assoc (JAMA)
  This JAMA Patient Page describes strep throat, its signs and symptoms, diagnosis, treatment, and potential complications.
• 02:00
  Recurrent Gout and Serum Urate—Reply J Am Med Assoc (JAMA)
  In Reply Our recent article quantified the role of serum urate, the central causal biomarker for gout, and found graded associations with recurrent gout flares, including those resulting in hospitalizations (with 100% of these cases associated with serum urate ?5 mg/dL). Regarding the comments (...)
• 02:00
  Aspirin vs Placebo as Adjuvant Therapy for Breast Cancer J Am Med Assoc (JAMA)
  This study examines the potential benefits of aspirin as adjuvant therapy for survivors of early breast cancer.
• 02:00
  At-Home Diagnostics Solutions for Chlamydia and Gonorrhea J Am Med Assoc (JAMA)
  This Viewpoint discusses the US Food and Drug Administration’s authorization of marketing an at-home testing system for chlamydia and gonorrhea as a good first step in boosting access to screening and treatment and in reducing infection rates.
• 02:00
  Outcomes Following Localized Prostate Cancer Treatment J Am Med Assoc (JAMA)
  To the Editor In a recent article that compared adverse outcomes of localized prostate cancer treatment modalities, persistent urinary incontinence after radical prostatectomy was highlighted as a significant difference compared with other therapeutic options. However, the authors overlooked (...)
• 02:00
  Outcomes Following Localized Prostate Cancer Treatment—Reply J Am Med Assoc (JAMA)
  In Reply In response to our recent article, Drs Huang and Ding question the validity of using questionnaires to assess sexual function. While a patient’s responses are subjective (ie, indicating how their function seems to them rather than it being measured more objectively), the use of (...)
• 02:00
  Global Production of Active Pharmaceutical Ingredients for US Generic Drugs Experiencing Shortages J Am Med Assoc (JAMA)
  This study evaluates the characteristics of generic active pharmaceutical ingredients (APIs) used to manufacture drugs with shortages in the US and facilities producing APIs worldwide.
• 02:00
  Outcomes Following Localized Prostate Cancer Treatment J Am Med Assoc (JAMA)
  To the Editor A recent study reported approximately 10-year follow-up data on functional outcomes of patients after treatment for localized prostate cancer, providing essential evidence-based medical evidence for clinical decision-making. We have 2 concerns regarding the data analyses on (...)
• 02:00
  The FDA and Gene Therapy for Duchenne Muscular Dystrophy J Am Med Assoc (JAMA)
  This Viewpoint examines the appropriateness of FDA accelerated approval of novel gene therapies to treat boys with Duchenne muscular dystrophy following clinical trials with surrogate outcomes that did not demonstrate net benefits.
• 02:00
  Aspirin Use and Management of Breast Cancer J Am Med Assoc (JAMA)
  The Alliance trial led by Chen and colleagues and published in this issue of JAMA addresses an important topic in the management of breast cancer: can daily use of 300 mg of aspirin improve invasive disease–free survival among persons with a diagnosis of nonmetastatic, high-risk breast cancer? (...)
• 02:00
  Illness, Isolation, and the Poetry of Illumination J Am Med Assoc (JAMA)
  Commentators on the illness experience, from Broyard to Woolfe, confirm what clinicians frequently observe in patients—to be sick is to feel alone. Whether on a physician’s orders (the tuberculosis sanitorium or COVID-19 social distancing), or due to the lassitude caused by symptoms (...)
• 02:00
  The Women’s Health Initiative Randomized Trials and Clinical Practice J Am Med Assoc (JAMA)
  This review of the Women’s Health Initiative (WHI) summarizes the results of the 4 WHI clinical trials on menopausal hormone therapy, calcium plus vitamin D supplementation, and low-fat diet and their applications to current clinical practice.
• 02:00
  Climate Change and Mental Health J Am Med Assoc (JAMA)
  This JAMA Insights discusses the adverse effects of climate change on mental health and proposes solutions to help mitigate those effects.
• 02:00
  Race and Ethnicity of Reproductive-Age Females Affected by US Abortion Bans J Am Med Assoc (JAMA)
  This study compares the race and ethnicity of reproductive-age females between states that implemented restrictive abortion policies after the Dobbs v Jackson Women’s Health Organization decision and states that did not.
• 02:00
  After the Diagnosis, You Find a Moth J Am Med Assoc (JAMA)
  You have found another one, this time landing on the floor of the living room,
• 02:00
  Incorrect Degree J Am Med Assoc (JAMA)
  In a Letter to the Editor titled “Pharmacotherapy for Alcohol Use Disorder,” published in the March 5, 2024, issue of JAMA, Wenming Shi’s degree was incorrectly listed; it should have been “MSc.” This article was corrected online.
• 02:00
  Table Data Errors J Am Med Assoc (JAMA)
  In the Original Investigation titled “Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial,” published in the April 9, 2024, issue of JAMA, several data errors occurred. The correct risk ratio for the secondary outcome of (...)
• 02:00
  Recurrent Gout and Serum Urate J Am Med Assoc (JAMA)
  To the Editor A recent Review supported use of baseline serum urate level to assess the risk of recurrent gout. A concern raised by the accompanying Editorial pertained to the reliability of a single serum urate measurement.
• 02:00
  Acronymity J Am Med Assoc (JAMA)
  The endemic disease that I call acronymia continues to spread exponentially. New governmental agencies sprout at an alarming rate, and for a long time only their minions know the meaning of the alphabetical nomenclature with which they live. Equally prolific are the trains of capital letters (...)
• 02:00
  Recurrent Gout and Serum Urate J Am Med Assoc (JAMA)
  To the Editor A recent study found that serum urate levels were associated with the risk of subsequent gout flares and hospitalizations for recurrent gout. However, urate-lowering therapy did not significantly alter the association between serum urate levels and the risk of acute gout flares. (...)
• 02:00
  How AI Could Transform Global Mental Health Care J Am Med Assoc (JAMA)
  This Medical News article is an interview with psychiatrist Vikram Patel, chair of the Department of Global Health and Social Medicine at Harvard Medical School.
• 02:00
  “Super Gonorrhea” Has Arrived J Am Med Assoc (JAMA)
  This Medical News article discusses approaches to slow the spread of antimicrobial resistance in Neisseria gonorrhoeae.
• 02:00
  Therapeutic Psilocybin's Adverse Effects Mostly Resolved Within 2 Days J Am Med Assoc (JAMA)
  People who received high or moderate doses of psilocybin for anxiety or depression treatment seemed to manage adverse effects of the drug well, with most issues improving within 1 to 2 days, a recent meta-analysis of 6 studies involving more than 500 participants found. The findings, published (...)
• 02:00
  Young Patients Without Genetic Risk Have Low Chance of Second Breast Cancer J Am Med Assoc (JAMA)
  Previous research has suggested that young people with breast cancer had 2 to 3 times the risk of being diagnosed with secondary breast cancer. But a new study in JAMA Oncology suggests that may not be true for those who do not have a genetic change linked with higher risk of the disease, such (...)
• 02:00
  Swapping Salt for a Substitute May Lower Deaths, Reduce Heart Problems J Am Med Assoc (JAMA)
  Using a salt substitute instead of table salt might lower all-cause and cardiovascular mortality, according to a meta-analysis in Annals of Internal Medicine. The data were based on 16 randomized clinical trials involving more than 35 000 participants, most of whom were from China or Taiwan.
• 02:00
  Encouraging Exercise Through Games, Money Built Long-Term Habits J Am Med Assoc (JAMA)
  People who received financial incentives or gained points for meeting their step goals increased their average daily steps by more than 1500—the equivalent of about three-quarters of a mile—from baseline after 1 year, a recent study published in Circulation found. The randomized clinical trial (...)
• 02:00
  Meta-Analysis: Touch Tied to Improved Mental, Physical Health J Am Med Assoc (JAMA)
  People who received touch interventions, such as massage or gentle stroking for adults and skin-to-skin contact for infants, experienced moderate reductions in pain, depression, and anxiety, according to a meta-analysis of more than 130 studies that involved about 13 000 participants. The (...)
• 02:00
  Prostate Cancer Cases Might Rise to 3 Million Globally by 2040 J Am Med Assoc (JAMA)
  The number of people diagnosed with prostate cancer will more than double worldwide over the next 2 decades, from 1.4 million in 2020 to 2.9 million by 2040, according to findings from a Lancet Commission. More people will also die from the condition, with an estimated 700 000 patients dying (...)
• 02:00
  ?-Blockers After Heart Attacks Might Not Lower Deaths for Some J Am Med Assoc (JAMA)
  Patients typically receive a series of medications, including ?-blockers such as metoprolol and bisoprolol, after experiencing a myocardial infarction, or heart attack. Now, results from a registry-based randomized trial involving more than 5000 participants suggests that some people who’ve (...)
• 02:00
  Oral Drug as Effective as Topical Cream for Male Pattern Baldness J Am Med Assoc (JAMA)
  Oral minoxidil works as well as topical minoxidil 5% for treating people with androgenetic alopecia, also known as male pattern baldness, a double-blind, randomized study found. The results are based on data from 68 men in Brazil aged 18 to 55 years.
• 02:00
  Deaths of Despair Surged Among Black People Over Past Decade J Am Med Assoc (JAMA)
  Guided by findings reported in 2015, researchers have thought that the uptick in midlife deaths of despair—those resulting from suicide, drug overdose, and alcoholic liver disease—disproportionately affected White people. Now, new data published in JAMA Psychiatry illustrate that the decrease (...)
• 02:00
  Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US Youth J Am Med Assoc (JAMA)
  This cross-sectional study compares all-cause and cause-specific mortality trends and rates among youth from different races and ethnicities between 1999 and 2021.
• 02:00
  Youth Parental Death Due to Drug Poisoning and Firearm Violence in the US J Am Med Assoc (JAMA)
  This cross-sectional study uses a demographic projection model and publicly available vital statistics data to estimate the national incidence of parental death due to drugs and firearms overall and by race and ethnicity.
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Injury Prevention Science and Firearm Injury in Pediatric Health J Am Med Assoc (JAMA)
  In this issue of JAMA, Wolf et al found that during the period from 2019 to 2021, the US experienced the greatest increase in all-cause pediatric fatalities (aged 1-19 years) in more than 50 years, with increased mortality disproportionately resulting from preventable injuries. Importantly, (...)
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.

21 mai

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Including Pregnant and Lactating Women in Clinical Research J Am Med Assoc (JAMA)
  This Viewpoint summarizes a new report from the National Academies of Sciences, Engineering, and Medicine that encourages the inclusion of pregnant and lactating individuals in clinical research.
• 02:00
  Accelerating Climate Action Through Academic Health Systems J Am Med Assoc (JAMA)
  This Viewpoint makes the case for academic health systems to lead the way on climate change action in the US, including planning to reduce greenhouse gas emissions, educating current and future clinicians, and communicating with their patients and communities.
• 02:00
  Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity—Reply J Am Med Assoc (JAMA)
  In Reply Mr Xiao and colleagues raise 5 issues related to our trial of tirzepatide. First, the glucagon-like peptide-1 (GLP-1) receptor agonist class has been available for the treatment of type 2 diabetes since 2005 and for the treatment of obesity since 2014 and has been the subject of (...)
• 02:00
  Tirzepatide for Maintenance of Weight Reduction in Adults with Obesity J Am Med Assoc (JAMA)
  To the Editor As reported by Dr Aronne and colleagues, tirzepatide demonstrates therapeutic benefits in weight loss; adults with obesity completing the 36-week lead-in period of the trial experienced a mean weight reduction of 20.9%. From randomization at week 36, those who switched to (...)
• 02:00
  The Overdose Crisis in the 2024 Election—Political Fights and Practical Problems J Am Med Assoc (JAMA)
  This Viewpoint discusses the 2024 presidential election in the context of the addiction and overdose crisis in the US, which has been a unifying challenge and a source of major ideological division in US politics.
• 02:00
  Interstitial Lung Disease J Am Med Assoc (JAMA)
  This review summarizes current evidence regarding the diagnosis and treatment of interstitial lung disease.
• 02:00
  Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments J Am Med Assoc (JAMA)
  This study examines the strength of association between surrogate markers used as primary end points in clinical trials to support FDA approval of drugs treating nononcologic chronic diseases and clinical outcomes.
• 02:00
  Measuring Equity in Readmission as an Assessment of Hospital Performance—Reply J Am Med Assoc (JAMA)
  In Reply We agree with Drs Gallo and Santiago that research is needed to identify and target the upstream contributors to disparities in hospital readmissions. These root causes function both at the level of the hospital and outside of the hospital via the social determinants of health. In our (...)
• 02:00
  Measuring Equity in Readmission as an Assessment of Hospital Performance J Am Med Assoc (JAMA)
  To the Editor A recent study that used Medicare administrative data reported disparities in readmission rates for Black compared with White beneficiaries and notable segregation in the care of Black and White patients among hospitals. These findings necessitate attention to additional (...)
• 02:00
  GLP-1 Receptor Agonist Use and Risk of Postoperative Complications J Am Med Assoc (JAMA)
  This cohort study evaluates the risk of postoperative respiratory complications among patients with diabetes undergoing surgery who had vs those who had not a prescription fill for glucagon-like peptide 1 receptor agonists.
• 02:00
  Is Myocardial Infarction Overdiagnosed? J Am Med Assoc (JAMA)
  This Viewpoint examines whether overdiagnosis rather than underdiagnosis may now be the dominant form of myocardial infarction misdiagnosis.
• 02:00
  Toward the End of My Dad’s Life We Go Back to Arguing, and Soon After He Dies, I Break My Elbow J Am Med Assoc (JAMA)
  —but I prefer not to disentangle it,because it is more accurate.Tony Hoagland, “Entanglement”
• 02:00
  Neurodevelopmental Outcomes After Late Preterm Corticosteroids J Am Med Assoc (JAMA)
  This prospective follow-up study of a randomized clinical trial evaluates whether antenatal corticosteroids administered to birthing parents at risk of late preterm delivery were associated with adverse neurodevelopmental effects on their offspring.
• 02:00
  Diagnosis of Cancer After Recent Weight Loss—Reply J Am Med Assoc (JAMA)
  In Reply We thank Mr Lu and colleagues for their interest in our recent article. In response to their first comment, it is important to note that body weights in this study were self-reported by participants approximately every 2 years and were not measured at clinic visits. Therefore, the (...)
• 02:00
  Diagnosis of Cancer After Recent Weight Loss J Am Med Assoc (JAMA)
  To the Editor A recent study provided valuable insights into the complex relationship between weight loss and cancer risk. In addition to the limitations mentioned by the authors, we have some concerns about the study methods and the interpretation of the results.
• 02:00
  X (Formerly Twitter) Community Notes Addressing COVID-19 Vaccine Misinformation J Am Med Assoc (JAMA)
  This study evaluated the topics, accuracy, and credibility of X (formerly Twitter) Community Notes addressing COVID-19 vaccination.
• 02:00
  Lower Gastrointestinal Hemorrhage J Am Med Assoc (JAMA)
  This JAMA Clinical Guidelines Synopsis summarizes the 2023 American College of Gastroenterology guidelines on management of patients with acute lower gastrointestinal bleeding.
• 02:00
  Late Preterm Corticosteroids Exposure and Neurodevelopmental Outcomes J Am Med Assoc (JAMA)
  In recent years, there has been a reevaluation of the upper gestational age limit recommended for administration of antenatal corticosteroids. Seven randomized clinical trials (RCTs) published between 2010 and 2022 have evaluated the effects of expanding the limit from 34 to 37 weeks’ (...)
• 02:00
  In Praise of Hospice J Am Med Assoc (JAMA)
  In this narrative medicine essay, a retired physician describes the kindness, companionship, and skill of the hospice workers who helped his wife and him prepare for her death.
• 02:00
  Patient Information: Autism Spectrum Disorder J Am Med Assoc (JAMA)
  This JAMA Patient Page describes autism spectrum disorder (ASD) and its signs and symptoms, diagnosis, and therapy options.
• 02:00
  Disparities in Mortality by Sexual Orientation in a Cohort of Female Nurses J Am Med Assoc (JAMA)
  This prospective cohort study compares the differences in time to mortality across sexual orientation in female nurses participating in the Nurses’ Health Study II.
• 02:00
  US Breast Cancer Mortality—Reply J Am Med Assoc (JAMA)
  In Reply Dr Jatoi suggests that a reduction in the incidence of ER-negative breast cancer over the past decades could have contributed to the decline in breast cancer mortality observed in SEER between 1975 and 2019. Indeed, a decline in cancer incidence can have a primary role in decline of (...)
• 02:00
  US Breast Cancer Mortality J Am Med Assoc (JAMA)
  To the Editor In their recent study, Dr Caswell-Jin and colleagues used 4 Cancer Intervention and Surveillance Modeling Network (CISNET) models and ascribe the 58% reduction in US breast cancer mortality between 1975 and 2019 to the use of effective treatments and screening. However, the (...)
• 02:00
  Rehabilitation J Am Med Assoc (JAMA)
  The family physician, after seeing a patient through the acute stages of an illness and subsequent convalescence, watched him until his ultimate return to work. The patient, usually stimulated by the daily needs of life on the farm and in the home, was chiefly interested in regaining his (...)
• 02:00
  APOL1-Mediated Kidney Disease J Am Med Assoc (JAMA)
  This JAMA Insights reviews the origin of APOL1 high-risk genetic variants, defines APOL1-mediated kidney disease, and discusses recommendations for screening and management.
• 02:00
  Patients with Long COVID May Tolerate Cautious Exercise Rehabilitation J Am Med Assoc (JAMA)
  This Medical News story discusses a clinical trial that tested symptom-guided exercise for patients with long COVID and postexertional malaise.
• 02:00
  WHO Launches Broad Coronavirus Surveillance Network J Am Med Assoc (JAMA)
  A new initiative, known as the Coronavirus Network or CoViNet, will bring together experts in human, animal, and environmental health to monitor known coronaviruses such as SARS-CoV-2 and Middle East respiratory syndrome coronavirus, or MERS-CoV, the World Health Organization (WHO) said in a (...)
• 02:00
  CDC: H5N1 Bird Flu Confirmed in Person Exposed to Cattle J Am Med Assoc (JAMA)
  Highly pathogenic avian influenza A(H5N1), also known as H5N1 bird flu, has been circulating among birds and mammals for the past few years. This March, US officials detected it in dairy cattle in several states. Later that month, a farm worker who was exposed to dairy cattle in Texas tested (...)
• 02:00
  Climbers at High Altitudes at Risk of Heart Rhythm Abnormalities J Am Med Assoc (JAMA)
  More than one-third of climbers who were exposed to the low-pressure and low-oxygen environment of Mount Everest experienced a cardiac arrhythmia during their climb, a small study found. The data came from 41 healthy men who were, on average, in their mid-30s.
• 02:00
  Limited Pregnancy Weight Gain for People With Obesity Might Be Safe J Am Med Assoc (JAMA)
  People with obesity who gained less than the recommended 5 kg to 9 kg of weight during pregnancy did not experience adverse outcomes, and neither did their children, according to data from about 15 800 pregnancies among people with obesity in Sweden.
• 02:00
  Abnormal Glucose, Triglycerides Linked to Later Psychiatric Conditions J Am Med Assoc (JAMA)
  People with high levels of blood glucose and triglycerides tended to have a greater risk of mental health conditions later than those who had normal levels of both, according to data from more than 211 000 participants in Sweden published in JAMA Network Open. Changes in some biomarkers were (...)
• 02:00
  Dengue Cases Surge in Latin America and Caribbean J Am Med Assoc (JAMA)
  Millions of people in the Americas have been infected with dengue and more than 1000 have died in the first 3 months of 2024, tripling the number of dengue cases that occurred in 2023 during the same period, according to a statement by the Pan American Health Organization (PAHO). Last year, (...)
• 02:00
  New Rules Require Explicit Consent for Students to Perform Sensitive Exams J Am Med Assoc (JAMA)
  Clinicians must now get written consent for medical students to conduct examinations or invasive procedures—such as breast, pelvic, prostate, and rectal checks—on patients for the trainees’ education, the US Department of Health and Human Services announced in a recent letter to teaching (...)
• 02:00
  CDC Warns of Surge in Meningococcal Disease in US J Am Med Assoc (JAMA)
  As of late March 2024, health officials in the US have recorded 143 cases of meningococcal disease, 101 of them caused by a strain of the bacteria Neisseria meningitidis known as sequence type (ST) 1466. The total number of cases of the disease represents a more than 75% increase over those (...)
• 02:00
  US Updates Race, Ethnicity Categories for First Time Since 1997 J Am Med Assoc (JAMA)
  People answering survey questions and filling out administrative forms from federal agencies will now answer 1 combined question about race and ethnicity and be able to select more than 1 option that represents their identity, the US Office of Management and Budget (OMB) announced in a recent (...)
• 02:00
  Introducing JAMA Data Brief J Am Med Assoc (JAMA)
  How people consume information is evolving. So is JAMA Medical News. This issue debuts JAMA Data Brief, a new department in the journal’s long-standing Medical News & Perspectives.
• 02:00
  Poll: Patients Still Trust Their Physicians the Most J Am Med Assoc (JAMA)
  This Medical News article discusses a KFF poll about the public’s exposure to and beliefs about inaccurate health information, as well as media use and trust in sources.
• 02:00
  Addition of Name to List of Investigators J Am Med Assoc (JAMA)
  The Original Investigation titled “Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials,” published on November 14, 2023, has been updated to add Christopher Horvat, MD, MHA, to the list of LOVIT-COVID Investigators, on behalf of the Canadian (...)
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.

14 mai

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Even Low Levels of Albumin in Urine Tied to Worsened Kidney Disease J Am Med Assoc (JAMA)
  For decades, researchers characterized normal albuminuria as a urine albumin-creatinine ratio of less than 30 mg/g. That has led some clinicians to believe that patients with lower ratios don’t need additional treatment. But a new study in Annals of Internal Medicine challenges that assumption (...)
• 02:00
  Study: Younger Deaths Driving Maternal Mortality Increase J Am Med Assoc (JAMA)
  Maternal mortality rates in the US almost doubled between 2014 and 2021, from about 17 deaths to about 32 deaths per 100 000 live births. The steepest increase in deaths occurred between 2019 and 2021. But only a minor portion of the increased mortality was driven by people aged 35 years or (...)
• 02:00
  Heart Disease Outcomes Improve After Mental Health Treatments J Am Med Assoc (JAMA)
  Patients with heart disease as well as anxiety or depression who received mental health treatments tended to have a substantially lower risk of mortality as well as a reduced chance of hospital readmissions and emergency department (ED) visits, according to a cohort study in Journal of the (...)
• 02:00
  Bacterial Subspecies Linked With Aggressive Colorectal Cancer Tumors J Am Med Assoc (JAMA)
  Previous research has tied the presence of Fusobacterium nucleatum, a bacterium normally found in the mouth, with colorectal cancer tumors. High amounts of F nucleatum in the tumor are linked with worse prognosis. A recent study clarified that risk, showing that what was thought to be a single (...)
• 02:00
  Blockbuster Obesity Drugs Have Potential New Uses J Am Med Assoc (JAMA)
  This Medical News story examines other potential uses of GLP-1 receptor agonists, the popular type 2 diabetes and weight-loss drugs.
• 02:00
  Heart Health Highlights from ACC.24 J Am Med Assoc (JAMA)
  This Medical News article is an interview with Douglas Drachman, MD, an interventional cardiologist and chair of the American College of Cardiology’s annual meeting.
• 02:00
  Type of Prenatal Antiseizure Drug Matters for Children’s Autism Risk J Am Med Assoc (JAMA)
  Children born to people who received valproate, an antiseizure medication, during pregnancy had about a 2.7 times higher chance of being diagnosed with autism spectrum disorder by age 8 years than those born to people who were not treated with antiseizure medications prenatally, according to (...)
• 02:00
  Use of Progestogen Tied to Higher Chance of Benign Brain Tumor J Am Med Assoc (JAMA)
  Many people worldwide use progestogen-based hormonal contraception or hormone replacement therapy to manage menopause symptoms. Previous research has linked a handful of high-dose progestogens—cyproterone acetate, nomegestrol acetate, and chlormadinone acetate—with increased risk of (...)
• 02:00
  Loneliness Tied to Worse Physical, Mental Health Among Older Adults J Am Med Assoc (JAMA)
  About 53% of people aged 65 years or older experienced loneliness between April 2020 and September 2021, a recent study involving 603 primary care patients found. Older adults who reported loneliness tended to score lower on measures of physical– and mental health–related quality of life. (...)
• 02:00
  Controlling Multidrug-Resistant Organisms Across Patient-Sharing Networks J Am Med Assoc (JAMA)
  Antimicrobial resistance is a major public health problem that threatens to reverse many of the medical therapy advances achieved over the past 4 decades. Infections caused by multidrug-resistant organisms (MDROs) are estimated to cause 35 000 deaths in the US every year and increase medical (...)
• 02:00
  Decolonization and Multidrug-Resistant Organisms in Hospitals and Nursing Homes J Am Med Assoc (JAMA)
  This quality improvement study evaluates whether implementation of a decolonization collaborative is associated with reduced regional multidrug-resistant organism prevalence, incident clinical cultures, infection-related hospitalizations, costs, and deaths.
• 02:00
  Provision of Medications for Self-Managed Abortion Before and After the Dobbs Decision J Am Med Assoc (JAMA)
  This study assesses whether the provision of medications for self-managed abortion outside the formal US health care setting increased during the 6 months after the Supreme Court decision in Dobbs v Jackson Women’s Health Organization overturned the right to choose abortion in the US.
• 02:00
  Impacts of the Supreme Court Decision in FDA v Alliance for Hippocratic Medicine J Am Med Assoc (JAMA)
  This Viewpoint outlines the potential effects of the Supreme Court case regarding mifepristone restrictions: a decision for the FDA would allow current dispensing, while ruling against the FDA would severely curtail access to reproductive health options.
• 02:00
  Improving Medical Communication J Am Med Assoc (JAMA)
  To the Editor Dr Cappola and Ms Cohen’s article highlighted the importance of medical communication. The study of communication dates to ancient Greece when Aristotle first studied the rhetoric of Western civilizations. Modern communication scholars draw from this long and rich history, (...)
• 02:00
  Improving Medical Communication—Reply J Am Med Assoc (JAMA)
  In Reply Drs Anderson and Ledford bring to our attention meaningful classifications for medical communication. It is indeed helpful to categorize medical communication into interpersonal, organizational, and mass media since each type has different needs and stipulations.
• 02:00
  Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban J Am Med Assoc (JAMA)
  This cohort study assesses the association of diltiazem with risk of serious bleeding compared with metoprolol in older adults with atrial fibrillation receiving apixaban or rivaroxaban.
• 02:00
  Does This Infant Have a Dislocated Hip? J Am Med Assoc (JAMA)
  This Rational Clinical Examination systematic review summarizes studies that examined the diagnostic accuracy of clinical examination in determining dislocated hips in infants.
• 02:00
  Protecting Privacy of Pregnant and LGBTQ+ Research Participants J Am Med Assoc (JAMA)
  This Viewpoint summarizes existing federal regulations aimed at protecting research data, describes the challenges of enforcing these regulations, and discusses how evolving privacy technologies could be used to reduce health disparities and advance health equity among pregnant and LGBTQ+ (...)
• 02:00
  Single Ascending and Multiple-Dose Trial of Zerlasiran, a Short Interfering RNA Targeting Lipoprotein(a) J Am Med Assoc (JAMA)
  This phase 1 randomized study assesses the safety and tolerability of zerlasiran, a short interfering RNA targeting hepatic synthesis of apolipoprotein(a), and its effects on serum concentrations of lipoprotein(a), in healthy participants and patients with stable atherosclerotic cardiovascular (...)
• 02:00
  Open MRI J Am Med Assoc (JAMA)
  I keep my mother’s dentures warm; they fog the plastic case on my lap. Lips pursed, arms raised above her head, she lies on a table about to slide through the doughnut of an apparatus that looks like a spaceship. I hear David Bowie’s voice: This is Ground Control to Major Tom as the (...)
• 02:00
  Understatement in Poetry (Quieter Than an MRI) J Am Med Assoc (JAMA)
  Understatement, or “showing without telling,” makes writing in prose and especially in poetry pleasing to read. Medical training, in contrast, is rife with exhaustive explanation. “Open MRI” demonstrates the effect of understatement. The poem brims with implied yet revealing comparisons: the (...)
• 02:00
  Incorrect Text J Am Med Assoc (JAMA)
  In the Editorial titled “Struggling to Stem the Tide of Child Maltreatment,” published in the March 19, 2024, issue of JAMA, incorrect text appeared. In the first full paragraph on the second page, the second sentence should have read “Research on some primary care interventions, such as Safe (...)
• 02:00
  Leave of Absence and Medical Student GME Placement by Race and Ethnicity J Am Med Assoc (JAMA)
  This study examines the association between taking a leave of absence from medical school and placement into graduate medical education (GME) by race and ethnicity.
• 02:00
  Estrogen-Only Hormone Therapy and Dementia—Reply J Am Med Assoc (JAMA)
  In Reply The Letters about our study suggest that the observed positive association between estrogen-only hormone therapy and dementia could have been influenced by (1) potential confounding by indication of hysterectomy-induced early menopause among estrogen-only hormone therapy users or (2) (...)
• 02:00
  Patient Information: Hepatitis D Infection J Am Med Assoc (JAMA)
  This JAMA Patient Page describes hepatitis D infection and its risk factors, outcomes of acute and chronic infection, diagnosis, treatment, and prevention.
• 02:00
  “The Patient” J Am Med Assoc (JAMA)
  When a resident announced that “the patient has no chance of surviving,” a medical student, in this narrative medicine essay, has pondered for years how her mother could have been so reduced and advocates using patients’ names when summarizing their conditions.
• 02:00
  A Patient with Diabetes Mellitus and Acute Rhinosinusitis J Am Med Assoc (JAMA)
  A 41-year-old with type 1 diabetes had generalized weakness, muffled voice, and slurred speech. Neck computed tomography showed soft-tissue gas in the nasopharynx and prevertebral fascia; examination of sinus mucosal samples identified numerous broad, nonseptate right-angled hyphae and (...)
• 02:00
  Main Residency Match for Applicants With Disability J Am Med Assoc (JAMA)
  This cohort study assesses match rates of US applicants with and without disability into specialty residence programs.
• 02:00
  Study: Roughly 1 in 8 Patients Wrongly Diagnosed With Pneumonia J Am Med Assoc (JAMA)
  About 12% of patients were inappropriately diagnosed with community-acquired pneumonia (CAP), according to results from more than 17 000 hospitalized patients across 48 hospitals in Michigan. Older people as well as those with dementia or altered mental status were at particularly high risk of (...)
• 02:00
  People With Genetic Risk of Obesity Need More Exercise to Mitigate It J Am Med Assoc (JAMA)
  People with increased polygenic risk scores for higher body mass index (BMI) would need to walk about 2300 more steps each day to have the same risk of obesity as those with lower scores, a recent retrospective study in JAMA Network Open found. Polygenic risk scores reflect the risk of disease (...)
• 02:00
  Estrogen-Only Hormone Therapy and Dementia J Am Med Assoc (JAMA)
  To the Editor A recent study reported that estrogen-only menopausal hormone therapy in women who underwent hysterectomy without oophorectomy was associated with an increased dementia rate vs nonuse. This article has several limitations that should be considered when interpreting the study’s (...)
• 02:00
  Estrogen-Only Hormone Therapy and Dementia J Am Med Assoc (JAMA)
  To the Editor A recent study reported an increased dementia risk in women using estrogen-only menopausal hormone therapy, which mirrors findings of an earlier study by these authors that demonstrated an increased dementia risk associated with combined menopausal hormone therapy. These studies (...)
• 02:00
  The Promise of a Longer Lifetime J Am Med Assoc (JAMA)
  Modern hygiene has been described as the reaction against the old fatalistic creed that deaths inevitably occur at a constant rate. The study of vital statistics shows that there is no “iron law of mortality.” According to a report prepared for the National Conservation Commission fifteen (...)
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)

7 mai

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  COVID-19 Vaccination Linked With Lower Risk of Cardiac Problems J Am Med Assoc (JAMA)
  People who received a SARS-CoV-2 vaccination had a lower risk of heart failure and blood clots in their veins and arteries after COVID-19 infection than those who had not been vaccinated, a recent study involving more than 20 million participants in Estonia, Spain, and the UK found.
• 02:00
  Measles Outbreaks in US and Abroad Prompt CDC Vaccination Alert J Am Med Assoc (JAMA)
  Amid an uptick in measles cases and outbreaks both in the US and abroad, the US Centers for Disease Control and Prevention (CDC) issued an alert on March 18 encouraging clinicians to work with schools and educators to ensure children are up-to-date on their measles-mumps-rubella (MMR) (...)
• 02:00
  FDA Okays First Drug for Scarring From Fatty Liver Disease J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) recently approved resmetirom, marketed as Rezdiffra, for adults with nonalcoholic steatohepatitis (NASH) without cirrhosis. NASH is a progressive fatty liver disease that affects up to 8 million people in the US and can cause liver inflammation and (...)
• 02:00
  Safety Concerns Put a Stop to Maternal RSV Vaccine Study J Am Med Assoc (JAMA)
  A vaccine given during pregnancy that prevents respiratory syncytial virus (RSV) in infants was about 66% effective at protecting against RSV-associated respiratory illness, and about 69% effective at protecting against severe disease, according to a study in the New England Journal of (...)
• 02:00
  Trials Will Evaluate Treatments for Long COVID Nervous System Problems J Am Med Assoc (JAMA)
  For some individuals, post–COVID-19 condition, or long COVID, can result in symptoms of autonomic nervous system dysfunction, such as a heart palpitations and lightheadedness that occur when standing up, and fatigue. Together, these symptoms are known as postural orthostatic tachycardia (...)
• 02:00
  AI-Drafted Responses to Patients Reduced Clinician Burnout J Am Med Assoc (JAMA)
  Experts have predicted that large language models, or LLMs, could help tackle physician burnout by offloading administrative tasks, such as answering questions in patient portals. Recently, a 5-week study involving 162 clinicians who worked in primary care, gastroenterology, and hepatology (...)
• 02:00
  Study Examines Intermittent Fasting and Cardiovascular Mortality J Am Med Assoc (JAMA)
  Limiting time spent eating to an 8-hour window or less each day—a type of so-called intermittent fasting—was linked with a 91% increased risk of death from cardiovascular disease compared with eating throughout a 12- to 16-hour period, according to preliminary observational data presented at (...)
• 02:00
  More Than 1 in 10 US Children Diagnosed With ADHD J Am Med Assoc (JAMA)
  About 11% of US children aged 5 to 17 years have been diagnosed with attention-deficit/hyperactivity disorder (ADHD), based on data from the National Health Interview Survey conducted between 2020 and 2022. This survey confirms estimates from earlier reports.
• 02:00
  Neurological Conditions Are Leading Cause of Disability Worldwide J Am Med Assoc (JAMA)
  More than 3 billion people—about 43% of the global population—lived with neurological conditions in 2021, according to results from the Global Burden of Disease Study published in The Lancet Neurology. Although this represented an 18.2% increase from 1990, once researchers adjusted for age, (...)
• 02:00
  An Explosion of Food Is Medicine Research Could Change Health Care J Am Med Assoc (JAMA)
  This Medical News article discusses research initiatives to support produce prescriptions and other “food is medicine” nutrition programs in health care settings.
• 02:00
  Why “Just the Facts” Fails in Vaccine Conversations J Am Med Assoc (JAMA)
  This Medical News article discusses an intervention that uses empathy to address vaccine hesitancy in the clinic.
• 02:00
  Tilt Table Testing J Am Med Assoc (JAMA)
  This Diagnostic Test Interpretation uses a patient case to illustrate tilt table testing, useful for evaluating patients with syncope of unknown cause or postural orthostatic tachycardia syndrome (POTS).
• 02:00
  Medicine and Meteorology J Am Med Assoc (JAMA)
  Few, indeed, are the physicians who do not now and then advise a patient to make a change of climate. However difficult it might be to justify such a recommendation in every instance, or even in most cases, on the basis of precise physiologic knowledge or strictly scientific therapeutic (...)
• 02:00
  Patient Information: Flat Head Syndrome in Infants J Am Med Assoc (JAMA)
  This JAMA Patient Page describes the types of flat head syndrome and its prevention and treatment.
• 02:00
  Good Enough J Am Med Assoc (JAMA)
  In this narrative medicine essay, a pediatric critical care physician mulls a discussion about a patient’s status with a male colleague in front of her all-female medical team, a discussion that led her to question herself until she concludes that she can’t be all things to all people at all times.
• 02:00
  Consortium Authors and Nonauthor Collaborators Added J Am Med Assoc (JAMA)
  The Original Investigation titled “Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection,” published in the June 13, 2023, issue of JAMA, has been corrected to include additional consortium authors and nonauthor collaborator names in a supplement.
• 02:00
  Uterine Fibroids J Am Med Assoc (JAMA)
  This JAMA Insights in the Women’s Health series discusses the incidence, diagnosis, and treatment of uterine fibroids.
• 02:00
  Manufacturer Payments to Cardiologists and Use of Devices J Am Med Assoc (JAMA)
  This study examines whether payments from a left ventricular assist device manufacturer to cardiologists performing percutaneous coronary intervention were associated with any use of the devices.
• 02:00
  Sternotomy J Am Med Assoc (JAMA)
  Armour I built over slow weeks in my first trimester
• 02:00
  Cardiac Function Before Sepsis and Clinical Outcomes J Am Med Assoc (JAMA)
  This cohort study characterizes heterogeneity in cardiac function prior to sepsis and describes associations with hospitalization outcomes and mortality.
• 02:00
  Systemic Lupus Erythematosus J Am Med Assoc (JAMA)
  This review summarizes current evidence regarding the diagnosis, treatment, and prognosis of systemic lupus erythematosus.
• 02:00
  Data Checks Before Registering Study Protocols for Health Care Database Analyses J Am Med Assoc (JAMA)
  This Viewpoint discusses the challenges involved with secondary health care data collection vs primary data collection and provides a list of suggested data checks before registration of a study protocol using secondary data.
• 02:00
  Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval J Am Med Assoc (JAMA)
  This study aims to determine whether cancer drugs granted accelerated approval from the US Food and Drug Administration ultimately demonstrate clinical benefit and to evaluate the basis of conversion to regular approval.
• 02:00
  A Pragmatic Approach to Prostate Cancer Screening J Am Med Assoc (JAMA)
  The introduction of prostate-specific antigen (PSA)–based screening for prostate cancer in the early 1990s was followed by a nearly 2-decade long decline in prostate cancer metastasis and mortality. However, clinical trial data revealed that screening was associated with substantial harms. (...)
• 02:00
  Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI J Am Med Assoc (JAMA)
  This preliminary descriptive report compares the detection rates of high-grade and low-grade prostate cancer in men invited for prostate cancer screening vs those of the control group not offered screening.
• 02:00
  Prostate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality J Am Med Assoc (JAMA)
  This secondary analysis of a randomized clinical trial assesses whether screening for prostate-specific antigen reduces prostate cancer mortality at 15-year follow-up.
• 02:00
  Introducing the JAMA Summit J Am Med Assoc (JAMA)
  Over the past year, JAMA editors have been developing the concept of the JAMA Summit—forums for catalyzing discussion and action on pressing issues in science, medicine, and public health. Over its more than 140-year history, JAMA has been a leader in publishing on critical issues related to (...)
• 02:00
  Error in Conflict of Interest Disclosures J Am Med Assoc (JAMA)
  In the Editorial titled “Shedding Patterns of Genital Herpes Simplex Virus Infections,” published online on October 22, 2022, and in the November 1, 2022, issue of JAMA, Dr Whitley omitted potential conflict of interest disclosures. The disclosure statement has been corrected to include (...)
• 02:00
  Noninvasive Airway Management of Comatose Patients With Acute Poisoning J Am Med Assoc (JAMA)
  To the Editor A recent study suggested clinical benefits of noninvasive airway management in comatose patients with acute poisoning. An accompanying editorial lauded the study as a practice-changing trial providing rigorous evidence. Although we have recommended against indiscriminate (...)
• 02:00
  Noninvasive Airway Management of Comatose Patients With Acute Poisoning J Am Med Assoc (JAMA)
  To the Editor We read with interest the recent article that reported among comatose patients with suspected acute poisoning, a conservative strategy of withholding intubation was associated with a greater clinical benefit for the composite end point of in-hospital death, length of ICU stay, (...)
• 02:00
  Noninvasive Airway Management of Comatose Patients With Acute Poisoning J Am Med Assoc (JAMA)
  To the Editor A recent study reported that withholding intubation among patients with acute poisoning and coma, defined by a GCS score of up to 8, was safe and led to lower rates of ICU admission and adverse events.
• 02:00
  Noninvasive Airway Management of Comatose Patients With Acute Poisoning J Am Med Assoc (JAMA)
  To the Editor We read with great interest the recent study about the effect of noninvasive airway management of comatose patients with acute poisoning, but are concerned about potential issues related to selection bias, confounding factors, and the unblinded study design that might have biased (...)
• 02:00
  Noninvasive Airway Management of Comatose Patients With Acute Poisoning—Reply J Am Med Assoc (JAMA)
  In Reply In response to our recent article, Dr Schober and colleagues suggest that reduction of length of stay in the ICU and hospital may not be considered a clinically relevant outcome. However, in the context of stretched resources and ICU bed shortages, we believe this is an important end (...)
• 02:00
  Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Pregnancy J Am Med Assoc (JAMA)
  To the Editor The MOMPOD study revealed that for pregnant individuals with preexisting type 2 or early gestational diabetes, metformin, 1000 mg twice daily, starting before 23 weeks’ gestation and taken until delivery, did not reduce a composite adverse neonatal outcome but resulted in reduced (...)
• 02:00
  Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Pregnancy—Reply J Am Med Assoc (JAMA)
  In Reply We thank Drs Pourkarim and Entezari-Maleki for their thoughtful comment about our recent study that described outcomes following metformin plus insulin for the treatment of early gestational and preexisting type 2 diabetes in pregnancy. We agree that based on available data, the use (...)
• 02:00
  Implications for Public Health Regulation if Chevron Deference Is Overturned J Am Med Assoc (JAMA)
  This Viewpoint describes implications for medicine and public health if the US Supreme Court decides to overturn or narrow Chevron deference.
• 02:00
  US Supreme Court Limits on the Power of US Health Agencies J Am Med Assoc (JAMA)
  This Viewpoint describes how the overturning of Chevron deference would shift the ability to make policy decisions about public health and the environment from administrative agencies to the courts.

23 avril

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Narrative Play—Promoting Adolescent Health With Interactive Games J Am Med Assoc (JAMA)
  This Arts and Medicine feature discusses INSPIRE, a digital health game designed to foster adolescent health behavior change.
• 02:00
  Error in Conflict of Interest Disclosure Statements J Am Med Assoc (JAMA)
  In several JAMA articles published in 2022 and 2023, an incorrect institution was published in Dr Califf’s conflict of interest disclosure statements: the Center for Policy Analysis on Trade and Health should have been listed as the Critical Path Institute. The articles have been corrected online.
• 02:00
  Meta-Analysis: “Limited” Benefits to Rapid Viral Tests in EDs J Am Med Assoc (JAMA)
  Observational studies have suggested that rapid viral testing for respiratory viruses is tied to lower use of antibiotics. Now, a meta-analysis published in JAMA Internal Medicine suggests that may not be the case, based on results from 11 randomized clinical trials involving about 6100 (...)
• 02:00
  Less Sleep Tied to Increased Risk of Diabetes Despite Healthy Diet J Am Med Assoc (JAMA)
  People who slept 5 or fewer hours each night had a higher risk of being diagnosed with type 2 diabetes than those who slept 7 to 8 hours, even if they followed a healthy diet, a cohort study published in JAMA Network Open found. Sleeping 5 hours or 3 to 4 hours per day was linked with a 16% (...)
• 02:00
  WHO Documents Rising Resistance to First-Line HIV Drug J Am Med Assoc (JAMA)
  Currently, the World Health Organization (WHO) recommends using dolutegravir, an integrase strand transfer inhibitor approved by the US Food and Drug Administration in 2013, as a first- and second-line drug for treating people with HIV. But resistance to the treatment is on the rise. About 4% (...)
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  Selective Androgen Receptor Modulators: Transformative or Abuse Potential? J Am Med Assoc (JAMA)
  This Viewpoint examines whether selective androgen receptor modulators have the potential to be transformative drugs or whether they herald the next drug epidemic.
• 02:00
  Deaths From Excessive Drinking Rose in the US During Pandemic J Am Med Assoc (JAMA)
  Deaths associated with excessive alcohol use have been rising over the past 20 years. But during 2020-2021 they went up dramatically—from an average of about 138 000 deaths during 2016-2017 to more than 178 000 deaths during the COVID-19 pandemic. The change represents a 29% increase in lives (...)
• 02:00
  How Generative AI Done Right Could Help Democratize Health Care J Am Med Assoc (JAMA)
  This Medical News article is an interview with JAMA Editor in Chief Kirsten Bibbins-Domingo and Virologist Davey Smith, head of the Division of Infectious Diseases and Global Public Health at the University of California, San Diego.
• 02:00
  Multitarget Stool RNA Testing J Am Med Assoc (JAMA)
  To the Editor The study by Dr Barnell and colleagues raises methodological and clinical concerns. First, sessile serrated lesions (SSLs) 1 cm or larger are widely considered to be advanced precancerous lesions comparable to advanced adenomas, and their categorization as a nonfinding and part (...)
• 02:00
  Multitarget Stool RNA Testing J Am Med Assoc (JAMA)
  To the Editor Dr Barnell and colleagues reported an mt-sRNA colorectal cancer screening test with higher sensitivity for colorectal cancer compared with FIT (94.4% for mt-sRNA vs 77.8% for FIT). Although sensitivity is important in colorectal cancer screening, I believe the description of the (...)
• 02:00
  Multitarget Stool RNA Testing—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the Letters from Drs Imperiale and colleagues and Dr Baird. Regarding SSLs of at least 1 cm in size, we are following the most recent US Multi-Society Task Force guidelines, which were cited by Imperiale and colleagues. These guidelines state “Because evidence of the (...)
• 02:00
  Reporting on Health and War in Medical Journals J Am Med Assoc (JAMA)
  We write to respond to the Viewpoint by Greenland et al that proposes a form of content moderation for medical journals. Greenland et al suggest that articles dealing with health care and health consequences during war should assiduously avoid discussing the politics of war. While JAMA and (...)
• 02:00
  Reporting Health Consequences of War in Medical Journals J Am Med Assoc (JAMA)
  This Viewpoint suggests that medical and public health journals should publish articles focused singularly on health without political bias when reporting on the health consequences of war.
• 02:00
  Nostrums J Am Med Assoc (JAMA)
  By H. C. Wood, M.D., Philadelphia, Pa.
• 02:00
  Patient Information: Hyperthyroidism J Am Med Assoc (JAMA)
  This JAMA Patient Page describes hyperthyroidism causes, symptoms, diagnosis, and treatment options.
• 02:00
  How’s Your Soul J Am Med Assoc (JAMA)
  In this narrative essay, a physician reflects on the way in which his residency program director’s unique background as a Master of Divinity helped him to focus on his growth as a human being rather than concentrating solely on clinical evaluations.
• 02:00
  Donor Heart Acceptance and Race and Gender of Patients on the Transplant Waiting List J Am Med Assoc (JAMA)
  This cohort study assesses differences in donor heart acceptance by transplant center teams for Black and White men and women on the transplant waiting list in the US.
• 02:00
  Guidelines on Falls Prevention in Older Adults J Am Med Assoc (JAMA)
  This article summarizes a 2022 clinical practice guideline on falls prevention and management in older adults from the World Falls Guidelines Initiative.
• 02:00
  Lepodisiran for Elevated Lipoprotein(a) J Am Med Assoc (JAMA)
  To the Editor In a recent randomized clinical trial, Dr Nissen and colleagues found that lepodisiran, an extended-duration short interfering RNA targeting lipoprotein(a), demonstrated high tolerability while decreasing serum lipoprotein(a) concentrations in a dose-dependent way over an (...)
• 02:00
  Lepodisiran for Elevated Lipoprotein(a)—Reply J Am Med Assoc (JAMA)
  In Reply We disagree with Drs Endo and Kami that the long duration of action of lepodisiran raises special safety concerns. Although we acknowledged in the article that a small phase 1 trial cannot definitively establish the safety of any new therapeutic agent, the observed incidence of minor (...)
• 02:00
  Health Equity Adjustment and Hospital Performance in the Medicare Value-Based Purchasing Program J Am Med Assoc (JAMA)
  This cross-sectional study discusses hospital performance after the incorporation of health equity adjustment into Medicare’s Hospital Value-Based Purchasing program.
• 02:00
  Let Her Home J Am Med Assoc (JAMA)
  “I'm sorry, darling, that I missed your text; I've had 14 admissions overnight.” “Lucky and then some! Are the residents showing some pluck and helping in the fight?” “You know I find such metaphors distasteful; it's not a war; there are no enemies (except our charting software, which is (...)
• 02:00
  In Love: the Sonnet and Medicine J Am Med Assoc (JAMA)
  Of the so-called received forms in poetry, the sonnet is most well-known and easily recognizable. Arriving into the English language in the 16th century from Italy, the most common variation is the so-called Shakespearian or English sonnet, comprising 14 lines in iambic pentameter (5 pairs of (...)
• 02:00
  Risk Assessment and Prevention of Falls in Older Community-Dwelling Adults J Am Med Assoc (JAMA)
  This Review summarizes current best practices for risk stratification, clinical assessment, and selection of risk reduction interventions for falls in community-dwelling older adults.
• 02:00
  Reported Political Participation by Physicians vs Nonphysicians J Am Med Assoc (JAMA)
  This study uses survey data to compare rates of political participation between US physicians and nonphysicians from 2017 to 2021.
• 02:00
  Prevalence of Type 1 Diabetes Among US Children and Adults by Age, Sex, Race, and Ethnicity J Am Med Assoc (JAMA)
  This study uses data from the 2019 to 2022 cycles of the National Health Interview Survey to estimate the prevalence of type 1 diabetes among US youths and adults.
• 02:00
  School Shootings in US Reach Highest Recorded Levels J Am Med Assoc (JAMA)
  School shootings in the US surged over the past 25 years and mass shootings that occurred at kindergarten through 12th-grade school sites became more deadly, according to a study in Pediatrics.
• 02:00
  Plastic in Arteries Tied With Higher Risk of Cardiovascular Problems J Am Med Assoc (JAMA)
  Past research has linked people’s exposure to microplastics and nanoplastics (MNPs) to health problems. MNPs have been found in a range of products, including food containers, cosmetics, and drinking water.
• 02:00
  Over-the-Counter Birth Control Pill Now Available in US J Am Med Assoc (JAMA)
  People will be able to buy an over-the-counter contraceptive pill, marketed by Perrigo Company as Opill, at major retailers and pharmacies in the US in late March, the manufacturer announced. A 1-month pack of the progestin-only pills costs $19.99, and a 3-month supply costs $49.99.
• 02:00
  Medical Debt in US Linked With Worse Health, More Deaths J Am Med Assoc (JAMA)
  An estimated 8% of US adults, or about 20 million people, live with medical debt of at least $250, based on recent survey results from the nonprofits Peterson Health Center and KFF (formerly Kaiser Family Foundation). The majority of those with medical debt owe more than $1000. Now, a study (...)
• 02:00
  Momentum Grows for Disaggregated Asian American Health Data J Am Med Assoc (JAMA)
  This Medical News article discusses how aggregated data obscure large health disparities among the 24 million Asian American people in the US.
• 02:00
  Integrated Hepatitis C–Opioid Use Disorder Care Through Telemedicine J Am Med Assoc (JAMA)
  This study discusses whether facilitated telemedicine for hepatitis C treatment increases cure rates compared with standard-of-care referral to hepatitis specialists.
• 02:00
  Medicine—Both a Science (Care) and an Art (CARE) J Am Med Assoc (JAMA)
  This Viewpoint discusses the concept of CARE (compassion, assistance, respect, and empathy) as a way physicians can practice the art of medicine in the current era of care that increasingly incorporates predictive analytics and artificial intelligence.
• 02:00
  Is Equity Being Traded for Access to Heart Transplant? J Am Med Assoc (JAMA)
  Disparities in care and outcomes are common, complex problems and are well illustrated by heart failure, from the initial diagnosis to the treatment of advanced disease. In the US, Black individuals develop heart failure at a much younger age than individuals of other races, and the incidence (...)
• 02:00
  Eosinophilic Gastrointestinal Disease J Am Med Assoc (JAMA)
  This JAMA Insights Clinical Update discusses the symptoms, diagnosis, and management of eosinophilic gastrointestinal diseases.
• 02:00
  Gender Eligibility Descriptions for Clinical Trials J Am Med Assoc (JAMA)
  To the Editor A recent Research Letter by Dr Burton and colleagues revealed that almost two-thirds of the trials included in ClinicalTrials.gov reported applying gender-based eligibility between 2017 and 2022 when, in fact, sex-based eligibility was used instead. According to the National (...)
• 02:00
  Gender Eligibility Descriptions for Clinical Trials—Reply J Am Med Assoc (JAMA)
  In Reply Our Research Letter analyzed free-text entries for the optional ClinicalTrials.gov data element, Gender Eligibility Description, as provided by study sponsors and investigators during trial registration. Of 1573 trials initiated between 2017 and 2022, nearly two-thirds described (...)