500 articles

23 mai

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

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#1236 Translation reprogramming in autosomal dominant polycystic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsGlobal regulation of mRNA translation has emerged as a central mechanism driving cellular adaptation to innate or acquired metabolic challenges. tRNA modifications are emerging as key drivers in the reprogramming of mRNA translation. Metabolic dysregulation is a (…)
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#1854 Prevalence of Fabry disease in chronic hemodialysis patients: a multicenter screening approach Nephrol Dial Transplant

AbstractBackground and AimsFabry disease (FD), an X-linked lysosomal storage disorder caused by alpha-galactosidase A (?-Gal A) deficiency, leads to significant morbidity and early mortality due to progressive organ failure. Given the availability of enzyme replacement therapy, early (…)
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#1493 Upregulated miR-205 as a biomarker of diet-induced obesity-related glomerulopathy Nephrol Dial Transplant

AbstractBackground and AimsObesity is a modifiable risk factor for the development and progression of chronic kidney disease (CKD). Pathways through which obesity might cause renal disease are not completely understood, as not all obese subjects develop CKD. In terms of deepening the knowledge (…)
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#862 Prevalence and surrogate predictors of acute kidney injury in tropical infections in eastern India Nephrol Dial Transplant

AbstractBackground and AimsAcute kidney injury (AKI) in tropical countries is strikingly different from the other countries with a temperate climate. The epidemiology of AKI is largely influenced by environmental factors and climatic conditions and differ significantly its outcome and the (…)
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#1777 Proteomic profiling of laser capture microdissection kidneys from diabetic nephropathy patients Nephrol Dial Transplant

AbstractBackground and AimsDiabetes nephropathy (DN) remains the primary cause of end-stage renal disease (ESRD), warranting equal attention and separate analysis of glomerular, tubular, and interstitial lesions in its diagnosis and intervention. This study aims to identify the specific (…)
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#1786 Correlation of electrolyte disturbances in community-acquired acute kidney injury Nephrol Dial Transplant

AbstractBackground and AimsAcute renal injury can cause electrolyte disorders that increase patient morbidity and mortality. There are few data in the literature describing these alterations and the possible correlation between them in patients with community-acquired AKI (CA-AKI).The purpose of (…)
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#3051 Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a case report Nephrol Dial Transplant

AbstractBackground and AimsProliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is an entity characterized by glomerular deposition of monoclonal immunoglobulins, typically IgG. Recently, a cohort of 17 patients presenting with light chain only variant of PGNMID was (…)
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#2518 The decrease of the filtration slit density, not proteinuria, is the early indication of the filtration barrier dysfunction Nephrol Dial Transplant

AbstractBackground and AimsIntact podocyte foot processes (FP) play a crucial role in ensuring proper selective filtration in the kidney. Changes in FP morphology are thought to be the initial trigger for proteinuria, but definitive proof is still missing. As FP structures are below the optical (…)
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#865 Autologous cephalic vein transposition in the placement of forearm arteriovenous fistulas Nephrol Dial Transplant

AbstractBackground and AimsThe autologous vein transposition was commonly used for hemodialysis vascular access (VA) in selected patient. The saphenous vein was used as a vascular graft; while, the contralateral cephalic vein was used as a bridge. We describe a new technique of autologous (…)
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#2922 The role of urinary extracellular-derived miRNAs dysregulation in IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is one of the most common forms of glomerulonephritis and causes hematuria and proteinuria by damaging the mesangial and podocyte cells. Urinary extracellular vesicles (uEVs) derived from damaged podocytes may reflect podocyte damage in various (…)
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#1703 Role of early AV fistula creation among elderly and its impact on estimated decline in GFR among pre dialysis patients Nephrol Dial Transplant

AbstractBackground and AimsRecent evidence suggests that AVF creation may slow estimated glomerular filtration rate (eGFR) decline. The aim of the present study was to assess the impact of the pre dialysis AVF creation on eGFR decline and the need for dialysis, after controlling for key (…)
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#799 M1-M2 macrophages in postmortem biopsies from patients with acute kidney injury with COVID-19 compared to pulmonary bacterial sepsis Nephrol Dial Transplant

AbstractBackground and AimsAKI associated with COVID19 is highly prevalent; there is controversy if it is similar to AKI in sepsis of bacterial origin. Macrophage differentiation M1-M2 is a predictor of outcomes. Macrophage expression in kidney tissue is not known in patients with severe COVID19 (…)
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#3144 Improving care for patients on maintenance haemodialysis effectiveness: a novel multidisciplinary approach Nephrol Dial Transplant

AbstractBackground and AimsCare for patients receiving maintenance haemodialysis (MH) is critically dependent on multi-professional coordination of care for multimorbidity and complex care needs. Design and coordination of care models is an important clinical concern (Kharbanda et al., 2020). We (…)
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#2615 Altered peroxidasin expression pattern in IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsPXDN is a multifunctional heme peroxidase responsible for the crosslinking of type IV collagen protomers at basement membranes, playing a crucial role in the extracellular matrix dynamics. In renal pathophysiology, increased PXDN expression has been associated with (…)
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#2947 Exploring various approaches for assessing fatigue in patients receiving hemodialysis using the CONVINCE study population Nephrol Dial Transplant

AbstractBackground and AimsIn nephrology, there is a growing interest in identifying patients’ priorities to achieve meaningful outcomes. A particular relevant outcome in end stage kidney disease is fatigue, with prevalence ranging from 60% to 97% in patients receiving hemodialysis. Different (…)
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#2858 Immunohistochemical study reveals increased GLUT1 expression in proximal tubules of patients with acute interstitial nephritis Nephrol Dial Transplant

AbstractBackground and AimsInterstitial inflammation in acute interstitial nephritis can advance into tubular epithelial cells and produce proximal tubular dysfunction, which may be clinically expressed as renal glycosuria. Previous studies have shown that the presence of renal glycosuria in (…)
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#831 Associations of quality of life with hospitalization for infection and subsequent death in hemodialysis patients: Osaka Dialysis Complication Study Nephrol Dial Transplant

AbstractBackground and AimsHealth-related quality of life (HRQOL) as self-reported health status is known to predict mortality in hemodialysis (HD) patients. Infection is one of the major causes for death in those patients, although limited studies have examined possible associations of HRQOL (…)
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#1874 Comparative analysis of rehabilitation outcomes in hospitalized hemodialysis vs. non-hemodialysis patients: a retrospective cohort study Nephrol Dial Transplant

AbstractBackground and AimsThe hospitalization rate of patients undergoing hemodialysis (HD) is high, due to complications related to renal failure and hemodialysis treatment. Therefore, it is crucial to provide rehabilitation for hospitalized HD patients to improve their activities of daily (…)
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#400 A new notable compression source of left renal vein entrapment: the Right Renal Artery Nephrol Dial Transplant

AbstractBackground and AimsClinically, left renal vein (LRV) entrapment is almost equivalent to the nutcracker phenomenon (NCP). However, there is still much uncertainty and debate about the prevalence of NCP and its diagnostic criteria. As a particular type of LRV entrapment, the LRV (…)
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#1749 Influence of high saline diet on myocardial remodeling, microRNA-21i and NFkB expression in myocardium Nephrol Dial Transplant

AbstractBackground and AimsThere is now increased interest in the study of morpho-functional myocardial changes in excess NaCl consumption, which develop independently of AD dynamics. Myocardial remodeling may involve microRNAs that modulate gene expression at the post-transcription level. (…)
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#3038 Plasma exchange for refractory IgA Vasculitis Nephrol Dial Transplant

AbstractBackground and AimsIgA Vasculitis (IgAV) frequently has a relapsing/refractory course despite glucocorticoids and immunosuppressive therapies and the management of severe disease remains controversial [1]. Plasma exchange (PLEX) has been used as a rescue treatment in other vasculitides, (…)
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#1792 Phenotypic variability in PAX2-related nephropathies: a monocentric study Nephrol Dial Transplant

AbstractBackground and AimsPax2 mutations are known to cause kidney disease; both syndromic conditions, as kidney coloboma syndrome, and kidney specific disorders, as FSGS, have been described. Due to the rarity of Pax2-related nephropathies, data on genotype-phenotype correlation are (…)
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#1355 Albuminuria after Induction Treatment and Kidney Prognosis in ANCA-associated Glomerulonephritis Nephrol Dial Transplant

AbstractBackground and AimsPersisting proteinuria has been associated with worse kidney outcomes in ANCA-associated glomerulonephritis (AAGN). However, it remains unclear whether this reflects damage from the initial injury or ongoing inflammation.MethodA retrospective, single centre study of (…)
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#2675 Role of ANXA4 as a modifier in VHL-dependent ccRRC Nephrol Dial Transplant

AbstractBackground and AimsThe von Hippel-Lindau (VHL) syndrome is a rare genetic disease caused by inactivating mutations of the VHL tumor suppressor gene. VHL syndrome patients frequently develop clear cell renal cell carcinomas (ccRCCs). pVHL acts as the substrate recognition subunit of an E3 (…)
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#2663 Assessment of in situ alternative and classical convertases as indicators of ongoing glomerular complement activation in IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsComplement activation is involved in IgA nephropathy (IgAN), opening up new avenues for complement-targeting therapies. However, precise patient selection and optimal timing for these therapies are essential. Current diagnostic methods of complement activation in IgAN, (…)
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#1558 Mutational spectrum of X-linked hypophosphatemia (XLH) in Hungarian patients Nephrol Dial Transplant

AbstractBackground and AimsX?linked hypophosphatemia (XLH), the most common form of hypophosphatemic rickets, is caused by genetic alterations in the PHEX gene. Prevalence of the X?linked disease is ?1/20,000. The PHEX gene has 22 exons and encodes a 749 amino acid protein with homology to zinc (…)
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#1356 Kidney phenotype in interstitial lung disease associated with ANCA-vasculitis: European Multicentre Study Nephrol Dial Transplant

AbstractBackground and AimsInterstitial lung disease (ILD) in ANCA-associated vasculitis (AAV) has the appearance of a progressive fibrotic disease on imaging and primarily affects the interstitial lung compartment and is usually associated with MPO-ANCA. Whether patients with AAV-ILD display a (…)
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#1215 Association between dietary magnesium intake and incident chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsRecent studies suggest a close association between low serum magnesium levels and kidney injury. However, whether dietary magnesium intake relates with kidney function is not well known. In this study, the relationship of dietary magnesium intake with the development (…)
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#71 Dysregulation of ITGAM and ITGB2 in the pathogenesis of diabetic kidney disease—results from bioinformatics analysis and in vitro studies Nephrol Dial Transplant

AbstractBackground and AimsActivated neutrophils can release web-like chromatin structures known as neutrophil extracellular traps (NETs), but their roles in the immunopathogenesis of diabetic kidney disease (DKD) remains elusive.MethodThe characteristic NETs associated targets of differentially (…)
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#2931 Advancing personalized extracorporeal therapies for albumin bound toxins through serum albumin binding function Nephrol Dial Transplant

AbstractBackground and AimsLiver failure poses a significant clinical challenge with compromised functionality of the liver and accumulation of toxic metabolites. The lack of bedside-compatible methods to evaluate treatment response during therapy underscores the urgent need for refined (…)
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#2904 Chronic kidney disease staging in the very old: the role of cystatin C Nephrol Dial Transplant

AbstractBackground and AimsOver the past decade, an unanswered question has emerged: which is the best equation for estimating glomerular filtration rate (eGFR) in older patients with chronic kidney disease (CKD)? Despite the lack of consensus, cystatin C appears to hold promise, as it is not (…)
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#1774 ANCA vasculitis with renal involvement: age as a prognostic factor Nephrol Dial Transplant

AbstractBackground and AimsOlder patients with antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) commonly experience renal impairment and poor prognosis. The European Vasculitis Study Group trials showed that approximately 16.7% and 22.5% of older patients with AAV suffered (…)
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#2302 Bleeding risk stratification following kidney biopsy using “MAJOR BLEEDING RISK SCORE” Nephrol Dial Transplant

AbstractBackground and AimsKidney biopsy (KB) is the gold standard in diagnosing the majority of kidney diseases. While generally KB is a safe procedure, a complication rate of 6-8% has been reported, mainly bleeding. Halimi et al. proposed “The Major Bleeding Risk Score” (MBRS) identifying 11 (…)
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#2079 The impact of body composition measures on survival and cardiovascular events in patients with chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsMultimorbidity, frailty and sarcopenia are increasingly prevalent in people with chronic kidney disease (CKD). Creatinine Muscle Index (CMI) has been proposed as a novel surrogate marker of muscle mass, and lower CMI was associated with frailty and increased mortality (…)
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#1585 Ten years’ practice with calcimimetics and paricalcitol for the treatment of secondary hyperparathyroidism. Experience of one dialysis center Nephrol Dial Transplant

AbstractBackground and AimsSecondary hyperparathyroidism (SHPT) remains one of the main problems in patients with chronic kidney disease (CKD), associated with deterioration in quality of life, progression of cardiovascular complications and mortality.MethodPatients on HD (n = 2517) were treated (…)
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#1619 Factors associated with malnutrition in the very elderly with chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsThe presence of malnutrition in elderly patients with chronic kidney disease (CKD) is associated with adverse events such as mortality, functional decline, and worse outcomes during hospital admission. However, it is not well defined which subgroups would benefit most (…)
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#485 Studying the features of heart remodeling processes depending on the degree of renal dysfunction Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) and heart failure (HF) affect many people worldwide and both diseases remain associated with considerable morbidity and mortality. Aim of the study was to features of changes in cardiac remodelling parameters depending on the degree of (…)
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#2061 Perirenal fat thickness as a potential marker for cardiovascular risk in chronic kidney disease: the influence of vitamin D analogs Nephrol Dial Transplant

AbstractBackground and AimsPatients with CKD show high cardiovascular complication rates. There are classical cardiovascular risk factors, such as obesity, dyslipidemia, and diabetes; however, other cardiovascular disease risk factors are associated with mineral metabolism disorders (phosphorus, (…)
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#3096 Exploratory population-based screening of kidney function and heavy metal water source levels in a highly incident CKDu area in Guatemala Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease of unknown etiology (CKDu) has exponentially increased in the rural areas of the Pacific Coast in Central America. A multifactorial etiology has been postulated including exposure to environmental nephrotoxins such as heavy metals. The Pacific (…)
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#1816 CA 125 as a surrogate marker for plasma volume in patients with cardiorenal syndrome Nephrol Dial Transplant

AbstractBackground and AimsAssessing volume status in heart failure (HF) and end-stage chronic kidney disease (CKD) is challenging. Plasma volume expansion is an early step in the pathophysiology of decompensated HF and an independent risk factor for death and HF hospitalization, and should be (…)
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#1483 Creatinine excretion can serve more than a marker of kidney function in patients in the late postoperative period of bariatric surgery Nephrol Dial Transplant

AbstractBackground and AimsBariatric and metabolic surgery is the treatment of choice for severe obesity aiming to improve quality of life and control comorbidities, including chronic kidney disease (CKD). Careful monitoring of metabolic components, including markers of kidney function, are (…)
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#1185 Cardiovascular, renal and mortality risk by the KDIGO risk classification: the first observational study in Japan Nephrol Dial Transplant

AbstractBackground and AimsThe prevalence of chronic kidney disease (CKD) has been increasing, affecting 850 million people worldwide and 13 million individuals in Japan. CKD is a risk factor for cardiovascular complications including heart failure, and dialysis. KDIGO risk classification is (…)
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#1682 Myocardial remodeling in Wistar rats with renal dysfunction treated with a high-salt ration Nephrol Dial Transplant

AbstractBackground and AimsHigh food intake of NaCl is the traditional factor of increase in blood pressure (BP) and cardiovascular risks also hurts kidneys. The purpose of the paper is to evaluate the morphological changes in the myocardium of normotensive Wistar rats with an early stage of (…)
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#2514 Clinical impact of the CKD-EPI 2021 versus the CKD-EPI 2012 formula on GFR estimation and CKD prevalence: results from a Dutch routine-care cohort Nephrol Dial Transplant

AbstractBackground and AimsQuantifying the kidney function is crucial for diagnosing and monitoring kidney disorders in clinical practice. Recently, the CKD-EPI 2021 formula was developed for estimating glomerular filtration rate (eGFR), excluding the ethnicity variable. In this study, we aimed (…)
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#2085 Testosterone and markers of nutritional status correlate with leptin in chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsLeptin, the anorexic hormone, also appears to have a proatherogenic effect, contributing to the development of cardiovascular morbidity and mortality. Current data on factors related to serum leptin levels in different stages of chronic kidney disease (CKD) are (…)
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#1433 Geographical variation in chronic kidney disease: a nationwide cohort study in Denmark Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) represents a significant and growing global health challenge, especially among aging populations. Despite declines in mortality from other non-communicable diseases, CKD-related mortality has remained stable, underscoring the need for (…)
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#2137 Systemic inflammation as a main factor in CKD-MBD development Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is a progressive disorder that affects more than 10% of the general population worldwide. Despite great achievements in the field of treatment of CKD, patient mortality remains at a high level. Research into the pathophysiology and (…)
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#2402 Reproducibility of memory B-cell and HLA antibody detection in patients on kidney transplant waiting list Nephrol Dial Transplant

AbstractBackground and AimsDetection of HLA antibodies (HLA-Abs) impacts on the access and outcomes of kidney transplantation (KT). Currently, evaluation of HLA-Abs in serum is performed using single antigen bead assays (SAB). The analysis of circulating HLA-specific memory B cells (mBc), (…)
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#2123 Ageing, renal function and frailty: analysis of the FRASNET study Nephrol Dial Transplant

AbstractBackground and AimsFrailty is a common geriatric syndrome of significant public health importance. The kidney is one of the organs that progressively loses function with aging leading a decrease of glomerular filtration rate (GFR). In elderly the definition of eGFR threshold for the (…)
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#1167 Examination of subsets of CD4+ lymphocyte subpopulations in long-surviving renal transplant patients Nephrol Dial Transplant

AbstractBackground and AimsSubpopulations of CD4+ cells, play a major role in mediation of rejection and tolerance to a renal transplant. This study examined subsets of CD4+ T cells and CD4+CD25+CD127lo Treg in blood of renal graft recipients with grafts surviving >10 years for changes in (…)
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#1441 COVID-19 vaccination and risk of infection and subsequent death in patients with kidney disease Nephrol Dial Transplant

AbstractBackground and AimsThe effect of vaccinations against SARS-CoV-2 on risk of infection and subsequent adverse outcomes in patients with kidney dysfunction beyond end-stage kidney disease remains uncertain. Based on nationwide data from multiple health care registers, the study aims to (…)
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#3020 A novel copy number analysis identifies human patients with NPHP1 whole gene deletions in previously genetically unsolved cases Nephrol Dial Transplant

AbstractBackground and AimsGenome sequencing is rapidly becoming a routine approach to investigating inherited human diseases in clinical practice. Nevertheless, data generated from genome sequencing requires extensive bioinformatic analysis and filtering of variants to determine pathogenicity (…)
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#1181 The relationship between renal ischaemia-reperfusion injury and circadian rhythm Nephrol Dial Transplant

AbstractBackground and AimsKidney disease is a global health problem in which various aetiologies contribute to renal injury and dysfunction. Renal ischaemia-reperfusion injury (IRI) is a condition caused by early oxidative stress due to renal tissue ischaemia and a rapid immune response after (…)
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#2040 Effect of donor–recipient size mismatch on long-term graft survival in pediatric kidney transplantation: a multicenter cohort study Nephrol Dial Transplant

AbstractBackground and AimsKidney transplantation (KT) is the main treatment option for patients with end-stage kidney disease (ESKD). However, it is limited by the low number of donor organs. Moreover, donor–recipient size mismatching is a common problem in KT given the various types of donors. (…)
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#1428 Rnd3, a novel gene involved in ADPKD Nephrol Dial Transplant

AbstractBackground and AimsAutosomal dominant polycystic kidney disease (ADPKD) is an adult-onset, multi-systemic disorder, that affects ?12.5 million people worldwide. ADPKD is characterised by progressive kidney enlargement caused by uncontrollable growth of cysts, alongside extra-renal (…)
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#650 Predictive value of LKDPI on recipient's renal function one year after kidney transplantation: single-centre experience Nephrol Dial Transplant

AbstractBackground and AimsThe selection of the appropriate living kidney donor can be challenging, given the absence of a definitive method to determine the quality of the renal graft. This decision requires a delicate balance, weighing the recipient's benefits while prioritizing the safety of (…)
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#1289 The effect of desmopressin in reducing post-kidney biopsy bleeding complication in patients with reduced renal function: a randomised control trial Nephrol Dial Transplant

AbstractBackground and AimsPercutaneous kidney biopsy remains the gold standard for diagnosis of kidney disease. The incidence of bleeding complications following kidney biopsy ranges from 13 to 34%. This study aimed to evaluate the effect of prebiopsy administration of intranasal desmopressin (…)
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#2132 Recipient outcomes after laparoscopic versus open living donor nephrectomy: a propensity score-matched cohort study Nephrol Dial Transplant

AbstractBackground and AimsKidney transplantation is the optimal treatment for end-stage renal disease. To meet the growing demand for kidney allografts and to ensure the well-being of donors, laparoscopic nephrectomy has been adopted leading to superior donor outcomes. However, data on (…)
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#2988 Use of rivaroxaban for prevention of thrombotic events in patients with nephrotic syndrome Nephrol Dial Transplant

AbstractBackground and AimsPatients with nephrotic syndrome are at increased risk of thrombotic events. The risk of thromboembolism is particularly high in patients with primary membranous nephropathy, elderly patients and patients with severe hypoalbuminemia. Although increased incidence of (…)
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#621 The effect of intra-operative mean arterial pressure on early graft function in deceased donor kidney transplantation Nephrol Dial Transplant

AbstractBackground and AimsThe adequate perfusion pressure to the graft is essential for proper graft function in kidney transplantation, especially in deceased donor kidney transplantation. In particular, Mean arterial pressure (MAP) during operation can affect early graft function because MAP (…)
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#684 Safety and Tolerability of adipose-derived mesenchymal stem cell “ADR-001” in the treatment of immunoglobulin A nephropathy Nephrol Dial Transplant

AbstractBackground and AimsImmunoglobulin A (IgA) nephropathy is one of the most frequent glomerular diseases and is sometimes refractory, requiring kidney replacement therapy. Although corticosteroids are mainly used for treatment, infection is a serious adverse event, and evidence for (…)
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#189 Aortic stenosis is an independent risk factor for mortality in end-stage kidney disease patients on the transplant waitlist Nephrol Dial Transplant

AbstractBackground and AimsValvular heart disease (VHD) is a risk factor for adverse outcomes in end-stage kidney disease (ESKD) patients. However, the impact of individual valvular heart lesions on outcomes in patients on the kidney transplant waitlist is unclear. This study aims to analyse the (…)
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#254 PaCE CKD: examining health status and financial burden in patients with chronic kidney disease: assessing the non-clinical burden of disease Nephrol Dial Transplant

AbstractBackground and AimsThere is a detrimental effect of chronic kidney disease (CKD) on health states, with many patients worldwide experiencing considerable symptom burden and development of comorbidities, leading to frequent medical appointments and hospitalisations. Patients experience (…)
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#1474 COVID-19-infection in kidney transplant recipients during the omicron surge, a sigh of relief Nephrol Dial Transplant

AbstractBackground and AimsThe COVID-19 pandemic had a profound impact on global health, particularly affecting high-risk individuals such as solid organ transplant recipients (SOTRs). SOTRs have an elevated risk of severe COVID-19 disease and increased mortality. Kidney transplant recipients (…)
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#255 PaCE CKD: the impact of caregiving on health states and work productivity in chronic kidney disease: results from an international survey Nephrol Dial Transplant

AbstractBackground and AimsPatients with chronic kidney disease (CKD) often rely on informal caregivers for support with their condition, but the effect of these responsibilities on caregivers’ lives is poorly understood. The aim of this study was to quantify the effect of CKD on caregivers’ (…)
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#1436 Donor plasma cystatin C, but not creatinine, is associated with measured GFR at one year after kidney transplantation Nephrol Dial Transplant

AbstractBackground and AimsAlthough widely used during deceased kidney donor selection, donor plasma creatinine has limited capacity to predict future recipient kidney graft function. Cystatin C is a muscle-mass independent kidney function marker that could serve as alternative for this purpose. (…)
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#1321 Long term outcomes in people with fluctuating criteria for the diagnosis of chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsThe diagnostic criteria for chronic kidney disease (CKD) recognise that measures of kidney function may fluctuate in the short term by requiring that abnormalities must persist for at least 90 days to support the diagnosis. Nevertheless, studies have reported that even (…)
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#1590 Human papilloma virus vaccination rates in kidney transplant recipients Nephrol Dial Transplant

AbstractBackground and AimsKidney transplant recipients are predisposed to chronic infections and malignancies because they receive chronic immunosuppressive therapy. Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. HPV is a significant cause of cervical, (…)
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#2296 Time to get calciphylaxis on clinicians’ RaDaR?—a multicentre case series Nephrol Dial Transplant

AbstractBackground and AimsCalciphylaxis is a rare, severe complication of chronic kidney disease mineral bone disorder. It is hosphorzed by arteriolar calcification of the subcutaneous fat and dermis, and associated with a mortality rate of approximately 50% within a year of diagnosis. The (…)
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#515 The clinical utility of systematic screening using aortoiliac CT angiography before kidney transplantation Nephrol Dial Transplant

AbstractBackground and AimsSeveral guidelines suggest screening for peripheral artery disease before kidney transplantation including the Kidney Disease: Improving Global Outcomes. There is currently no consensus on whom or how to screen for peripheral artery disease. We examined the clinical (…)
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#60 Implementation of chronic kidney disease guidelines for sodium-glucose co-transporter-2 inhibitor use in primary care: a cross-sectional study Nephrol Dial Transplant

AbstractBackground and AimsThe cardiovascular and kidney benefits of sodium-glucose co-transporter-2 (SGLT2) inhibitors in people with chronic kidney disease (CKD) are well established. The implementation of updated SGLT2 inhibitor guidelines and prescribing in the real-world CKD population (…)
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#2859 Clinical and morphological characteristics of biopsy-proven kidney graft rejection in Latvia Nephrol Dial Transplant

AbstractBackground and AimsKidney transplantation is a treatment for many patients with end stage renal disease leading to increased quality of life. In last decades results in kidney transplantation have been improving, but allograft rejection remains an important clinical problem. Graft biopsy (…)
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#3080 Response to mRNA SARS-CoV-2 vaccination in kidney transplant recipients with HIV Nephrol Dial Transplant

AbstractBackground and AimsNo data exists on humoral or cellular responses to mRNA vaccines in kidney transplant recipients (KTR) with HIV. We compared these responses in HIV-positive and negative KTR, as well as in people living with HIV (PLWH) without kidney transplantation.MethodIn a (…)
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#960 Trends in eGFR and ultra-processed food intake in relationship to income among United States adults Nephrol Dial Transplant

AbstractBackground and AimsUltra-processed foods (UPF) are formulations of ingredients that are mostly of exclusive industrial use and may contain additives like artificial colors, flavors, or stabilizers. The sale and consumption of these foods has been increasing despite their associations (…)
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#2146 Gender difference in hospital-acute kidney injury epidemiology and outcome: not just a matter of sex Nephrol Dial Transplant

AbstractBackground and AimsHospital Acute kidney injury (H-AKI) is a complex entity associated with an increased risk of complications and mortality. Its occurrence and outcome are influenced by several patient and organizational-related factors.Due to the biological and genetic differences, sex (…)
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#3066 Long-term outcomes after AKI in hospitalized patients with COVID-19 Nephrol Dial Transplant

AbstractBackground and AimsAcute kidney injury (AKI) is frequent in hospitalized patients and contributes to adverse short- and long-term outcomes. We aimed to evaluate the association of AKI and long-term adverse renal events and mortality in a cohort of patients hospitalized with (…)
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#908 The effect of obesity and fat distribution on estimated glomerular filtration rate (eGFR): A Mendelian randomization and image data analysis study Nephrol Dial Transplant

AbstractBackground and AimsObesity is intimately linked to the initiation and progression of chronic kidney disease, but questions on causality still remain. The diagnosis of chronic kidney disease is often based solely on creatinine- and/or cystatin C-based estimated glomerular filtration rate (…)
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#2972 Comparison cTPE & DFPP in PIDC patients for procedure time, clinical, biological tolerance and microcosting estimation: lymphapheresis study Nephrol Dial Transplant

AbstractBackground and AimsTherapeutic plasmapheresis (TP) is an established therapy in different pathology according to international guidelines. There is different method of TP such as single plasma exchange (SPE) and Double plasmafiltration (DFPP) defined as non selective or semi selective (…)
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#1869 Acute kidney injury is associated with long-term liver-related outcomes in patients with hepatitis B virus infection Nephrol Dial Transplant

AbstractBackground and AimsHepatitis B virus (HBV) infection presents a global health burden. Despite notable advancements over recent decades, it still accounts for 42% of liver cirrhosis, 40% of hepatocellular carcinoma (HCC) and 60% of viral hepatitis-related deaths. Acute kidney injury (AKI) (…)
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#2243 The experience from the use of citric acid blood purification solution (CD) with l-ascorbic acid (Vitamin-C) in patients under HD Nephrol Dial Transplant

AbstractBackground and AimsThe use of CD offers anticoagulation with a reduced dose of heparin while the use of L-Ascorbic acid offers better management of the patients' anemia. The purpose of the study is to record the experience of using CD solution with Vitamin-C in patients with ESRD under (…)
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#2053 The third-day blood lactate levels and APACHE III are important for predicting mortality in intensive care unit patients: Physionet data Nephrol Dial Transplant

AbstractBackground and AimsIntensive care patients had higher mortality and SOFA score is used for mortality prediction. The SOFA score was developed more than 25 years ago to monitor organ dysfunction. Nowadays, blood lactate levels indicate septic shock and work as a new vital sign. This study (…)
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#1723 Genetic landscape of polycystic kidney disease in a Chinese cohort – experience using whole genome sequencing in a tertiary renal unit Nephrol Dial Transplant

AbstractBackground and AimsGenetic testing has increasingly been employed to provide definitive diagnoses and prognostic information in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). We aim to explore the genetic landscape of ADPKD in a Chinese cohort utilizing whole genome (…)
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#858 The efficacy of preoperative ultrasound mapping prior to arteriovenous fistula creation: a meta-analysis and systematic review Nephrol Dial Transplant

AbstractBackground and AimsCurrent literature presents conflicting evidence regarding the benefits of Color Doppler Ultrasound (DUS) in the preoperative vascular mapping of arteriovenous fistula (AVF) for haemodialysis. Thus, we conducted a systematic review and meta-analysis of RCTs to evaluate (…)
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#1498 Higher body mass index in patients with diabetes mellitus and hemodialysis associated with a better survival in contrast to peritoneal dialysis Nephrol Dial Transplant

AbstractBackground and AimsThe association between Body Mass Index (BMI) and the risk of mortality in patients with end stage renal diseases and dialysis treatment is debated. The aim of this study was to assess the association between BMI and the risk of all-cause mortality in patients with (…)
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#2406 Echocardiographic characteristics of autosomal dominant polycystic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsCardiovascular complications in patients with autosomal dominant polycystic kidney disease (ADPKD) are one of the most frequently investigated extrarenal manifestations. The results are many times contradictory. This is caused by a limited size of studied populations (…)
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#2438 ADPKD and collagen genes (COL4A3, COL4A4, COL4A5) Nephrol Dial Transplant

AbstractBackground and AimsFamilial hematuria diseases are a heterogeneous group of monogenic conditions caused by mutations in one of the collagen IV genes: COL4A3 (2q36.3), COL4A4 (2q36.3), and COL4A5 (Xq22.3) that are expressed in the glomerular basement membranes (GBM) and are responsible (…)
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#654 Double-blind randomised controlled trial of nitrate-replete beetroot juice on blood pressure in autosomal dominant polycystic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsHypertension in autosomal dominant polycystic kidney disease is in part mediated by reduced polycystin-regulated nitric oxide synthase activity. In this study, the hypothesis that beetroot juice (BRJ, a rich natural dietary source of nitrate) reduces blood pressure in (…)
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#2556 Therapeutic monitoring in patients with APRT deficiency using UPLC-MS/MS-based plasma assay Nephrol Dial Transplant

AbstractBackground and AimsAdenine phosphoribosyltransferase (APRT) deficiency is a rare disorder of purine metabolism, characterized by urinary excretion of the poorly soluble 2,8-dihydroxyadenine (DHA), leading to nephrolithiasis and chronic kidney disease (CKD). Treatment with xanthine (…)
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#662 Characterization of novel gene mutation sites associated with autosomal dominant polycystic kidney disease on 19 chromosomes Nephrol Dial Transplant

AbstractBackground and AimsAutosomal dominant polycystic kidney disease (ADPKD) is the most common single-gene inherited kidney disorder, affecting approximately 1 in 500-1000 newborns and often leading to end-stage renal disease. It involves cyst formation in various organs, with renal (…)
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#3084 Familial nephropathy associated with a combined mutations of Alport and Nail Patella syndrome genes in the same family Nephrol Dial Transplant

AbstractIntroductionAlport syndrome is a genetic condition stemming from mutation in Type IV collagen and is characterized by kidney disease and frequently hearing loss and ocular abnormalities. Renal involvement is from an abnormality of the glomerular basement membrane with hematuria and (…)
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#2199 Kidney involvement aspects in women with Fabry disease from the Romanian cohort Nephrol Dial Transplant

AbstractBackground and AimsFabry disease (FD) is an X-linked rare lysosomal storage disease causing progressive nervous system, kidney and heart disorders. Progressive kidney impairment is common, and an important cause of morbidity and mortality. In FD females, treatment guidelines recommend (…)
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#2961 Association of polygenic risk scores for blood pressure with incidence of hypertension and chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsGenetic risk for elevated blood pressure (BP) has been associated with a higher risk of hypertension and cardiovascular disease. However, the generalizability of previous findings has been limited due to a lack of studies among Asian populations. This study aimed to (…)
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#426 “Predict-PD”: a machine learning tool to predict patient survival in peritoneal dialysis patients Nephrol Dial Transplant

AbstractBackground and AimsWith the rising prevalence of chronic kidney disease (CKD), particularly among the elderly, the need for effective renal replacement therapy has become increasingly crucial. Peritoneal dialysis (PD), recognized as a gentler alternative to haemodialysis, offers (…)
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#2009 FGF23 in patients with diabetic kidney disease and atherosclerosis Nephrol Dial Transplant

AbstractBackground and AimsDiabetes mellitus (DM) and chronic kidney disease (CKD) are risk factors for vascular atherosclerosis, a pathological process with an important inflammatory component. The coexistence of these conditions in patients with diabetic kidney disease (DKD) has additive (…)
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#1088 Interaction of general obesity and abdominal obesity with frailty in patients with chronic kidney disease: a nationally representative analysis Nephrol Dial Transplant

AbstractBackground and AimsGeneral and abdominal obesity are prevalent, with established associations to frailty in the elderly. However, few studies investigated these associations in patients with chronic kidney disease (CKD), yielding inconsistent results. We explored the relationship between (…)
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#2099 Long term outcomes in chronic kidney disease patients with heart failure with preserved ejection fraction Nephrol Dial Transplant

AbstractBackground and AimsHeart failure (HF) is frequent in chronic kidney disease (CKD) and leads to high morbidity and mortality in this patient category. The aim of our study is to assess the clinical and biological profile, and outcomes in CKD patients with preserved left ventricular (…)
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#1657 Impact of cumulative fluid and sodium imbalance exposure on cause-specific mortality in hemodialysis Nephrol Dial Transplant

AbstractBackground and AimsEven mild fluid overload and prolonged exposure to salt excess showed to be associated with all-cause mortality in hemodialysis patients. This analysis aims to estimate the effect of fluid and sodium imbalance on cause-specific mortality.MethodThe study followed 68,196 (…)
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#635 Effect of multi-biomarker panels based on urinary N-terminal osteopontin on prediction of diabetic kidney disease in patients with diabetes mellitus Nephrol Dial Transplant

AbstractBackground and AimsDiabetic kidney disease (DKD), occurs in 20–40% of patients with diabetes mellitus (DM), is the leading cause of end-stage renal disease (ESRD). DKD is a clinical diagnosis mainly based on the persistent albuminuria and reduced estimated glomerular filtration rate (…)
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#329 Effectiveness of dosing strategies of polymyxin B among sepsis patients with and without renal replacement therapies Nephrol Dial Transplant

AbstractBackground and AimsDespite numerous population pharmacokinetic studies on polymyxin B, a gap exists in establishing uniform dosing strategies among sepsis patients due to various clinical and patient related factors. The International Consensus guidelines, provide detailed dosing (…)
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#347 Long-term effectiveness of a village doctor-led multifaceted strategy on blood pressure control: a cluster randomized trial Nephrol Dial Transplant

AbstractBackground and AimsWe tested the effectiveness of a village doctor-led multifaceted strategy on blood pressure (BP) control over 36 months among patients with hypertension in rural China. Village doctors are community health workers who provide basic primary health care in rural (…)
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#1751 Validation of the ReDO Death Score in a Portuguese cohort Nephrol Dial Transplant

AbstractBackground and AimsMortality within the first year after dialysis start is estimated to be 20-30%, and it is mostly due to cardiovascular disease. Prognostic assessment after starting hemodialysis is challenging. Clark et al. developed the Recovery and Death Outcome risk score, which (…)
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#803 Identification and validation of immune and cuproptosis-related genes for diabetic nephropathy by WGCNA and machine learning Nephrol Dial Transplant

AbstractBackground and AimsAs the leading cause of chronic kidney disease, diabetic kidney disease (DKD) is an enormous burden for all healthcare systems around the world. However, its early diagnosis has no effective methods.MethodFirst, gene expression data in GEO database were extracted, and (…)
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#472 Cardiorenal relations in patients with chronic heart failure Nephrol Dial Transplant

AbstractBackground and AimsTo study the functional state of the kidneys and cardiorenal relationships in patients with chronic heart failure, depending on the representation of components of metabolic syndromeMethodTo achieve the objectives, 227 male patients with chronic heart failure (CHF) of (…)
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#1189 ?orrelations between laser doppler flowmetry spectral indicators and glycated hemoglobin level in patients with diabetic nephropathy Nephrol Dial Transplant

AbstractBackground and AimsDiabetic microangiopathy is a specific vascular complication of diabetes mellitus type 2, which matters to patients' mortality and individual prognosis. Therefore, an important problem is the development of non-invasive methods for the diagnosis of diabetic (…)
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#2534 Classification of patients with acute kidney damage on the base of blood pressure value as a risk factor using a neural network Nephrol Dial Transplant

AbstractBackground and AimsIn acute kidney damage, the monitoring of hemodynamic status is best achieved by determining the blood pressure value. It is considered that the values of diastolic blood pressure in young and healthy people are constant from the aorta to the periphery, and the values (…)
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#2237 Preliminary results of Protection of Renal Function after Conversion of fast IR-Tac Metabolizers to Envarsus® study (The Protect RENvarsus study) Nephrol Dial Transplant

AbstractBackground and AimsAs shown in a proof-of-concept study, renal function of fast immediate-release tacrolimus (IR-Tac) metabolizers can recover after conversion to prolonged-release tacrolimus (LCP-Tac), whereas slow Tac metabolizers showed no benefit over a 3-year follow-up [1]. The aim (…)
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#1348 Acute kidney injury: evaluation of factors to predict the need of dialysis therapy Nephrol Dial Transplant

AbstractBackground and AimsAcute kidney injury (AKI) is a clinical syndrome with heterogeneous pathophysiological mechanisms, associated with higher morbidity and mortality risk. The existing evidence shows that an episode of AKI increases the risk of chronic kidney disease and end-stage kidney (…)
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#2238 In kidney transplant recipients, response to vaccination with Tozimameran is associated with T-cell activation, but not senescence or exhaustion Nephrol Dial Transplant

AbstractBackground and AimsResponses to vaccinations among kidney transplant recipients (KTRs) tend to be impaired compared to those of healthy individuals, a fact that can, to some degree, be attributed to their more senescent immune system profile. However, in the current literature, few data (…)
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#1900 Should we prescind of KDIGO Stage 2 in AKI severity classification? Nephrol Dial Transplant

AbstractBackground and AimsThe most worldwide used classification system for staging AKI is KDIGO-2012, it was based on a combination of the RIFLE and AKIN criteria. KDIGO severity stages are defined:Stage 1 ? in SCr by >0.3 mg/dl or increase in SCr to >1.5x baseline.Stage 2 ? in SCr ?2.0–2.9x (…)
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#3100 Adsorption membranes in continuous renal replacement therapy (CRRT) in acute renal failure associated with sepsis: preliminary clinical results Nephrol Dial Transplant

AbstractBackground and AimsAcute kidney INJURY (AKI) is a common complication (40%) in ICU patients, especially in septic patients, and it´s associated with high morbidity and mortality [2, 4].Even though sepsis-associated AKI (S-AKI) is multifactorial, the elevation of cytokines plays a major (…)
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#1148 Polycystic kidney disease—beyond PKD1 and PKD2 Nephrol Dial Transplant

AbstractBackground and AimsAutosomal dominant polycystic kidney disease (ADPKD) is a common form of hereditary kidney disease, with an estimated prevalence of 1 out of 1000 individuals worldwide. Although its key clinical manifestation is progressive formation and growth of renal cysts, (…)
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#2507 Enhancing critical care nephrology: analyzing continuous renal replacement therapy with a citrate-based anticoagulation focus Nephrol Dial Transplant

AbstractBackground and AimsContinuous renal replacement therapy (CRRT) is pivotal for managing acute kidney injury (AKI) unstable patients. However, questions persist regarding prescription and the role of anticoagulation. This study aims to examine CRRT practices, focus on citrate-based (…)
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#382 Unexpected diagnoses of ADTKD-MUC1 with the help of VNtyper Nephrol Dial Transplant

AbstractBackground and AimsAutosomal dominant tubulointerstitial kidney disease (ADTKD) due to pathogenic variants in the MUC1 gene is difficult to diagnose since these variants lie in a large variable number tandem repeats (VNTR) and require specialized genetic testing, such as SNaPshot (…)
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#787 Kidney genetics—a reproducible and curated database of kidney-disease associated genes Nephrol Dial Transplant

AbstractBackground and AimsGenetic insights are becoming increasingly influential in the understanding and treatment of various kidney diseases (KD). Hundreds of genes associated with monogenic kidney disease have been identified, providing valuable insights into their diagnosis, management, and (…)
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#1891 Evaluating the safety and effectiveness of Tolvaptan for management of adult Korean ADPKD patients (ESSENTIAL study): final report Nephrol Dial Transplant

AbstractBackground and AimsTolvaptan, a selective vasopressin V2 receptor antagonist, was first approved by Korean FDA in 2015 as a treatment option in autosomal dominant polycystic kidney disease (ADPKD). In order to prescribe Tolvaptan safely and effectively, we designed the phase 4 clinical (…)
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#1905 Sex differences in primary distal renal tubular acidosis: a single-centre retrospective study Nephrol Dial Transplant

AbstractBackground and AimsThe kidney has been described as one of the most estrogen-responsive organs after reproductive ones. Many non-X-linked renal diseases present with sex differences. Although not completely elucidated, an influence of estrogens has been described in several transporters (…)
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#2724 Renal amyloidosis cohort registry in our health area Nephrol Dial Transplant

AbstractBackground and AimsRenal amyloidosis is the pathological phenomenon of amyloid deposition in the kidney with marked differences in renal function impairment, proteinuria, need for renal replacement therapy (RRT) and exitus, depending on the protein involved.Light chain amyloidosis (AL) (…)
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#886 Prevalence and prognostic relevance of electrocardiographic abnormalities among patients with ANCA-associated vasculitis Nephrol Dial Transplant

AbstractBackground and AimsCardiovascular disease (CVD) is one of the leading causes of death in patients with ANCA-associated vasculitis (AAV). However, in current clinical guidelines, limited evidence is available to support the recommendation of AAV-specific screening for cardiovascular (…)
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#482 Implementation of trans-esophageal echocardiography in pre-transplant recipient's basic preparation Nephrol Dial Transplant

AbstractBackground and AimsKidney transplantation is the module of choice to reduce mortality in comparison with dialysis [1]. Many patients on transplant waiting list undergoing haemodialysis via central venous catheters [2]. Cardiovascular morbidity control is one of the pillars of successful (…)
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#1864 Phosphorilation of SHP-1 switch does not indicate lupus nephritis activity Nephrol Dial Transplant

AbstractBackground and AimsProtein tyrosine kinases (PTKs) are enzymes responsible for the phosphorylation of tyrosine residues in lymphocytes. In 2017, Mkaddem et al. suggested that unique PTK signatures in peripheral leukocytes (PBMC) are associated with lupus nephritis (LN) activity [1]. (…)
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#1960 Incidence of cancer in ANCA associated vasculitis (AAV) Nephrol Dial Transplant

AbstractBackground and AimsWe investigated the incidence rate and type of cancer in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in our Institute.MethodWe retrospectively included 210 patients with AAV [106 patients with microscopic polyangiitis (MPA), 93 (…)
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#3070 Machine learning glomerulonephritis diagnosis on single glomeruli Nephrol Dial Transplant

AbstractBackground and AimsDiagnostic applications of machine learning in nephropathology are only beginning to emerge. We hypothesized that we could develop a machine learning classifier for 12 different classes of glomerulonephritis with CNN and self-attention-based architectures, following (…)
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#2592 Tubular cell polyploidy is involved in kidney compensatory hypertrophy Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) affects more than 10% of the population and it is associated with high risk of death for cardiovascular causes or progression towards end stage kidney disease (ESKD) requiring dialysis or kidney transplantation. CKD is characterized by (…)
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#2231 The efficacy of anti-viral therapies for hepatitis B in kidney transplant recipients Nephrol Dial Transplant

AbstractBackground and AimsThe efficacy and long-term outcomes of anti-viral therapies used for hepatitis B treatment or prevention continue to be a challenging area in kidney transplantation practice. This study aimed to determine the effectiveness of anti-viral treatment in a hepatitis B (…)
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#2084 Biologic effect evaluation of de novo long-term release tacrolimus on metabolizer phenotype and T cell composition after kidney transplantation Nephrol Dial Transplant

AbstractBackground and AimsKidney transplantation (KTX) is the current treatment of choice in patients with kidney failure. Since immunosuppressive medication to prevent acute rejection is still needed in high doses with frequent adverse events, new strategies to achieve risk-appropriate (…)
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#1451 Calcimimetics reduce the progression of high-phosphate diet-induced tubular damage Nephrol Dial Transplant

AbstractBackground and AimsDuring chronic kidney disease (CKD) progresses, there is an increased phosphate load and the concentration of the phosphaturic hormones PTH and FGF23 rises. In patients, phosphate and FGF23 are discussed as risk factors for CKD progression. We have recently shown that (…)
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#2572 Sodium-glucose transport protein 2 (SGLT-2) inhibitors in diabetic and non-diabetic kidney transplant recipients Nephrol Dial Transplant

AbstractBackground and AimsThe beneficial effects of administering sodium-glucose transport protein 2 (SGLT2i) inhibitors in patients with Chronic Kidney Disease, with or without Type 2 Diabetes (T2D), has been proven in large randomized controlled trials. Nevertheless, there is limited data (…)
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#2723 10-hydroxy-trans-2-decenoic and nonanoic acid delayed senescence in adult renal progenitor cells and increased the anti-aging Klotho protein secretion Nephrol Dial Transplant

AbstractBackground and AimsRecent investigations have elucidated the complex system involving human adult renal stem/progenitor cells (ARPCs) and their pivotal role in maintaining homeostasis and in facilitating regenerative processes within the adult kidneys. CD133+/CD24+ ARPCs can repair (…)
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#1985 Tocilizumab in chronic active antibody-mediated rejection: a randomized controlled open-label multi-center trial (INTERCEPT study) Nephrol Dial Transplant

AbstractBackground and AimsChronic active antibody mediated graft rejection (caAMR) caused by immune-mediated injury is the leading cause of long-term graft loss in kidney transplant recipients. Nevertheless, no effective treatment exists for caAMR to date, highlighting a great unmet need for (…)
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#49 Uremic toxins and inflammation: Metabolic pathways affected in stage 5 kidney disease Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is a global health threat, affecting around 12% of the population. The uremic phenotype associated with CKD is considered a predictor for the high cardiovascular and overall mortality in these patients and inflammation is regarded as an (…)
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#2811 Factor B inhibition with iptacopan in C3 glomerulopathy recurrence after transplantation: a case presentation Nephrol Dial Transplant

AbstractBackground and AimsC3 glomerulopathy (C3G) is a clinical-pathological entity resulting from dysregulation of the alternative pathway of the complement system (APC) in the fluid phase. The recurrence risk of C3G after kidney transplantation is about 70% with high risk of graft loss. (…)
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#1496 High levels of sclerostin promote bone resorption and changes and mineral metabolism Nephrol Dial Transplant

AbstractBackground and AimsThe physiological function of sclerostin (SOST) remains unknown. It is known that SOST is produced in osteocytes and functions as an inhibitor of the Wnt/?-catenin pathway. Similarly, it is well-established that low levels of SOST lead to bone alterations affecting (…)
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#1714 The treatment of antibody-mediated rejection in kidney transplantation with recent drugs: a network meta-analysis Nephrol Dial Transplant

AbstractBackground and AimsThe recent treatments for antibody-mediated rejection (AMR) have been carried out in a small number of controlled clinical trials and are based on limited data. In recent research on AMR treatment, new drugs targeting B cells, plasma cells, the complement system, and (…)
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#3095 Pinpointing specific circulating microRNAs as putative biomarkers for chronic kidney disease and cardiovascular outcomes Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) affects over 10% of the worldwide population and entails a significant risk for cardiovascular disease (CVD), leading to an up to 500-fold increase in cardiovascular mortality in advanced stages. However, the pathophysiological mechanisms (…)
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#2258 Hypochloremia and inflammation in a cohort of patients undergoing cardiac catheterization: a disturbing association Nephrol Dial Transplant

AbstractBackground and AimsSerum chloride is an emerging marker of mortality in patients with hypertension, heart failure, sepsis, and chronic kidney disease. The causes of this finding are still unknown, although it is suggested that both haemodynamic and inflammatory factors may play a role. (…)
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#2742 Artificial intelligence accurately approximates MGPE dose response relationship in a North American Dialysis Population Nephrol Dial Transplant

AbstractBackground and AimsThe Anemia Control Model (ACM) is a certified medical device aimed at optimizing the management of CKD-related anemia among patients on dialysis. ACM is based on an artificial neural network (ANN) trained on over 900’000 patients treated in the European Nephrocare (…)
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#2305 Mice with a PAX2 missense variant are susceptible to experimental focal segmental glomerulosclerosis (FSGS) and display impaired glomerular repair Nephrol Dial Transplant

AbstractBackground and AimsFocal segmental glomerulosclerosis (FSGS) is a histopathologic lesion observed in chronic kidney disease characterized by scarring of the glomerulus due to the injury and irreversible loss of highly specialized glomerular epithelial cells called podocytes. Recent (…)
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#718 N-Ethylmaleimide Sensitive Factor (NSF) is essential for maintaining podocyte focal adhesion Nephrol Dial Transplant

AbstractBackground and AimsCell-matrix adhesion molecules in podocytes play a critical role in attaching these cells to the glomerular basement membrane, ensuring the proper functioning of the glomerular filtration barrier. Previous studies have shown that patients with proteinuric glomerular (…)
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#861 Intradialytic oxygen saturation in chronic hemodialysis patients—results from a large U.S. population Nephrol Dial Transplant

AbstractBackground and AimsThe study of intradialytic oxygen saturation (SO2) in hemodialysis (HD) patients is a significant yet under-explored area. This study's objective was to evaluate the epidemiological aspects of SO2 during HD. MethodSO2 levels during HD were measured using the Crit-Line (…)
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#57 Tubular biomarkers in proteinuric kidney diseases Nephrol Dial Transplant

AbstractBackground and AimsProteinuria is not only a biomarker of chronic kidney disease (CKD) and a risk predictor of adverse outcomes but also a driver of kidney disease progression. The excessive filtration of plasma proteins through the glomerular filtration barrier exerts a toxic effect on (…)
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#2225 Educational level and gender are associated with emotional well-being in a cohort of Dutch dialysis patients Nephrol Dial Transplant

AbstractBackground and AimsPatients undergoing dialysis have an impaired health-related quality of life (HRQOL). There are conflicting data from small series whether patient-related factors such as educational level have an impact on experienced HRQOL. The aim of this study was to investigate (…)
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#520 Trends in kidney replacement therapy in Central and Eastern Europe—data from the ERA Registry Nephrol Dial Transplant

AbstractBackground and AimsDespite huge efforts to accomplish equitable access to high-quality healthcare, large disparities in kidney care delivery remain across Europe. Economic factors are considered to be the driving force behind differences in access to kidney replacement therapy (KRT), (…)
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#1656 Ezetimibe improves diabetic nephropathy by upregulating Nrf2 to alleviate endoplasmic reticulum stress Nephrol Dial Transplant

AbstractBackground and AimsDiabetic nephropathy (DN), a prevalent complication of diabetes mellitus, stands as the primary contributor to chronic kidney disease and end-stage renal disease. The progression of diabetic nephropathy is facilitated by endoplasmic reticulum stress and the excessive (…)
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#1635 In hemodialysis patients, COVID-19 vaccination mitigates the variability of clinical and laboratory variables Nephrol Dial Transplant

AbstractBackground and AimsDespite prior studies on the clinical impact of COVID-19 and the documented efficacy of COVID-19 vaccinations in hemodialysis (HD) patients, the exact effects of COVID-19 vaccinations on various clinical biomarkers before and after the diagnosis of COVID-19 have not (…)
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#2372 Investigating the effects of low-level and transient DNA damage on kidney health in a novel mouse model of aging Nephrol Dial Transplant

AbstractBackground and AimsIncreasing life expectancy worldwide underscores the importance of addressing the effects of aging on organ and cell function. Aging is characterized by a gradual decline in organ function that varies among individuals and is influenced by lifestyle choices and various (…)
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#2155 Evaluating the health-related quality of life of patients undergoing haemodialysis: highlights from a multicentric nationwide study Nephrol Dial Transplant

AbstractBackground and AimsHaemodialysis (HD) represents the most common renal replacement therapy for end-stage renal disease worldwide. Despite recent advances in HD the health-related quality of life (HRQoL) should be monitored in conjunction with clinical variables to optimize a (…)
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#2809 Peroxiredoxins, the potential predictor of eGFR decline in patients with IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsMultiple factors may contribute to development and progression of glomerulopathies (GN), one of them is oxidative stress (OS). 2-cysteine-peroxiredoxins (PRDXs) possess the ability to reduce excessive levels of OS mediators and are crucial for cellular OS regulation. (…)
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#968 Impact of the presence of acute kidney injury at the time of renal biopsy on long-term prognosis of IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy is the most common primary glomerular disease and an important cause of end-stage renal disease. Factors such as decreased renal function, persistent proteinuria, hypertension, and older age predict a poor prognosis in IgA nephropathy. Current (…)
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#2535 Development of a patient-centered outcome strategy for the CONVINCE trial Nephrol Dial Transplant

AbstractBackground and AimsPatient-centered outcomes play an important role when assessing treatment effects. Patient-reported outcome (PRO) measures assessing symptoms and impacts are important tools to capture the patient perspective in clinical trials. However, careful consideration is needed (…)
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#388 IONIS-FB-LRx, an antisense oligonucleotide to complement factor B for treatment of IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsPathogenesis of IgA nephropathy (IgAN) is known to be dependent upon multiple factors, one being the complement system. Since overactivity of the complement Alternative Pathway (AP) has been proposed to contribute to pathogenesis of IgAN, it has been hypothesized that (…)
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#2628 A haemodialysis patient-centred model of care with a multidisciplinary programme: what is its clinical and health efficiency impact? Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) constitutes a public health concern due to its notable morbidity & mortality and associated costs. The Patient Care Coordination program (PCC) provides comprehensive and personalized care to haemodialysis (HD) patients. This study (…)
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#844 Renal manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: an updated systematic review Nephrol Dial Transplant

AbstractBackground and AimsImmune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a systemic autoimmune genetic disorder caused by mutation of the forkhead box protein 3 (FOXP3) gene. We performed this study to analyze the clinical and demographic characteristics of (…)
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#2401 Association of clinical characteristics with relative changes in plasma lyso-Gb3 levels by enzyme replacement therapy in patients with Fabry disease Nephrol Dial Transplant

AbstractBackground and AimsEnzyme replacement therapy (ERT) is an established treatment for Fabry disease (FD), notably for its efficacy in reducing plasma globotriaosylceramide (Gb3) levels. FD is characterized by the accumulation of Gb3 in lysosomes, resulting in the formation of (…)
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#1507 Genetics in suspected cases of hereditary kidney diseases Nephrol Dial Transplant

AbstractBackground and AimsHereditary kidney diseases are the fifth cause of chronic kidney disease (CKD). They are responsible for around 10% of adults with kidney replacement therapy. Genetic testing in suspected cases allows us to make a definitive diagnosis, prognosis, therapeutic options (…)
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#234 Clinical spectrum and genetic variants of Alport syndrome and thin basement membrane nephropathy—single center experience Nephrol Dial Transplant

AbstractBackground and aimsAlport syndrome (AS) and thin basement membrane nephropathy (TBMN) are genetically heterogeneous kidney diseases that manifest with kidney involvement, AS also with hearing and visual impairment. Electron microscopic examination shows characteristic ultrastructural (…)
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#1344 Molecular signatures of assembloids generated from stem cell derived nephron progenitors and ureteric bud cells as potential kidney organoid therapy Nephrol Dial Transplant

AbstractBackground and AimsNovel therapies are needed to address the unmet clinical need of patients suffering from end stage kidney disease (ESKD) and cell therapy is an innovative strategy to deliver effective, curative treatment options to renal patients. There are several reports that have (…)
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#1957 Microbial and metabolomic remodeling by Sichuan dark tea-based formula improves obesity-induced renal lipid metabolism disorder in mice Nephrol Dial Transplant

AbstractBackground and AimsThe theory of medicine-food homology is long-standing and has been widely applied in traditional Chinese medicine. The Sichuan dark tea-based medicated dietary formula (alternatively referred to as Qing, or clarity in Chinese) is previously used for its lipid-lowering (…)
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#1825 Treating hyperphosphatemia in CKD via targeting Npt2a in the kidney Nephrol Dial Transplant

AbstractBackground and AimsTargeting the renal sodium phosphate cotransporter 2a (Npt2a) offers a novel strategy for treating hyperphosphatemia in chronic kidney disease (CKD). In patients with and without reduced kidney function, hyperphosphatemia is associated with cardiovascular complications (…)
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#1551 The presence of proteinuria is associated with impaired cerebral oxygenation during exercise in chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsCognitive impairment and reduced exercise tolerance are common in patients with chronic kidney disease (CKD), in part due to reduced brain function. Cerebral perfusion and oxygenation are significant determinants of brain activation and have been shown to be (…)
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#2909 Molecular mechanisms of early vascular damage in children with chronic renal failure Nephrol Dial Transplant

AbstractBackground and AimsThe risk of developing cardiovascular disease is exceedingly high in patients with chronic kidney disease (CKD), therapeutic options are limited. In order to develop specific therapies, a comprehensive molecular understanding of the underlying pathomechanisms is (…)
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#2069 Elucidating the function of novel Arg1+/Clec4d+ scar-associated monocyte-derived macrophage population in driving fibrosis in kidney disease models Nephrol Dial Transplant

AbstractBackground and AimsFibrosis is the final common pathway in all progressive kidney disease. Macrophages are a major myeloid cell component of the renal mononuclear phagocyte system, with roles in defence against infection, renal injury, and repair. Using single-cell RNA sequencing, we (…)
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#1750 Burden and excess risk of adverse outcomes in patients with type 1 diabetes utilizing KDIGO classification: a national cohort study Nephrol Dial Transplant

AbstractBackground and AimsOur investigation was motivated by the underutilization of the “Kidney Disease Improving Global Outcomes” (KDIGO) classification in evaluating the burden and impact of renal and cardiovascular (CV) adverse outcomes in individuals with type 1 diabetes mellitus (T1DM). (…)
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#1186 Novel T-cell subsets as early non-invasive biomarkers of vascular damage in chronic kidney disease progression Nephrol Dial Transplant

AbstractBackground and AimsThe exploration of early biomarkers for diagnosing vascular alterations in CKD-MBD holds significant clinical potential. Previous evidence has demonstrated profound alterations in immune cell populations linked to vascular homeostasis in CKD dialysis patients. This (…)
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#1081 Associations of MRI-derived kidney volume, kidney function, body composition, and physical performance in >38 000 UK Biobank participants Nephrol Dial Transplant

AbstractBackground and AimsKidney volume is used as predictive and therapeutic marker for several clinical conditions. However, there is a lack of large-scale studies examining the relationship between kidney volume and various clinicodemographic factors, including kidney function, body (…)
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#1322 VEGF therapy improves cardio-renal pathophysiology in a novel model of CKD-HFpEF Nephrol Dial Transplant

AbstractBackground and AimsPatients with chronic kidney disease (CKD) have a higher risk of developing heart failure with preserved ejection fraction (HFpEF). We developed a model of CKD-HFpEF and showed that renal-cardio pathophysiology is associated with decreased expression and availability (…)
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#2692 Mayo Clinic Chronicity Score: a helpful tool to establish the prognosis of patients with chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsKidney biopsy is a useful tool to establish the diagnosis and provide information about the activity and chronicity of kidney disease. Chronic changes are generally irreversible and act as a prognostic marker. The Mayo clinic chronicity score (MCCS) standardizes and (…)
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#2755 NURTuRE-CKD: outcomes by primary renal diagnosis Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) represents a major global healthcare challenge, affecting approximately 850 million people worldwide [1], and is an independent risk factor for the progression to kidney replacement therapy (KRT) and all-cause mortality [2]. However, CKD (…)
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#3043 Epidemiology of infective endocarditis in long term hemodialysis patients in France, from 2014 to 2019 Nephrol Dial Transplant

AbstractBackground and AimsInfective endocarditis (IE) is a frequent pathology among patients treated with long-term hemodialysis (HD). Its epidemiology and risk factors are scarcely reported in this specific population in France. This study aims to describe the frequency and characteristics of (…)
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#2280 Kidney elastometry, X-flow algorithms to interrogate adult and pediatric number of nephrons Nephrol Dial Transplant

AbstractBackground and AimsStandard ultrasound mainly provides information about structural changes in the kidney, whereas parenchymal Doppler ultrasound provides the renal resistance index (RI), which correlates with plasma creatinine levels. Unfortunately, in the case of isolated proteinuria (…)
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#676 Correlation between dietary live microbe intake and all-cause mortality based on baseline characteristics: results from NHANES 2011-2018 Nephrol Dial Transplant

AbstractBackground and AimsThe gut microbiome plays a beneficial role in human health, including kidney function and chronic kidney disease progression. Potential therapeutic strategies for CKD and hypertension that target the gut microbiota include dietary interventions, mainly probiotic, (…)
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#1737 Kidney function, kidney function decline, and the risk of abdominal aortic aneurysm: the Stockholm CREAtinine Measurements (SCREAM) project Nephrol Dial Transplant

AbstractBackground and AimsSmall, cross-sectional, cohort studies suggest a relationship between low estimated glomerular filtration rate (eGFR) and risk of developing abdominal aortic aneurysm (AAA). We here explored the possible association between eGFR and annual eGFR decline with future risk (…)
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#553 Renal tubular damage is an independent risk factor for all-cause and cardiovascular mortality in a community-based population: the Takahata Study Nephrol Dial Transplant

AbstractBackground and AimsRenal tubulointerstitial damage is a risk for renal failure. However, the association between renal tubulointerstitial damage and all-cause and cardiovascular mortality in the general population remains unclear. In this prospective cohort study, we examined this point (…)
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#1481 Renin-angiotensin-aldosterone system inhibitor (RAASi) optimisation after initiating outpatient SZC therapy: the GALVANIZE RAASi real-world study Nephrol Dial Transplant

AbstractBackground and AimsHyperkalaemia often occurs in patients with comorbidities that are treated with renin-angiotensin-aldosterone system inhibitors (RAASi), e.g., chronic kidney disease (CKD), heart failure or resistant hypertension. However, RAASi use can exacerbate hyperkalaemia. The (…)
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#2818 Clinical outcomes of a pre-dialysis cohort in a tertiary renal centre in the United Kingdom Nephrol Dial Transplant

AbstractBackground and AimsPatients with advanced chronic kidney disease (CKD) require significant resources in order to manage the complications of CKD, and provide education and planning for renal replacement therapy (RRT). To better gauge the clinical trajectory of these patients, we aimed to (…)
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#853 Kidney-protective medication and risk of adverse clinical outcomes in patients with chronic kidney disease: preliminary findings from DISCOVER CKD Nephrol Dial Transplant

AbstractBackground and AimsRenin-angiotensin-system inhibitors (RASi) have been a foundational therapy in chronic kidney disease (CKD) for several decades. Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have also emerged as a critical disease-modifying therapy in CKD, with contemporary data (…)
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#2144 Expression profile induced by TGF-?1 in senescent human peritoneal mesothelial cells is less pronounced than in young cells Nephrol Dial Transplant

AbstractBackground and AimsTransforming growth factor ?1 (TGF-?1) is a recognized driver of both mesothelial-to-mesenchymal transition (MMT) and cellular senescence observed in vitro in human peritoneal mesothelial cells (HPMCs), and have a significant role in adverse peritoneal remodelling of (…)
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#208 Obesity is associated with incident chronic kidney disease in individuals with normal renal function Nephrol Dial Transplant

AbstractBackground and AimsObesity is a representative modifiable risk factor for chronic kidney disease (CKD). This study aimed to investigate whether both body mass index (BMI), waist-to-hip ratio (WHR) and changes of WHR during follow-up are risk factors for development of incident (…)
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#1616 Pregnancy and fetal outcome in women with Alport syndrome Nephrol Dial Transplant

AbstractBackground and AimsPregnancy in patients with CKD is associated with maternal and fetal risks. The data about pregnancy outcome in Alport syndrome (AS) is limited. The aim was to evaluate the fetal and maternal pregnancy outcome in women with AS.MethodOne center retrospective study (…)
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#2485 CellMatchR—RNA-seq based matching of kidney cell lines to kidney reference cell types Nephrol Dial Transplant

AbstractBackground and AimsCultured kidney cell lines are broadly used to model the physiology and pathophysiology of the kidney. Due to immortalization, passaging and culture conditions, a cell line's gene expression profile might differ greatly from the primary cells it was originally derived (…)
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#1556 An unusually high prevalence of TMEM67 c.1843T>C (p.Cys615Arg) variant in Russia Nephrol Dial Transplant

AbstractBackground and AimsA hypomorphic TMEM67 variant c.1843T>C (p.Cys615Arg) (rs201893408) is associated with an autosomal-recessive condition characterized by a combination of nephronophthisis and liver fibrosis, and, in some cases, neurologic manifestations. According to the gnomAD (…)
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#2215 Early molecular and cellular features of aortic remodeling in a mild CKD-MBD model with low bone turnover Nephrol Dial Transplant

AbstractBackground and AimsVascular calcification associated with a maladaptive bone response is common in CKD and is a major cause of mortality (up to 60% depending on CKD stage). Alterations in several intracellular signaling pathways have been reported during the cellular phenotype transition (…)
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#3124 How well do risk assessment guidelines perform for ADPKD? Nephrol Dial Transplant

AbstractBackground and AimsThe approval of Tolvaptan for treatment of ADPKD heralds a new era when mechanism-based therapy is now possible. However, Tolvaptan is an expensive drug associated with potentially serious side effects and is currently reserved for patients at high-risk for progression (…)
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#636 A phase 4, open label, multicenter prospective study of the safety and efficacy of agalsidase beta in Chinese patients with Fabry disease Nephrol Dial Transplant

AbstractBackground and AimsFabry disease (FD) is a rare inherited lysosomal storage disease caused by pathogenic GLA gene variants which result in a deficiency of the enzymatic activity of ?-galactosidase A. Enzyme replacement therapy (ERT) is the mainstay of FD-specific treatment, but there are (…)
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#1515 Myocardial remodeling is associated with redistribution of phosphate, PIT1/ERK1/2 up-regulation and signaling pathways alterations in mild CKD model Nephrol Dial Transplant

AbstractBackground and AimsPatients with CKD have significantly increased cardiovascular risk, and heart failure is a leading cause of morbidity and mortality in these patients. Myocardial hypertrophy is a hallmark of cardiac remodeling and dysfunction in CKD and is known to be mediated by (…)
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#1368 Podocytopathy associated with IgA nephropathy: is it really a prognostic factor? Nephrol Dial Transplant

AbstractBackground and AimsSince 2017, the clinical value of podocyte injury in IgA nephropathy (IgAN) has been studied, the presence of podocyte hypertrophy and tip- lesions are markers of podocyte damage. It has been observed that these histological findings tend to be treated with (…)
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#1293 Endothelial calcification induced by high-phosphate is characterized by mesenchymal and osteoblastic transdifferentiation Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is a prevalent condition that affects millions of people. Patients with CKD have an increased cardiovascular risk, mostly due to vascular calcification (VC). By now, it's quite clear how, in vitro and in vivo, vascular smooth muscle cells (…)
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#1422 Exploring BAFF, APRIL, and clinical characteristics in IgA nephropathy: a decade-long study in the Bulgarian population Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) represents a significant global health concern, contributing substantially to chronic kidney disease and renal failure. Despite its widespread impact, the Bulgarian population lacks comprehensive epidemiological data and specific biomarkers for (…)
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#2421 Kidney injury in scleroderma: serum level of fibroblast growth factor-23, klotho and neutrophil gelatinase-associated lipocalin after iloprost infusion Nephrol Dial Transplant

AbstractBackground and AimsSystemic sclerosis (SSc) is characterized by progressive derangement of the microcirculation leading to a state of chronic tissue hypoxia with release of several inflammatory cytokines such as neutrophil gelatinase-associated lipocalin (NGAL), fibroblast growth (…)
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#2659 Clinical characteristics of patients with minimal change disease (MCD) that evolved to focal sclerosing glomerulosclerosis (FSGS) Nephrol Dial Transplant

AbstractBackground and AimsMinimal change disease (MCD) and focal sclerosing glomerulosclerosis (FSGS) are both podocytopathies and are possibly diseases that lie on a similar spectrum with FSGS being the severe form. We aim to describe the clinical and laboratory parameters along with treatment (…)
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#2161 Phosphodiesterase V inhibitor attenuates the fibrotic gene expression of human renal fibroblast derived from IgA nephropathy: an in-vitro study Nephrol Dial Transplant

AbstractBackground and AimsRenal fibrosis (RF) is the final common pathway that determines the progression of many glomerular disease including IgA nephropathy (IgAN). Till date there is no definite therapy available to retard RF. Being the key mediator of fibrosis, TGF-? is being targeted in (…)
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#1941 About a case: ABBA disease in a patient with thymoma Nephrol Dial Transplant

AbstractBackground and AimsABBA (antibrush border antibody) disease is a rare autoimmune tubulointerstitial kidney disease with few descriptions in the literature. Diagnosis is based on light microscopy, immunofluorescence, electron microscopy and immunostaining for LRP2 (LDL receptor related (…)
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#2641 MiR-200b induces ZEB1 mediated upregulation of Matriptase and affects expression of podocin Nephrol Dial Transplant

AbstractBackground and AimsDiabetic kidney disease (DKD) is the leading cause of chronic kidney disease and a predominant reason for renal failure. Evidence from previous research indicates that abnormal expression of microRNAs (miRs) links closely to the occurrence and progression of (…)
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#2284 Clinical characteristics and renal survival of patients with monoclonal gammopathy of renal significance (MGRS) Nephrol Dial Transplant

AbstractBackground and AimsMonoclonal gammopathy of renal significance (MGRS) comprises a diverse group of renal disorders related to a nephrotoxic monoclonal immunoglobulin. Due to the rarity of the disease and the recent definition of MGRS-associated kidney lesions, data about long-term (…)
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#1116 Hyperuricemia worsens bacterial sepsis by suppressing neutrophil functions in CKD Nephrol Dial Transplant

AbstractBackground and AimsPatients with kidney disease, especially those on dialysis, are more susceptible to infections such as peritonitis, sepsis, pneumonia, and are at a higher risk for infection-related mortality. Pathogenic mechanisms underlying the secondary immunodeficiency in kidney (…)
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#2607 Generation of a tissue resident macrophage depleted reporter rat to examine cardiovascular homeostasis and kidney disease Nephrol Dial Transplant

AbstractCardiovascular disease (CVD) and chronic kidney disease (CKD) are currently the 1st and 10th leading cause of global mortality, respectively. By 2050, CKD is predicted to be the 5th leading cause, with most of those individuals dying of CVD. Recent single cell RNA sequencing data has (…)
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#777 Renal recovery for patients with ANCA-associated vasculitis and low eGFR in a Spanish cohort Nephrol Dial Transplant

AbstractBackground and AimsRenal failure secondary to ANCA-associated vasculitis (AAV) represents a clinical and therapeutic challenge [1]. Fifteen percent to 38% of the patients develop end-stage kidney disease within 5 years, and once patients need dialysis, 29% to 82% die or remain on (…)
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#1984 Extracellular vesicles drive loss of endothelial homeostasis in pediatric chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsCardiovascular disease (CVD) is the main cause of mortality in chronic kidney disease (CKD). However, the pathogenesis of CVD in CKD remains incompletely understood. Extracellular vesicles (EVs) emerged as mediators of inter-organ cross-talk and endothelial EVs (…)
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#281 AVF formation is a common complication of percutaneous ultrasound-guided renal biopsy: a single-center analysis of risk factors and clinical outcome Nephrol Dial Transplant

AbstractBackground and AimsPercutaneous renal biopsy is a key procedure for the work-up of renal diseases. Among the possible complications of such procedure, prevalence, risk factors and clinical outcome of arterio-venous fistula (AVF) formation is unclear. We present here a single-center (…)
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#2814 Characterization of cardiological manifestations in patients with sodium-wasting tubulopathies Nephrol Dial Transplant

AbstractBackground and AimsBartter (BS) and Gitelman (GS) syndromes are rare tubulopathies caused by mutations affecting renal NaCl transporters, resulting in similar symptoms like muscle weakness, cramps, and electrolyte imbalances, with GS also presenting with hypomagnesemia. Treatment focuses (…)
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#3001 MtDNA copy number correlates to coronary artery calcium score and biological age in kidney failure patients Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) and kidney failure are connected to increased oxidative stress and vascular calcification, which are indicators for development of comorbidities and mortality outcome. Mitochondrial (mt)DNA copy number has been reported as independent (…)
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#2639 Unraveling complement activation profiles on endothelial cells in healthy donors using an ex vivo model Nephrol Dial Transplant

AbstractBackground and AimsComplement is involved in numerous kidney diseases. However, functional approaches to properly examine individual's susceptibility to complement dysregulation are limited.MethodWe assessed ex vivo complement activation induced by sera from 38 healthy donors on resting (…)
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#395 Gut dysbiosis in ADPKD patients: a controlled pilot study Nephrol Dial Transplant

AbstractBackground and AimsGut dysbiosis has been associated with chronic kidney disease (CKD) and nephrolithiasis and may thus be a factor explaining variability of outcome in autosomal dominant polycystic kidney disease (ADPKD). However, beside a single pilot study the gut microbiome has not (…)
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#1552 The role of osteocytes in bone remodeling: comparison between biopsies from patients with osteitis fibrosa and mixed uremic osteodystrophy disease Nephrol Dial Transplant

AbstractBackground and AimsOsteocytes represent about 95% of bone cells. They are located in mineralized bone tissue and connect with each other, with osteoblasts, osteoclasts, blood vessels and bone marrow cells. These cells express several proteins that regulate phosphorus-calcium metabolism (…)
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#1677 Initiation of Vericiguat and short-term cardiovascular function improvement in heart failure patients with worsened renal function Nephrol Dial Transplant

AbstractBackground and AimsVericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is approved for treating heart failure (HF) with reduced ejection fraction (HFrEF). This study aims to assess the short-term improvement in cardio-function resulting from in-hospital initiation of (…)
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#604 Oral administration of UNI-494 ameliorates acute kidney injury in a rat model of delayed graft function Nephrol Dial Transplant

AbstractBackground and AimsThere are no FDA approved drugs for the treatment of acute kidney injury (AKI), which affects 10-15% of hospitalized patients and often results in renal transplantation or lifelong dialysis. UNI-494 is a novel nicotinamide ester derivative and selective mitochondrial (…)
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#1114 Rate and reasons for peritoneal dialysis dropout following haemodialysis to peritoneal dialysis switch: a systematic review and meta-analysis Nephrol Dial Transplant

AbstractBackground and AimsPatient outcomes can be influenced by dialysis initiation and subsequent modality choices. This systematic review and meta-analysis aimed to explore the rate and reasons for peritoneal dialysis (PD) dropout following a haemodialysis (HD) to PD switch.MethodThis (…)
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#3092 Case report: Renal cystic disease caused to heterozygous NEK8 variant in pediatric patient Nephrol Dial Transplant

AbstractBackground and AimsPolycystic kidney diseases (PKDs) are the most prevalent inherited kidney disease [1]. They are caused by pathogenic variants in genes encoding for proteins with roles in the functioning of primary cilium, a sensory organelle at the cell surface of almost all cells (…)
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#2920 Peritoneal dialysis for volume overload in heart failure: a single-center experience Nephrol Dial Transplant

AbstractBackground and AimsWhile diuretics are considered the first-line therapy to control volume overload in heart failure (HF), diuretic resistance can develop, limiting the effectiveness of pharmacological therapy. Peritoneal dialysis (PD) is a kidney replacement therapy usually implemented (…)
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#2201 Assessment of long-term cardiovascular comorbidities in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis Nephrol Dial Transplant

AbstractBackground and AimsANCA associated vasculitis (AAV) is closely correlated to elevated cardiovascular disease (CVD) rates, positioning it a one of the leading causes of death among these patients. The impact of AAV on the risk of CVD has not been described in large prospective cohorts (…)
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#2458 Factors associated with cytomegalovirus infection in kidney transplant patients: analysis from a nationwide registry data Nephrol Dial Transplant

AbstractBackground and AimsCytomegalovirus (CMV) has had a significant impact on solid organ transplantation. It can affect allograft function and increase patient morbidity and mortality. We have made several efforts to prevent CMV infection after kidney transplantation (KT), but we have not (…)
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#1771 ANXA13 protects against acute kidney injury by inhibiting TGF-?/Smad3 pathway Nephrol Dial Transplant

AbstractBackground and AimsAcute kidney injury (AKI) is a common clinical syndrome characterized by rapid loss of kidney function but with limited diagnostic and treatment options. Annexins (ANXA) are a superfamily of calcium-dependent and lipid-binding proteins involved in multiple (…)
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#829 Renoprotective effects of laxative linaclotide: inhibition of acute kidney injury and fibrosis in a rat model of renal ischemia-reperfusion Nephrol Dial Transplant

AbstractBackground and AimsAcute kidney injury caused by renal ischemia/reperfusion (I/R) is a major clinical problem in many aspects of urology fields such as kidney transplantation and partial nephrectomy, but there is no effective treatment. Linaclotide, a guanylate cyclase C agonist (…)
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#2871 Effect of parathyroidectomy on kidney function in adults with primary hyperparathyroidism Nephrol Dial Transplant

AbstractBackground and AimsMultidisciplinary guidelines recommend parathyroidectomy to slow the progression of chronic kidney disease in patients with primary hyperparathyroidism (PHPT) and an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2. However, this is a weak (…)
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#362 Dosing low, winning high: unlocking the promise of endothelin antagonism for the treatment of CKD in the zibotentan/dapagliflozin ZENITH trials Nephrol Dial Transplant

AbstractBackground and AimsThe Phase 2b ZENITH-CKD trial demonstrated that combined treatment with the endothelin A receptor (ETAR) antagonist zibotentan and the sodium-glucose co-transporter-2 inhibitor (SGLT2i) dapagliflozin yields a robust and significant reduction in albuminuria in (…)
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#1755 Cardio-protective effect of soy proteins during long-term consumption of Cynomolgus Monkeys high-saline diet Nephrol Dial Transplant

AbstractBackground and AimsHigh salt intake is accompanied by the development of cardiovascular disorders, not always associated with an increase in blood pressure (BP). Recently, it has been found that the introduction of soy protein into the diet can have some nephroprotective and (…)
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#2366 Beneficial effects of TRIM33 on myokine-mediated renal function recovery in diabetic and obese mice Nephrol Dial Transplant

AbstractBackground and AimsMyokines secreted from myocytes are related to improving metabolic diseases such as diabetes, obesity, and chronic kidney disease (CKD). Patients with diabetic kidney disease (DKD) have lower irisin levels, suggesting that a low level of irisin is a risk factor for the (…)
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#150 Effect of dapagliflozin in patients with CKD depending on primary kidney disease Nephrol Dial Transplant

AbstractBackground and AimsMultiple trials have reported that SGLT2 inhibitors reduce the risk of its primary composite outcome of kidney disease progression or cardiovascular death in a wide range of patients with CKD. Our aim was to compare effects on kidney outcomes among the different types (…)
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#1309 Case-based online medical education improves physicians’ knowledge and competence in the healthcare of patients with type 2 diabetes and CKD Nephrol Dial Transplant

AbstractBackground and AimsKidney disease, including chronic kidney disease (CKD), affects more than 850 million people globally. At least 40% of people with diabetes develop CKD, and many progress to end-stage kidney disease (ESKD) and kidney failure. Globally, diabetes is the leading cause of (…)
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#1110 The AHR antagonist CH223191 alleviates kidney injury and renal fibrosis in adenine-induced chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsThe aryl hydrocarbon receptor (AhR) is a transcription factor that can be activated by a variety of endogenous and exogenous ligands, and is involved in varieties of biological processes. It has been confirmed that the expression of AhR in kidney is elevated in chronic (…)
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#2341 WS016, a novel potassium binder: safety, tolerability and pharmacodynamics in first-in-human phase 1 healthy volunteer study Nephrol Dial Transplant

AbstractBackground and AimsHyperkalemia is a common and potentially serious medical condition in patients with chronic kidney disease and is associated with high rates of mortality. Partiromer and Lokelma are available recently, however, edema is the common adverse event resulted from the exceed (…)
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#1284 Proteinuria causes excessive proliferation and senescence in proximal tubular cells via receptor-mediated endocytosis Nephrol Dial Transplant

AbstractBackground and AimsProteinuria induces proximal tubule (PT) injury, oxidative stress, lysosomal dysfunction, and inflammation, which contribute to the progression of CKD. Cellular senescence and the associated secretory phenotype, where cells secrete proinflammatory and profibrotic (…)
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#2481 Reduction in ultra-processed food by providing medically tailored healthy food baskets to patients with CKD: the HELPFUL trial Nephrol Dial Transplant

AbstractBackground and AimsOver the past decade, there has been a growing interest in classifying foods based on the extent and purpose of industrial processing according to the NOVA system, which outlines four main food categories: unprocessed and minimally processed foods, processed culinary (…)
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#1073 Changes in endothelial function in patients with impaired central and renal hemodynamics respiratory pathology Nephrol Dial Transplant

AbstractBackground and AimsTo determine the degree of influence of endothelial dysfunction on the hemodynamics of renal and central vessels in respiratory pathology, as well as to determine the effectiveness of complex therapy regimens with carvedilol.MethodStudies were conducted in 26 patients (…)
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#206 The effect of dapagliflozin on anemia in patients with CKD Nephrol Dial Transplant

AbstractBackground and AimsSGLT2 inhibitors confer kidney and cardiovascular protection in patients with chronic kidney disease (CKD). Some studies have analyzed the effects of SGLT2is on hemoglobin levels. Potential mechanisms for rising hemoglobin include hypoxia-induced activation of HIF2?, (…)
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#1190 Expression of metabolic disorders in patients with hypertension and chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsTo study the frequency of metabolic disorders in patients with hypertension depending on the stage of chronic kidney disease (CKD).MethodThe study analyzed 594 case histories of patients with AH of I-III degree (ESC/ESH 2018). CKD stages were determined according to (…)
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#2330 Fisetin supplement ameliorates aging related changes in the kidney Nephrol Dial Transplant

AbstractBackground and AimsAs the ageing population continues to grow worldwide, aging-related diseases are becoming an excessive burden on the global healthcare system. The kidney is one of the organs most affected by aging, which undergoes changes of decreased glomerular filtration rate (GFR), (…)
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#1214 Post-kidney transplant cancer: incidence, risk factors and future perspectives. Real-world analysis of a single Italian center Nephrol Dial Transplant

AbstractBackgroundOur retrospective observational study aims to describe the epidemiology of cancer after KTx and to investigate its risk factors and the impact on therapeutic management and survival, in a big monocentric cohort of kidney transplant patients (KT-ps). The association between a (…)
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#516 Cancer after kidney transplantation in the single transplant center Nephrol Dial Transplant

AbstractBackground and AimsA retrospective analysis of peculiarities of development of malignant neoplasms in patients after kidney transplantation receiving long-term immunosuppression.MethodIn this study we evaluated incidence of malignancies observed among 718 renal transplant recipient with (…)
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#681 Bw4/6 mismatch or missing donor Bw6 allele is a risk of early acute rejection in panel reactive antibodies negative kidney transplant recipients Nephrol Dial Transplant

AbstractBackground and AimsEpitope and antibody diversity allows Bw4+ or Bw6+ patients to produce antibodies to Bw4 or Bw6 epitopes without breaking self-tolerance. This study assessed the prevalence of mismatched Bw4/6 or missing donor Bw6 allele in kidney transplant (KT) recipients with early (…)
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#2418 Effects of correction of acidosis on body composition and biochemical parameters in CKD patients on maintenance hemodialysis Nephrol Dial Transplant

AbstractBackground and AimsMetabolic acidosis is a common problem in patients of chronic kidney disease and patients on maintenance hemodialysis. In resource poor countries, due to financial constraints frequency of dialysis and compliance to medication is adversely affected. This leads to (…)
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#833 Spectrum of tuberculosis after kidney transplantation: a case-control study in a middle-endemic area Nephrol Dial Transplant

AbstractBackground and AimsTuberculosis (TB) is the leading cause of infectious-disease death worldwide. Post-transplant TB is a problem in successful long-term outcome of kidney transplantation recipients (KT) and is often associated with high morbidity and mortality. The aim of this study was (…)
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#1294 The impact of plant-based diet on renal function and metabolic profile in kidney transplant recipients Nephrol Dial Transplant

AbstractBackground and AimsControlling and reducing protein intake is the most used approach to preserve renal function in CKD patients. Compared to protein restriction alone, plant-based diets have received particular attention. However, data on the potential risks and benefits of a plant-based (…)
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#1171 Effect of methoxy polyethylene glycol-epoetin beta on delaying dialysis in anemic patients with Stage 4-5 chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsThe optimal hemoglobin (Hb) target for treating anemia in pre-dialysis chronic kidney disease (CKD) remains controversial. This study investigates the efficacy and safety of methoxy polyethylene glycol-epoetin beta, in delaying the initiation of kidney replacement (…)
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#2907 Characterization of patients needing red blood cell transfusion after kidney transplant Nephrol Dial Transplant

AbstractBackground and AimsAfter kidney transplant there is often need of red blood cell (RBC) transfusion because acute bleeding associated with surgery; or because multifactorial progressive anemization the days after. The aim of this work is to describe the characteristics of transfused (…)
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#749 Components in blood collection tubes interfere with the spectral signatures of patients with kidney disease: analysis by infrared microspectroscopy Nephrol Dial Transplant

AbstractBackground and AimsKidney disease is a worldwide public health problem, affecting between 8%-16% of the global population. Chronic Kidney Disease (CKD) is a silent disease and its detection is often late, making the treatment difficult. Considering the emerging Fourier-Transform Infrared (…)
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#2986 Patiromer for hyperkalemia in the early post-transplant period Nephrol Dial Transplant

AbstractBackground and AimsHyperkalemia is a serious condition among kidney transplant (KT) recipients, which can lead to life-threatening complications such as cardiac arrhythmias.Following kidney transplantation, the causes of hyperkalemia are multifactorial owing to graft function, excess (…)
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#2967 C-reactive protein/serum chloride ratio: a novel marker of all-cause mortality in prevalent chronic haemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsSerum chloride (Cl-) is an emerging marker of mortality in hypertension, sepsis, heart failure and chronic kidney disease. The pathophysiological mechanism is unclear, but haemodynamic and inflammatory factors have been suggested. As C-reactive protein (CRP) is an (…)
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#3048 Short and long term follow up of living Tunisian kidney donors Nephrol Dial Transplant

AbstractBackground and AimsOver the years, concerns have increased about the harmlessness of kidney donation. This is more relevant in an Arab Muslim developing country like Tunisia, where lack of cadaveric donors is continuously leading to an increase in living donor numbers. The aim of this (…)
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#2786 Effect of intradialytic virtual reality exercise program on lower limb muscle strength in patients on hemodialysis Nephrol Dial Transplant

AbstractBackground and AimsIn patients on hemodialysis, muscle weakness is highly prevalent and may lead to frailty, limitation of mobility and functional impairment. Moreover, low muscle strength was associated with an increase in mortality risk in these patients. Despite the fact that some (…)
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#1622 Minimal changes disease and myasthenia gravis: a logical association Nephrol Dial Transplant

AbstractBackground and AimsMinimal changes disease (MCD) is responsible for 10-25% of nephrotic syndrome cases in adults. It can have a primary or secondary aetiology, being associated with diseases like infections, atopy or even haematological malignancies. There is a described association (…)
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#729 Application of ChatGPT to support nutritional recommendations for dialysis patients Nephrol Dial Transplant

AbstractBackground and AimsThe rising diversity of food preferences and the desire to provide better personalized care provide challenges to renal dietitians working in dialysis clinics. To address this situation, we explored the use of a Large Language Model (LLM), specifically, ChatGPT using (…)
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#1720 Insights from sodium-glucose transport 2 (SGLT2) inhibitors treatment in patients with systemic lupus erythematosus Nephrol Dial Transplant

AbstractBackground and AimsKidney involvement is common among patients with systemic lupus erythematosus (SLE) and it is an important cause of morbidity and mortality among this population. Recently, the EULAR 2023 update of the recommendations for the management of SLE advised considering the (…)
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#2475 Glomerulonephritis associated with anti -TNF-? therapy Nephrol Dial Transplant

AbstractBackground and AimsBiologic agents like tumor necrosis factor ? inhibitors/ anti-TNF-?/, IL6 and CD80/26 are widely used in many rheumatologic diseases but these may also elicit effects on renal function. These drugs, as well as rheumatic diseases themselves, can cause autoimmune renal (…)
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#1384 Obstructive sleep apnea and fluid management in the hemodialysis: are clinicians putting existing scientific evidence into practice? Nephrol Dial Transplant

AbstractBackground and AimsObstructive Sleep Apnea (OSA) prevalence was found to be higher in an intermittent hemodialysis (iHD) population of the French-speaking Switzerland than in the general population of the same geographical area. The high prevalence of OSA in iHD patients was linked to (…)
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#2984 SLE associated fibrillary glomerulonephritis vs SLE nephritis with fibrils: can a straightforward distinction always be made? Nephrol Dial Transplant

AbstractBackground and AimsFibrillary glomerulonephritis (FGN) is an uncommon but serious kidney disease with unclear aetiology, variable prognosis, and a not well-established treatment. FGN has been associated with autoimmune diseases including SLE. Other aetiologies comprise diabetes, (…)
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#2063 Safety and efficacy of vadadustat vs darbepoetin alfa in patients on maintenance dialysis by prespecified subgroups of baseline ESA dose Nephrol Dial Transplant

AbstractBackground and AimsVadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor approved in Europe, Australia, Japan for the treatment of anemia in patients with dialysis-dependent (DD)-CKD. In the INNO2VATE global phase 3 trials in patients with DD-CKD, including 2 (…)
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#1063 Presentation, treatment, and outcome of IgA nephropathy in children: comprehensive characterization of a Croatian single centre cohort Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is a complex disease diagnosed only upon evaluation of a kidney biopsy. Since the threshold to perform this invasive procedure is higher and symptoms usually more indolent in children, the true prevalence might be underestimated, with fewer (…)
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#941 Pentraxin-3 as a marker of coronary artery disease in hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsPentraxin-3 (PTX3), a novel inflammatory biomarker, has been recognized as a predictor of cardiovascular events in the general population, including coronary artery disease (CAD). Although PTX3 is elevated in dialysis patients, its potential diagnostic value for the (…)
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#2367 Membranoproliferative glomerulonephritis preceding non-Hodgkin lymphoma recurrence : a case report Nephrol Dial Transplant

AbstractBackground and AimsGlomerulonephritis (GN) have been known to be associated with both chronic lymphocytic leukemia and non-Hodgkin's lymphoma. Membranoproliferative Glomerulonephritis (MPGN) is the most commonly reported histological diagnosis in these diseases.MethodThis report (…)
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#747 The digital intradialytic health intervention GoodRENal: feasibility and participants’ opinion Nephrol Dial Transplant

AbstractBackground and AimsPeople with chronic kidney disease on hemodialysis present many comorbidities, including malnutrition and frailty. These factors contribute to a sedentary lifestyle, cognitive impairment, and decreased emotional well-being. Intradialytic exercise with non-immersive (…)
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#2072 Impact of the GoodRENal platform on lower-limbs muscle strength in a Spanish sample Nephrol Dial Transplant

AbstractBackground and AimsPeople with chronic kidney disease on hemodialysis have low levels of physical activity and low lower-limbs muscle strength, partly due to the sedentary lifestyle, and a big number of hours sitting or in a recumbent position.The GoodRENal project aimed at creating an (…)
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#1908 Characterization of the gut mycobiome composition in patients with end-stage renal disease Nephrol Dial Transplant

AbstractBackground and AimsThe serum uremic toxins of end-stage renal disease (ESRD) patients is intricately linked to the metabolism of gut microbiota. Despite the pivotal role played by gut mycobiome in the pathogenesis of several renal diseases, limited investigations have been conducted on (…)
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#2492 The GLIM classification of malnutrition in an elderly population of patients on maintenance haemodialysis Nephrol Dial Transplant

AbstractBackground and AimsThe prevalence of malnutrition increases with age and is common in elderly patients on haemodialysis. Malnutrition increases complications, disability, mortality, length of hospital stay and healthcare costs. The Global Leadership Initiative on Malnutrition (GLIM) (…)
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#924 Characteristics and outcomes of emergency department patients with acute kidney injury (AKI) stage 2 and 3 electronic alerts at a single UK centre Nephrol Dial Transplant

AbstractBackground and AimsThe epidemiology of Acute Kidney Injury (AKI) in hospitalized and critically ill populations has been well described but less is known about AKI in the emergency department (ED) patients. Community-acquired AKI represents about a quarter of AKI events observed in the (…)
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#1312 Warfarin-related nephropathy in two patients with mechanical valves Nephrol Dial Transplant

AbstractBackground and AimsWarfarin-related nephropathy (WRN) is defined as acute kidney injury subsequent to excessive anticoagulation with warfarin. Patients with mechanical valves required long-term anticoagulant therapy, and warfarin remains the sole available option for anticoagulant (…)
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#2823 High doses and levels of cholecalciferol for secondary hyperparathyroidism in hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsVitamin D is crucial for musculoskeletal and general health. Low levels are associated with an increased risk of death and morbidity, including cancer, cardiovascular, autoimmune diseases and infections. In hemodialysis (HD) patients vitamin D deficiency plays (…)
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#1902 Remdesivir ameliorates ferroptotic renal injury in hamster after SARS-CoV-2 infection Nephrol Dial Transplant

AbstractBackground and AimsThe purpose of this study was to see how remdesivir affected renal ferroptotic damage in hamsters following a human Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. We evaluated the inhibitory effects of remdesivir on the ferroptosis of (…)
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#2895 Erythropoietin Resistance Index (ERI) between mortality and metabolic changes in a cohort of hemodialysis patients. What acts below the surface? Nephrol Dial Transplant

AbstractBackground and AimsThe management of anemia in hemodialysis patients (HD-ps) is influenced by many factors, including inflammation, martial balance (MB) and mineral metabolism (MM). Recent data would identify the Erythropoietin Resistance Index (ERI) as an indicator of mortality risk in (…)
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#3049 Differences on fatigue characterization in two distinct populations of chronic hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsChronic fatigue remains, despite all the technological advances, one of the most important symptoms in prevalent hemodialysis (HD) subjects and has a strong impact on mortality and health-related quality of life. The objective of our work was to characterize fatigue in (…)
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#1613 Gadolinium and gadoteric acid's short-term impact on kidney function and lipid profile Nephrol Dial Transplant

AbstractBackground and AimsConcerns regarding the safety of gadolinium-based contrast agents (GBCA), which are often employed in medical imaging, have been raised in light of reports of free gadolinium's [Gd (III)] cytotoxicity. It appears that GBCAs having macrocyclic structures, like gadoteric (…)
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#233 Marine n-3 polyunsaturated fatty acids and cardiovascular events in patients with end-stage renal disease receiving hemodialysis Nephrol Dial Transplant

AbstractBackground and AimsCardiovascular (CV) disease is the leading cause of death in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD). The two major marine n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may have (…)
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#1305 Analysis of clinicopathological characteristics of membranous nephropathy with concomitant malignancy and literature review Nephrol Dial Transplant

AbstractBackground and AimsIn recent years, the incidence of membranous nephropathy (MN) with malignancy has gradually increased, but the clinical and pathological characteristics of these patients are still unclear.MethodPatients diagnosed with renal biopsy-proven MN and comorbid malignancy (…)
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#3010 Characteristics of a Brazilian cohort with primary hyperoxaluria type 1 (PH1), an admixed population with different ethnic origins Nephrol Dial Transplant

AbstractBackground and AimsPrimary Hyperoxaluria type 1 (PH1) is caused by biallelic variants in the AGXT gene, leading to alanine:glyoxylate aminotransferase deficiency, hepatic overproduction of oxalate, hyperoxaluria, nephrolithiasis (NL), and/or nephrocalcinosis (NC), often progressing to (…)
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#1028 Experience with ravulizumab in atypical hemolytic uremic syndrome Nephrol Dial Transplant

AbstractBackground and AimsThe arrival of eculizumab revolutionized the treatment of Atypical Hemolytic Uremic Syndrome (aHUS). Ravulizumab also offers C5 inhibition, but with 3-4 times longer half- life. We describe the experience with ravulizumab in patients with aHUS in two scenarios: 1. (…)
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#2888 Measured glomerular filtration rate and risk of adverse outcomes in 6059 patients from the Stockholm CREAtinine Measurements (SCREAM) project Nephrol Dial Transplant

AbstractBackground and AimsEvidence on the risks of adverse outcomes associated with glomerular filtration rate (GFR) has been limited to estimated GFR (eGFR), due to limited availability of large-scale data with measured GFR (mGFR). These studies either used creatinine (eGFRcr), cystatin C (…)
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#2954 A comparative view of IgA nephropathy care across four global regions Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is a chronic, rare, and slow progressing glomerular disease. IgAN treatment currently consists of angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB), sodium-glucose co-transporter 2 (SGLT2) inhibitors, (…)
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#1993 Analysis of the characteristics of IgA nephropathy patients using real-world data from five European countries Nephrol Dial Transplant

AbstractBackground and AimsImmunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerulonephritis globally; it has a significant health burden and a highly variable disease course. As IgAN is a heterogeneous disease, it is important to appreciate the associated patient (…)
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#1942 Social deprivation and chronic kidney disease: a population based cohort study in Italy Nephrol Dial Transplant

AbstractBackground and AimsThe impact of social deprivation on the progression of Chronic Kidney Disease (CKD) to End Stage Kidney Disease (ESKD) requiring Renal Replacement Therapies (RRTs) and death has been demonstrated by large cohort studies produced both in the US and the UK. Nonetheless, (…)
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#1834 Prevalence of nephrolithiasis in patients with idiopathic hypercalciuria after two decades of follow-up Nephrol Dial Transplant

AbstractBackground and AimsIdiopathic hypercalciuria (IH) is the main metabolic abnormality that causes kidney stones. It is linked to high intestinal calcium absorption and osteopenia. However, not all patients diagnosed with IH develop kidney stones. In this study, we examined a cohort of (…)
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#613 Is there a relationship between kidney stiffness identified by 2D shear wave elastography and the estimated glomerular filtration rate? Nephrol Dial Transplant

AbstractBackground and AimsUltrasound-based elastography has been utilized as an imaging method with high utility in the liver or thyroid, but it is not yet being implemented in evaluating the chronic kidney disease (CKD) because current research indicates a high level of heterogeneity between (…)
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#1246 The impact of severe nephrotic syndrome on thyroid function Nephrol Dial Transplant

AbstractBackground and AimsNephrotic syndrome (NS) is a clinical condition characterized by massive urinary loss of proteins, mostly albumin, but also hormones and their carrier proteins among others. The most frequently reported hormonal complication is thyroid dysfunction. The study aimed to (…)
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#2509 Longitudinal haemoglobin levels and mortality in an elderly population with advanced chronic kidney disease: insights from the EQUAL Study Nephrol Dial Transplant

AbstractBackground and AimsThe relationship between haemoglobin (Hb) levels and clinical outcomes in chronic kidney disease (CKD) is more intricate than previously understood, as both low and high values can have detrimental effects. Although the association between Hb and patient outcomes is (…)
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#822 Effect of renal Doppler ultrasound on the detection of nutcracker syndrome in children presenting orthostatic proteinuria Nephrol Dial Transplant

AbstractBackground and AimsTo assess the Doppler sonographic findings of the left renal vein (LRV) in children with orthostatic proteinuria compared to normal urine children.MethodRenal Doppler ultrasound examinations were routinely performed on 50 consecutive children with orthostatic (…)
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#2740 Pregnancy outcomes in patients with IgA nephropathy and the impact of pregnancy on the renal disease Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN), the predominant primary glomerulonephritis in adults,, frequently affects women in childbearing age. There is a dearth of information about the impact of pregnancy on the outcome in IgAN especially in the Indian population where it is known to (…)
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#1137 Association between cognitive function, depressive symptoms and quality of life in older patients with severely reduced GFR and kidney failure Nephrol Dial Transplant

AbstractBackground and AimsImpaired cognitive function and reduced health-related quality of life (HRQoL) are common in older patients with chronic kidney disease (CKD) with severely reduced GFR and kidney failure. Older patients with CKD often regard HRQoL as a health priority, but it is (…)
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#509 Idiopathic nephrotic syndrome in children in Chad Nephrol Dial Transplant

AbstractBackground and AimsThe objective of our study was to describe the characteristics and outcomes of Nephrotic Syndrome (SN) in children from three major hospitals in one of the world's poorest countries, Chad.MethodThis observational, cross-sectional, descriptive, and multicenter study (…)
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#1443 Bone and mineral metabolism in patients with nephropathic cystinosis as a function of age and eGFR Nephrol Dial Transplant

AbstractBackground and AimsCystinosis-associated metabolic bone disease (CMBD) is a major challenge in the treatment of patients with infantile nephropathic cystinosis (NC). Study data are limited due to small case numbers, lack of adults or patients on renal replacement therapy and/or (…)
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#2538 Asymptomatic perirenal lymphoma: an unusual presentation of primary lymphoma Nephrol Dial Transplant

AbstractBackground and AimsIsolated perinephric lymphoma is uncommon clinicopathological entity, reported in less than 10% of cases. Although this is rare finding, every perirenal mass require prompt diagnosis and multidisciplinary approach if needed.MethodWe described a case of a asymptomatic (…)
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#1078 Prevalence of iron deficiency in patients admitted to a geriatric unit: analysis according to the stages of chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsIron deficiency (ID) is a poor prognostic factor in chronic diseases such as chronic kidney disease (CKD). Indeed, independently of anemia, ID is associated with more rapid clinical worsening of CKD and is a risk factor for mortality in this condition. In older (…)
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#2095 Genetic kidney disease in pregnancy – experience of tertiary referral hospital Nephrol Dial Transplant

AbstractBackground and AimsGenetic kidney diseases (GKD) are rarely seen in pregnancy and some diagnosis will only be made during gestation, due to a high proportion of chronic kidney diseases (CKD) of unknown etiology and recent advances in genetic testing. Genetic counseling and, when (…)
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#2570 Non-invasive blood pressure monitoring in dialysis patients using pulse wave velocity Nephrol Dial Transplant

AbstractBackground and AimsDialysis patients are at high risk of circulatory dysregulation and hypotension during treatment. Intradialytic hypotension (IDH) is a potentially life-threatening complication. The main causes are high ultrafiltration volumes and high ultrafiltration rates when (…)
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#1218 Investigating the association of chronic obstructive pulmonary disease with outcomes in patients with non-dialysis dependent chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsKidneys and lungs have a strong pathophysiological link. However, studies on the association between chronic conditions involving these two organs, chronic kidney disease (CKD) and chronic obstructive pulmonary disease (COPD), are limited. Nephrologists better (…)
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#883 P-cresyl sulphate and Indoxyl sulphate: two uremic toxins stimulating colon cancer progression in patients with chronic renal failure Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) leads to the accumulation and production of uremic toxins, such as Indoxyl Sulphate (IS) and P-cresyl sulphate (p-CS). These toxins have been found to activate various processes that promote tumor growth. The literature has reported a (…)
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#705 Survival of expanded hemodialysis and high-flux hemodialysis patients in Colombia: a cohort's study Nephrol Dial Transplant

AbstractBackground and AimsSurvival is a core outcome of hemodialysis (HD) therapy. Progressive improvement in the permeability and biocompatibility of membranes for HD, dialysis techniques and clinical processes around these therapies have been developed. Recently, expanded hemodialysis (HDx) (…)
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#953 Preliminary results of the peripheral T follicular cells and their subsets in ANCA associated glomerulonephritis Nephrol Dial Transplant

AbstractBackground and AimsT cells play crucial role in the pathogenesis of autoimmune diseases such as ANCA associated vasculitis-glomerulonephritis (AAV/GN) by secreting immune mediators and helping B cell-mediated long-lived humoral immunity development. Specific T and B cells subsets can be (…)
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#1042 A real-life experience with dapagliflozin in the treatment of patients with IgA Nephropathy at high risk of progression Nephrol Dial Transplant

AbstractBackground and AimsEven though IgA nephropathy is the most common primary glomerular disease worldwide, being accounted with 22% of kidney biopsy results in Europe and despite great advances in comprehending its pathogenesis, little has changed in the standard of care over the last (…)
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#2019 Comparing survival outcomes between hemodialysis and hemodiafiltration using real-world data from Brazil Nephrol Dial Transplant

AbstractBackground and AimsThe CONVINCE trial and others studies, demonstrates that high-dose hemodiafiltration offers a survival advantage and benefits in reducing cardiovascular complications for patients in high-flux hemodiafiltration group compared to hemodialysis.MethodWe compared the (…)
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#2291 ANCA negative vasculitis—the unmet need within small vessel vasculitis Nephrol Dial Transplant

AbstractBackground and AimsANCA negative small vessel vasculitis with renal involvement has been described in a number of cohorts. Though comprehensive studies comparing these individuals to ANCA positive patients are lacking and they are routinely excluded from clinical trials. Whilst the (…)
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#2799 Myoglobin removal by hemadsorption: ex-vivo adsorption kinetics Nephrol Dial Transplant

AbstractBackground and AimsMyoglobin, due to its molecular weight of 17 kDa and a Einstein-Stoke radius greater than expected, is classed as a middle molecular weight uremic toxin and presents a two-compartment model of distribution in the body. Rhabdomyolysis is a condition in which muscle cell (…)
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#2887 Interdialytic weight gain and low dialysate sodium concentration in patients on chronic hemodialysis: a systematic review and meta-analysis Nephrol Dial Transplant

AbstractBackground and AimsIn many patients on chronic hemodialysis, interdialytic weight gain (IDWG) is greater than 4.0%-4.5% of dry weight, the value recommended by the international guidelines. High IDWG is a condition associated with risk of all-cause mortality and hospitalization and it (…)
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#1001 Model-based profiling of bicarbonate supplementation during a hemodialysis cycle Nephrol Dial Transplant

AbstractBackground and AimsBicarbonate is delivered to hemodialysis (HD) patients via diffusion following a concentration gradient across the dialyzer membrane. However, the concentration of bicarbonate in the dialysis fluid ([HCO3]d) is usually not individualized for the specific patient's (…)
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#2549 Real world data of dapagliflozin effect on proteinuria in primary glomerulopathies in Croatia Nephrol Dial Transplant

AbstractBackground and AimsSGLT2 inhibitors, namely dapagliflozin, proved to slow progression of kidney disease in randomized clinical trials. Our aim was to assess real world efficacy of dapagliflozin on proteinuria level in primary glomerulopathies (GN).Methodadult patients with biopsy proven (…)
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#1511 The immune cell ‘signature’ of incident hypertension Nephrol Dial Transplant

AbstractBackground and AimsHypertension results from complex genetic and environmental interactions, mediated by cardiac, vascular, endocrine, and renal systems. The immune system may modulate all of these, though the exact mechanisms linking immune activation with hypertension and organ damage (…)
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#1089 Urinary Protein Biomarkers for Assessing Disease Activity and Chronicity in IgA Nephropathy Nephrol Dial Transplant

AbstractBackground and ObjectivesIgA nephropathy (IgAN) is a progressive kidney disease characterized by the mesangial deposition of galactose-deficient IgA1, leading to kidney damage and may eventually lead to end-stage kidney disease. Current treatment decisions for IgAN patients rely on the (…)
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#1040 Correlation of genotype to disease onset age and hypertension diagnosis in autosomal dominant polycystic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsAutosomal Dominant Polycystic Kidney Disease (ADPKD) is the predominant genetic disease leading to End Stage Kidney Disease (ESKD). Genetic identity could correlate to the disease profile. Correlations between genetic and phenotype characteristics in a cohort of ADPKD (…)
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#2003 Genetic association in patients with chronic kidney disease of unknown etiology: an observational study Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD), impacting over 850 million people worldwide, is a diverse group of inherited and acquired nephropathies. While only about 10% of adult CKD is hereditary, predominantly due to mutations in genes like PKD1, PKD2, and PKHD1, the etiology (…)
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#1804 Long-term outcomes of CKD patients with lupus nephritis: a nationwide cohort study Nephrol Dial Transplant

AbstractBackground and AimsHealth trajectories of patients with lupus nephritis (LN) are poorly understood in the setting of moderate and advanced chronic kidney disease (CKD). Furthermore, data on comparison of outcomes of LN to other forms of CKD are scarce. Therefore, the aim of this study (…)
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#326 Features of intrarenal hemodynamics in patients with chronic glomerulonephritis on the background of taking anticoagulants Nephrol Dial Transplant

AbstractBackground and AimsChronic glomerulonephritis (CGN)-glomerular, autoimmune kidney disease, where baseline therapy is clinically proven to be successful. The study evaluates hemodynamic disorders of renal blood flow in patients with CGN on the background of baseline treatment with the (…)
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#2633 Navigating complexity: a case report of chronic kidney disease with renal stone unravelling a rare metabolic disorder Nephrol Dial Transplant

AbstractClinical PresentationA 48-year-old female of Asian heritage was referred for renal assessment after experiencing recurrent acute kidney injury (AKI) with incomplete recovery between episodes. This was initially attributed to dehydration and interstitial nephritis stemming from (…)
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#409 Correlation between ha factor concentration and urinary syndrome in patients with chronic glomerulonephritis when using rivaroxaban Nephrol Dial Transplant

AbstractBackground and AimsConsidering the pathogenetic role of factor X of the coagulation system in the formation and progression of chronic glomerulonephritis (CGN), as well as the mechanism of action of rivaroxaban, this study examined the concentration of coagulation factor X in peripheral (…)
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#646 SGLT2 inhibitor alleviates hypomagnesemia in patients with chronic kidney disease: a retrospective observational study Nephrol Dial Transplant

AbstractBackground and AimsMagnesium (Mg2+) is a critical component in numerous biological processes. Hypomagnesemia is associated with an increased risk of cardiovascular events and vascular calcification in individuals with and without chronic kidney disease (CKD). Sodium-glucose (…)
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#971 Effects of arsenic trioxide on MMP9/IL-17A expression in lupus nephritis—results from bioinformatics analysis and in vitro studies Nephrol Dial Transplant

AbstractBackground and AimsPrevious research has indicated that ATO treatment at low doses may decrease the likelihood of flares in active systemic lupus erythematosus (SLE) patients, but the pharmacological mechanisms of such effect have not been studied.MethodMachine learning and network (…)
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#3060 Assessment of differences in management and outcomes of severe hypophosphatemia secondary to refeeding syndrome Nephrol Dial Transplant

AbstractBackground and AimsRefeeding syndrome is a severe, potentially life-threatening condition characterized by fatal shifts in fluids and electrolytes that may occur in malnourished patients receiving parenteral or enteral artificial refeeding. This condition may present with hypokalemia, (…)
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#1337 Evolution of ANCA-associated vasculitis in a population with confirmed renal involvement. Myeloperoxidase and proteinase 3 antibodies, which is worse? Nephrol Dial Transplant

AbstractBackground and AimsAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare but potentially serious diseases with high mortality. Renal involvement is frequent in AAV with patients developing end-stage renal disease (ESRD) or becoming dependent on (…)
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#1425 Anemia in patients with IgA nephropathy: an impact on the prognosis of IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsImmunoglobulin A Nephropathy (IgAN) has several well-known predictors of renal outcomes, including persistent proteinuria, hypertension, and baseline eGFR at the time of diagnosis. However, the effect of hemoglobin (Hb) levels on the progression of IgAN is rarely (…)
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#2800 AL amyloidosis with renal involvement: TAPSE and new therapies Nephrol Dial Transplant

AbstractBackground and AimsLight chain (LA) deposition amyloidosis is the most common type of renal amyloidosis. It may be associated with monoclonal gammopathy of uncertain significance (MGUS), meeting criteria for monoclonal gammopathy of renal significance (MGRS), or present in the course of (…)
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#2698 Regression of amyloid deposits after treatment with tocilizumab Nephrol Dial Transplant

AbstractBackground and AimsAA amyloidosis is a multisystem disease characterized by the deposition of serum amyloid A protein, which is secondary to chronic inflammation. Tocilizumab (an interleukin-6 inhibitor monoclonal antibody) is effective in suppressing inflammation, normalizing serum (…)
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#2267 IL-33 Inhibition with tozorakimab for diabetic kidney disease: a randomized, placebo-controlled phase 2b study Nephrol Dial Transplant

AbstractBackground and AimsIn patients with type 2 diabetes (T2D) and chronic kidney disease (CKD), persistent, low-grade inflammation is a significant risk factor for adverse kidney outcomes. Previously, we identified interleukin-33 (IL-33) as an over-expressed inflammatory cytokine in kidney (…)
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#1381 Economic evaluation of an integrated care program versus conventional care for chronic kidney disease patients in rural communities of Thailand Nephrol Dial Transplant

AbstractBackground and AimsThis study evaluates an integrated care program for chronic kidney disease (CKD), which has demonstrated effectiveness in delaying kidney function decline in the rural population of Thailand. Efficacy of the program was initially established through the ESCORT-1 study, (…)
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#3050 Hemodynamic study of hypertensive disorders in pregnancy using cardiothoracic bioimpedance Nephrol Dial Transplant

AbstractBackground and AimsHypertensive disorders in pregnancy (HDP) are a major cause of maternal and perinatal morbidity and mortality. There is still a need for the development of biomarkers for early diagnosis of the severity of the condition. Thoracic electrical bioimpedance (TEB) is a (…)
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#972 A Novel Single Compound from Chinese Herbs as a Potential Candidate for Reducing obesity induced diabetic nephropathy via ATF3-RARRES1 axis pathway Nephrol Dial Transplant

AbstractBackground and AimsBillions of people have obesity induced diabetic nephropathy. Promoting the browning of white adipose tissue has been suggested as a potential strategy for, but a drug still needs to be identified.MethodFirst, WT and ATF3 knockout mice fed a high-fat diet were treated (…)
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#1549 The effect of sglt2 inhibitors (dapaglifozin) on albuminuria in patients of diabetic nephropathy above standard of care Nephrol Dial Transplant

AbstractBackground and AimsAlbuminuria is the hallmark of diabetic nephropathy (DN) and progression of albuminuria denotes declining renal functions culminating in End Stage Renal Disease. Intensive blood glucose control (HbA1c Methodit is an observational study including patients who attended (…)
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#3023 Dietary protein intake modulates the tubular handling of the uremic retention solute indoxyl sulfate Nephrol Dial Transplant

AbstractBackground and AimsNutritional intervention constitutes a key part of the clinical management of individuals with chronic kidney disease (CKD). The gut emerged as an important source of uremic retention solutes, including indoxyl sulfate, p-cresyl sulfate and TMAO among the others. (…)
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#2528 Comparing patient-reported and performance-based physical function assessments in hemodialysis: insights from the CONVINCE trial Nephrol Dial Transplant

AbstractBackground and AimsPhysical function is a crucial outcome in nephrology. In alignment with the Patient-Reported Outcomes Measurement Information System (PROMIS) Initiative, physical function is characterized as the ability to execute activities involving physical actions, ranging from (…)
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#1664 Assessing vascular access thrombectomy service adherence to GIRFT recommendations: single centre experience Nephrol Dial Transplant

AbstractBackground and AimsStudies showed that early thrombectomy of dialysis vascular access (VA) is associated with better outcomes [1], especially for native VA [2]. Timely treatment of VA thrombosis within 24-48 hours is recommended by GIRFT to minimize access loss and requirement for (…)
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#2036 Mitochondrial copper overload promotes renal fibrosis via inhibiting pyruvate dehydrogenase activity Nephrol Dial Transplant

AbstractBackground and AimsCopper is a trace element essential for numerous biological activities, whereas the mitochondria serve as both major sites of intracellular copper utilization and copper reservoir. Pyruvate dehydrogenase complex (PDHC) is a rate-limiting enzyme of glucose oxidation in (…)
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#2646 Precision verification and method comparison of anti-MPO anti-hsPR3 immunoassay on Alegria2 instrument Nephrol Dial Transplant

AbstractBackground and AimsAntibodies to myeloperoxidase (anti-MPO) and proteinase 3 (anti-PR3) are recognized as the only clinically relevant antineutrophil cytoplasmic antibodies (ANCA) specificities so far. ANCA testing can be used in different clinical settings, especially in situations that (…)
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#211 Low albumin levels are associated with intrarenal complement C4d deposits in critically ill patients with ANCA-associated renal vasculitides Nephrol Dial Transplant

AbstractBackground and AimsDespite serum albumin levels being predictive for clinical outcome in ANCA-associated renal vasculitis, implications providing a direct link between low serum albumin levels and intrarenal lesions remain elusive. Therefore, we here aimed to systematically assess the (…)
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#1059 Value of urine transcription factor 21 as a diagnostic tool for preeclampsia Nephrol Dial Transplant

AbstractBackground and AimsPrediction of pre-eclampsia early in pregnancy can reduce its incidence and subsequent maternal and fetal morbidity and mortality. The sensitivity of current biomarkers is fair despite being used in clinical settings. Podocyturia was found to be a useful biomarker of (…)
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#2885 Thrombosis complicating the first native arteriovenous fistula: what are the risk factors? Nephrol Dial Transplant

AbstractBackground and AimsThe native arteriovenous fistula is considered the best vascular access for hemodialysis, whose ultimate complication is thrombosis. The risk factors for this complication are multiple. The aim of our work is to determine the risk factors for thrombosis of the first (…)
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#2427 A multi-targeted treatment approach to induce early remission in high-risk primary membranous nephropathy Nephrol Dial Transplant

AbstractBackground and AimsA considerable proportion of primary membranous nephropathy (PMN) patients do not achieve early clinical remission with current immunosuppression regimens. The goal of the study was to evaluate efficacy and safety of the multi-targeted treatment regimen including (…)
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#2744 Analysis of bacteremia and mortality in patients with tunneled catheter for hemodialysis: a 14-years observational study Nephrol Dial Transplant

AbstractBackground and AimsInfections are a leading cause of morbidity and mortality in hemodialysis patients. Tunneled catheters (TC) have been associated with increased risk of infection and death, but mortality rates are not widely reported. Our study aimed to analyse catheter infection-free (…)
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#1649 Obinutuzumab is effective for the treatment of rituximab-resistant membranous nephropathy Nephrol Dial Transplant

AbstractBackground and AimsMembranous nephropathy (MN) is a leading cause of nephrotic syndrome in nondiabetic adults. Rituximab has become the first-line therapy for patients with MN after the recognition of MN as an autoimmune disease. However, 40% of patients with MN do not respond to (…)
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#3076 A UK parallel cohort study on renal ANCA associated vasculitis outcomes for avacopan exposed and matched unexposed cohorts Nephrol Dial Transplant

AbstractBackground and AimsAvacopan was approved in the UK for severe ANCA associated vasculitis (AAV) in December 2022. The ADVOCATE trial found the differential effect of avacopan on kidney function was greatest in patients with the lowest estimated glomerular filtration rate (eGFR), at (…)
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#1743 Kidney outcomes associated with SGLT2 inhibitors compared to other glucose-lowering drugs: a real-world study from China Nephrol Dial Transplant

AbstractBackground and AimsCurrently, there is insufficient real-world study on the kidney outcomes of SGLT2i in mainland Chinese patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). This study aimed to investigate the association between the utilization of Sodium-dependent (…)
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#376 Self-efficacy, social support and hemodiafiltration are independently associated with better Self-Reported Health Status over time Nephrol Dial Transplant

AbstractBackground and AimsPatients with kidney disease receiving dialysis are a highly vulnerable population. Psychosocial determinants of Self-Efficacy (SE) and Social Support (SS) have been suggested as potentially important outcomes for people with end stage kidney disease. We investigated (…)
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#3008 Very low protein diet with ketoanalogues supplementation could start haemodialysis with AVF without additional CVCs insertion Nephrol Dial Transplant

AbstractBackground and AimsNutritional interventions and a low-protein diet (LPD) are a critical point in the management of chronic kidney disease (CKD). Several protein-restricted dietary regimens have been proposed in patients with end stage kidney disease: a typical LPD provides around (…)
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#2361 The influence of glucose biocompatible solutions to the clinical outcomes of patients treated with continuous ambulatory peritoneal dialysis Nephrol Dial Transplant

AbstractBackground and AimsThe use of biocompatible glucose solutions is associated with longer preservation of residual renal function and less frequent occurrence of complications in patients on peritoneal dialysis. The aim of this study was to examine the influence of conventional and (…)
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#2691 Treatment naive membranous nephropathy patients treated with rituximab in COVID19 era Nephrol Dial Transplant

AbstractBackground and AimsStandard of care of high-risk idiopathic membranous nephropathy patients is immunosuppressive treatment with cyclophosphamide and corticosteroids or rituximab. Our aim was to assess outcome and safety of rituximab therapy in COVID19 era in comparison to modified (…)
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#494 Analysis of technique failure and reasons for the end of follow-up in a peritoneal dialysis unit Nephrol Dial Transplant

AbstractBackground and AimsCurrently, there are various definitions for peritoneal dialysis technique failure, and several related factors are described. There is controversy regarding whether mortality should be considered a form of technique failure or not, as it involves an event of a (…)
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#2075 Impact of chronic obstructive pulmonary disease on the outcomes of hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsChronic obstructive pulmonary disease, COPD, is a common cause of morbidity and mortality. Comorbidities are frequent among COPD patients, some of which are explained by shared risk factors of smoking and increased age. Chronic kidney disease, leading to end-stage (…)
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#1833 Analysis of clinical and laboratory manifestations in different classes of lupus nephritis—a Serbian single center experience Nephrol Dial Transplant

AbstractBackground and AimsLupus nephritis represents one of the most serious manifestations of systemic lupus erythematosus. The gold standard for determining the class of lupus nephritis is percutaneous kidney biopsy and the histopathological analysis of the biopsy specimen. The aim of this (…)
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#1841 Trimethylamine N-oxide (TMAO) induces the formation of endothelial extracellular vesicles Nephrol Dial Transplant

AbstractBackground and AimsEndothelial dysfunction caused by the accumulation of uremic toxins is an important contributor to the development of cardiovascular disease in patients with chronic kidney disease (CKD). The uremic toxin trimethylamine n-oxide (TMAO) is associated with oxidative (…)
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#2285 Potentially modifiable factors influencing longitudinal health-related quality of life for those with chronic kidney disease in the NURTuRE-CKD cohort Nephrol Dial Transplant

AbstractBackground and AimsFactors affecting poor health-related quality of life (HRQoL) for people with chronic kidney disease (CKD) have been previously described in literature, and worse HRQoL is associated with CKD progression and death. Little emphasis has been placed on which factors may (…)
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#3017 Renal-friendly lamivudine dosages are unlikely to contribute to HIV-1 shedding into PD effluents—an open label non-randomized pharmacokinetics study Nephrol Dial Transplant

AbstractBackground and AimsRenally adjusted lamivudine dosages are effective. However, some of the kidney failure patients managed with lamivudine-containing regimens are failing to suppress HIV in peritoneal dialysis (CAPD) effluent. The steady-state lamivudine pharmacokinetics among these (…)
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#1602 Lupus nephritis multidisciplinary consultation: a new strategy for increasingly complex patients Nephrol Dial Transplant

AbstractBackground and AimsLupus nephritis (LN) is a major course of morbidity and mortality in patients with systemic lupus erythematosus (SLE), best managed by a multidisciplinary group. Recent management advances require greater collaboration between specialists and individualized treatments (…)
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#1828 Venous thromboembolic events in ANCA associated vasculitis patients—data from Croatian referral center Nephrol Dial Transplant

AbstractBackground and AimsOur aim was to investigate the prevalence of venous thromboembolic events (VTE) in a cohort of patients with ANCA-associated vasculitis (AAV) and define factors associated with the frequency of VTE considering there is data on high incidence of VTE in AAV patients. In (…)
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#2630 Current perceptions and interests of Spanish Nephrology Fellows Nephrol Dial Transplant

AbstractBackground and AimsThe Spanish Peritoneal Dialysis Support Group (GADDPE) aim to enhance peritoneal dialysis (PD) education among young nephrologists to increase the incidence and prevalence of PD in Spain.MethodAiming to develop initiatives to make PD a more attractive and suitable for (…)
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#2385 Inhibition of histone lysine demethylases 5 attenuates acute kidney injury but not acute kidney disease or chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsThe histone lysine demethylases 5 (KDM5) are members of the family of Jumonji C domain-containing histone demethylases and catalyze the removal of di- and tri-methyl moieties from the fourth lysine of histone 3 (H3K4me2/3). It has been reported that the KDM5 family (…)
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#1350 Finerenone in real-life clinical practice: first results from a pilot study Nephrol Dial Transplant

AbstractBackground and AimsFinerenone is a new drug for the treatment of patients with albuminuric diabetic kidney disease (DKD) that has protective cardiorenal effects, with hyperkalemia being a possible side effect. Our pilot study aimed to obtain real-life clinical data in patients with DKD (…)
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#1948 Transcriptome analysis of the effect of roxadustat on osteoclasts Nephrol Dial Transplant

AbstractBackground and AimsIn recent years, hypoxia-inducing factor prolyl hydroxylase inhibitors (HIF-PHIs) have been widely used in the treatment of renal anemia, bringing a revolutionary breakthrough in the treatment of anemia in CKD patients. However, HIF-PHIs acts on a variety of cells and (…)
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#2347 Multi-omics analysis identifies traditional Chinese medicine targets for chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsAs a major public health problem, chronic kidney disease (CKD) has substantial comorbidities and disease burden. It is necessary to discover new therapeutic targets considering its irreversibly. Traditional Chinese medicine (TCM) has become indispensable for the (…)
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#3055 Replacement of tunneled cuffed hemodialysis catheters on coated guidewire: a strategic approach to treat CVC-related infections Nephrol Dial Transplant

AbstractBackground and AimsInfections of tunneled hemodialysis central venous catheters (CVCs) are a serious problem, and the outcome of dialysis patients strongly depends on their clinical management. Several specialists are involved in choosing the appropriate technical and clinical strategy (…)
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#1476 Impact of frailty on maturation of native arteriovenous fistula in patients with end-stage kidney disease Nephrol Dial Transplant

AbstractBackground and AimsMorbimortality and quality of life in hemodialysis patients is directly related to the reliability and integrity of the vascular access. Current guidelines recommend a shift from a "fistula first" approach to a patient-centered approach due to the aging dialysis (…)
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#2778 The Charlson Index can be used prospectively to identify patients who will need a close follow up of surveillance for the vascular access Nephrol Dial Transplant

AbstractBackground and AimsThe primary screening methods for monitoring vascular access in haemodialysis involve measuring access blood flow and dialysis venous pressure. However, challenges are present in both aspects, potentially hindering the attainment of desired results. Research in this (…)
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#2709 Genome wide association study regarding disturbed AVF patency Nephrol Dial Transplant

AbstractBackground and AimsVeins are frequently exposed to arterial circulation, as coronary artery bypass grafts (CABG) and as a peripheral venous bypass to treat atherosclerotic disease, or in the case of arterio-venous fistulas (AVF) to provide a vascular access for hemodialysis. Therapeutic (…)
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#2465 How do renal clinicians present treatment options to older patients with advanced kidney disease and what difference does it make? Nephrol Dial Transplant

AbstractBackground and AimsFor older people with kidney failure, especially those with comorbidities or poor performance status, the survival benefits of dialysis are uncertain and its quality of life impact greatest. Conservative kidney management (CKM) can be a beneficial alternative. However, (…)
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#2192 Aging dialysis population and late referral: two factors influencing the choice of vascular access Nephrol Dial Transplant

AbstractBackground and AimsThe decision on the type of vascular access for hemodialysis is based on several factors including the timing of renal replacement therapy initiation and certain patients’ clinical and demographic features. We hypothesized that the increasing age of patients on (…)
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#1927 Efficacy and safety of ripertamab in paediatic glomerular disease Nephrol Dial Transplant

AbstractBackground and AimsAnti-B-cell treatment has been shown to be an efficient tactic for glomerular disease. Ripertamab as a novel anti-CD20 monoclonal antibody developed by China, has been structurally optimized to specifically bind to the transmembrane antigen CD20, with an amino acid (…)
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#3109 Sarcopenia in peritoneal dialysis patients Nephrol Dial Transplant

AbstractBackground and AimsSarcopenia is considered a frequent cause of morbidity and mortality among patients with chronic kidney disease (CKD). In clinical practice, tools such as handgrip strength and bioelectrical impedance analysis (BIA) can help us diagnose sarcopenia and possibly predict (…)
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#1303 Hyperkalaemia-related RAASi reduction and estimated number needed to treat to avoid a first hospitalisation by maintaining RAASi Nephrol Dial Transplant

AbstractBackground and AimsGuidelines recommend renin-angiotensin-aldosterone system inhibitor (RAASi) therapy at the maximum tolerated dose in patients with chronic kidney disease (CKD) and/or heart failure (HF). Hyperkalaemia (HK) may be a barrier to achieving guideline-directed targets, with (…)
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#3131 Catheter placement by the nephrologist: a safe and effective method for improving access to peritoneal dialysis Nephrol Dial Transplant

AbstractBackground and AimsPeritoneal dialysis (PD) is as effective as hemodialysis and provides a better quality of life. However, it remains underused, particularly in our country, for several reasons, especially the unavailability of surgeons with the necessary skills to insert catheters. The (…)
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#1817 Decrease in hospital-acquired blood stream infection by using automated sensor technology to improve and keep a high level of hand hygiene compliance Nephrol Dial Transplant

AbstractBackground and AimsHospital-acquired infection (HAIs) is a problem for 6-8% of hospitalized patients. HAIs has personal costs, prolongs the hospital stay, increasing the risk of morbidity, mortality, time and staff consuming. Hand hygiene (HH) is essential for preventing infections. (…)
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#784 Peritoneal dialysis-related infections by Kocuria kristinae: cases from a Mexican hospital Nephrol Dial Transplant

AbstractBackground and AimsKocuria species, gram-positive actinobacteria, are typically found in the environment, on human skin and as oral flora. These microorganisms are considered saprophytes and non-pathogenic. They rarely cause infections. Patients generally have some compromise due to (…)
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#217 Renin-angiotensin-aldosterone system blockers effect in CKD progression in hypertensive elderly patients without proteinuria: PROERCAN trial Nephrol Dial Transplant

AbstractBackground and AimsEvidence about nefroprotective effect with RAAS blockers in elderly patients with chronic kidney disease (CKD) without proteinuria is lacking. The primary outcome of our study is to evaluate the impact of RAAS blockers in CKD progression in elderly patients without (…)
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#1615 Working without peritoneal dialysate and urine collections during the COVID-19 pandemic: how to assure sufficient small solute removal Nephrol Dial Transplant

AbstractBackground and AimsThe guidelines of the International Society of Peritoneal Dialysis suggest regular control of small solute removal. During the COVID-19 pandemic we did not perform additional controls of dialysis adequacy in our peritoneal dialysis patients. We judged patients (…)
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#330 Pattern of short-term outcomes of renal function in postpartum acute kidney injury patients: a single-center study in Bangladesh Nephrol Dial Transplant

AbstractBackground and AimsPostpartum acute kidney injury (PPAKI) is a formidable health problem in pregnant woman especially in developing country. Monitoring outcomes like serum creatinine levels and glomerular filtration rates is vital. Understanding these short-term results is crucial for (…)
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#1302 Maintained renin-angiotensin-aldosterone system inhibitor therapy with sodium zirconium cyclosilicate in patients with chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsHyperkalaemia is a barrier to achieving guideline-directed renin-angiotensin-aldosterone system inhibitor (RAASi) therapy. This observational cohort study compared the likelihood of maintained (stabilised or up-titrated) RAASi therapy at 6 months following an episode (…)
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#710 Rare manifestation of minimal change disease associated with prostate cancer Nephrol Dial Transplant

AbstractBackground and AimsProstate cancer is the most common malignancy in men. Secondary nephrotic syndrome as part of the paraneoplastic syndrome occurs in 11% of cases and is most often associated with membranous glomerulopathy. The association of minimal change disease (MCD) and prostate (…)
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#2121 The Kidney-specific Psychosocial ASSessment and support (Kidney PASSPORT) feasibility trial Nephrol Dial Transplant

AbstractBackground and AimsPsychosocial interventions for depressive and anxiety symptoms are effective in CKD, but studies mainly focus on people on dialysis. Little is known about the role of screening and prevention of common mental health difficulties in early CKD.This trial assessed the (…)
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#2411 Inflammation in hypervolemic hemodialysis patients is linked to increased caspase-4 activity Nephrol Dial Transplant

AbstractBackground and AimsHypervolemia is associated with inflammation in hemodialysis patients (HD). How hypervolemia triggers inflammation is not entirely known. We hypothesized that hypervolemia affects signaling via the NF-kB transcription factor system and thus analyzed the phosphorylated (…)
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#1982 Transcriptomic approach to predict drug targets in late-stage hypertensive nephropathy Nephrol Dial Transplant

AbstractBackground and AimsHypertensive nephropathy (HN) is a significant contributor to chronic kidney disease, yet the factors influencing the disease progression remains elusive. Notably, late-stage chronic kidney disease significantly impacts patient outcome. This project aims to unveil (…)
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#1614 Fenofibrates and chronic kidney disease – Is there anything to worry about? Nephrol Dial Transplant

AbstractBackground and AimsChronic Kidney Disease (CKD) patients have increased risk of cardiovascular disease and dyslipidemia is a frequent comorbidity. Many patients are medicated with anti-lipidemic agents to reduce atherosclerotic disease and coronary vascular events. Fenofibrates are (…)
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#3006 Therapeutic apheresis in Fabry disease Nephrol Dial Transplant

AbstractBackground and AimsFabry's disease (FD) is a rare lysosomal disorder linked to the X chromosome due to a mutation in the gene encoding alpha-galactosidase A (alpha-Gal A). This mutation leads to a defect in the metabolism of glycosphingolipids, causing the progressive accumulation of (…)
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#302 Proteomic study reveals indoxyl sulfate induced changes in endothelial cells: role of extracellular vesicles in cardiovascular disease Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) lead to the accumulation of uremic toxins in the bloodstream, among which indoxyl sulfate (IS) is the most prominent. IS causes damage to endothelial cells lining blood vessels, ultimately leading to cardiovascular diseases in patients with (…)
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#2168 Lupus nephritis histopathological classification system: a questionnaire-based survey of the Renal Pathology Society (RPS) Nephrol Dial Transplant

AbstractBackground and AimsKidney biopsy is the gold standard for lupus nephritis diagnosis, defining histologic class, disease activity and chronicity in detail and providing guidance for treatment. The updated 2018 ISN/RPS histopathological classification in lupus nephritis is widely used for (…)
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#322 Are platelet-related parameters prognostic predictors of renal and cardiovascular outcomes in IgA nephropathy? Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is associated with chronic inflammation. Platelet-related parameters, such as platelet (PLT) count, platelet-to-albumin ratio (PAR) and platelet-to-lymphocyte ratio (PLR), were examined as potential prognostic indicators for renal and (…)
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#1029 Factors associated with chronic kidney disease in patients with recurrent kidney stones: a case-control study Nephrol Dial Transplant

AbstractBackground and AimsKidney stones have been described in multiple studies as an independent risk factor for chronic kidney disease (CKD). However, this relationship remains partially understood, and there is limited local, regional, and national information available. While common factors (…)
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#627 C3 glomerulonephritis and C3-dominant infection related glomerulonephritis—are they similar? Nephrol Dial Transplant

AbstractBackgroundC3 glomerulonephritis (C3GN) and C3 dominant infection related glomerulonephritis (C3-IRGN) comprise two important immune complex mediated diseases. C3GN is caused by dysregulation of the alternate pathway by congenital or acquired abnormalities in the complement pathway. (…)
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#1852 When ‘pebbles’ affect the kidney: nephrolithiasis and chronic renal failure in Crohn's disease. The experience of a 3rd level centre Nephrol Dial Transplant

AbstractBackground and AimsNephrolithiasis is the most common expression of kidney involvement in chronic inflammatory bowel disease (IBD), especially in Crohn's disease (CD). Stone formation favoring factors are hyperoxaluria, dehydration, acidosis, common conditions in CD patient, who present (…)
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#2191 Platelet function in chronic kidney disease; can flow cytometry guide in the difficult balance between risk for bleeding versus thrombotic events? Nephrol Dial Transplant

AbstractBackground and AimsIncreased risk of bleeding is a well-known complication of chronic kidney disease (CKD). However, these patients also have an increased risk of thrombotic events. Several studies have implicated both impaired and enhanced platelet function in patients with chronic (…)
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#1357 Regional and national hospitalization burden of lupus nephritis and systemic lupus erythematous in Spain Nephrol Dial Transplant

AbstractBackground and AimsThe regional epidemiology of Systemic lupus erythematosus (SLE) and lupus nephritis (LN) within the same country is poorly understood. Being a rare disease, its severity may be influenced by local expertise and treatment protocols, especially when healthcare systems (…)
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#2247 Influence of the diagnosis of atopic dermatitis in childhood on the course of kidney function in young adulthood: a single-center study Nephrol Dial Transplant

AbstractBackground and AimsSeveral studies demonstrated non-osmotic sodium-storage, especially in the skin. Patients with chronic kidney disease often suffer from skin symptoms and furthermore an association of advanced CKD-stages with inflammatory skin diseases has been shown. Additionally, in (…)
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#1584 Development and validation of risk prediction models according to different clinical settings of IgA nephropathy: nationwide multicenter cohort study Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is the most common glomerulonephritis with a high risk of progression to end-stage renal disease (ESRD). Because machine learning models developed for research have limited use in clinical settings, this study developed and validated prediction (…)
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#1471 The role of genealogy in patients with CKD in primary health care Nephrol Dial Transplant

AbstractBackground and AimsImproving the risk prediction of adverse outcomes of chronic kidney disease at the level of primary care physicians, through early diagnosis of chronic kidney disease, can help reduce the progression of the disease, improve the clinical condition of patients and the (…)
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#978 Interstitial fibrosis and tubular atrophy of immune checkpoint inhibitor-related interstitial nephritis associate mortality and kidney prognosis Nephrol Dial Transplant

AbstractBackground and AimsSeveral studies have been conducted on immune checkpoint inhibitor (ICI)-associated nephrotoxicity. However, current clinical analyses for nephrotoxicity are inadequate owing to the diagnostic criteria, which are mostly based on an increase in serum Cre levels rather (…)
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#2266 Removal of middle size molecules: effects on the modifications of subgroups of white cell types Nephrol Dial Transplant

AbstractBackground and AimsIn both classical hemodialysis (HD) and its high convective version, the hemodiafiltration (HDF), the unavoidable contact of blood cells with the filters (e.g. polysulfone), may cause the formation of microaggregates and the release of Inflammatory cytokines. Reducing (…)
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#2565 Urine amino acid profiles enlighten new prediction models for renal Fanconi syndrome and its association with eGFR level Nephrol Dial Transplant

AbstractBackground and AimsRenal Fanconi syndrome (FS) presented dysfunctions of renal proximal tubular (PT) transport with or without excessive urine amino acids (AAs) excretion, which might contribute to the progression of eGFR decline. This study aimed to explore the clinical benefit of 21 (…)
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#1024 Lung ultrasound in 28 versus 8 places and volume status in chronic hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsOverhydration is considered a significant risk factor for cardiovascular and all-cause mortality in end-stage kidney disease patients. Measurement of total and extracellular water with bioelectrical impedance analysis (BIA), inferior vena cava diameter (IVCd) (…)
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#2056 Epigenetic profiles differ by level of kidney function in idiopathic nephrotic syndrome Nephrol Dial Transplant

AbstractBackground and AimsDNA methylation (DNAm) is an epigenetic mechanism which can therefore induce changes in gene expression without any change to the underlying DNA sequence. Although generally quite stable, DNAm patterns in whole blood do vary across individuals, with DNAm levels (…)
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#2545 Hemodialysis for salbutamol intoxication: patient case report Nephrol Dial Transplant

AbstractBackground and AimsSalbutamol/albuterol is a moderately selective beta-2-adrenergic receptor agonist that acts as an airway smooth muscle relaxant. It is used to prevent and treat acute bronchospasm in various respiratory conditions. Due to its large volume of distribution, it is not (…)
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#755 Endotrophin as an early marker of kidney outcomes in persons with type 2 diabetes: findings from the PROVALID study Nephrol Dial Transplant

AbstractBackground and AimsDiabetic kidney disease (DKD) is driven by a set of pathophysiological processes, including fibrosis. Endotrophin (ETP), a pro-fibrotic fragment generated during collagen type VI formation, has previously been shown to be a biomarker of DKD progression. The aim of this (…)
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#1351 Assessment of safety and efficacy of expanded hemodialysis in comparison to HDF Nephrol Dial Transplant

AbstractBackground and AimsIn end-stage kidney disease, solutes with a wide spectrum of molecular weight, called uremic toxins, are retained due to impaired kidney cleansing capacity. Particularly, the retention of toxins in the middle molecular weight range 15–45 kDa might negatively affects (…)
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#900 Endotrophin is associated with long-term risk of kidney function decline in normoalbuminuric persons with type 2 diabetes in the Joslin Kidney Study Nephrol Dial Transplant

AbstractBackground and AimsEndotrophin is a pro-fibrotic and pro-inflammatory molecule derived from the post-translational processing of type VI collagen. Evidence for an association of increased circulating levels of endotrophin with increased risk of kidney and cardiovascular-related outcome (…)
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#2107 Therapeutic apheresis for the management of lipid disorders: a case series Nephrol Dial Transplant

AbstractBackground and AimsHypertriglyceridemia (HTG) is defined as the plasmatic concentration of triglycerides above 150 mg/dl. With a current prevalence ranging from 15% to 20% in clinical practice, it's a prevalent condition that´s increasing alongside other cardiovascular risk factors such (…)
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#1320 Differential microRNA expression profile in obesity-induced kidney disease driven by high-fat diet in mice Nephrol Dial Transplant

AbstractBackground and AimsObesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney dysfunction in obesity-induced kidney disease (OIKD) remain unclear. MicroRNAs (miRNAs) have been implicated in the development and (…)
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#3132 The effect of the number of transfusions received and hemodialysis centers attended on the prevalence of hepatitis B and C in hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsHepatitis B (HBV) and hepatitis C (HCV) viral infections significantly contribute to morbidity and mortality among hemodialysis patients, posing substantial challenges in the management of these individuals. These infections present a critical global public health (…)
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#2359 Kinetic modifications in cardiac remodeling in a rat model of CKD Nephrol Dial Transplant

AbstractBackground and AimsThe bi-directional relationship between the kidneys and heart leads to different forms of cardiorenal syndrome (CRS) in which acute or chronic dysfunction in one organ affects the other. CRS type 4 is characterized by chronic kidney disease leading to the impairment of (…)
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#1827 Myeloma cast nephropathy: is high cut-off hemodialysis effective? Nephrol Dial Transplant

AbstractBackground and AimsLight-chain cast nephropathy is the result of intra-tubular precipitation of light-chains produced by a multiple myeloma. Treatment often includes high cut-off filters hemodialysis (HCO) with the purpose of purifying these chains until the chemotherapy response is (…)
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#2577 Sodium-mediated blood pressure rise is associated with a lower vasodilation response to nitroglycerin in healthy controls, but not in CKD Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is characterized by endothelial dysfunction, that is partly caused by reduced bioavailability of NO. In addition to volume overload, endothelial dysfunction may contribute to hypertension in CKD. High sodium consumption affects NO levels, (…)
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#2603 Focus on a crucial moment in decision making: evaluate peritoneal dialysis as incident renal replacement therapy Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease affects 10% of the world population (15.1% in Spain, ENRICA 2019 study), being a health problem with important physical, emotional, and socio-occupational repercussions.Deciding on the most appropriate renal replacement therapy (RRT) for each (…)
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#1244 Rates of eGFR and UACR testing in patients with chronic kidney disease in England: Clinical Practice Research Datalink 2010-2019 Nephrol Dial Transplant

AbstractBackground and AimsThe NICE chronic kidney disease (CKD) treatment guidelines recommend regular laboratory measurements of both kidney function (eGFR) and damage (proteinuria) to appropriately inform efforts to prevent and treat progression of CKD. Recommendations also indicate frequency (…)
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#1820 Use of MiDiálisis App in peritoneal dialysis patients Nephrol Dial Transplant

AbstractBackground and AimsTechnological innovation has revolutionized medical assistance. Peritoneal dialysis (PD) patients, who prioritize their autonomy and freedom choosing to undergo dialysis at home, are the paradigm of patients willing to use telemedicine. Remote monitoring allows (…)
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#2484 Diffusion magnetic resonance imaging, a noninvasive tool to assess fibrosis level in both native and allograft kidneys Nephrol Dial Transplant

AbstractBackground and AimsRenal cortical interstitial fibrosis is a well-established prognostic indicator for renal health, conventionally estimated by biopsy. Our prior research has enhanced DW-MRI sequencing, facilitating precise distinction between the renal cortex and medulla. This has (…)
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#2055 Variations in free water transport condition ultrafiltration capacity since basal times Nephrol Dial Transplant

AbstractBackground and AimsThere is great variability in free water carrying capacity (FFWC) in incident patients, but the extent to which this variability impacts inherent ultrafiltration failure (UF) is unknown. The peritoneal equilibration test (PET) with 3.86% glucose allows measurement of (…)
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#1439 Risk factors and significance of a reduction of serum albumin after start of PD Nephrol Dial Transplant

AbstractBackground and AimsA reduction in the serum level of albumin following the initiation of peritoneal dialysis (PD) has been reported to associate with impaired survival. Our aim was to identify pre-PD risk factors of drop of serum albumin, and to estimate how a decrease in albumin level (…)
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#1928 Stepwise incremental hemodialysis and low-protein diet supplemented with keto-analogues to preserve residual kidney function: a pilot study Nephrol Dial Transplant

AbstractBackground and AimsStudies have demonstrated that chronic dialysis with residual kidney function (RKF) had better survival rates in comparison to those with diminished or absent RKF and are also further associated with improved cardiovascular outcomes. Thus, the strategic preservation of (…)
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#1814 Infection associated pancreatitis in peritoneal dialysis, a case report Nephrol Dial Transplant

AbstractBackground and AimsPeritoneal dialysis (PD) patients seem to have a higher incidence of acute alithiasic pancreatitis. Though rare and with some suggested triggers described in the literature, this is still a poorly understood and potentially life-threatening complication. We present a (…)
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#995 Effectiveness of Semaglutide once weekly as add-on to SGLT-2Is in T2DM and CKD: a single-center observational study with body composition assessment Nephrol Dial Transplant

AbstractBackground and AimsTo explore body composition and metabolic profile changes in type 2 diabetes mellitus and chronic kidney disease (T2DM-CKD) using Semaglutide added to sodium-glucose transporter 2 inhibitors (SGLT-2Is).MethodThe study was performed on patients with T2DM-CKD in West (…)
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#2426 Diabetes treatment in CKD patients—do we treat according to the guidelines? Nephrol Dial Transplant

AbstractBackground and AimsT2DM is a global pandemic, frequently complicated by DKD, that may result in ESRD and cardiovascular complications. Despite advancements in diabetes and cardiovascular risk management, the prevalence of DKD continues to grow.During the last years SGLT2i and GLP1RAs (…)
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#1390 Differences in the detection of anti-HLA antibodies between two single antigen bead methods in kidney transplantation patients Nephrol Dial Transplant

AbstractBackground and AimsTwo semiquantitative single-antigen bead (SAB) methods are currently available for the detection of anti-HLA antibodies and the estimation of their activity, depending on complement binding. However, data on accordance of the two methods on specificities detection and (…)
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#1377 Evaluation of state-wide health system implementation of renal supportive care shows substantial net benefits Nephrol Dial Transplant

AbstractBackground and AimsIn 2016, the New South Wales (NSW) Health system implemented a service to make the principles and practice of palliative medicine comprehensively available to patients receiving chronic kidney disease (CKD) care across NSW. Summative evaluation of the economic value (…)
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#2593 Comparison of four predictive scoring models as assessment tools for cardiac surgery-associated acute kidney injury in post cardiac surgery patients Nephrol Dial Transplant

AbstractBackground and AimsCardiac surgery-associated acute kidney injury (CSA-AKI) is a predominant contributor to hospital-acquired AKI in ICU following sepsis. Despite a rising frequency of CSA-AKI, currently examined predictive models have not consistently delivered accurate stratification. (…)
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#2500 Renal perfusion and SGLT2i Nephrol Dial Transplant

AbstractBackground and AimsSodium-Glucose Cotransporter 2 inhibitors (SGLT2i) have revolutionized treatment of type 2 diabetes mellitus (DM2) and chronic kidney disease (CKD), improving cardiovascular and renal endpoints. This improvement could be due to a decrease in renal perfusion (RP), (…)
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#2431 Vascular access outcomes among patients on maintenance hemodialysis in Perpetual Succour Hospital: a 3-year cross-sectional analysis Nephrol Dial Transplant

AbstractBackground and AimsHemodialysis (HD) is the most widely used treatment modality worldwide in the care of patients with end stage renal disease (ESRD). The success of the therapy depends largely on the quality of the VA and its proper functioning, which has a bearing on the patient's (…)
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#1819 Cardio-fistular recirculation in patients with chronic heart failure and preserved ejection fraction Nephrol Dial Transplant

AbstractBackground and AimsCardio-fistular recirculation (CFR)—ratio of cardiac output (CO) to AVF volume blood flow (Qa)—is a well-known risk factor for death and cardiovascular adverse events. Currently, there are no clear limits for this index that definitely indicate AVF cardiotoxicity. In (…)
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#1204 Measuring needling experience: development and validation of the Needling Patient Reported Experience Measure (NPREM) Nephrol Dial Transplant

AbstractBackground and AimsMost people on haemodialysis rely on having reliable access to their vascular system, often via surgically created arteriovenous fistula or graft. At the beginning of each dialysis session, needles must be inserted. While ‘needling’ is a key step, an annual UK survey (…)
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#1129 Systematic reporting of extracorporeal blood losses in a large dialysis provider organization Nephrol Dial Transplant

AbstractBackground and AimsThe assessment of adverse safety events is important for the risk assessment of major blood loss from the extracorporeal blood circuit during hemodialysis (HD). Such blood loss has been proven to result in a low double-digit number of fatal events per year in the USA. (…)
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#1818 Association of combined systemic inflammatory indices with the severity and outcome of tunnelled hemodialysis catheter-related bacteremia Nephrol Dial Transplant

AbstractBackground and AimsSystemic inflammation plays a critical role in sepsis. Multiple inflammatory parameters have been used in clinical practice to diagnose and predict outcomes. More recently, systemic inflammatory indices derived from the complete blood count (CBC) such as the (…)
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#2924 Comparison of large language models and traditional natural language processing techniques in predicting arteriovenous fistula failure Nephrol Dial Transplant

AbstractBackground and AimsLarge language models (LLMs) have gained significant attention in the field of natural language processing (NLP), marking a shift from traditional techniques like Term Frequency-Inverse Document Frequency (TF-IDF). We developed a traditional NLP model to predict (…)
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#2104 Neutrophil extracellular traps have a pivotal role in tubulointerstitial fibrosis Nephrol Dial Transplant

AbstractBackground and AimsTubulointerstitial fibrosis (TIF) is a typical pathological change in chronic kidney disease (CKD). However, the mechanisms underlying tubulointerstitial fibrosis are still to be fully elucidated. Neutrophil extracellular traps (NETs) participate in the (…)
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#726 The ugly face of shunt nephritis Nephrol Dial Transplant

AbstractBackground and AimsShunt nephritis is a rare immune complex-mediated reversible glomerulonephritis due to infected ventricular shunts, most commonly ventriculo-peritoneal shunts (VP) for the treatment of hydrocephalus. Although infection of CSF is common, shunt nephritis is rare, however (…)
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#2699 Rare glomerular microangiopathy: clinicopathological characteristics and prognosis Nephrol Dial Transplant

AbstractBackground and AimsDifferent from the typical histologic changes of thrombotic microangiopathy (TMA), we identified a group of patients whose pathology with glomerular involvement without blood vessel lesions, which was rare and known as glomerular microangiopathy (GMA).MethodIn Peking (…)
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#2622 Very late renal recovery in patient with light chain cast nephropathy: the prognostic value of renal biopsy Nephrol Dial Transplant

AbstractBackground and AimsRenal biopsy is not necessary to assess LCCN (Light Chain Cast Nephropathy) in patients with laboratory features suggestive of the disease. However, it has been shown that the histological picture often correlates with renal outcome.We present the case of a 55-year-old (…)
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#314 Systemic lupus erythematous (SLE) and isolated multiple sclerosis: analysis of BAFF—VAR variant on gene TNSF13B Nephrol Dial Transplant

AbstractBackground and AimsWe report a case of young a woman (33 years old) affected by SLE since 2007. In this year, a renal biopsy showed class IV lupus nephritis and the patient received corticosteroids and immunosuppressant for 3 years. The patient remained thereafter in disease remission (…)
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#207 Early single session of hyperbaric oxygen therapy mitigates renal apoptosis in lipopolysaccharides-induced endotoxemia in rats Nephrol Dial Transplant

AbstractBackground and AimsSepsis-associated acute kidney injury (SA-AKI) is a prominent sepsis complication, often having adverse clinical outcomes. Hyperbaric oxygen therapy (HBOT), known for its anti-inflammatory characteristics, antioxidant effects, and ability to deliver high oxygen tension (…)
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#3068 Fibrosis and CD-163+ macrophages: making a difference between MPO-AAV and PR3-AAV Nephrol Dial Transplant

AbstractBackground and AimsAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a necrotizing vasculitis characterized by inflammation of small blood vessels, with the kidney being one of the most affected organs. Its pathogenesis is a complex, multifactorial process (…)
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#1772 Comparison of interpretation of acid-base disorder in patients with critical illness: nephrologist versus ChatGPT Nephrol Dial Transplant

AbstractBackground and AimsThe generative pre-trained transformer (GPT), a type of large language model (LLM), is now playing a huge role in driving innovation in fields of medical education, diagnosis and treatment and with a process of continuous improvement it will itself be able to become (…)
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#1706 LncRNA EGOT regulates hypoxia-induced mitophagy through the EGOT/PARKIN axis in renal tubular cells Nephrol Dial Transplant

AbstractBackground and AimsThe activation of mitophagy plays a crucial role in hypoxia signaling during acute kidney injury (AKI). The process involves coordinating the action of coding and non-coding RNA expressions to eliminate damaged mitochondria selectively. However, the specifics of how (…)
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#2101 Beyond corticosteroids: rituximab in managing minimal change disease and glucocorticoid-related toxicity Nephrol Dial Transplant

AbstractBackground and AimsMinimal Change Disease (MCD) is the primary cause of Nephrotic Syndrome in children, accounting for 10 to 20% of cases in adults. Glucocorticoids (GC) remain the cornerstone of treatment. Despite a positive response in the majority of patients, up to 25% experience (…)
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#2644 Clinical impact of proteinuria and hematuria remission criteria in IgA nephropathy patients defined by the Japanese Society of Nephrology Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is one of the most common glomerulonephritis worldwide, especially in the Pacific Rim and Mediterranean countries. Hematuria is almost inevitable clinical findings and massive proteinuria is well established risk factor in IgAN. However, a few (…)
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#2459 Matching-adjusted indirect comparison of eGFR in patients with immunoglobulin A nephropathy treated with Nefecon (TRF budesonide) or sparsentan Nephrol Dial Transplant

AbstractBackground and AimsPrimary immunoglobulin A nephropathy (IgAN) is an immune-mediated disease that can lead to kidney failure, need for dialysis and kidney transplantation, and early death. IgAN is the most common type of primary glomerulonephritis globally, with an estimated worldwide (…)
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#1739 Combination rituximab & low-dose IV cyclophosphamide induction therapy for severe multi-system eosinophilic granulomatosis with polyangiitis Nephrol Dial Transplant

AbstractBackground and AimsCurrent guidelines advise rituximab (RTX) or cyclophosphamide treatment for organ-threatening disease in eosinophilic granulomatosis with polyangiitis (EGPA). However, conventional treatment is often limited by partial efficacy, toxicity, high relapse rate and steroid (…)
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#1021 A phase 3 randomized controlled trial of ravulizumab in adult patients with IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsThe pathogenesis of IgA nephropathy (IgAN) includes the deposition of immune complexes in the kidney and activation of the complement system. Complement components, including C5a (anaphylatoxin) and C5b-9 (membrane attack complex), are generated leading to mesangial (…)
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#2487 Deleterious renal outcome in patients with thrombotic microangiopathy after lung transplantation: the lung TMA trial Nephrol Dial Transplant

AbstractBackground and AimsThrombotic microangiopathy (TMA) is a rare but severe complication following lung transplantation. The pathogenesis is poorly understood, involving endothelial damage and various risk factors, including calcineurin inhibitor (CNI) toxicity. We aimed to evaluate (…)
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#1467 Pegcetacoplan for post-transplant recurrent C3 glomerulopathy or immune complex membranoproliferative glomerulonephritis in NOBLE: 12-week evolution Nephrol Dial Transplant

AbstractBackground and AimsC3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases caused by uncontrolled complement activation, resulting in excess deposition of C3 breakdown products in the kidneys, which leads to kidney damage (…)
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#2349 Lysyl oxidase-like 2 inhibitor ameliorates tubulointerstitial fibrosis and albuminuria in cyclosporine induced nephropathy Nephrol Dial Transplant

AbstractBackground and AimsLysyl oxidase-like 2 (LOXL2), an amine oxidase, contributes to fibrotic scarring in the tissue by facilitating collagen cross-linking. Recent data demonstrated upregulation of lysyl oxidase and LOXL2 in the fibrotic kidneys after administration of cylosporine A (CsA). (…)
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#894 Dynamic multi-omics and mechanistic modelling approach provides deeper insight into kidney fibrosis progression Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) affects more than 10% of the world's population and causes millions of deaths annually. Organ fibrosis is the main driver of CKD, leading to excessive accumulation of extracellular matrix (ECM). The presence of myofibroblasts correlates (…)
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#753 Targeted anti-IL-1? bacteroides fragilis outer membrane vesicles alleviate inflammatory injury in diabetic nephropathy Nephrol Dial Transplant

AbstractBackground and AimsIt is accepted that diabetic nephropathy (DN) is not only a disease caused by impaired glucose metabolism, but also a chronic inflammatory disease. The interleukin-1? (IL-1?) plays an important role in inflammation-mediated renal injury in DN. IL-1? blocking therapy (…)
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#3042 Prevalence and associations of impaired cognitive function for people with chronic kidney disease: baseline findings from the NURTuRE-CKD cohort study Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is known to be associated with impaired cognitive function, with lower estimated glomerular filtration rate (eGFR) associated with poorer cognitive performance [1]. Though CKD prevalence increases with age, the association with cognitive (…)
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#2770 Evaluation of the effect of IV iron therapy on eGFR and Pro-BNP in patients with chronic kidney disease and heart failure with preserved EF Nephrol Dial Transplant

AbstractBackground and AimsIron replacement in treating heart failure (HF) is an issue whose importance has been better understood in recent years. Although controversies exist, randomized controlled studies have shown that IV iron treatment reduces mortality and improves symptomatology in heart (…)
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#1174 Prevalence and factors contributing to erythropoietin hyporesponsiveness in CKD patients on hemodialysis: a single center, cross sectional study Nephrol Dial Transplant

AbstractBackground and AimsAnemia, one of the most frequent early complications of CKD is associated with a reduced QOL, cardiovascular morbidity, accelerated CKD progression, and it is an independent predictor of mortality. The successful management of anemia is a vital part of patient care, (…)
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#377 Assessment of kidney function by creatinine and cystatin C and cardiovascular outcomes in patients with atrial fibrillation Nephrol Dial Transplant

AbstractBackground and AimsAtrial fibrillation (AF) in patients with chronic kidney disease are at an increased risk for ischemic and bleeding events and all-cause mortality. Accurate kidney function estimation is key for risk assessment. Creatinine is commonly used to calculate the Glomerular (…)
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#1311 Cardiac damage in a multifactorial DKD/CKD mouse model resembles HFpEF and can be reduced by standard-of-care treatment Nephrol Dial Transplant

AbstractBackground and AimsWe developed a diet-induced hypertension-accelerated mouse model of diabetic kidney disease characterized by progressive loss of GFR resulting in chronic kidney disease. Since cardiovascular disease is the major cause of death in CKD, we characterized the functional (…)
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#1910 Echocardiographic findings in patients with advanced diabetic kidney disease and obstructive sleep apnea Nephrol Dial Transplant

AbstractBackground and AimsObstructive sleep apnea (OSA) is associated with accelerated development of cardiovascular disease. The prevalence of OSA is increased in both type 2 diabetes (DM2) and in chronic kidney disease, and is very high in patients with diabetic kidney disease. However, the (…)
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#1564 Clinical implication of hyperfiltration and metabolic syndrome on the cardiovascular events, kidney failure, and all-cause mortality Nephrol Dial Transplant

AbstractBackground and AimsRenal hyperfiltration (RHF) and metabolic syndrome (MetS) increase the risk of cardiovascular disease, end stage kidney disease (ESKD), and all-cause mortality. While RHF is strongly related to the metabolic risk, it is little known how the combined association of (…)
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#2595 Evolution of hemoglobin and serum uric acid levels after SGLT2i initiation in patients with and without diabetic nephropathy Nephrol Dial Transplant

AbstractBackground and AimsSodium-glucose cotransporter 2 inhibitors (SGLT2i) are glucose-lowering drugs that inhibit glucose reabsorption in the proximal tubule, enhancing urinary glucose excretion. SGLT2i exhibit significant cardio- and renoprotective effects due to their capacity to increase (…)
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#289 Lipocalin-2 promotes cardiovascular calcification in chronic kidney disease by upregulating STAT3/NCOA4-mediated ferritinophagy and ferroptosis Nephrol Dial Transplant

AbstractBackground and AimsCardiovascular calcification (CVC) is a common complication of chronic kidney disease (CKD) and contributes to cardiovascular morbidity and mortality without any effective therapies. To date, the underlying mechanism of CKD-CVC has not been elucidated. Recent studies (…)
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#2175 Sodium-glucose cotransporter 2 (SGLT2) inhibitors-induced erythropoiesis and cardiovascular events in chronic kidney patients Nephrol Dial Transplant

AbstractBackground and AimsPrior research has established that in chronic kidney disease (CKD), elevating hemoglobin (Hb) levels above 11.5 g/dl correlates with heightened thromboembolic event risks and increased mortality. Similar findings are seen in heart failure patients with Hb levels (…)
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#2605 Evaluation of cardiac fetal gene program in experimental uremia Nephrol Dial Transplant

AbstractBackground and AimsHeart failure (HF) and uremia share several potent cardiac hypertrophic stimuli such as wall stress, sympathetic activation, renin angiotensin system activation and oxidative stress. In heart failure, induction of fetal gene program is one of the major processes (…)
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#2034 CKD-MBD management: results from a national survey on bone turnover biomarkers practice and therapeutic strategies among Italian nephrologists Nephrol Dial Transplant

AbstractBackground and AimsAdvanced stages of chronic kidney disease (CKD) are constantly characterized by a mineral and bone disorders (MBD) syndrome concerning a complex systemic condition that includes laboratory abnormalities of bone and mineral metabolism involving calcium, phosphorus, (…)
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#796 Obstetric nephrology in Europe: a survey of nephrologists’ self-reported experience and training Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is estimated to affect 3% of pregnant women in high-income countries. The prevalence of CKD in pregnancy is predicted to rise due to advancing maternal age, obesity, and co-morbidities. There is a paucity of evidence regarding (…)
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#989 Fund and incentivize multidisciplinary CKD care: what can we learn from the French CKD bundled payment program? Nephrol Dial Transplant

AbstractBackground and AimsMultidisciplinary care (MDC) is crucial to slow down the progression of Chronic Kidney Disease (CKD) and prevent or post-pone kidney replacement therapy. To incentivize the development of that care, France launched a nationwide bundled payment program (CKD-BP) targeted (…)
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#3104 Adequacy of nephroprotective prescription in an elderly diabetic population in a primary care setting Nephrol Dial Transplant

AbstractBackground and AimsThe prevalence of chronic kidney disease (CKD) has been increasing and one of the main risk factors is diabetes mellitus (DM). The addition of sodium-glucose cotransporter 2 inhibitors (SGLT2i) to the renin-angiotensin inhibitors (RASi) is recommended in patients with (…)
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#2643 CD4+ T cells are associated with mortality in males with type 2 cardiorenal syndrome independently of the Seattle Heart Failure Model score Nephrol Dial Transplant

AbstractBackground and AimsImmune system dysregulation appears to contribute to the pathogenesis and prognosis of the reciprocal dysfunction that occurs in cardiorenal syndrome (CRS). However, there is little evidence available regarding the potential alterations of the cellular components of (…)
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#2898 Exposure response model describing hematologic changes with chronic treatment of CKD anemia with vadadustat Nephrol Dial Transplant

AbstractBackground and AimsVadadustat (VADA) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, a class of drugs that stabilize HIF and stimulate endogenous erythropoietin production, increasing iron mobilization and red blood cell production. VADA is approved in 36 (…)
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#1454 Usefulness of the clinical frailty scale in Dutch patients with end-stage kidney disease Nephrol Dial Transplant

AbstractBackground and AimsFrailty is common in end-stage kidney disease (ESKD) patients which may benefit from advance care planning. Currently there are multiple frailty screening instruments available, of which the Frailty Index is commonly used to estimate frailty in ESKD patients. The (…)
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#1382 Kidney outcomes after bariatric surgery: a population-based cohort study Nephrol Dial Transplant

AbstractBackground and AimsObesity is associated with nephrolithiasis, chronic kidney disease (CKD), and kidney failure. Bariatric surgeries, including Roux en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), are effective treatments of severe obesity and may mitigate obesity-related kidney (…)
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#804 The nonlinear association between body mass index and chronic kidney disease: a prospective cohort study and Mendelian randomization analysis Nephrol Dial Transplant

AbstractBackground and AimsPrevious studies mainly focused on linear association between body mass index (BMI) and the risk of chronic kidney disease (CKD). In the current research, we conducted a prospective cohort observational study and Mendelian Randomization analysis to explore whether (…)
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#1434 A study of the factors related to the change in eGFR after arteriovenous fistula creation in CKD patients and its impact on kidney prognosis Nephrol Dial Transplant

AbstractBackground and AimsOccasionally, we observe cases of transiently increased estimated glomerular filtration rate (eGFR) after arteriovenous fistula (AVF) creation in patients with chronic kidney disease (CKD). However, there is limited research on the factors influencing the change in (…)
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#1415 The association between social isolation and all-cause mortality in patients with chronic kidney disease: a prospective cohort study Nephrol Dial Transplant

AbstractBackground and AimsSocial isolation has been linked to several diseases and adverse outcomes, such as type 2 diabetes and cardiovascular events. The current study aimed to evaluate the association between social isolation and all-cause mortality in patients with chronic kidney disease (…)
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#1164 Smoking cessation and atherosclerotic cardiovascular events and mortality in chronic kidney disease Nephrol Dial Transplant

AbstractBackground and AimsSmoking cessation is recommended to reduce excess atherosclerotic cardiovascular disease (ASCVD) and mortality in patients with chronic kidney disease (CKD). However, this recommendation is largely based on observational studies on the general population, involving (…)
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#518 Fatigue in all stages of chronic kidney disease: patients’ experiences and needs for support Nephrol Dial Transplant

AbstractBackground and AimsFatigue is a commonly reported symptom in all stages of chronic kidney disease (CKD) and has a major impact on patients’ daily lives. Until now, predominantly qualitative research has contributed to our knowledge about CKD patients' experiences and perceptions of (…)
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#305 Global health inequalities of CKD: a systematic review and meta-analysis examining prevalence and disparities in age, sex and socio-economic status Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is a significant contributor to global morbidity and mortality. Age, sex and socio-economic status are considered to be influential in the development, progression and outcomes from CKD. This study investigated disparities in age, sex and (…)
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#2832 Lean tissue mass is associated with mortality across different stages of chronic kidney disease: a systematic review and meta-analysis Nephrol Dial Transplant

AbstractBackground and AimsLoss of lean tissue mass (LLTM) commonly occurs in multiple long-term conditions (LTC), including chronic kidney disease (CKD), and is thought to be associated with adverse outcomes including mortality, frailty surrogates and poor quality of life. It remains unclear (…)
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#1022 Vulnerability in onconephrology: women and people who live alone are at greater risk of depression and anxiety Nephrol Dial Transplant

AbstractBackground and AimsCancer is a common entity that after the new therapeutic advances is becoming chronic disease. For that reason, kidney disease prevalence is increasing in cancer patients. Consequently, Onconephrology is becoming an essential subspecialty. Psychiatric disorders are (…)
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#2717 Fermentable and viscous dietary fiber types improve cortical bone in a rat model of chronic kidney disease-mineral and bone disorder Nephrol Dial Transplant

AbstractBackground and AimsRenal osteodystrophy is highly prevalent among people with chronic kidney disease (CKD). We recently showed that inulin, a prebiotic fermentable dietary fiber, improved cortical bone parameters in rats with moderate-to-severe CKD. Our objective was to evaluate if this (…)
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#1912 Assessment of the dynamics of renal anemia in patients with atrial fibrillation and chronic kidney disease stage IIIb-V during anticoagulant therapy Nephrol Dial Transplant

AbstractBackground and AimsTherapy with oral anticoagulants prevents the development of most ischemic strokes and systemic embolisms in patients with atrial fibrillation (AF) and chronic kidney disease (CKD), and also helps to increase life expectancy, improving its quality. It should be (…)
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#1018 Profiles of medication use in dialysis patients globally Nephrol Dial Transplant

AbstractBackground and AimsGlobal patterns of medication use in dialysis have not been defined so far. This project aims to provide a real-world view of medication use in dialysis and to characterize therapeutic classes and types of medications. An anonymized dialysis dataset of a global kidney (…)
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#1595 Use of machine learning directed interventions to reduce fluid related hospital admissions in hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsPatients with end-stage kidney disease (ESKD) are hospitalized nearly two times per year on average; volume overload, infections and other cardiovascular complications are amongst the most common causes of hospitalization. We developed a machine learning (ML) model to (…)
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#1003 Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of AZD2373, an antisense oligonucleotide targeting APOL1 Nephrol Dial Transplant

AbstractBackground and AimsAPOL1 mediated kidney disease (AMKD) is associated with toxic gain of function variants in people of African ancestry carrying the high-risk APOL1 genotypes (G1 and G2). APOL1 protein is part of the innate immune system but not considered essential. AZD2373, an (…)
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#192 Intradialytic cognitive and physical training to enhance functional capacity: a randomized controlled trial Nephrol Dial Transplant

AbstractBackground and AimsHaemodialysis (HD) patients frequently experience cognitive and physical impairments due to various factors, including age, comorbidities, and the demanding nature of the treatment. This study explores the impact of a 12-week integrated cognitive and physical training (…)
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#2332 Systemic immune-inflammation index is associated with chronic kidney disease: evidence from NHANES 2009-2018 Nephrol Dial Transplant

AbstractBackground and AimsThe systemic immune-inflammation index (SII), a novel inflammation index, reflects systemic inflammatory and immunologic conditions throughout the human body. However, the relationship between SII and chronic kidney disease (CKD) remains unknown. The purpose of this (…)
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#2559 “Remote software technology to assist clinical decision in vascular access surveillance: single UK centre experience” Nephrol Dial Transplant

AbstractBackground and AimsOptimal arteriovenous access monitoring and surveillance aims for early detection of dysfunctional access, enabling pre-emptive referral for angioplasty or surgery to prevent access loss or thrombosis. Here we compared the addition of remote software surveillance to (…)
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#2430 Comparison of the efficacy of gentamicin-citrate and gentamicin-citrate/Taurolock-urokinase locks for non-tunneled catheters in hemodialysis patients Nephrol Dial Transplant

AbstractBackground and AimsCatheter-related complications, such as dysfunction, thrombosis and infection, are associated with significant morbidity and mortality in patients on hemodialysis (HD) receiving dialysis through temporary non-tunneled double-lumen central venous catheters (CVC). (…)
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#806 Predicting arteriovenous fistula success using ferumoxytol-enhanced MRI (Fe-MRI) and computational flow dynamics (CFD) Nephrol Dial Transplant

AbstractBackground and AimsArteriovenous fistula (AVF) failure is common and is invariably associated with preexisting anatomic problems of the inflow and outflow circuit. Ferumoxytol, an iron oxide nanoparticle, provides a safe alternative to gadolinium contrast material for MR angiography in (…)
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#540 Investigation of vascular sound visualization system using electronic stethoscope Nephrol Dial Transplant

AbstractBackground and AimsThe routine evaluation of VA involves visual, palpatory, and auscultatory examinations, as well as monitoring of venous pressure and other parameters. Surveillance indices include Flow Volume (FV) and Resistance Index (RI) obtained by Doppler ultrasound (DU) and Access (…)
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#2616 AVF volume blood flow reduction in NYHA III patients—is it too late? Nephrol Dial Transplant

AbstractBackground and AimsHeart failure (HF) with preserved / high cardiac output (CO) is a well-known syndrome in patients with high-flow AVF. However, the threshold for classifying an AVF as high-flow is currently undefined. Cardio-fistular recirculation (CFR) is often used as a criterion, (…)
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#898 Acceleration in kidney function decline after COVID-19 infection: the Stockholm CREAtinine Measurements (SCREAM) project Nephrol Dial Transplant

AbstractBackground and AimsSevere COVID-19 infection, which usually presents as a viral pneumonia, has been observed to frequently be accompanied by acute kidney injury (AKI). However, possible effects of COVID-19 on long-term kidney function decline are not well quantified. We investigated (…)
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#996 Validation of peritoneal NGAL as a biomarker for peritonitis: a comparison between laboratory-base method and rapid stick test Nephrol Dial Transplant

AbstractBackground and AimsNeutrophil gelatinase-associated lipocalin (NGAL) is a protein involved in iron homeostasis, inflammation, and fibrosis. Initially discovered in human granulocytes, NGAL is found in various tissues. In renal contexts, NGAL's small size (23-25 kDa) and positive charge (…)
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#1253 Predicting renal outcomes in ANCA-associated vasculitis—validation of ANCA Renal Risk Score in a Portuguese cohort Nephrol Dial Transplant

AbstractBackground and AimsAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare cause of glomerulonephritis and clinical presentation can be diverse. Despite recent developments in immunosuppressive treatments, AAV with renal involvement is still associated with poor (…)
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#348 Neutrophil membrane-derived nanovesicles deliver IL-37 to repair renal endothelial cells in ischemia?reperfusion injury Nephrol Dial Transplant

AbstractBackground and AimsRenal ischemia?reperfusion injury (IRI) is one of the most important causes of acute kidney injury (AKI). Interleukin (IL)-37 is a novel anti-inflammatory factor, but its application is still limited by its low stability and delivery efficiency. In recent years, (…)
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#2477 Longitudinal serum bicarbonate and mortality risk in older patients with advanced chronic kidney disease: analyses from the EQUAL cohort Nephrol Dial Transplant

AbstractBackground and AimsSerum bicarbonate (SBC) disorders have been consistently linked to mortality in chronic kidney disease (CKD) patients. Low SBC levels have been extensively associated with increased mortality in CKD patients, possibly due to the detrimental effects of acidosis on (…)
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#694 Effects of nonsteroidal mineralocorticoid receptor antagonists on kidney of cirrhotic rats Nephrol Dial Transplant

AbstractBackground and AimsAldosterone binds to renal mineralocorticoid receptors (MRs) to regulate fluid and electrolytes homeostasis. In addition, aldosterone can be deleterious as a driver of inflammation and tissue fibrosis in several organs. Thus, blockade of aldosterone represents an (…)
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#2505 PTEN ablation in osteocytes exacerbates anemia in mice with subtotal nephrectomy Nephrol Dial Transplant

AbstractBackground and AimsThe identification of novel roles for bone as a principal endocrine organ has grown in recent decades, being now recognized for its contribution to the regulation of numerous systemic functions. In previous studies, we observed that 5/6Nx mice with osteocytic deletion (…)
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#2339 All-trans retinoic acid enhances the efficacy of mesenchymal stem cells in acute kidney injury Nephrol Dial Transplant

AbstractBackground and AimsMesenchymal stem cells (MSCs) have emerged as a promising therapeutic strategy for acute kidney injury (AKI), but still suffer from the drawbacks of low survival rate, low homing rate, and uncertain differentiation. In search of better therapeutic strategies, we (…)
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#337 Renal 3D photoacoustic imaging and contrast-enhanced ultrasound to assess oxygenation and perfusion and to predict fibrosis after ischemia-reperfusion Nephrol Dial Transplant

AbstractBackground and AimsRenal 3D photo-acoustic imaging (3D-PAI) and contrast-enhanced ultrasound (CEUS) are promising tools in mice models to assess repeatedly and non-invasively renal ischemia-reperfusion (RIR) consequences and damages, or their improvement by nephroprotective strategies (…)
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#2246 Cardiovascular changes and outcomes across the early CKD spectrum: a UK Biobank cardiovascular MRI substudy Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) patients are at a significant risk of accelerated cardiovascular (CV) disease (CVD), which increases as glomerular filtration rate (GFR) declines. The prevalence of CVD in early CKD is high but there is lack of data on early myocardial (…)
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#1763 Risk factors and clinical prediction models for osteoporosis in predialysis chronic kidney disease patients Nephrol Dial Transplant

AbstractBackground and AimsThe research concerning osteoporosis among individuals with predialysis chronic kidney disease (CKD) has been relatively neglected in existing literature. Furthermore, the risk factors for osteoporosis in this demographic have not been adequately investigated. The (…)
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#2387 Case study of a patient with gouty nephropathy treated with immunosorbent therapy Nephrol Dial Transplant

AbstractBackground and AimsGouty nephropathy is a kidney disease caused by chronic hyperuricemia, in which uric acid crystals are deposited in the kidneys leading to tubular and glomerular damage, which in turn affects kidney function.Patientfemale, 68 years old, 7 years ago, no obvious cause of (…)
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#2551 Treatment and prognosis for myocardial infarction in patients with chronic kidney disease 2010-2022: a nationwide cohort study Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is present in >30% of patients with acute coronary syndrome. Although prognosis following myocardial infarction (MI) has improved throughout the last decades, patients with CKD remain at considerably increased risk of recurrent (…)
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#1506 Uremic toxicity: gaining novel insights through AI-driven literature review Nephrol Dial Transplant

AbstractBackground and AimsThe rapidly growing scientific literature poses a significant challenge for researchers seeking to distill key insights. We utilized Retrieval-Augmented Generation (RAG), a novel AI-driven approach, to efficiently process and extract meaningful information from (…)
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#2033 Patient characteristics and outcomes of an inter- and multidisciplinary nephrology and cardiology clinic Nephrol Dial Transplant

AbstractBackground and AimsThe prevalence of cardiorenal syndrome is increasing due to the growing number of patients with chronic kidney disease (CKD) and heart failure (HF). To further improve outcomes in this high risk population, an interdisciplinary, evidence-based and patient-centered (…)
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#2035 Use of ETElcalcetidefor pReserving vitamiN K-dependent proteInactivitYITAlian Study (ETERNITY-ITA Study) Nephrol Dial Transplant

AbstractBackground and AimsVascular calcifications (VCs) are prevalent in chronic kidney disease (CKD) and mineral disorders, associated with aortic calcification and increased bone fracture risk. The complex pathogenesis involves factors like calcium overload, phosphate imbalance, and secondary (…)
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#1880 Disease outcomes associated with decreased estimated glomerular filtration rate: a Phenome-wide association study Nephrol Dial Transplant

AbstractBackground and AimsThis study aimed to identify associations between decreased creatinine-based estimated glomerular filtration rate (eGFR) and a broad range of related outcomes.MethodPolygenic risk score (PRS) was calculated using PLINK1.9 software according to the tutorial with summing (…)
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#2979 Patients referred to nephrology consultation from African countries of Portuguese official language: a Portuguese single-center cohort study Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is a main cause of morbidity and mortality worldwide, with African population being at increased risk. Nevertheless, access to treatment for CKD is restricted in African countries resulting in premature death. The latest statistics point to (…)
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#1637 Diverging trends in kidney replacement therapy (KRT) incidence in Madrid and Catalonia in the past decade Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is one of the fastest growing global causes of death and the number of persons on KRT is increasing. A critical assessment of current clinical practice across regions may identify best clinical practice, providing a benchmark to improve (…)
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#2649 Blood pressure tend to decrease following COVID-19 infection in patients with chronic kidney disease—lessons learned from a community based cohort Nephrol Dial Transplant

AbstractBackground and AimsPre-existing hypertension (HTN) has been implicated as one of the most common co-morbidities in COVID-19 patients, likely contributing to disease severity. Additionally, the port of viral entry to the host cell—ACE2 receptor, which is a part of the (…)
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#986 Sarcopenia and chronic kidney disease among adults over 45 years old: findings from CHARLS Nephrol Dial Transplant

AbstractBackground and AimsLittle is known about the association between sarcopenia and chronic kidney disease (CKD) among Chinese adults older than 45. The present study sought to investigate the relationship between sarcopenia and CKD based on a large, nationally representative (…)
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#2590 Electrolyte abnormalities in HIV patients with CKD Nephrol Dial Transplant

AbstractBackground and AimsIndividuals with HIV infection and CKD are prone to various water & electrolyte disorders with previous studies showing prevalence of 70%. Many of these disturbances remain clinically silent until they reach an advanced stage, emphasizing the need for a high level (…)
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#2661 High albuminuria in CKD: prevalence and characteristics in a real-world clinical setting Nephrol Dial Transplant

AbstractBackground and AimsChronic kidney disease (CKD) is estimated to affect 1 in 10 adults globally. CKD is associated with increased morbidity, mortality and decreased quality of life, and places a financial burden on the healthcare system. Furthermore, persistently high albuminuria is (…)
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#2617 Impact of CKD screening in high?risk populations and guideline-directed therapy on RRT, CV events, and mortality in Europe: an IMPACT CKD analysis Nephrol Dial Transplant

AbstractBackground and AimsDespite the rising and substantial burden of chronic kidney disease (CKD), there is a lack of recognition of CKD as a health priority in Europe. This contributes to underdiagnosis of CKD despite the potential for early detection and effective intervention to delay (…)
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#2840 Early tolerance of SGLT2i therapy in patients with ATTR V30M amyloidosis: staging the disease to establish standard of care Nephrol Dial Transplant

AbstractBackground and AimsStudies of sodium-glucose co-transporter 2 inhibitors (SGLT2i) therapy on ATTR cardiomyopathy are scarce and focus wild-type and V122I. In ATTRv, namely V30M, SGLT2i introduction to preserve kidney function or improve cardiorenal syndrome is not an outlined practice. (…)
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#689 Obinutuzumab in patients with previously untreated primary membranous nephropathy Nephrol Dial Transplant

AbstractBackground and AimsPrimary membranous nephropathy (PMN) is the most common cause of nephrotic syndrome (NS) in adults and is currently considered an autoimmune-related disease. B cell depleting treatments, currently the most commonly used is rituximab, are usually effective in treating (…)
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#2640 Hyperuricemia in Gitelman syndrome 132 patients Nephrol Dial Transplant

AbstractBackground and AimsThiazide diuretics, the most common prescription for hypertension, were partly restricted by the hyperuricemia induced by the impairment of uric acid clearance serum uric acid. Gitelman syndrome (GS, OMIM263800), caused by mutations of the SLC12A3 gene encodes the (…)
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#2862 Genetics and electron microscopy: complementary tools for management of focal segmental glomerulosclerosis? Nephrol Dial Transplant

AbstractBackground and AimsFocal segmental glomerular sclerosis (FSGS) defines a histologic lesion that represents a pattern of injury associated to different pathologic conditions affecting both children and adults. It is classified into primary forms, presumably immune-mediated, secondary (…)
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#1170 Efficacy and safety of telitacicept in IgA nephropathy: a real-world study Nephrol Dial Transplant

AbstractBackground and AimsIgA nephropathy (IgAN) is the most common primary glomerular disease in the world, and the specific therapeutic methods are limited in IgAN. Telitacicept is a humanized fusion protein composed of a transmembrane activator and calcium-modulating cyclophilin ligand (…)
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#145 Subgroup and secondary endpoint evaluation of a phase 2 randomized placebo-controlled trial of ravulizumab in IgA nephropathy Nephrol Dial Transplant

AbstractBackground and AimsThe pathogenesis of IgA nephropathy (IgAN) involves immune complex deposition and activation of the complement system, causing formation of the terminal pathway components C5a and C5b-9, leading to inflammation and glomerular damage. Elevated levels of activated C3 in (…)
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#1342 Updated results from the RUBY-3 study of povetacicept, an enhanced dual BAFF/APRIL antagonist, in autoantibody-associated glomerulonephritis Nephrol Dial Transplant

AbstractBackground and AimsInhibition of BAFF and/or APRIL has shown promise in IgA nephropathy (IgAN), systemic lupus erythematosus (SLE), lupus nephritis (LN), and primary membranous nephropathy (pMN), and has the potential to exert a disease-modifying effect. Povetacicept (ALPN-303) is an Fc (…)
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#123 Impact of atacicept on hematuria in IGA nephropathy: post-hoc analysis of the phase 2b ORIGIN study Nephrol Dial Transplant

AbstractBackground and AimsPatients with IgA nephropathy (IgAN) and persistent hematuria during follow up have a greater decline in renal function than those with minimal or no hematuria, while hematuria resolution has been independently associated with less decline in renal function [1, 2]. (…)

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23 mai

Nephrol Dial Transplant http://ndt.oxfordjournals.org/