99 articles
2 juillet
24 juin
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Potassium-Alkali–Enriched Diet, Hypertension, and Proteinuria following Uninephrectomy -
Ralph, Donna L.; Ha, Darren; Lei, Hillmin; Priver, Taylor S.; Smith, Scotti D.; McFarlin, Brandon E.; Schwindt, Seth; Pandya, Drishti; Koepsell, Hermann; Pastor-Soler, Nuria M.; Edwards, Aurelie; McDonough, Alicia A.
J Am Soc Nephrol
Background: Losing or donating a kidney is associated with risks of developing hypertension and albuminuria. Few studies address mechanisms or interventions. We investigate potential benefits of a K+- alkali–enriched diet and the mechanisms underlying proteinuria. Methods: Male Sprague Dawley (…) -- Original Article: Acid Base and Electrolyte Disorders
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Background: Chronic Angiotensin-II (Ang-II) perfusion stimulates Kir4.1/Kir5.1 of the DCT via angiotensin-II-type-1a-receptor (AT1aR) and low-sodium-intake also stimulates Kir4.1/Kir5.1. However, it is not explored the role of AT1aR in mediating the effect of LS on Kir4.1/Kir5.1. Methods: We (…) -- Original Article: Acid Base and Electrolyte Disorders
18 juin
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Association between Acute Declines in Estimated Glomerular Filtration Rate during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes -
Ku, Elaine; Tighiouart, Hocine; McCulloch, Charles E.; Inker, Lesley A.; Adingwupu, Ogechi; Greene, Tom; Estacio, Raymond O.; Woodward, Mark; de Zeeuw, Dick; Lewis, Julia B.; Hannedouche, Thierry; Hou, Fan Fan; Jafar, Tazeen H.; Ima, Enyu; Remuzzi, Guiseppe; Heerspink, Hiddo J.L.; Toto, Robert D.; Sarnak, Mark J.
J Am Soc Nephrol
Background: Declines in glomerular filtration rate (GFR) occur commonly when renin-angiotensin system (RAS) inhibitors are started. Our objective was to determine the relation between declines in estimated GFR during trials of RAS inhibition and kidney outcomes. Methods: We included participants (…) -- Original Article: Chronic Kidney Disease
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Estimated Effect of Restarting Renin-Angiotensin System Inhibitors after Discontinuation on Kidney Outcomes and Mortality -
Hattori, Koki; Sakaguchi, Yusuke; Oka, Tatsufumi; Asahina, Yuta; Kawaoka, Takayuki; Doi, Yohei; Hashimoto, Nobuhiro; Kusunoki, Yasuo; Yamamoto, Satoko; Yamato, Masafumi; Yamamoto, Ryohei; Matsui, Isao; Mizui, Masayuki; Kaimori, Jun-Ya; Isaka, Yoshitaka
J Am Soc Nephrol
Background: While renin-angiotensin system inhibitors (RASi) have been the mainstream treatment for patients with CKD, they are often discontinued due to adverse effects such as hyperkalemia and acute kidney injury. It is unknown whether restarting RASi after discontinuation improves clinical (…) -- Original Article: Chronic Kidney Disease
14 juin
12 juin
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Background Information on metabolomic profiles in kidney stone formers is limited. To examine independent associations between plasma metabolomic profiles and the risk of incident, symptomatic kidney stones in adults, we conducted prospective nested case-control studies in two large cohorts. (…) -- Original Article: Acid Base and Electrolyte Disorders
10 juin
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METTL3-Mediated N6-methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis -
Tsai, Yu-Cheng; Hsieh, Tsung-Han; Liao, Yuan-Ru; Tsai, Ming-Tsun; Lin, Tzu-Ping; Lee, Der-Yen; Park, Jihwan; Kim, Donggun; Susztak, Katalin; Yang, Shang-Feng; Lin, Chih-Ching; Li, Szu-Yuan
J Am Soc Nephrol
Background Chemical modifications on RNA profoundly impact RNA function and regulation. m6A, the most abundant RNA modification in eukaryotes, plays a pivotal role in diverse cellular processes and disease mechanisms. However, its importance is understudied in human chronic kidney disease (CKD) (…) -- Original Article: Genetics
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Kidney Volume and Risk of Incident Kidney Outcomes -
Wu, Jianhan; Wang, Yifan; Vlasschaert, Caitlyn; Lali, Ricky; Feiner, James; Gaheer, Pukhraj; Yang, Serena; Perrot, Nicolas; Chong, Michael; Paré, Guillaume; Lanktree, Matthew B.
J Am Soc Nephrol
Background: Low total kidney volume (TKV) is a risk factor for chronic kidney disease (CKD). However, evaluations of nonlinear relationships, incident events, causal inference, and prognostic utility beyond traditional biomarkers are lacking. Methods: TKV, height-adjusted TKV, and body surface (…) -- Original Article: Chronic Kidney Disease
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7 juin
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Key Points Polycystic kidney disease (PKD) is characterized by continuous cyst growth, which results in a decline in kidney function.Deletion of P2Y2R and pharmacological antagonism of purinergic signaling significantly reduced cyst growth in an orthologous PKD mouse model.P2Y2R was expressed in (…) -- Basic Research: Cystic Kidney Disease
6 juin
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Glomerular Endothelial Cell Receptor ADGRF5 and the Integrity of the Glomerular Filtration Barrier -
Nagase, Miki; Ando, Hikaru; Beppu, Yoshiaki; Kurihara, Hidetake; Oki, Souta; Kubo, Fumimasa; Yamamoto, Kazuki; Nagase, Takashi; Kaname, Shinya; Akimoto, Yoshihiro; Fukuhara, Hiroshi; Sakai, Tatsuo; Hirose, Shigehisa; Nakamura, Nobuhiro
J Am Soc Nephrol
Background: Glomerular endothelial cells are recognized to be important for maintaining the glomerular filtration barrier. ADGRF5, an adhesion G protein-coupled receptor, has been suggested to be involved in endothelial cell function. However, the role of ADGRF5 in the glomerular filtration (…) -- Original Article: Normal Kidney Structure and Function
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Serum and Urine Metabolites and Kidney Function -
Yeo, Wan-Jin; Surapaneni, Aditya L.; Hasson, Denise; Schmidt, Insa M.; Sekula, Peggy; Köttgen, Anna; Eckardt, Kai-Uwe; Rebholz, Casey M.; Yu, Bing; Waikar, Sushrut S.; Rhee, Eugene P.; Schrauben, Sarah J.; Feldman, Harold I.; Vasan, Ramachandran S.; Kimmel, Paul L.; Coresh, Josef; Grams, Morgan E.; Schlosser, Pascal
J Am Soc Nephrol
Background Metabolites represent a read-out of cellular processes underlying states of health and disease. Methods We evaluated cross-sectional and longitudinal associations between 1255 serum and 1398 urine known and unknown (denoted with “X” in name) metabolites (Metabolon HD4, 721 detected in (…) -- Original Article: Chronic Kidney Disease
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3 juin
31 mai
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MondoA and AKI and AKI-to-CKD Transition -
Maeda, Shihomi; Sakai, Shinsuke; Takabatake, Yoshitsugu; Yamamoto, Takeshi; Minami, Satoshi; Nakamura, Jun; Namba-Hamano, Tomoko; Takahashi, Atsushi; Matsuda, Jun; Yonishi, Hiroaki; Matsui, Sho; Imai, Atsuhiro; Edahiro, Ryuya; Yamamoto-Imoto, Hitomi; Matsui, Isao; Takashima, Seiji; Imamura, Ryoichi; Nonomura, Norio; Yanagita, Motoko; Okada, Yukinori; Ballabio, Andrea; Nakamura, Shuhei; Yoshimori, Tamotsu; Isaka, Yoshitaka
J Am Soc Nephrol
Key Points The expression of MondoA was decreased in the renal tubules of patients with CKD.Genetic ablation of MondoA in proximal tubules inhibited autophagy and increased vulnerability to AKI through increased expression of Rubicon.MondoA ablation during the recovery phase after (…) -- Basic Research: Acute Kidney Injury and ICU Nephrology
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Key Points Maintaining parathyroid gland integrity is a dynamic process regulated by the parathyroid microRNA–mechanistic target of rapamycin complex 1 axis.This axis is essential for preserving intact parathyroid glands throughout life, with relevance to CKD-induced secondary (…) -- Basic Research: Chronic Kidney Disease
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30 mai
29 mai
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Lipolysis-Stimulated Lipoprotein Receptor in Proximal Tubule, BMP-SMAD Signaling, and Kidney Disease -
Jiang, Min; Wang, Xiangdong; Chen, Zhenni; Wang, Xin; An, Yanan; Ding, Lixia; Xu, Mengyuan; Fan, Baozhen; Jiao, Peng; Wang, Chao; Wang, Mingxia; Sun, Hui; Zhao, Shengtian; Gong, Yongfeng
J Am Soc Nephrol
Key Points We identify that lipolysis-stimulated lipoprotein receptor is highly enriched in the nucleus of mouse and human kidney.This study provides new insights into the role of lipolysis-stimulated lipoprotein receptor in kidney disease. Background Lipolysis-stimulated lipoprotein receptor (…) -- Basic Research: Chronic Kidney Disease
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25 mai
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Effect of Avenciguat on Albuminuria in Patients with CKD: Two Randomized Placebo-Controlled Trials -
Heerspink, Hiddo J.L.; Cherney, David; Gafor, Abdul Halim Abdul; Górriz, Jose Luis; Pergola, Pablo E.; Tang, Sydney C.W.; Desch, Marc; Iliev, Hristo; Sun, Zhichao; Steubl, Dominik; Nangaku, Masaomi
J Am Soc Nephrol
Key Points Despite new treatments for CKD, kidney failure risk remains high, particularly where albuminuria remains.We report a prespecified pooled analysis of two randomized controlled trials assessing a soluble guanylate cyclase activator for CKD.Avenciguat led to improvements in albuminuria (…) -- Clinical Research: Chronic Kidney Disease
24 mai
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Key Points High K stimulates mechanistic target of rapamycin complex 2 (mTORc2) in the distal convoluted tubule (DCT).Inhibition of mTORc2 decreased the basolateral Kir4.1/Kir5.1 and Na-Cl cotransporter in the DCT.Inhibition of mTORc2 of the DCT compromised kidneys' ability to excrete potassium (…) -- Basic Research: Acid Base and Electrolyte Disorders
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Background: Renal mTORc2 plays a role in regulating renal K+-excretion (renal-EK) and K+-homeostasis. Inhibition of renal mTORc2 caused hyperkalemia due to suppressing epithelial-Na+-channel (ENaC) and ROMK (Kir1.1) in the collecting duct. We now explore whether mTORc2 of DCT regulates (…) -- Original Article: Acid Base and Electrolyte Disorders
22 mai
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Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes -
Leroy, Claire; Lang, Konrad; Spitz, Dominik; Milosavljevic, Julian; Heinkele, Helena; Kayser, Séverine; Helmstädter, Martin; Walz, Gerd; Ulbrich, Maximilian H.; Hermle, Tobias
J Am Soc Nephrol
Key Points Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier.Silencing of Drosophila laminin and collagen IV genes reduced the density of slit diaphragms in nephrocytes, showing a direct effect of the (…) -- Basic Research: Genetics
21 mai
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Protein N-Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease -
Veli?kovi?, Dušan; Shapiro, John P.; Parikh, Samir V.; Rovin, Brad; Toto, Robert D.; Vazquez, Miguel A.; Poggio, Emilio D.; O'Toole, John F.; Sedor, John R.; Alexandrov, Theodore; Jain, Sanjay; Bitzer, Markus; Hodgin, Jeffrey; Veli?kovi?, Marija; Sharma, Kumar; Anderton, Christopher R.; for the Kidney Precision Medicine Project
J Am Soc Nephrol
Key Points Multiomics performed on diabetic kidney disease biopsies revealed five N-glycan signatures of sclerotic glomeruli that significantly differed compared with healthy glomeruli.Integrative spatial glycomics, proteomics, and transcriptomics revealed protein N-glycosylation characteristic (…) -- Basic Research: Chronic Kidney Disease
20 mai
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Climate Change, Kidney Health, and Environmentally Sustainable Kidney Care: A Multinational Survey of Health Care Professionals -
Sandal, Shaifali; Ethier, Isabelle; Onu, Ugochi; Fung, Winston; Bajpai, Divya; Bilchut, Workagegnehu Hailu; Bagasha, Peace; De Chiara, Letizia; Hafiz, Ehab; Smyth, Brendan; Kelly, Dearbhla; Pippias, Maria; Jha, Vivekanand
J Am Soc Nephrol
Key Points A multinational survey of health care professionals on the kidney health impacts of climate change and the environmental burden of kidney care was conducted.Most participants reported knowledge gaps and high level of concern on these interconnected issues.Only a minority report (…) -- Clinical Research: Clinical Nephrology
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15 mai
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Individualized Risk of CKD Progression among US Adults -
Tio, Maria Clarissa; Butler, Javed; Zhu, Xiaoqian; Obi, Yoshitsugu; Yen, Timothy E.; Kalantar-Zadeh, Kamyar; Streja, Elani; Dossabhoy, Neville R.; Hall, Michael E.; Shafi, Tariq
J Am Soc Nephrol
Key Points A total of 8.42 million US adults have high CKD progression risk, and 4.77 million of them have eGFR >60 ml/min per 1.73 m2.An individual's absolute risk of CKD progression is important in the diagnosis and prognostication of CKD. Background CKD is currently defined using GFR or (…) -- Clinical Research: Chronic Kidney Disease
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Individualized Risk for CKD Progression among US Adults -
Tio, Maria Clarissa; Butler, Javed; Zhu, Xiaoqian; Obi, Yoshitsugu; Yen, Timothy E.; Kalantar-Zadeh, Kamyar; Streja, Elani; Dossabhoy, Neville R.; Hall, Michael E.; Shafi, Tariq
J Am Soc Nephrol
Background: Chronic kidney disease (CKD) is currently defined using glomerular filtration rate (GFR) or albuminuria. This is based on the relative risk of mortality and kidney outcomes compared to a healthy population and does not consider an individual’s absolute risk of CKD progression. (…) -- Original Article: Chronic Kidney Disease
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9 mai
7 mai
6 mai
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Mounting evidence indicates that monogenic disorders are the underlying cause in a significant proportion of patients with CKD. In recent years, the diagnostic yield of genetic testing in these patients has increased significantly as a result of revolutionary developments in genetic sequencing (…) -- Mechanisms of Kidney Diseases
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Complement Terminal Pathway Activation and Intrarenal Immune Response in C3 Glomerulopathy -
Meuleman, Marie-Sophie; Petitprez, Florent; Pickering, Matthew C.; Le Quintrec, Moglie; Artero, Mikel Rezola; Duval, Anna; Rabant, Marion; Gilmore, Alyssa; Boyer, Olivia; Hogan, Julien; Servais, Aude; Provot, François; Gnemmi, Vivianne; Eloudzeri, Maeva; Grunenwald, Anne; Buob, David; Boffa, Jean-Jacques; Moktefi, Anissa; Audard, Vincent; Goujon, Jean-Michel; Bridoux, Frank; Thervet, Eric; Karras, Alexandre; Roumenina, Lubka T.; Frémeaux Bacchi, Véronique; Duong Van Huyen, Jean-Paul; Chauvet, Sophie
J Am Soc Nephrol
Key Points We evidenced terminal pathway activation (C5b-9 deposits) in most of the glomeruli on kidney biopsy of C3 glomerulopathy.The amount of C5b-9 deposits correlated with disease prognosis in C3 glomerulopathy.Increased terminal pathway activation was found predominantly in a subgroup (…) -- Basic Research: Glomerular and Tubulointerstitial Diseases
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Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants -
Yoshida, Teruhiko; Latt, Khun Zaw; Santo, Briana A.; Shrivastav, Shashi; Zhao, Yongmei; Fenaroli, Paride; Chung, Joon-Yong; Hewitt, Stephen M.; Tutino, Vincent M.; Sarder, Pinaki; Rosenberg, Avi Z.; Winkler, Cheryl A.; Kopp, Jeffrey B.
J Am Soc Nephrol
Key Points Apolipoprotein L1 (APOL1)-G1 induced kidney disease in the two APOL1 transgenic mouse models, HIV-associated nephropathy and IFN-? administration.Glomerular single-nuclear RNA-sequencing identified genes differentially expressed among mice with APOL1-G1 and G0 variants at single-cell (…) -- Basic Research: Glomerular and Tubulointerstitial Diseases
2 mai
30 avril
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Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury -
Xue, Rui; Yiu, Wai Han; Chan, Kam Wa; Lok, Sarah W.Y.; Zou, Yixin; Ma, Jingyuan; Li, Hongyu; Chan, Loretta Y.Y.; Huang, Xiao Ru; Lai, Kar Neng; Lan, Hui Yao; Tang, Sydney C.W.
J Am Soc Nephrol
Key Points Long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) was upregulated in human and murine AKI. It returned to baseline after recovery in humans. Its knockdown preserved kidney function in animals.In vitro, LPS upregulated NEAT1 by TLR4/NF-?B signaling and caused (…) -- Basic Research: Acute Kidney Injury and ICU Nephrology
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Key Points A multiancestry proteome-wide Mendelian randomization analysis was conducted for IgA nephropathy.The findings from the study would help prioritize new drug targets and drug-repurposing opportunities. Background The therapeutic options for IgA nephropathy are rapidly evolving, but (…) -- Basic Research: Chronic Kidney Disease
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Long Non-coding RNA Neat1, NLRP3 Inflammasome, and Acute Kidney Injury -
Xue, Rui; Yiu, Wai Han; Chan, Kam Wa; Lok, Sarah W.Y.; Zou, Yixin; Ma, Jingyuan; Li, Hongyu; Chan, Loretta Y.Y.; Huang, Xiao Ru; Lai, Kar Neng; Lan, Hui Yao; Tang, Sydney C.W.
J Am Soc Nephrol
Background Acute kidney injury (AKI) is common in hospitalized patients and is associated with high mortality. Inflammation plays a key role in the pathophysiology of AKI. Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of the inflammatory and immune response, but its (…) -- Original Article: Acute Kidney Injury and ICU Nephrology
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Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early diagnosis and targeted treatment remain challenging. We aimed to identify circulating plasma proteins associated with IgA nephropathy by proteome-wide mendelian randomization studies across multiple (...) -- Original Article: Chronic Kidney Disease
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26 avril
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Key Points Automated peritoneal dialysis (APD) had a higher carbon impact than continuous ambulatory peritoneal dialysis (CAPD).This was due to higher emissions from the manufacture and disposal of APD consumables, and their higher weight, meaning greater transport emissions.Polyvinyl chloride (…) -- Clinical Research: Dialysis
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Neighborhood Racial and Ethnic Segregation and the Risk of Dementia in Older Adults Living with Kidney Failure -
Li, Yiting; Menon, Gayathri; Long, Jane J.; Chen, Yusi; Metoyer, Garyn T.; Wu, Wenbo; Crews, Deidra C.; Purnell, Tanjala S.; Thorpe, Roland J. Jr.; Hill, Carl V.; Szanton, Sarah L.; Segev, Dorry L.; McAdams-DeMarco, Mara A.
J Am Soc Nephrol
Key Points Regardless of race and ethnicity, older adults with kidney failure residing in or receiving care at dialysis facilities located in high-segregation neighborhoods were at a 1.63-fold and 1.53-fold higher risk of dementia diagnosis, respectively.Older adults with kidney failure residing (…) -- Clinical Research: Dialysis
24 avril
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Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria -
Faivre, Anna; Bugarski, Milica; Rinaldi, Anna; Sakhi, Imene B.; Verissimo, Thomas; Legouis, David; Correia, Sara; Kaminska, Monika; Dalga, Delal; Malpetti, Daniele; Cippa, Pietro E.; de Seigneux, Sophie; Hall, Andrew M.
J Am Soc Nephrol
Key Points Glomerular proteinuria induces large-scale changes in gene expression along the nephron.Increased protein uptake in the proximal tubule results in axial remodeling and injury.Increased protein delivery to the distal tubule causes dedifferentiation of the epithelium. Background Large (…) -- Basic Research: Chronic Kidney Disease
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Plasma Proteins Associated with Chronic Histopathologic Lesions on Kidney Biopsy -
Kim, Taesoo; Surapaneni, Aditya L.; Schmidt, Insa M.; Eadon, Michael T.; Kalim, Sahir; Srivastava, Anand; Palsson, Ragnar; Stillman, Isaac E.; Hodgin, Jeffrey B.; Menon, Rajasree; Otto, Edgar A.; Coresh, Josef; Grams, Morgan E.; Waikar, Sushrut S.; Rhee, Eugene P.; for the Kidney Precision Medicine Project
J Am Soc Nephrol
Key Points Proteomic profiling identified 35 blood proteins associated with chronic histopathologic lesions in the kidney.Testican-2 was expressed in the glomerulus, released by the kidney into circulation, and inversely associated with glomerulosclerosis severity.NELL1 was expressed in tubular (…) -- Clinical Research: Chronic Kidney Disease
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Key Points Our study reveals segment-specific mechanisms in cystic kidney disease and suggests Grhl2 as a modifier of collecting duct–derived cyst progression.Our data demonstrate that genetic deletion of Grhl2 accelerates disease progression in a cystic mouse model. Background The transcription (…) -- Basic Research: Cystic Kidney Disease
23 avril
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In response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney Tutored Research and Education for Kidney Scholars (TREKS) to stimulate interest in nephrology among medical students, graduate students, and postdoctoral (…) -- Special Article
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The number of patients with AKI receiving outpatient hemodialysis (AKI-D) is increasing. At present, on the basis of limited data, approximately one third of patients with AKI-D who receive outpatient dialysis after hospital discharge survive and regain sufficient kidney function to discontinue (…) -- Review
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In response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney TREKS (Tutored Research and Education for Kidney Scholars) to stimulate interest in nephrology among medical students, graduate students, and postdoctoral (...) -- Special Article
19 avril
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The Clinical Relevance of the Infiltrating Immune Cell Composition in Kidney Transplant Rejection -
Vaulet, Thibaut; Callemeyn, Jasper; Lamarthée, Baptiste; Antoranz, Asier; Debyser, Tim; Koshy, Priyanka; Anglicheau, Dany; Colpaert, Jill; Gwinner, Wilfried; Halloran, Philip F.; Kuypers, Dirk; Tinel, Claire; Van Craenenbroeck, Amaryllis; Van Loon, Elisabet; Marquet, Pierre; Bosisio, Francesca; Naesens, Maarten
J Am Soc Nephrol
Key Points The estimated composition of immune cells in kidney transplants correlates poorly with the primary rejection categories defined by Banff criteria.Spatial cell distribution could be coupled with a detailed cellular composition to assess causal triggers for allorecognition.Intragraft (…) -- Basic Research: Transplantation
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Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression -
Schlosser, Pascal; Surapaneni, Aditya L.; Borisov, Oleg; Schmidt, Insa M.; Zhou, Linda; Anderson, Amanda; Deo, Rajat; Dubin, Ruth; Ganz, Peter; He, Jiang; Kimmel, Paul L.; Li, Hongzhe; Nelson, Robert G.; Porter, Anna C.; Rahman, Mahboob; Rincon-Choles, Hernan; Shah, Vallabh; Unruh, Mark L.; Vasan, Ramachandran S.; Zheng, Zihe; Feldman, Harold I.; Waikar, Sushrut S.; Köttgen, Anna; Rhee, Eugene P.; Coresh, Josef; Grams, Morgan E.; on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators and the CKD Biomarkers Consortium
J Am Soc Nephrol
Key Points Integrated analysis of proteome and metabolome identifies modules associated with CKD progression and kidney failure.Ephrin transmembrane proteins and podocyte-expressed CRIM1 and NPNT emerged as central components and warrant experimental and clinical investigation. Background (…) -- Clinical Research: Chronic Kidney Disease
17 avril
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Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells -
Maxwell, Scott; Okabe, Jun; Kaipananickal, Harikrishnan; Rodriguez, Hanah; Khurana, Ishant; Al-Hasani, Keith; Chow, Bryna S.M.; Pitsillou, Eleni; Karagiannis, Tom C.; Jandeleit-Dahm, Karin; Ma, Ronald C.W.; Huang, Yu; Chan, Juliana C.N.; Cooper, Mark E.; El-Osta, Assam
J Am Soc Nephrol
Key Points Set7 knockout improves diabetic glomerular structure and function and prevents diabetes-induced endothelial–mesenchymal transition (EDMT) by regulating Igfbp5.Set7 knockdown prevents, and (R)-PFI-2 hydrochloride reverses, diabetes-induced EDMT by regulating insulin growth factor (...) -- Basic Research: Diabetes and the Kidney
16 avril
15 avril
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Key Points We constructed a single-cell long noncoding RNA atlas of various tissues, including normal and aged kidneys.We identified age- and cell type–specific expression changes of long noncoding RNAs in kidney cells. Background Accumulated evidence demonstrates that long noncoding RNAs (…) -- Basic Research: Genetics
11 avril
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Key Points In this post hoc analysis of a randomized controlled trial, the proton pump inhibitor pantoprazole led to a faster rate of eGFR decline as compared with placebo.Additional studies are needed to determine the effect of proton pump inhibitors on those at higher risk of adverse kidney (…) -- Clinical Research: Chronic Kidney Disease
10 avril
9 avril
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The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline -
Wang, Meng; Tang, W.H. Wilson; Li, Xinmin S.; de Oliveira Otto, Marcia C.; Lee, Yujin; Lemaitre, Rozenn N.; Fretts, Amanda; Nemet, Ina; Sotoodehnia, Nona; Sitlani, Colleen M.; Budoff, Matthew; DiDonato, Joseph A.; Wang, Zeneng; Bansal, Nisha; Shlipak, Michael G.; Psaty, Bruce M.; Siscovick, David S.; Sarnak, Mark J.; Mozaffarian, Dariush; Hazen, Stanley L.
J Am Soc Nephrol
Key Points In community-based US adults, higher plasma trimethylamine N-oxide levels associated with higher risk of incident CKD and greater rate of kidney function decline.Findings from our study support future clinical trials to examine whether lowering plasma trimethylamine N-oxide levels (...) -- Clinical Research: Chronic Kidney Disease
8 avril
26 mars
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Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31 -
Silvaroli, Josie A.; Bisunke, Bijay; Kim, Ji Young; Stayton, Amanda; Jayne, Laura A.; Martinez, Shirely A.; Nguyen, Christopher; Patel, Prisha S.; Vanichapol, Thitinee; Verma, Vivek; Akhter, Juheb; Bolisetty, Subhashini; Madhavan, Sethu M.; Kuscu, Cem; Coss, Christopher C.; Zepeda-Orozco, Diana; Parikh, Samir V.; Satoskar, Anjali A.; Davidson, Alan J.; Eason, James D.; Szeto, Hazel H.; Pabla, Navjot S.; Bajwa, Amandeep
J Am Soc Nephrol
Key Points Szeto–Schiller-31–mediated mitoprotection is phospholipid scramblase 3–dependent.Phospholipid scramblase 3 is required for recovery after AKI. Background The synthetic tetrapeptide Szeto–Schiller (SS)-31 shows promise in alleviating mitochondrial dysfunction associated with common (...) -- Basic Research: Acute Kidney Injury and ICU Nephrology
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Key Points Loss of Rab35 leads to nonobstructive hydronephrosis because of loss of ureter epithelium.Rab35 regulates kidney and ureter epithelial cell adhesion and polarity.Rab35 is required for embryonic development. Background Rab35 is a member of a GTPase family of endocytic trafficking (...) -- Basic Research: Development of the Kidney
22 mars
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Decision-Making Engagement Preferences among Older Adults with CKD -
Gonzales, Kristina M.; Koch-Weser, Susan; Kennefick, Kristen; Lynch, Mary; Porteny, Thalia; Tighiouart, Hocine; Wong, John B.; Isakova, Tamara; Rifkin, Dena E.; Gordon, Elisa J.; Rossi, Ana; Weiner, Daniel E.; Ladin, Keren
J Am Soc Nephrol
Key Points Clinicians’ uncertainty about the degree to which older patients prefer to engage in decision making remains a key barrier to shared decision making.Most older adults with advanced CKD preferred a collaborative or active role in decision making. Background Older adults with kidney (...) -- Clinical Research: Dialysis
21 mars
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Development and Validation of Staging Systems for AA Amyloidosis -
Basset, Marco; Schönland, Stefan O.; Obici, Laura; Günther, Janine; Riva, Eloisa; Dittrich, Tobias; Milani, Paolo; Ferretti, Virginia Valeria; Pasquinucci, Ettore; Foli, Andrea; Kimmich, Christoph; Nanci, Martina; Bellofiore, Claudia; Benigna, Francesca; Beimler, Jörg; Benvenuti, Pietro; Fabris, Francesca; Mussinelli, Roberta; Nuvolone, Mario; Klersy, Catherine; Albertini, Riccardo; Merlini, Giampaolo; Hegenbart, Ute; Palladini, Giovanni; Blank, Norbert
J Am Soc Nephrol
Key Points Patients with AA amyloidosis and age ?65 years, eGFR 1000 ng/L and/or type-B natriuretic peptide >130 ng/L at diagnosis have poorer survival.Proteinuria >3.0 g/24 hours and eGFR 130 ng/L and/or N-terminal type-B natriuretic peptide >1000 ng/L) were associated with overall survival (...) -- Clinical Research: Chronic Kidney Disease
19 mars
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06:00
WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts -
Chen, Huimei; You, Ran; Guo, Jing; Zhou, Wei; Chew, Gabriel; Devapragash, Nithya; Loh, Jui Zhi; Gesualdo, Loreto; Li, Yanwei; Jiang, Yuteng; Tan, Elisabeth Li Sa; Chen, Shuang; Pontrelli, Paola; Pesce, Francesco; Behmoaras, Jacques; Zhang, Aihua; Petretto, Enrico
J Am Soc Nephrol
Key Points WWP2 expression is elevated in the tubulointerstitium of fibrotic kidneys and contributes to CKD pathogenesis and progression.WWP2 uncouples the profibrotic activation and cell proliferation in renal myofibroblasts.WWP2 controls mitochondrial respiration in renal myofibroblasts (...) -- Basic Research: Chronic Kidney Disease
29 février
27 février
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07:00
Key Points In hemodialysis, ondansetron initiation versus initiation of lesser QT-prolonging antiemetics associated with higher 10-day sudden cardiac death risk.Analyses considering additional cardiac outcomes had consistent findings. Background Individuals receiving hemodialysis have a high (...) -- Clinical Research: Dialysis
14 février
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07:00
Kidney injury molecule-1 (KIM-1), also known as T-cell Ig and mucin domain-1 (TIM-1), is a widely recognized biomarker for AKI, but its biological function is less appreciated. KIM-1/TIM-1 belongs to the T-cell Ig and mucin domain family of conserved transmembrane proteins, which bear the (...) -- Mechanisms of Kidney Diseases
7 février
13 décembre
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07:00
Background In the phase 2 RESCUE clinical trial, ziltivekimab, a fully human monoclonal antibody against the IL-6 ligand, significantly reduced the biomarkers of inflammation compared with placebo, in patients with CKD and systemic inflammation (high-sensitivity C-reactive protein ?2 mg/L). The (…) -- Clinical Research: Chronic Kidney Disease
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