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The mineralocorticoid hormone aldosterone plays a major role in sodium and potassium homeostasis and blood volume regulation. Aldosterone binds to the mineralocorticoid receptor (MR) in the cytosol, and this complex translocates into the nucleus and binds to DNA, regulating target gene (…) (Kidney International 105, 6 (2024))
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In diabetic and nondiabetic glomerular disease, the magnitude of the reduction of podocyte numbers is a critical determinant in the development of glomerulosclerosis. Experimental studies show that a decline of podocyte numbers by 21%–40% leads to mild persistent proteinuria and focal segmental (…) (Kidney International 105, 6 (2024))
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A 61-year-old man presented to the emergency department with a 1-week history of low back pain. Three years prior, he had been diagnosed with myeloperoxidase–antineutrophil cytoplasmic-associated vasculitis, with normal kidney function, and had received term treatment with prednisone and (…) (Kidney International 105, 6 (2024))
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A 79-year-old man with lung cancer treated with chemotherapy was admitted for acute kidney injury. One week before admission, the patient was aware of abdominal distension and difficulty urinating. Admission laboratory tests showed serum creatinine level of 8.92 mg/dl (baseline, 0.94 mg/dl), (…) (Kidney International 105, 6 (2024))
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Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms’ tumor 1, and worsened podocyte injury in a (…) (Kidney International 105, 6 (2024))
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In this commentary, a novel approach to the reclassification of chronic kidney disease is reviewed. In the revisited study, the investigators identify 4 distinct subtypes of kidney disease derived from an unbiased self-organizing map of transcriptomic data from kidney biopsy samples. These (…) (Kidney International 105, 6 (2024))
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We thank Rovira et al.1 for their interest in our recent work.2 We fully agree that the use of chimeric autoantibody receptor (CAAR) cells, which specifically target pathogenic B-cell clones, represents a highly innovative therapeutic strategy for antibody-mediated diseases. In this direction, (…) (Kidney International 105, 6 (2024))
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We read with interest the research letter by Seifert et al.1 recently published in Kidney International. They demonstrated the basic efficacy of PLA2R1- and THSD7A-based chimeric autoantibody receptor (CAAR) natural killer (NK) and T cells for the antigen-specific elimination of (…) (Kidney International 105, 6 (2024))
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A 38-year-old man with active IV heroin use presented with progressive lethargy and an evolving rash on his extremities for 1 week. The patient was afebrile and hemodynamically stable. Examination revealed multiple, painful purpuric lesions on his fingertips with painful petechiae on his upper (…) (Kidney International 105, 6 (2024))
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In the healthy adult kidney, cellular homeostasis is maintained by the balance between nutrient surplus and nutrient deprivation signaling.1 The primary nutrient deprivation signals are sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK), which are activated by low intracellular (…) (Kidney International 105, 6 (2024))
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Sodium-glucose cotransporter-2 (SGLT2) inhibitors were introduced a decade ago for the treatment of type 2 diabetes (T2D) and have emerged as a key therapy for the treatment of chronic kidney disease (CKD). In trials with primary kidney end points, SGLT2 inhibitors reduced the composite of (…) (Kidney International 105, 6 (2024))
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The Oxford histopathologic classification (MEST-C: scores for lesions indicating active glomerular inflammation, mesangial [M] and endocapillary [E] hypercellularity as well as cellular or fibrocellular crescents [C], and for segmental glomerulosclerosis [S] and interstitial fibrosis and/or (…) (Kidney International 105, 6 (2024))
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Measurement of glomerular filtration rate (GFR) is crucial in assessing kidney function status. Estimating GFR using clearance methodologies is cumbersome, as plasma and urinary concentrations and timed urine collections are required. Recently, a transcutaneous sensor has been developed whereby (…) (Kidney International 105, 6 (2024))
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Lafayette et al. report on the progress of the ORIGIN trial (ClinicalTrials.gov: NCT04716231), a phase 2B study of atacicept for the treatment of IgA nephropathy (IgAN). Atacicept inhibits the B-cell survival factors B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). (…) (Kidney International 105, 6 (2024))
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Shohei Ohtani became an amazing 2-way player in a modern-day game of baseball that basically never sees them, and he won his second American League most valuable player award unanimously in 2023. (Kidney International 105, 6 (2024))
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Colombijn et al. (Representation of patients with chronic kidney disease in clinical trials of cardiovascular disease medications: a systematic review. JAMA Netw Open. 2024;7:e240427.) (Kidney International 105, 6 (2024))
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DOI of original article: https://doi.org/10.1016/j.kint.2024.01.018 (Kidney International 105, 6 (2024))
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(Kidney International 105, 6 (2024))
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(Kidney International 105, 6 (2024))
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(Kidney International 105, 6 (2024))